Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages

Cardiovascular Research

Volumn 74, Issue 3, 2007, Pages 526-536

  Llorente Cortés, Vicenta ^a   Royo, Teresa ^b   Otero Viñas, Marta ^a   Berrozpe, Maria ^a   Badimon, Lina ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Cholesterol accumulation; Human monocyte derived macrophages; Low density lipoprotein receptor related protein; Sterol regulatory element binding proteins

Indexed keywords

CHOLESTEROL ESTER; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MESSENGER RNA; N ACETYLLEUCYLLEUCYLNORLEUCINAL; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ARTICLE; CATABOLISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

ANALYSIS OF VARIANCE; ATHEROSCLEROSIS; BLOTTING, WESTERN; CELLS, CULTURED; CHOLESTEROL ESTERS; CORONARY VESSELS; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LEUPEPTINS; LIPOPROTEINS, LDL; MACROPHAGES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; STATISTICS, NONPARAMETRIC; STEROL REGULATORY ELEMENT BINDING PROTEINS;

EID: 34247851035     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2007.02.020     Document Type: Article

References (48)

1. Steinberg D., Parthasarathy S., Carew T., Khoo J., and Witztum J.L. Beyond cholesterol: modification of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320 (1989) 915-924
2. Camejo G., Fager G., Rosengren B., Hurt-Camejo E., and Bondjers G. Binding of low density lipoproteins by proteoglycans synthesized by proliferating and quiescent human arterial smooth muscle cells. J Biol Chem 268 (1993) 14131-14137
3. Maor I., Hayek T., Hirsh M., Iancu T.C., and Aviram M. Macrophage-released proteoglycans enhance LDL aggregation: studies in aorta from apolipoprotein E-deficient mice. Atherosclerosis 150 (2000) 91-101
4. Llorente-Cortés V., Otero-Viñas M., Hurt-camejo E., Martínez-González J., and Badimon L. Human coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptors. Arterioscler Thromb Vasc Biol 22 (2002) 387-393
5. Frank J.S., and Fogelman A.M. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching. J Lipid Res 30 (1989) 967-978
6. Hakala J.K., Öörni K., Pentikäinen M.O., Hurt-Camejo E., and Kovanen P.T. Lypolysis of LDL by human secretory phospholipase A2 induces particle fusion and enhances the retention of LDL to human proteoglycans. Arterioscler Thromb Vasc Biol 21 (2001) 1053-1061
7. Guyton J.R., Klemp K.F., and Mims P.M. Altered ultrastructural morphology of self-aggregated low density lipoproteins: coalescence of lipid domains forming droplets and vesicles. J Lipid Res 32 (1991) 953-961
8. Aviram M., Maor Y., Keidar S., Hayek T., Oiknine J., Bae E.I.Y., et al. Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient transgenic mice and in humans is oxidized and aggregated. Biochim Biophys Res Commun 216 (1995) 501-513
9. Pentikäinen M.O., Lehtonen E.M.P., and Kovanen P.T. Aggregation and fusion of modified low density lipoprotein. J Lipid Res 37 (1996) 2638-2649
10. Llorente-Cortés V., Otero-Viñas M., Hurt-Camejo E., Martínez-González J., and Badimon L. Human coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptors. Arterioscler Thromb Vasc Biol 22 (2002) 387-393
11. Khoo J.C., Miller E., Mc Loufhlin P., and Steinberg D. Enhanced macrophage uptake of low density lipoprotein after self-aggregation. Arteriosclerosis 8 (1988) 348-358
12. Zhang W.Y., Gaynor P.M., and Kruth H.S. Aggregated low density lipoprotein induces and enters surface-connected compartments on human monocyte-macrophages. J Biol Chem 272 (1997) 31700-31706
13. Buton X., Mamdouh Z., Ghosh R., Du H., Kuriakose G., Beatini N., et al. Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein. J Biol Chem 274 (1999) 32112-32121
14. Zhang W.Y., Ishii I., and Kruth H.S. Plasmin-mediated macrophage reversal of low density lipoprotein aggregation. J Biol Chem 275 (2000) 33176-33183
15. Kruth H.S. Sequestration of aggregated low-density lipoproteins by macrophages. Curr Opin Lipidol 13 (2002) 483-488
16. Sakr S.W., Eddy R.J., Barth H., Wang F., Greenberg S., Maxfield F.R., et al. The uptake of matrix-bound lipoproteins by macrophages require an intact actin cytoskeleton, Rho family GTPases, and myosin ATPase activity. J Biol Chem 276 (2001) 37649-37658
17. Morita S., Kawabe M., Sakurai A., Okuhira K., Vertut-Doï A., Nakano M., et al. Ceramide and lipid particles enhances heparan sulfate proteoglycan and low density lipoprotein receptor-related protein-mediated uptake by macrophages. J Biol Chem 279 (2004) 24355-24361
18. Llorente-Cortés V., Otero-Viñas M., Camino-López S., Costales P., and Badimon L. Cholesteryl esters of aggregated LDL are internalized by selective uptake in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 26 (2006) 117-123
19. Llorente-Cortés V., Martínez-González J., and Badimon L. LDL receptor-related protein mediates uptake of aggregated LDL in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20 (2000) 1572-1579
20. Llorente-Cortés V., Otero-Viñas M., and Badimon L. Differential role of heparan sulfate proteoglycans on aggregated LDL uptake in human vascular smooth muscle cells and mouse embryonic fibroblasts. Arterioscler Thromb Vasc Biol 22 (2002) 1905-1911
