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Volumn 85, Issue 1, 2014, Pages 105-115

CYP2J2-Derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ANGIOTENSIN II; BETA ACTIN; CYTOCHROME P450 2J2; EPOXYICOSATRIENOIC ACID; ISOPRENALINE; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC ENDOPLASMIC RETICULUM CALCIUM ADENOSINE TRIPHOSPHATASE; TEMPOL; UNCLASSIFIED DRUG;

EID: 84890711562     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.087122     Document Type: Article
Times cited : (80)

References (56)
  • 2
    • 38149090207 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis
    • Biagioli M, Pifferi S, Ragghianti M, Bucci S, Rizzuto R, and Pinton P (2008) Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis. Cell Calcium 43:184-195.
    • (2008) Cell Calcium , vol.43 , pp. 184-195
    • Biagioli, M.1    Pifferi, S.2    Ragghianti, M.3    Bucci, S.4    Rizzuto, R.5    Pinton, P.6
  • 3
    • 33646529673 scopus 로고    scopus 로고
    • Nitric-oxide-induced vasodilatation: Regulation by physiologic s-glutathiolation and pathologic oxidation of the sarcoplasmic endoplasmic reticulum calcium ATPase
    • Cohen RA and Adachi T (2006) Nitric-oxide-induced vasodilatation: Regulation by physiologic s-glutathiolation and pathologic oxidation of the sarcoplasmic endoplasmic reticulum calcium ATPase. Trends Cardiovasc Med 16:109-114.
    • (2006) Trends Cardiovasc Med , vol.16 , pp. 109-114
    • Cohen, R.A.1    Adachi, T.2
  • 4
    • 0033524720 scopus 로고    scopus 로고
    • Mechanism of nitric oxide-induced vasodilatation: Refilling of intracellular stores by sarcoplasmic reticulum Ca21 ATPase and inhibition of store-operated Ca21 influx
    • Cohen RA, Weisbrod RM, Gericke M, Yaghoubi M, Bierl C, and Bolotina VM (1999) Mechanism of nitric oxide-induced vasodilatation: Refilling of intracellular stores by sarcoplasmic reticulum Ca21 ATPase and inhibition of store-operated Ca21 influx. Circ Res 84:210-219.
    • (1999) Circ Res , vol.84 , pp. 210-219
    • Cohen, R.A.1    Weisbrod, R.M.2    Gericke, M.3    Yaghoubi, M.4    Bierl, C.5    Bolotina, V.M.6
  • 5
    • 38049155818 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis
    • Deniaud A, Sharaf el dein O, Maillier E, Poncet D, Kroemer G, Lemaire C, and Brenner C (2008) Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 27:285-299.
    • (2008) Oncogene , vol.27 , pp. 285-299
    • Deniaud, A.1    Sharaf El Dein, O.2    Maillier, E.3    Poncet, D.4    Kroemer, G.5    Lemaire, C.6    Brenner, C.7
  • 6
    • 77149134285 scopus 로고    scopus 로고
    • Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo
    • Dong Y, Zhang M, Liang B, Xie Z, Zhao Z, Asfa S, Choi HC, and Zou MH (2010) Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 121:792-803.
    • (2010) Circulation , vol.121 , pp. 792-803
    • Dong, Y.1    Zhang, M.2    Liang, B.3    Xie, Z.4    Zhao, Z.5    Asfa, S.6    Choi, H.C.7    Zou, M.H.8
  • 7
    • 35848970993 scopus 로고    scopus 로고
    • Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides
    • Dremina ES, Sharov VS, Davies MJ, and Schöneich C (2007) Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides. Chem Res Toxicol 20:1462-1469.
    • (2007) Chem Res Toxicol , vol.20 , pp. 1462-1469
    • Dremina, E.S.1    Sharov, V.S.2    Davies, M.J.3    Schöneich, C.4
  • 8
    • 84863124865 scopus 로고    scopus 로고
    • ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer
    • Duan Q, Wang X, Gong W, Ni L, Chen C, He X, Chen F, Yang L, Wang P, and Wang DW (2012) ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer. PLoS ONE 7:e31518.
    • (2012) PLoS ONE , vol.7
    • Duan, Q.1    Wang, X.2    Gong, W.3    Ni, L.4    Chen, C.5    He, X.6    Chen, F.7    Yang, L.8    Wang, P.9    Wang, D.W.10
  • 9
    • 0033781028 scopus 로고    scopus 로고
    • Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
    • Dzhura I, Wu Y, Colbran RJ, Balser JR, and Anderson ME (2000) Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat Cell Biol 2:173-177.
