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1
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84865415051
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Novel findings and future directions on the genetics of hypertension
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An outstanding review of the future directions of genetic studies in hyertension
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& Simino J, Rao DC, Freedman BI. Novel findings and future directions on the genetics of hypertension. Curr Opin Nephrol Hypertens 2012; 21:500-507. An outstanding review of the future directions of genetic studies in hypertension.
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(2012)
Curr Opin Nephrol Hypertens
, vol.21
, pp. 500-507
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Simino, J.1
Rao, D.C.2
Freedman, B.I.3
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2
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84860218599
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Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension
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Cowley AW Jr, Nadeau JH, Baccarelli A, et al. Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. Hypertension 2012; 59:899-905.
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(2012)
Hypertension
, vol.59
, pp. 899-905
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Cowley Jr., A.W.1
Nadeau, J.H.2
Baccarelli, A.3
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4
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84877770249
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Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension
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A key study demonstrating epigenetic changes in promoter DNA methylation of a-adducin (ADD1) gene in the pathogenesis of essential hypertension
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Zhang LN, Liu PP, Wang L, et al. Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension. PLoS One 2013; 8:e63455. A key study demonstrating epigenetic changes in promoter DNA methylation of a-adducin (ADD1) gene in the pathogenesis of essential hypertension.
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(2013)
PLoS One
, vol.8
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Zhang, L.N.1
Liu, P.P.2
Wang, L.3
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5
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0036182744
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Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism
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Grant FD, Romero JR, Jeunemaitre X, et al. Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism. Hypertension 2002; 39:191-196.
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(2002)
Hypertension
, vol.39
, pp. 191-196
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Grant, F.D.1
Romero, J.R.2
Jeunemaitre, X.3
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6
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77958554883
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Alpha-adducin Gly460Trp polymorphism and hypertension risk: A meta-analysis of 22 studies including 14303 cases and 15961 controls
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Liu K, Liu J, Huang Y, et al. Alpha-adducin Gly460Trp polymorphism and hypertension risk: A meta-analysis of 22 studies including 14303 cases and 15961 controls. PLoS One 2010; 5:e13057.
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PLoS One
, vol.5
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Liu, K.1
Liu, J.2
Huang, Y.3
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7
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84855858762
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Alpha-Adducin Gly460Trp gene mutation and essential hypertension in a Chinese population: A meta-analysis including 10,960 subjects
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Li YY. alpha-Adducin Gly460Trp gene mutation and essential hypertension in a Chinese population: A meta-analysis including 10,960 subjects. PLoS One 2012; 7:e30214.
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(2012)
PLoS One
, vol.7
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Li, Y.Y.1
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8
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77952543507
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High-salt diet during pregnancy and angiotensinrelated cardiac changes
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Ding Y, Lv J, Mao C, et al. High-salt diet during pregnancy and angiotensinrelated cardiac changes. J Hypertens 2010; 28:1290-1297.
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(2010)
J Hypertens
, vol.28
, pp. 1290-1297
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Ding, Y.1
Lv, J.2
Mao, C.3
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9
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84877342168
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A genome-wide methylation study on obesity: Differential variability and differential methylation
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Xu X, Su S, Barnes VA, et al. A genome-wide methylation study on obesity: Differential variability and differential methylation. Epigenetics 2013; 8:522-533.
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(2013)
Epigenetics
, vol.8
, pp. 522-533
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Xu, X.1
Su, S.2
Barnes, V.A.3
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10
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84879678934
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A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
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Ronn T, Volkov P, Davegardh C, et al. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet 2013; 9:e1003572.
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PLoS Genet
, vol.9
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Ronn, T.1
Volkov, P.2
Davegardh, C.3
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11
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0024777763
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Sodium-sensitive essential hypertension: Emerging insights into an old entity
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Williams GH, Hollenberg NK. Sodium-sensitive essential hypertension: Emerging insights into an old entity. J Am Coll Nutr 1989; 8:490-494.
