Report of the national heart, lung, and blood institute working group on epigenetics and hypertension

Hypertension

Volumn 59, Issue 5, 2012, Pages 899-905

  Cowley, Allen W ^a   Nadeau, Joseph H ^b   Baccarelli, Andrea ^c   Berecek, Kathleen ^d   Fornage, Myriam ^e   Gibbons, Gary H ^f   Harrison, David G ^g   Liang, Mingyu ^a   Nathanielsz, Peter W ^h   O'Connor, Daniel T ⁱ   Ordovas, Jose ^j,k,l   Peng, Weiqun ^m   Soares, Marcelo Bento ⁿ   Szyf, Moshe ^o   Tolunay, H Eser ^p   Wood, Katherine C ^p   Zhao, Keji ^p   Galis, Zorina S ^p  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^c Laboratory of Environmental Epigenetics   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^f MOREHOUSE SCHOOL OF MEDICINE   (United States)

^g VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h University of Texas Health Science Center at San Antonio   (United States)

ⁱ UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^j TUFTS UNIVERSITY   (United States)

^k CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^l IMDEA FOOD INSTITUTE   (Spain)

^m GEORGE WASHINGTON UNIVERSITY   (United States)

ⁿ NORTHWESTERN UNIVERSITY   (United States)

^o MCGILL UNIVERSITY   (Canada)

^p NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE;

BLOOD PRESSURE REGULATION; COST OF ILLNESS; DIZYGOTIC TWINS; DNA METHYLATION; ENVIRONMENTAL FACTOR; EPIGENETICS; ESSENTIAL HYPERTENSION; FAMILIAL DISEASE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HERITABILITY; HUMAN; HYPERTENSION; INHERITANCE; MOLECULAR GENETICS; MONOZYGOTIC TWINS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; REVIEW; UNITED STATES;

ADVISORY COMMITTEES; ANIMALS; BIOMEDICAL RESEARCH; COMORBIDITY; ENVIRONMENT; EPIGENOMICS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLORHINI; HUMANS; HYPERTENSION; MALE; MICE; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (U.S.); NEEDS ASSESSMENT; PREVALENCE; RATS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; UNITED STATES;

EID: 84860218599     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.190116     Document Type: Review

