Rapid Transcription Fosters Coordinate snail Expression in the Drosophila Embryo

Cell Reports

Volumn 3, Issue 1, 2013, Pages 8-15

  Boettiger, Alistair Nicol ^a   Levine, Michael ^b  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR SNAIL;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO PATTERN FORMATION; GASTRULATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMAGE PROCESSING; IN SITU HYBRIDIZATION; MESODERM; NONHUMAN; PRIORITY JOURNAL; SNAIL GENE;

ANIMALS; DOSAGE COMPENSATION, GENETIC; DROSOPHILA MELANOGASTER; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; KINETICS; MESODERM; PROTEIN BINDING; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

GASTROPODA;

EID: 84873115462     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.12.015     Document Type: Article

References (24)

1. Ardehali M.B., Lis J.T. Tracking rates of transcription and splicing in vivo. Nat. Struct. Mol. Biol. 2009, 16:1123-1124.
2. Boettiger A.N., Levine M. Synchronous and stochastic patterns of gene activation in the Drosophila embryo. Science 2009, 325:471-473.
3. Boettiger A.N., Ralph P.L., Evans S.N. Transcriptional regulation: effects of promoter proximal pausing on speed, synchrony and reliability. PLoS Comput. Biol. 2011, 7:e1001136.
4. Darzacq X., Shav-Tal Y., de Turris V., Brody Y., Shenoy S.M., Phair R.D., Singer R.H. In vivo dynamics of RNA polymerase II transcription. Nat. Struct. Mol. Biol. 2007, 14:796-806.
5. Davis I., Ish-Horowicz D. Apical localization of pair-rule transcripts requires 3' sequences and limits protein diffusion in the Drosophila blastoderm embryo. Cell 1991, 67:927-940.
6. Golding I., Paulsson J., Zawilski S.M., Cox E.C. Real-time kinetics of gene activity in individual bacteria. Cell 2005, 123:1025-1036.
7. Itzkovitz S., Lyubimova A., Blat I.C., Maynard M., van Es J., Lees J., Jacks T., Clevers H., van Oudenaarden A. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat. Cell Biol. 2011, 14:106-114.
8. Klumpp S., Hwa T. Stochasticity and traffic jams in the transcription of ribosomal RNA: Intriguing role of termination and antitermination. Proc. Natl. Acad. Sci. USA 2008, 105:18159-18164.
9. Kosman D., Ip Y.T., Levine M., Arora K. Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science 1991, 254:118-122.
10. Leptin M. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev. 1991, 5:1568-1576.
11. Munsky B., Neuert G., van Oudenaarden A. Using gene expression noise to understand gene regulation. Science 2012, 336:183-187.
12. Neuman K.C., Abbondanzieri E.A., Landick R., Gelles J., Block S.M. Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking. Cell 2003, 115:437-447.
13. Paré A., Lemons D., Kosman D., Beaver W., Freund Y., McGinnis W. Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting. Curr. Biol. 2009, 19:2037-2042.
14. Perry M.W., Boettiger A.N., Bothma J.P., Levine M. Shadow enhancers foster robustness of Drosophila gastrulation. Curr. Biol. 2010, 20:1562-1567.
15. Perry M.W., Boettiger A.N., Levine M. Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 2011, 108:13570-13575.
16. Raj A., Peskin C.S., Tranchina D., Vargas D.Y., Tyagi S. Stochastic mRNA synthesis in mammalian cells. PLoS Biol. 2006, 4:e309.
17. Raj A., van den Bogaard P., Rifkin S.A., van Oudenaarden A., Tyagi S. Imaging individual mRNA molecules using multiple singly labeled probes. Nat. Methods 2008, 5:877-879.
18. Raj A., Rifkin S.A., Andersen E., van Oudenaarden A. Variability in gene expression underlies incomplete penetrance. Nature 2010, 463:913-918.
19. Raser J.M., O'Shea E.K. Noise in gene expression: origins, consequences, and control. Science 2005, 309:2010-2013.
20. So L.H., Ghosh A., Zong C., Sepúlveda L.A., Segev R., Golding I. General properties of transcriptional time series in Escherichia coli. Nat. Genet. 2011, 43:554-560.
21. To T.-L., Maheshri N. Noise can induce bimodality in positive transcriptional feedback loops without bistability. Science 2010, 327:1142-1145.
22. Zeitlinger J., Stark A., Kellis M., Hong J.-W., Nechaev S., Adelman K., Levine M., Young R.A. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat. Genet. 2007, 39:1512-1516.
23. Zeitlinger J., Zinzen R.P., Stark A., Kellis M., Zhang H., Young R.A., Levine M. Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo. Genes Dev. 2007, 21:385-390.
24. Zenklusen D., Larson D.R., Singer R.H. Single-RNA counting reveals alternative modes of gene expression in yeast. Nat. Struct. Mol. Biol. 2008, 15:1263-1271.