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(1989)
J Am Coll Nutr
, vol.8
, pp. 490-494
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Williams, G.H.1
Hollenberg, N.K.2
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12
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77951294554
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A mechanism for salt-sensitive hypertension: Abnormal dietary sodium-mediated vascular response to angiotensin-II
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Chamarthi B, Williams JS, Williams GH. A mechanism for salt-sensitive hypertension: Abnormal dietary sodium-mediated vascular response to angiotensin-II. J Hypertens 2010; 28:1020-1026.
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(2010)
J Hypertens
, vol.28
, pp. 1020-1026
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Chamarthi, B.1
Williams, J.S.2
Williams, G.H.3
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13
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84867745758
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Genetic biomarkers of hypertension and future challenges integrating epigenomics
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El Shamieh S, Visvikis-Siest S. Genetic biomarkers of hypertension and future challenges integrating epigenomics. Clin Chim Acta 2012; 414:259-265.
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(2012)
Clin Chim Acta
, vol.414
, pp. 259-265
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El Shamieh, S.1
Visvikis-Siest, S.2
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14
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80355127953
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Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension
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Pojoga LH, Williams JS, Yao TM, et al. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol 2011; 301:H1862-H1871.
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Am J Physiol Heart Circ Physiol
, vol.301
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Pojoga, L.H.1
Williams, J.S.2
Yao, T.M.3
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15
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84863719221
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Lysine-specific demethylase 1: An epigenetic regulator of salt-sensitive hypertension
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A seminal translational study describing the role of LSD-1 as a crucial epigenetic regulator of salt sensitivity of BP in both human and rodents
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Williams JS, Chamarthi B, Goodarzi MO, et al. Lysine-specific demethylase 1: An epigenetic regulator of salt-sensitive hypertension. Am J Hypertens 2012; 25:812-817. A seminal translational study describing the role of LSD-1 as a crucial epigenetic regulator of salt sensitivity of BP in both human and rodents.
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(2012)
Am J Hypertens
, vol.25
, pp. 812-817
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Williams, J.S.1
Chamarthi, B.2
Goodarzi, M.O.3
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16
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35349006314
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Histone lysine demethylases: Emerging roles in development, physiology and disease
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Shi Y. Histone lysine demethylases: Emerging roles in development, physiology and disease. Nat Rev Genet 2007; 8:829-833.
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(2007)
Nat Rev Genet
, vol.8
, pp. 829-833
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Shi, Y.1
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17
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84890547154
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Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake
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An interesting study that highlights the important interaction between ageing, epigenetic changes and environment
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Krug AW, Tille E, Sun B, et al. Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake. Age (Dordr) 2013; 35:1809-1820. An interesting study that highlights the important interaction between ageing, epigenetic changes and environment.
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(2013)
Age (Dordr)
, vol.35
, pp. 1809-1820
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Krug, A.W.1
Tille, E.2
Sun, B.3
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18
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85027925594
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Epigenetic modulation of the renal betaadrenergic-WNK4 pathway in salt-sensitive hypertension
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Mu S, Shimosawa T, Ogura S, et al. Epigenetic modulation of the renal betaadrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med 2011; 17:573-580.
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(2011)
Nat Med
, vol.17
, pp. 573-580
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Mu, S.1
Shimosawa, T.2
Ogura, S.3
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19
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79956364204
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Cell membrane-associated mineralocorticoid receptors New evidence
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Krug AW, Pojoga LH, Williams GH, Adler GK. Cell membrane-associated mineralocorticoid receptors New evidence. Hypertension 2011; 57:1019-1025.
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(2011)
Hypertension
, vol.57
, pp. 1019-1025
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Krug, A.W.1
Pojoga, L.H.2
Williams, G.H.3
Adler, G.K.4
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20
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80555157695
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Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart
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Ricchiuti V, Lapointe N, Pojoga L, et al. Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart. J Endocrinol 2011; 211:47-54.
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(2011)
J Endocrinol
, vol.211
, pp. 47-54
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Ricchiuti, V.1
Lapointe, N.2
Pojoga, L.3
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21
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79954525355
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Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats
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Gildea JJ, Kemp BA, Howell NL, et al. Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats. Am J Physiol Renal Physiol 2011; 300:F914-F920.
