Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages

Cell and Tissue Research

Volumn 354, Issue 3, 2013, Pages 887-889

  May, Petra ^a,b   Bock, Hans H ^a,b   Nofer, Jerzy Roch ^c,d  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Anti inflammatory activity; Low density receptor related protein 1; Macrophage; Mouse

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW; CELL ISOLATION; CELL LINEAGE; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; GENE INACTIVATION; LRP 1 GENE; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WILD TYPE;

MURINAE; MUS;

ANIMALS; BONE MARROW CELLS; GENE SILENCING; MACROPHAGES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; PHENOTYPE; RECEPTORS, LDL; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84890570924     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-013-1699-2     Document Type: Article

References (12)

1. Baitsch D, Bock HH, Engel T, Telgmann R, Müller-Tidow C, Varga G, Bot M, Herz J, Robenek H, von Eckardstein A, Nofer JR (2011) Apolipoprotein E induces antiinflammatory phenotype in macrophages. Arterioscler Thromb Vasc Biol 31:1160-1168
2. Boucher P, Gotthardt M, Li WP, Anderson RG, Herz J (2003) LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300:329-332
3. Hoeksema MA, Stöger JL, de Winther MP (2012) Molecular pathways regulating macrophage polarization: implications for atherosclerosis. Curr Atheroscler Rep 14:254-263
4. Llorente-Cortés V, Martínez-González J, Badimon L (2000) LDL receptor-related protein mediates uptake of aggregated LDL in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20:1572-1579
5. Llorente-Cortés V, Royo T, Otero-Viñas M, Berrozpe M, Badimon L (2007) Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages. Cardiovasc Res 74:526-536
6. May P (2013) The low-density lipoprotein receptor-related protein 1 in inflammation. Curr Opin Lipidol 24:134-137
7. May P, Herz J, Bock HH (2005) Molecular mechanisms of lipoprotein receptor signalling. Cell Mol Life Sci 62:2325-2338
8. Overton CD, Yancey PG, Major AS, Linton MF, Fazio S (2007) Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res 100:670-677
9. Rohlmann A, Gotthardt M, Hammer RE, Herz J (1998) Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest 101:689-695
10. Yancey PG, Blakemore J, Ding L, Fan D, Overton CD, Zhang Y, Linton MF, Fazio S (2010) Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arterioscler Thromb Vasc Biol 30:787-795
11. Yancey PG, Ding Y, Fan D, Blakemore JL, Zhang Y, Ding L, Zhang J, Linton MF, Fazio S (2011) Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Circulation 124:454-464
12. Zurhove K, Nakajima C, Herz J, Bock HH, May P (2008) Gamma-secretase limits the inflammatory response through the processing of LRP1. Sci Signal 1:ra15