    • (2000) Nat Cell Biol , vol.2 , pp. 173-177
    • Dzhura, I.1    Wu, Y.2    Colbran, R.J.3    Balser, J.R.4    Anderson, M.E.5
  • 10
    • 77955173081 scopus 로고    scopus 로고
    • Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload
    • Fu HY, Okada K, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, and Sanada S et al. (2010) Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload. Circulation 122:361-369.
    • (2010) Circulation , vol.122 , pp. 361-369
    • Fu, H.Y.1    Okada, K.2    Liao, Y.3    Tsukamoto, O.4    Isomura, T.5    Asai, M.6    Sawada, T.7    Okuda, K.8    Asano, Y.9    Sanada, S.10
  • 11
    • 80051471896 scopus 로고    scopus 로고
    • Osmotic stabilizercoupled suppression of NDR defects is dependent on the calcium-calcineurin signaling cascade in Aspergillus nidulans
    • Gao L, Song Y, Cao J, Wang S, Wei H, Jiang H, and Lu L (2011) Osmotic stabilizercoupled suppression of NDR defects is dependent on the calcium-calcineurin signaling cascade in Aspergillus nidulans. Cell Signal 23:1750-1757.
    • (2011) Cell Signal , vol.23 , pp. 1750-1757
    • Gao, L.1    Song, Y.2    Cao, J.3    Wang, S.4    Wei, H.5    Jiang, H.6    Lu, L.7
  • 12
    • 1542512379 scopus 로고    scopus 로고
    • 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries
    • Gauthier KM, Falck JR, Reddy LM, and Campbell WB (2004) 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. Pharmacol Res 49:515-524.
    • (2004) Pharmacol Res , vol.49 , pp. 515-524
    • Gauthier, K.M.1    Falck, J.R.2    Reddy, L.M.3    Campbell, W.B.4
  • 15
    • 0023640537 scopus 로고
    • The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA
    • Harrison SM and Bers DM (1987) The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA. Biochim Biophys Acta 925:133-143.
    • (1987) Biochim Biophys Acta , vol.925 , pp. 133-143
    • Harrison, S.M.1    Bers, D.M.2
  • 16
  • 17
    • 79961032369 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca21-ATPase in patients with advanced heart failure
    • Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) Investigators
    • Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H, and Hajjar RJ; Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) Investigators (2011) Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca21-ATPase in patients with advanced heart failure. Circulation 124:304-313.
    • (2011) Circulation , vol.124 , pp. 304-313
    • Jessup, M.1    Greenberg, B.2    Mancini, D.3    Cappola, T.4    Pauly, D.F.5    Jaski, B.6    Yaroshinsky, A.7    Zsebo, K.M.8    Dittrich, H.9    Hajjar, R.J.10
  • 20
    • 35848942608 scopus 로고    scopus 로고
    • Heme oxygenase-1 in tumors: Is it a false friend
    • Jozkowicz A, Was H, and Dulak J (2007) Heme oxygenase-1 in tumors: Is it a false friend Antioxid Redox Signal 9:2099-2117.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 2099-2117
    • Jozkowicz, A.1    Was, H.2    Dulak, J.3
  • 21
    • 0024500282 scopus 로고
    • Depression of heart sarcolemmal Ca21-pump activity by oxygen free radicals
    • Kaneko M, Beamish RE, and Dhalla NS (1989a) Depression of heart sarcolemmal Ca21-pump activity by oxygen free radicals. Am J Physiol 256:H368-H374.
    • (1989) Am J Physiol , vol.256
    • Kaneko, M.1    Beamish, R.E.2    Dhalla, N.S.3
  • 22
    • 0024414262 scopus 로고
    • Mechanism for depression of heart sarcolemmal Ca21 pump by oxygen free radicals
    • Kaneko M, Elimban V, and Dhalla NS (1989b) Mechanism for depression of heart sarcolemmal Ca21 pump by oxygen free radicals. Am J Physiol 257: H804-H811.
    • (1989) Am J Physiol , vol.257
    • Kaneko, M.1    Elimban, V.2    Dhalla, N.S.3
  • 23
    • 0036853914 scopus 로고    scopus 로고
    • Orchestrating the unfolded protein response in health and disease
    • Kaufman RJ (2002) Orchestrating the unfolded protein response in health and disease. J Clin Invest 110:1389-1398.
    • (2002) J Clin Invest , vol.110 , pp. 1389-1398
    • Kaufman, R.J.1
  • 24
    • 50649097202 scopus 로고    scopus 로고
    • The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: A potent target for cardiovascular diseases
    • Kawase Y and Hajjar RJ (2008) The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: A potent target for cardiovascular diseases. Nat Clin Pract Cardiovasc Med 5:554-565.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 554-565
    • Kawase, Y.1    Hajjar, R.J.2
  • 25
    • 49849083662 scopus 로고    scopus 로고
    • Chronic treatment with insulin-like growth factor i enhances myocyte contraction by upregulation of Akt-SERCA2a signaling pathway
    • Kim SJ, Abdellatif M, Koul S, and Crystal GJ (2008) Chronic treatment with insulin-like growth factor I enhances myocyte contraction by upregulation of Akt-SERCA2a signaling pathway. Am J Physiol Heart Circ Physiol 295: H130-H135.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Kim, S.J.1    Abdellatif, M.2    Koul, S.3    Crystal, G.J.4
  • 26
    • 41749108854 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in disease pathogenesis
    • Lin JH, Walter P, and Yen TS (2008) Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol 3:399-425.
