메뉴 건너뛰기




Volumn 23, Issue 1, 2014, Pages 32-37

Aldosterone's mechanism of action: Roles of lysine-specific demethylase 1, caveolin and striatin

Author keywords

aldosterone; caveolin 1; lysine specific demethylase 1; mineralocorticoid receptor striatin

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; CAVEOLIN; CELL NUCLEUS RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPITHELIAL SODIUM CHANNEL; ESTROGEN RECEPTOR ALPHA; G PROTEIN COUPLED RECEPTOR; LYSINE SPECIFIC DEMETHYLASE 1; MINERALOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROGESTERONE; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAFFOLD PROTEIN; STRIATIN; UNCLASSIFIED DRUG;

EID: 84890548131     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/01.mnh.0000436543.48391.e0     Document Type: Review
Times cited : (32)

References (42)
  • 1
    • 84865415051 scopus 로고    scopus 로고
    • Novel findings and future directions on the genetics of hypertension
    • An outstanding review of the future directions of genetic studies in hyertension
    • & Simino J, Rao DC, Freedman BI. Novel findings and future directions on the genetics of hypertension. Curr Opin Nephrol Hypertens 2012; 21:500-507. An outstanding review of the future directions of genetic studies in hypertension.
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 500-507
    • Simino, J.1    Rao, D.C.2    Freedman, B.I.3
  • 2
    • 84860218599 scopus 로고    scopus 로고
    • Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension
    • Cowley AW Jr, Nadeau JH, Baccarelli A, et al. Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. Hypertension 2012; 59:899-905.
    • (2012) Hypertension , vol.59 , pp. 899-905
    • Cowley Jr., A.W.1    Nadeau, J.H.2    Baccarelli, A.3
  • 4
    • 84877770249 scopus 로고    scopus 로고
    • Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension
    • A key study demonstrating epigenetic changes in promoter DNA methylation of a-adducin (ADD1) gene in the pathogenesis of essential hypertension
    • Zhang LN, Liu PP, Wang L, et al. Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension. PLoS One 2013; 8:e63455. A key study demonstrating epigenetic changes in promoter DNA methylation of a-adducin (ADD1) gene in the pathogenesis of essential hypertension.
    • (2013) PLoS One , vol.8
    • Zhang, L.N.1    Liu, P.P.2    Wang, L.3
  • 5
    • 0036182744 scopus 로고    scopus 로고
    • Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism
    • Grant FD, Romero JR, Jeunemaitre X, et al. Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism. Hypertension 2002; 39:191-196.
    • (2002) Hypertension , vol.39 , pp. 191-196
    • Grant, F.D.1    Romero, J.R.2    Jeunemaitre, X.3
  • 6
    • 77958554883 scopus 로고    scopus 로고
    • Alpha-adducin Gly460Trp polymorphism and hypertension risk: A meta-analysis of 22 studies including 14303 cases and 15961 controls
    • Liu K, Liu J, Huang Y, et al. Alpha-adducin Gly460Trp polymorphism and hypertension risk: A meta-analysis of 22 studies including 14303 cases and 15961 controls. PLoS One 2010; 5:e13057.
    • (2010) PLoS One , vol.5
    • Liu, K.1    Liu, J.2    Huang, Y.3
  • 7
    • 84855858762 scopus 로고    scopus 로고
    • Alpha-Adducin Gly460Trp gene mutation and essential hypertension in a Chinese population: A meta-analysis including 10,960 subjects
    • Li YY. alpha-Adducin Gly460Trp gene mutation and essential hypertension in a Chinese population: A meta-analysis including 10,960 subjects. PLoS One 2012; 7:e30214.
    • (2012) PLoS One , vol.7
    • Li, Y.Y.1
  • 8
    • 77952543507 scopus 로고    scopus 로고
    • High-salt diet during pregnancy and angiotensinrelated cardiac changes
    • Ding Y, Lv J, Mao C, et al. High-salt diet during pregnancy and angiotensinrelated cardiac changes. J Hypertens 2010; 28:1290-1297.
    • (2010) J Hypertens , vol.28 , pp. 1290-1297
    • Ding, Y.1    Lv, J.2    Mao, C.3
  • 9
    • 84877342168 scopus 로고    scopus 로고
    • A genome-wide methylation study on obesity: Differential variability and differential methylation
    • Xu X, Su S, Barnes VA, et al. A genome-wide methylation study on obesity: Differential variability and differential methylation. Epigenetics 2013; 8:522-533.
    • (2013) Epigenetics , vol.8 , pp. 522-533
    • Xu, X.1    Su, S.2    Barnes, V.A.3
  • 10
    • 84879678934 scopus 로고    scopus 로고
    • A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