21. Llorente-Cortés V., Otero-Viñas M., Sánchez S., Rodríguez C., and Badimon L. Low density lipoprotein upregulates low density lipoprotein receptor-related protein expression in vascular smooth muscle cells: possible involvement of sterol regulatory element binding protein-2 dependent mechanism. Circulation 106 (2002) 3104-3110
22. Horton J.D., Shimomura I., Brown M.S., Hammer R.E., Goldstein J.L., and Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 101 (1998) 2331-2339
23. Horton J.D., Shimano H., Hamilton R.L., Brown M.S., and Goldstein J.L. Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL. J Clin Invest 103 (1999) 1067-1076
24. Eberle D., Hegarty B., Bossard P., Ferre P., and Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86 (2004) 839-848
25. Hirano Y., Yoshida M., Shimizu M., and Sato R. Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway. J Biol Chem 276 (2001) 36431-36437
26. Kawabe Y., Honda M., Wada Y., Yazaki Y., Suzuki T., Ohba Y., et al. Sterol mediated regulation of SREBP-1a,1b,1c and SREBP-2 in cultured human cells. Biochem Biophys Res Commun 202 (1994) 1460-1467
27. Wang X., Sato R., Brown M.S., Hua X., and Goldstein J.L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77 (1994) 53-62
28. Gaeta B.A., Borthwick I., and Stanley K.K. The 5′-flanking region of the a2-MR/LRP genes contains and enhancer-like cluster of Sp1 binding sites. Biochim Biophys Acta 1219 (1994) 307-313
29. Llorente-Cortés V., Costales P., Bernues J., Camino-López S., and Badimon L. Sterol regulatory element-binding protein-2 negatively regulates low density lipoprotein receptor-related protein transcription. J Mol Biol 359 (2006) 950-960
30. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37 (1959) 911-916
31. Huber L.A., Xu Q.B., Jurgens G., Bock G., Buhler E., Gey K.F., et al. Correlation of lymphocyte lipid composition membrane viscosity and mitogen response in the aged. Eur J Immunol 21 (1991) 2761-2765
32. Dignam J.D., Lebovitz R.M., and Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11 (1983) 1475-1489
33. Llorente-Cortés V., Otero-Viñas M., Berrozpe M., and Badimon L. Intracellular lipid accumulation, low density lipoprotein receptor-related protein expression, and cell survival in vascular smooth muscle cells derived from normal and atherosclerotic human coronaries. Eur J Clin Investig 34 (2004) 182-190
34. Hiltunen T.P., Luoma J.S., Nikkari T., and Yla-Herttuala S. Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions. Circulation 97 (1998) 1079-1086
35. 2-macroglobulin receptor in human normal and atherosclerotic arteries. Arterioscler Thromb 14 (1994) 1438-1444
36. Kotzka J., Muller-Wieland D., Roth G., Kremer L., Munck M., Schurmann S., et al. Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade. J Lipid Res 41 (2000) 99-108
37. Makar R.S., Lipsky P.E., and Cuthbert J.A. Sterol-independent, sterol response element-dependent, regulation of low density lipoprotein receptor gene expression. J Lipid Res 39 (1998) 1647-1654
38. Lange Y., Ye J., and Steck T.L. Effect of protein kinase C on endoplasmic reticulum cholesterol. Biochem Biophys Res Commun 290 (2002) 488-493
39. Brown A.J., Sun L., Feramisco J.D., Brown M.S., and Goldstein J.L. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Mol Cell 10 (2002) 237-245
40. Du X., Pham Y.H., and Brown A.J. Effect of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum. J Biol Chem 279 (2004) 47010-47016
41. Holtta-Vuori M., Tanhuanpaa K., Mobius W., Somerharju P., and Ikonen E. Modulation of cellular cholesterol transport and homeostasis by Rab11. Mol Biol Cell 13 (2002) 3107-3122
42. Hussaini I.M., Srikumar K., Quesenberry P.J., and Gonias S.L. Colony stimulating factor-1 modulates α-macroglobulin receptor expression in murine bone marrow macrophages. J Biol Chem 265 (1990) 19441-19446
43. Misra U.K., Gawdi G., González-Gronow M., and Pizzo S.V. Coordinate regulation of the a2-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/a2 macroglobulin receptor by insulin. J Biol Chem 274 (1999) 25785-25791
44. Hussaini I.M., LaMarre J., Lysiak J.J., Karns L.R., VanderBerg S.R., and Gonias S.L. Transcriptional regulation of LDL receptor-related protein by IFN-γ and the antagonistic activity of TFG-β1 in the RAW 264.7 macrophage-like cell line. J Leukoc Biol 59 (1996) 733-739
45. Boucher P., Gotthardt M., Li W.P., Anderson R.G., and Herz J. LRP: role in vascular integrity and protection from atherosclerosis. Science 300 (2003) 329-332
46. Willnow T.E. The low density lipoprotein receptor gene family: multiple roles in lipid metabolism. J Mol Med 77 (1999) 306-315
47. Llorente-Cortés V., and Badimon L. LDL receptor-related protein and the vascular wall. Implications for atherothrombosis. Arterioscler Thromb Vasc Biol 25 (2005) 497-504
48. Robinet P., Védie B., Chironi G., Gariépi J., Simon A., Moatti N., et al. Characterization of polymorphic structure of SREBP-2 gene: role in atherosclerosis. Atherosclerosis 168 (2003) 381-387