    • (2008) Annu Rev Pathol , vol.3 , pp. 399-425
    • Lin, J.H.1    Walter, P.2    Yen, T.S.3
  • 27
  • 28
    • 80054781373 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide
    • Liu L, Chen C, Gong W, Li Y, Edin ML, Zeldin DC, and Wang DW (2011) Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide. J Pharmacol Exp Ther 339:451-463.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 451-463
    • Liu, L.1    Chen, C.2    Gong, W.3    Li, Y.4    Edin, M.L.5    Zeldin, D.C.6    Wang, D.W.7
  • 29
    • 77957601657 scopus 로고    scopus 로고
    • NADPH oxidase inhibition ameliorates cardiac dysfunction in rabbits with heart failure
    • Liu Y, Huang H, Xia W, Tang Y, Li H, and Huang C (2010) NADPH oxidase inhibition ameliorates cardiac dysfunction in rabbits with heart failure. Mol Cell Biochem 343:143-153.
    • (2010) Mol Cell Biochem , vol.343 , pp. 143-153
    • Liu, Y.1    Huang, H.2    Xia, W.3    Tang, Y.4    Li, H.5    Huang, C.6
  • 30
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • Marciniak SJ and Ron D (2006) Endoplasmic reticulum stress signaling in disease. Physiol Rev 86:1133-1149.
    • (2006) Physiol Rev , vol.86 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 32
    • 0033615645 scopus 로고    scopus 로고
    • Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy
    • Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J, Jr, and Kranias EG et al. (1999) Chronic phospholamban- sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99:313-322.
    • (1999) Cell , vol.99 , pp. 313-322
    • Minamisawa, S.1    Hoshijima, M.2    Chu, G.3    Ward, C.A.4    Frank, K.5    Gu, Y.6    Martone, M.E.7    Wang, Y.8    Ross Jr., J.9    Kranias, E.G.10
  • 33
    • 0034716887 scopus 로고    scopus 로고
    • Tripartite management of unfolded proteins in the endoplasmic reticulum
    • Mori K (2000) Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101:451-454.
    • (2000) Cell , vol.101 , pp. 451-454
    • Mori, K.1
  • 34
    • 57349115098 scopus 로고    scopus 로고
    • Regulation of myocardial SERCA2a expression in ventricular hypertrophy and heart failure
    • Muller A and Simonides WS (2005) Regulation of myocardial SERCA2a expression in ventricular hypertrophy and heart failure. Future Cardiol 1:543-553.
    • (2005) Future Cardiol , vol.1 , pp. 543-553
    • Muller, A.1    Simonides, W.S.2
  • 35
    • 80355143466 scopus 로고    scopus 로고
    • B-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure
    • Ni L, Zhou C, Duan Q, Lv J, Fu X, Xia Y, and Wang DW (2011) b-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure. PLoS ONE 6: E27294.
    • (2011) PLoS ONE , vol.6
    • Ni, L.1    Zhou, C.2    Duan, Q.3    Lv, J.4    Fu, X.5    Xia, Y.6    Wang, D.W.7
  • 36
    • 0033588034 scopus 로고    scopus 로고
    • Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
    • Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, and Liao JK (1999) Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285:1276-1279.
    • (1999) Science , vol.285 , pp. 1276-1279
    • Node, K.1    Huo, Y.2    Ruan, X.3    Yang, B.4    Spiecker, M.5    Ley, K.6    Zeldin, D.C.7    Liao, J.K.8
  • 38
    • 4043076224 scopus 로고    scopus 로고
    • Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: Possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis
    • Okada K, Minamino T, Tsukamoto Y, Liao Y, Tsukamoto O, Takashima S, Hirata A, Fujita M, Nagamachi Y, and Nakatani T et al. (2004) Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: Possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Circulation 110:705-712.
    • (2004) Circulation , vol.110 , pp. 705-712
    • Okada, K.1    Minamino, T.2    Tsukamoto, Y.3    Liao, Y.4    Tsukamoto, O.5    Takashima, S.6    Hirata, A.7    Fujita, M.8    Nagamachi, Y.9    Nakatani, T.10
  • 42
    • 0037448784 scopus 로고    scopus 로고
    • Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction
    • Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virág L, Deb A, Szabó E, Ungvári Z, and Wolin MS et al. (2003) Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107:896-904.