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(2011)
Am J Physiol Renal Physiol
, vol.300
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Gildea, J.J.1
Kemp, B.A.2
Howell, N.L.3
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22
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77952653780
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Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice
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Pojoga LH, Adamova Z, Kumar A, et al. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol 2010; 298: H1776-H1788.
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(2010)
Am J Physiol Heart Circ Physiol
, vol.298
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Pojoga, L.H.1
Adamova, Z.2
Kumar, A.3
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23
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77149150918
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Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II
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Pojoga LH, Romero JR, Yao TM, et al. Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology 2010; 151:1236-1246.
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(2010)
Endocrinology
, vol.151
, pp. 1236-1246
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Pojoga, L.H.1
Romero, J.R.2
Yao, T.M.3
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24
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41549101998
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Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice
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Pojoga LH, Yao TM, Sinha S, et al. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol 2008; 294:H1258-H1265.
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(2008)
Am J Physiol Heart Circ Physiol
, vol.294
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Pojoga, L.H.1
Yao, T.M.2
Sinha, S.3
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25
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79959330833
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Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats
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Nakamura T, Fukuda M, Kataoka K, et al. Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats. Hypertens Res 2011; 34:817-824.
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(2011)
Hypertens Res
, vol.34
, pp. 817-824
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Nakamura, T.1
Fukuda, M.2
Kataoka, K.3
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26
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84866298370
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Caveolae, caveolins, cavins, and endothelial cell function: New insights
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Sowa G. Caveolae, caveolins, cavins, and endothelial cell function: New insights. Front Physiol 2012; 2:120.
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(2012)
Front Physiol
, vol.2
, pp. 120
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Sowa, G.1
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27
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62349089173
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Possible new druggable targets for the treatment of nephrosis. Perhaps we should find them in caveolae
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van Dokkum RP, Buikema H. Possible new druggable targets for the treatment of nephrosis. Perhaps we should find them in caveolae Curr Opin Pharmacol 2009; 9:132-138.
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(2009)
Curr Opin Pharmacol
, vol.9
, pp. 132-138
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Van Dokkum, R.P.1
Buikema, H.2
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28
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77950510305
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Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome
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Fujita T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension 2010; 55:813-818.
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(2010)
Hypertension
, vol.55
, pp. 813-818
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Fujita, T.1
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29
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57349168398
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Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease
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Shibata S, Nagase M, Yoshida S, et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease. Nat Med 2008; 14:1370-1376.
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(2008)
Nat Med
, vol.14
, pp. 1370-1376
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Shibata, S.1
Nagase, M.2
Yoshida, S.3
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30
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77953162073
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Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway
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Nethe M, Anthony EC, Fernandez-Borja M, et al. Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci 2010; 123:1948-1958.
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(2010)
J Cell Sci
, vol.123
, pp. 1948-1958
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Nethe, M.1
Anthony, E.C.2
Fernandez-Borja, M.3
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31
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67649816872
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The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism
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Lee IH, Campbell CR, Song SH, et al. The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. J Biol Chem 2009; 284:12663-12669.
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(2009)
J Biol Chem
, vol.284
, pp. 12663-12669
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Lee, I.H.1
Campbell, C.R.2
Song, S.H.3
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32
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84860848745
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Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment
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Li X, McClellan ME, Tanito M, et al. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem 2012; 287:16424-16434.
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(2012)
J Biol Chem
, vol.287
, pp. 16424-16434
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Li, X.1
McClellan, M.E.2
Tanito, M.3
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33
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84865475880
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Caveolin-Na/K-ATPase interactions: Role of transmembrane topology in nongenomic steroid signal transduction
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Morrill GA, Kostellow AB, Askari A. Caveolin-Na/K-ATPase interactions: Role of transmembrane topology in nongenomic steroid signal transduction. Steroids 2012; 77:1160-1168.
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(2012)
Steroids
, vol.77
, pp. 1160-1168
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Morrill, G.A.1
Kostellow, A.B.2
Askari, A.3
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34
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84863466207
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Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: Involvement of RhoA, Ca(2)/CaM, and ERK
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Park JH, Ryu JM, Yun SP, et al. Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: Involvement of RhoA, Ca(2)/CaM, and ERK. Biochim Biophys Acta 2012; 1820:1618-1627.