    • Ronn T, Volkov P, Davegardh C, et al. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet 2013; 9:e1003572.
    • (2013) PLoS Genet , vol.9
    • Ronn, T.1    Volkov, P.2    Davegardh, C.3
  • 11
    • 0024777763 scopus 로고
    • Sodium-sensitive essential hypertension: Emerging insights into an old entity
    • Williams GH, Hollenberg NK. Sodium-sensitive essential hypertension: Emerging insights into an old entity. J Am Coll Nutr 1989; 8:490-494.
    • (1989) J Am Coll Nutr , vol.8 , pp. 490-494
    • Williams, G.H.1    Hollenberg, N.K.2
  • 12
    • 77951294554 scopus 로고    scopus 로고
    • A mechanism for salt-sensitive hypertension: Abnormal dietary sodium-mediated vascular response to angiotensin-II
    • Chamarthi B, Williams JS, Williams GH. A mechanism for salt-sensitive hypertension: Abnormal dietary sodium-mediated vascular response to angiotensin-II. J Hypertens 2010; 28:1020-1026.
    • (2010) J Hypertens , vol.28 , pp. 1020-1026
    • Chamarthi, B.1    Williams, J.S.2    Williams, G.H.3
  • 13
    • 84867745758 scopus 로고    scopus 로고
    • Genetic biomarkers of hypertension and future challenges integrating epigenomics
    • El Shamieh S, Visvikis-Siest S. Genetic biomarkers of hypertension and future challenges integrating epigenomics. Clin Chim Acta 2012; 414:259-265.
    • (2012) Clin Chim Acta , vol.414 , pp. 259-265
    • El Shamieh, S.1    Visvikis-Siest, S.2
  • 14
    • 80355127953 scopus 로고    scopus 로고
    • Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension
    • Pojoga LH, Williams JS, Yao TM, et al. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol 2011; 301:H1862-H1871.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Pojoga, L.H.1    Williams, J.S.2    Yao, T.M.3
  • 15
    • 84863719221 scopus 로고    scopus 로고
    • Lysine-specific demethylase 1: An epigenetic regulator of salt-sensitive hypertension
    • A seminal translational study describing the role of LSD-1 as a crucial epigenetic regulator of salt sensitivity of BP in both human and rodents
    • Williams JS, Chamarthi B, Goodarzi MO, et al. Lysine-specific demethylase 1: An epigenetic regulator of salt-sensitive hypertension. Am J Hypertens 2012; 25:812-817. A seminal translational study describing the role of LSD-1 as a crucial epigenetic regulator of salt sensitivity of BP in both human and rodents.
    • (2012) Am J Hypertens , vol.25 , pp. 812-817
    • Williams, J.S.1    Chamarthi, B.2    Goodarzi, M.O.3
  • 16
    • 35349006314 scopus 로고    scopus 로고
    • Histone lysine demethylases: Emerging roles in development, physiology and disease
    • Shi Y. Histone lysine demethylases: Emerging roles in development, physiology and disease. Nat Rev Genet 2007; 8:829-833.
    • (2007) Nat Rev Genet , vol.8 , pp. 829-833
    • Shi, Y.1
  • 17
    • 84890547154 scopus 로고    scopus 로고
    • Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake
    • An interesting study that highlights the important interaction between ageing, epigenetic changes and environment
    • Krug AW, Tille E, Sun B, et al. Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake. Age (Dordr) 2013; 35:1809-1820. An interesting study that highlights the important interaction between ageing, epigenetic changes and environment.
    • (2013) Age (Dordr) , vol.35 , pp. 1809-1820
    • Krug, A.W.1    Tille, E.2    Sun, B.3
  • 18
    • 85027925594 scopus 로고    scopus 로고
    • Epigenetic modulation of the renal betaadrenergic-WNK4 pathway in salt-sensitive hypertension
    • Mu S, Shimosawa T, Ogura S, et al. Epigenetic modulation of the renal betaadrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med 2011; 17:573-580.
    • (2011) Nat Med , vol.17 , pp. 573-580
    • Mu, S.1    Shimosawa, T.2    Ogura, S.3
  • 19
    • 79956364204 scopus 로고    scopus 로고
    • Cell membrane-associated mineralocorticoid receptors New evidence
    • Krug AW, Pojoga LH, Williams GH, Adler GK. Cell membrane-associated mineralocorticoid receptors New evidence. Hypertension 2011; 57:1019-1025.
    • (2011) Hypertension , vol.57 , pp. 1019-1025
    • Krug, A.W.1    Pojoga, L.H.2    Williams, G.H.3    Adler, G.K.4
  • 20
    • 80555157695 scopus 로고    scopus 로고
    • Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart
    • Ricchiuti V, Lapointe N, Pojoga L, et al. Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart. J Endocrinol 2011; 211:47-54.
    • (2011) J Endocrinol , vol.211 , pp. 47-54
    • Ricchiuti, V.1    Lapointe, N.2    Pojoga, L.3
  • 21
    • 79954525355 scopus 로고    scopus 로고
    • Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats
    • Gildea JJ, Kemp BA, Howell NL, et al. Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats. Am J Physiol Renal Physiol 2011; 300:F914-F920.
    • (2011) Am J Physiol Renal Physiol , vol.300
    • Gildea, J.J.1    Kemp, B.A.2    Howell, N.L.3
  • 22
    • 77952653780 scopus 로고    scopus 로고
    • Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice
    • Pojoga LH, Adamova Z, Kumar A, et al. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol 2010; 298: H1776-H1788.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Pojoga, L.H.1    Adamova, Z.2    Kumar, A.3
  • 23
    • 77149150918 scopus 로고    scopus 로고
    • Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II
    • Pojoga LH, Romero JR, Yao TM, et al. Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology 2010; 151:1236-1246.
    • (2010) Endocrinology , vol.151 , pp. 1236-1246
    • Pojoga, L.H.1    Romero, J.R.2    Yao, T.M.3
  • 24
    • 41549101998 scopus 로고    scopus 로고
    • Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice
    • Pojoga LH, Yao TM, Sinha S, et al. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol 2008; 294:H1258-H1265.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Pojoga, L.H.1    Yao, T.M.2    Sinha, S.3
  • 25
    • 79959330833 scopus 로고    scopus 로고
    • Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats
    • Nakamura T, Fukuda M, Kataoka K, et al. Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats. Hypertens Res 2011; 34:817-824.
    • (2011) Hypertens Res , vol.34 , pp. 817-824
    • Nakamura, T.1    Fukuda, M.2    Kataoka, K.3
  • 26
    • 84866298370 scopus 로고    scopus 로고
    • Caveolae, caveolins, cavins, and endothelial cell function: New insights
    • Sowa G. Caveolae, caveolins, cavins, and endothelial cell function: New insights. Front Physiol 2012; 2:120.
    • (2012) Front Physiol , vol.2 , pp. 120
    • Sowa, G.1
  • 27
    • 62349089173 scopus 로고    scopus 로고
    • Possible new druggable targets for the treatment of nephrosis. Perhaps we should find them in caveolae
    • van Dokkum RP, Buikema H. Possible new druggable targets for the treatment of nephrosis. Perhaps we should find them in caveolae Curr Opin Pharmacol 2009; 9:132-138.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 132-138
    • Van Dokkum, R.P.1    Buikema, H.2
  • 28
    • 77950510305 scopus 로고    scopus 로고
    • Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome
    • Fujita T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension 2010; 55:813-818.
    • (2010) Hypertension , vol.55 , pp. 813-818
    • Fujita, T.1
  • 29
    • 57349168398 scopus 로고    scopus 로고
    • Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease
    • Shibata S, Nagase M, Yoshida S, et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease. Nat Med 2008; 14:1370-1376.
    • (2008) Nat Med , vol.14 , pp. 1370-1376
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3
  • 30
    • 77953162073 scopus 로고    scopus 로고
    • Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway
    • Nethe M, Anthony EC, Fernandez-Borja M, et al. Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci 2010; 123:1948-1958.
    • (2010) J Cell Sci , vol.123 , pp. 1948-1958
    • Nethe, M.1    Anthony, E.C.2    Fernandez-Borja, M.3
  • 31
    • 67649816872 scopus 로고    scopus 로고
    • The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism
    • Lee IH, Campbell CR, Song SH, et al. The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. J Biol Chem 2009; 284:12663-12669.
    • (2009) J Biol Chem , vol.284 , pp. 12663-12669
    • Lee, I.H.1    Campbell, C.R.2    Song, S.H.3
  • 32
    • 84860848745 scopus 로고    scopus 로고
    • Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment
    • Li X, McClellan ME, Tanito M, et al. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem 2012; 287:16424-16434.
    • (2012) J Biol Chem , vol.287 , pp. 16424-16434
    • Li, X.1    McClellan, M.E.2    Tanito, M.3
  • 33
    • 84865475880 scopus 로고    scopus 로고
    • Caveolin-Na/K-ATPase interactions: Role of transmembrane topology in nongenomic steroid signal transduction
    • Morrill GA, Kostellow AB, Askari A. Caveolin-Na/K-ATPase interactions: Role of transmembrane topology in nongenomic steroid signal transduction. Steroids 2012; 77:1160-1168.
    • (2012) Steroids , vol.77 , pp. 1160-1168
    • Morrill, G.A.1    Kostellow, A.B.2    Askari, A.3
  • 34