    • (2003) Circulation , vol.107 , pp. 896-904
    • Pacher, P.1    Liaudet, L.2    Bai, P.3    Mabley, J.G.4    Kaminski, P.M.5    Virág, L.6    Deb, A.7    Szabó, E.8    Ungvári, Z.9    Wolin, M.S.10
  • 44
    • 34547185623 scopus 로고    scopus 로고
    • Oxidative stress and redox signalling in cardiac hypertrophy and heart failure
    • Seddon M, Looi YH, and Shah AM (2007) Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart 93:903-907.
    • (2007) Heart , vol.93 , pp. 903-907
    • Seddon, M.1    Looi, Y.H.2    Shah, A.M.3
  • 46
    • 77957846150 scopus 로고    scopus 로고
    • PPARg-induced cardiolipotoxicity in mice is ameliorated by PPARa deficiency despite increases in fatty acid oxidation
    • Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, and Goldberg IJ (2010) PPARg-induced cardiolipotoxicity in mice is ameliorated by PPARa deficiency despite increases in fatty acid oxidation. J Clin Invest 120: 3443-3454.
    • (2010) J Clin Invest , vol.120 , pp. 3443-3454
    • Son, N.H.1    Yu, S.2    Tuinei, J.3    Arai, K.4    Hamai, H.5    Homma, S.6    Shulman, G.I.7    Abel, E.D.8    Goldberg, I.J.9
  • 47
    • 39149126992 scopus 로고    scopus 로고
    • High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration
    • Tong X, Ying J, Pimentel DR, Trucillo M, Adachi T, and Cohen RA (2008) High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration. J Mol Cell Cardiol 44:361-369.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 361-369
    • Tong, X.1    Ying, J.2    Pimentel, D.R.3    Trucillo, M.4    Adachi, T.5    Cohen, R.A.6
  • 48
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • Wellen KE and Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115:1111-1119.
    • (2005) J Clin Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 50
    • 26444442450 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: Cell life and death decisions
    • Xu C, Bailly-Maitre B, and Reed JC (2005) Endoplasmic reticulum stress: Cell life and death decisions. J Clin Invest 115:2656-2664.
    • (2005) J Clin Invest , vol.115 , pp. 2656-2664
    • Xu, C.1    Bailly-Maitre, B.2    Reed, J.C.3
  • 51
    • 84876771616 scopus 로고    scopus 로고
    • CYP2J3 gene delivery up-regulated adiponectin expression via reduced endoplasmic reticulum stress in adipocytes
    • Xu X, Tu L, Feng W, Ma B, Li R, Zheng C, Li G, and Wang DW (2013) CYP2J3 gene delivery up-regulated adiponectin expression via reduced endoplasmic reticulum stress in adipocytes. Endocrinology 154:1743-1753.
    • (2013) Endocrinology , vol.154 , pp. 1743-1753
    • Xu, X.1    Tu, L.2    Feng, W.3    Ma, B.4    Li, R.5    Zheng, C.6    Li, G.7    Wang, D.W.8
  • 53
    • 33748543968 scopus 로고    scopus 로고
    • Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/reperfusion
    • Yu J, Zhang HF, Wu F, Li QX, Ma H, Guo WY, Wang HC, and Gao F (2006) Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/reperfusion. Acta Pharmacol Sin 27: 919-926.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 919-926
    • Yu, J.1    Zhang, H.F.2    Wu, F.3    Li, Q.X.4    Ma, H.5    Guo, W.Y.6    Wang, H.C.7    Gao, F.8
  • 54
    • 17544392805 scopus 로고    scopus 로고
    • Decreased expression of cardiac sarcoplasmic reticulum Ca (21)-pump ATPase in congestive heart failure due to myocardial infarction
    • 285-290
    • Zarain-Herzberg A, Afzal N, Elimban V, and Dhalla NS (1996) Decreased expression of cardiac sarcoplasmic reticulum Ca(21)-pump ATPase in congestive heart failure due to myocardial infarction. Mol Cell Biochem 163-164:285-290.
    • (1996) Mol Cell Biochem , pp. 163-164
    • Zarain-Herzberg, A.1    Afzal, N.2    Elimban, V.3    Dhalla, N.S.4
  • 55
    • 77954061566 scopus 로고    scopus 로고
    • B(2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats
    • Zhang Q, Xiang J, Wang X, Liu H, Hu B, Feng M, and Fu Q (2010) b(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats. Br J Pharmacol 160:1561-1572.
    • (2010) Br J Pharmacol , vol.160 , pp. 1561-1572
    • Zhang, Q.1    Xiang, J.2    Wang, X.3    Liu, H.4    Hu, B.5    Feng, M.6    Fu, Q.7


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