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(2012)
Biochim Biophys Acta
, vol.1820
, pp. 1618-1627
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Park, J.H.1
Ryu, J.M.2
Yun, S.P.3
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35
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84868307171
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Dynamin2, clathrin, and lipid rafts mediate endocytosis of the apical Na/K/2Cl cotransporter NKCC2 in thick ascending limbs
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A key study documenting that cav-1 silencing by shRNA in the rat kidney decreases the rate of NKCC2 endocytosis consistent with a key role for cav-1 in renal sodium handling
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Ares GR, Ortiz PA. Dynamin2, clathrin, and lipid rafts mediate endocytosis of the apical Na/K/2Cl cotransporter NKCC2 in thick ascending limbs. J Biol Chem 2012; 287:37824-37834. A key study documenting that cav-1 silencing by shRNA in the rat kidney decreases the rate of NKCC2 endocytosis, consistent with a key role for cav-1 in renal sodium handling.
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(2012)
J Biol Chem
, vol.287
, pp. 37824-37834
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Ares, G.R.1
Ortiz, P.A.2
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36
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79953155650
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Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na/K-ATPase in human melanoma IGR39 cells
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Tajima N, Itokazu Y, Korpi ER, et al. Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na/K-ATPase in human melanoma IGR39 cells. J Biol Chem 2011; 286:5624-5638.
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(2011)
J Biol Chem
, vol.286
, pp. 5624-5638
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Tajima, N.1
Itokazu, Y.2
Korpi, E.R.3
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37
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80053604188
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Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3
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Gordon J, Hwang J, Carrier KJ, et al. Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3. BMC Biochem 2011; 12:54.
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(2011)
BMC Biochem
, vol.12
, pp. 54
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Gordon, J.1
Hwang, J.2
Carrier, K.J.3
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38
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10344237581
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Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha
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Lu Q, Pallas DC, Surks HK, et al. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc Natl Acad Sci U S A 2004; 101:17126-17131.
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(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17126-17131
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Lu, Q.1
Pallas, D.C.2
Surks, H.K.3
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39
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84867574392
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Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury
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Using a novel mouse model, these investigators documented the effect on vascular injury in an in-vivo study when the interaction between striatin and oestrogen receptor-a is blocked
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Bernelot Moens SJ, Schnitzler GR, Nickerson M, et al. Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation 2012; 126:1993-2004. Using a novel mouse model, these investigators documented the effect on vascular injury in an in-vivo study when the interaction between striatin and oestrogen receptor-a is blocked.
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(2012)
Circulation
, vol.126
, pp. 1993-2004
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Bernelot Moens, S.J.1
Schnitzler, G.R.2
Nickerson, M.3
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40
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84856057245
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Activation of the mineralocorticoid receptor increases striatin levels
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A key study providing evidence that mineralocorticoid receptor activation leads to increases in the scaffolding protein striatin, both in vivo and in vitro
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Pojoga LH, Coutinho P, Rivera A, et al. Activation of the mineralocorticoid receptor increases striatin levels. Am J Hypertens 2012; 25:243-249. A key study providing evidence that mineralocorticoid receptor activation leads to increases in the scaffolding protein striatin, both in vivo and in vitro.
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(2012)
Am J Hypertens
, vol.25
, pp. 243-249
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Pojoga, L.H.1
Coutinho, P.2
Rivera, A.3
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41
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20144376345
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Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
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Yanai I, Benjamin H, Shmoish M, et al. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics 2005; 21:650-659.
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(2005)
Bioinformatics
, vol.21
, pp. 650-659
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Yanai, I.1
Benjamin, H.2
Shmoish, M.3
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42
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77956062795
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Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy
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Meurs KM, Mauceli E, Lahmers S, et al. Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. Hum Genet 2010; 128: 315-324.
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(2010)
Hum Genet
, vol.128
, pp. 315-324
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Meurs, K.M.1
Mauceli, E.2
Lahmers, S.3
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