    • 84863466207 scopus 로고    scopus 로고
    • Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: Involvement of RhoA, Ca(2)/CaM, and ERK
    • Park JH, Ryu JM, Yun SP, et al. Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: Involvement of RhoA, Ca(2)/CaM, and ERK. Biochim Biophys Acta 2012; 1820:1618-1627.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 1618-1627
    • Park, J.H.1    Ryu, J.M.2    Yun, S.P.3
  • 35
    • 84868307171 scopus 로고    scopus 로고
    • Dynamin2, clathrin, and lipid rafts mediate endocytosis of the apical Na/K/2Cl cotransporter NKCC2 in thick ascending limbs
    • A key study documenting that cav-1 silencing by shRNA in the rat kidney decreases the rate of NKCC2 endocytosis consistent with a key role for cav-1 in renal sodium handling
    • Ares GR, Ortiz PA. Dynamin2, clathrin, and lipid rafts mediate endocytosis of the apical Na/K/2Cl cotransporter NKCC2 in thick ascending limbs. J Biol Chem 2012; 287:37824-37834. A key study documenting that cav-1 silencing by shRNA in the rat kidney decreases the rate of NKCC2 endocytosis, consistent with a key role for cav-1 in renal sodium handling.
    • (2012) J Biol Chem , vol.287 , pp. 37824-37834
    • Ares, G.R.1    Ortiz, P.A.2
  • 36
    • 79953155650 scopus 로고    scopus 로고
    • Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na/K-ATPase in human melanoma IGR39 cells
    • Tajima N, Itokazu Y, Korpi ER, et al. Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na/K-ATPase in human melanoma IGR39 cells. J Biol Chem 2011; 286:5624-5638.
    • (2011) J Biol Chem , vol.286 , pp. 5624-5638
    • Tajima, N.1    Itokazu, Y.2    Korpi, E.R.3
  • 37
    • 80053604188 scopus 로고    scopus 로고
    • Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3
    • Gordon J, Hwang J, Carrier KJ, et al. Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3. BMC Biochem 2011; 12:54.
    • (2011) BMC Biochem , vol.12 , pp. 54
    • Gordon, J.1    Hwang, J.2    Carrier, K.J.3
  • 38
    • 10344237581 scopus 로고    scopus 로고
    • Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha
    • Lu Q, Pallas DC, Surks HK, et al. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc Natl Acad Sci U S A 2004; 101:17126-17131.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17126-17131
    • Lu, Q.1    Pallas, D.C.2    Surks, H.K.3
  • 39
    • 84867574392 scopus 로고    scopus 로고
    • Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury
    • Using a novel mouse model, these investigators documented the effect on vascular injury in an in-vivo study when the interaction between striatin and oestrogen receptor-a is blocked
    • Bernelot Moens SJ, Schnitzler GR, Nickerson M, et al. Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation 2012; 126:1993-2004. Using a novel mouse model, these investigators documented the effect on vascular injury in an in-vivo study when the interaction between striatin and oestrogen receptor-a is blocked.
    • (2012) Circulation , vol.126 , pp. 1993-2004
    • Bernelot Moens, S.J.1    Schnitzler, G.R.2    Nickerson, M.3
  • 40
    • 84856057245 scopus 로고    scopus 로고
    • Activation of the mineralocorticoid receptor increases striatin levels
    • A key study providing evidence that mineralocorticoid receptor activation leads to increases in the scaffolding protein striatin, both in vivo and in vitro
    • Pojoga LH, Coutinho P, Rivera A, et al. Activation of the mineralocorticoid receptor increases striatin levels. Am J Hypertens 2012; 25:243-249. A key study providing evidence that mineralocorticoid receptor activation leads to increases in the scaffolding protein striatin, both in vivo and in vitro.
    • (2012) Am J Hypertens , vol.25 , pp. 243-249
    • Pojoga, L.H.1    Coutinho, P.2    Rivera, A.3
  • 41
    • 20144376345 scopus 로고    scopus 로고
    • Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    • Yanai I, Benjamin H, Shmoish M, et al. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics 2005; 21:650-659.
    • (2005) Bioinformatics , vol.21 , pp. 650-659
    • Yanai, I.1    Benjamin, H.2    Shmoish, M.3
  • 42
    • 77956062795 scopus 로고    scopus 로고
    • Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy
    • Meurs KM, Mauceli E, Lahmers S, et al. Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. Hum Genet 2010; 128: 315-324.
    • (2010) Hum Genet , vol.128 , pp. 315-324
    • Meurs, K.M.1    Mauceli, E.2    Lahmers, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.