References (54)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005; 365:217-223. (Pubitemid 40138015)
2. Institute of Medicine. Report on a population-based policy and systems change approach to prevent and control hypertension 2010. http://www. iom.edu/Reports/2010/A-Population-Based-Policy-and-Systems-Change-Approach-to- Prevent-and-Control-Hypertension.aspx. Accessed November 25, 2011.
3. Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodríguez-Artalejo F, Stegmayr B, Thamm M, Tuomilehto J, Vanuzzo D, Vescio F. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA. 2003;289:2363-2369. (Pubitemid 37430168)
4. Gaziano TA, Bitton A, Anand S, Weinstein MC. The global cost of nonoptimal blood pressure. J Hypertens. 2009;27:1472-1477.
5. Guyton AC. Long-term arterial pressure control: an analysis from animal experiments and computer and graphic models. Am J Physiol. 1990;259: R865-R877. (Pubitemid 20387146)
6. Cowley AW Jr. Long-term control of arterial blood pressure. Physiol Rev. 1992;72:231-300.
7. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001;104:545-556. (Pubitemid 32201949)
8. Saavedra JM. Opportunities and limitations of genetic analysis of hypertensive rat strains. J Hypertens. 2009;27:1129-1133.
9. Cowley AW Jr. The genetic dissection of essential hypertension. Nat Rev Genet. 2006;7:829-840.
10. Cowley AW Jr, Roman RJ. The role of the kidney in hypertension. JAMA. 1996;275:1581-1589. (Pubitemid 126570086)
11. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 2009;461:747-753.
12. Chakravarti A. Genomics is not enough. Science. 2011;334:15.
13. Altshuler D, Daly MJ, Lander ES. Genetic mapping in human disease. Science. 2008;322:881-888.
14. Lander ES. Initial impact of the sequencing of the human genome. Nature. 2011;470:187-197.
15. Frazer KA, Murray SS, Schork NJ, Topol EJ. Human genetic variation and its contribution to complex traits. Nat Rev Genet. 2009;10: 241-251.
16. Havlik RJ, Garrison RJ, Feinleib M, Kannel WB, Castelli WP, McNamara PM. Blood pressure aggregation in families. Am J Epidemiol. 1979;110:304-312. (Pubitemid 10204330)
17. Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a blood pressure gene on chromosome 17: genome scan results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study. Hypertension. 2000;36:477-483.
18. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009;41:677-687.
19. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL; Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009;41:666-676.
20. Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sõber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WH, Sjögren M, Vinay DG, Alexander M, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011; 478:103-109.
21. Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Parsa A, Ober CC, Welling PA, Chakravarti A, Weder AB, Cooper RS, Mitchell BD, Shuldiner AR, Chang YP. Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci USA. 2009;106:226-231.
22. Hirschhorn JN. Genetic approaches to studying common diseases and complex traits. Pediatr Res. 2005;57:74R-77R. (Pubitemid 40593249)
23. Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W, Courtland HW, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES, Nadeau JH. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci USA. 2008;105:19910-19914.
24. Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci USA. 2012;109:1193-1198.
25. Waddington CH. The Strategy of the Genes. London, United Kingdom: George Allen and Unwin Ltd; 1957.
26. Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011; 13:7-13.
27. Nadeau JH. Transgenerational genetic effects on phenotypic variation and disease risk. Hum Mol Genet. 2009;18:R202-R210.
28. Nelson VR, Nadeau JH. Transgenerational genetic effects. Epigenomics. 2010;2:797-806.
29. Guerrero-Bosagna C, Skinner MK. Environmentally induced epigenetic transgenerational inheritance of phenotype and disease. Mol Cell Endocrinol. Epub ahead of print October 13, 2011.
30. Youngson NA, Whitelaw E. Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet. 2008;9:233-257.
31. Ferguson-Smith AC. Genomic imprinting: the emergence of an epigenetic paradigm. Nat Rev Genet. 2011;12:565-575.
32. Millis RM. Epigenetics and hypertension. Curr Hypertens Rep. 2011;13: 21-28.
33. Baylin SB, Jones PA. A decade of exploring the cancer epigenome: biological and translational implications. Nat Rev Cancer. 2011;11: 726-734.
34. Baccarelli A, Rienstra M, Benjamin EJ. Cardiovascular epigenetics: basic concepts and results from animal and human studies. Circ Cardiovasc Genet. 2010;3:567-573.
35. Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs-cell dysfunction in female rat offspring. Nature. 2010;467:963-966.
36. Yazbek SN, Spiezio SH, Nadeau JH, Buchner DA. Ancestral paternal genotype controls body weight and food intake for multiple generations. Hum Mol Genet. 2010;19:4134-4144.
37. Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature. 2011;479:365-371.
38. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA. 2005;102:10604-10609. (Pubitemid 41061601)
39. Szyf M. The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics. 2011;6:971-978.
40. Gluckman PD, Hanson MA, Beedle AS. Non-genomic transgenerational inheritance of disease risk. Bioessays. 2007;29:145-154. (Pubitemid 46340249)
41. Gluckman PD, Hanson MA, Buklijas T, Low FM, Beedle AS. Epigenetic mechanismsthat underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol. 2009;5:401408.
42. Low FM, Gluckman PD, Hanson MA. Developmental plasticity and epigenetic mechanisms underpinning metabolic and cardiovascular diseases. Epigenomics. 2011;3:279-294.
43. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003;23: 5293-5300. (Pubitemid 36950884)
44. Schier AF. The maternal-zygotic transition: death and birth of RNAs. Science. 2007;316:406-407. (Pubitemid 46651481)
45. Xing Y, Shi S, Le L, Lee CA, Silver-Morse L, Li WX. Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genet. 2007;3:1598-1606. (Pubitemid 47510253)
46. Lam MY, Heaney JD, Youngren KK, Kawasoe JH, Nadeau JH. Transgenerational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet. 2007;16:2233-2240. (Pubitemid 47354905)
47. Yazbek SN, Buchner DA, Geisinger JM, Burrage LC, Spiezio SH, Zentner GE, Hsieh CW, Scacheri PC, Croniger CM, Nadeau JH. Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis. Genome Res. 2011;21:1065-1073.
48. Cuzin F, Rassoulzadegan M. Non-Mendelian epigenetic heredity: gametic RNAs as epigenetic regulators and transgenerational signals. Essays Biochem. 2010;48:101-106.
49. Bateson P. Fetal experience and good adult design. Int J Epidemiol. 2001;30:928-934. (Pubitemid 33049013)
50. Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science. 2004;305:1733-1736. (Pubitemid 39249632)
51. Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE. Developmental plasticity and human health. Nature. 2004;430:419-421. (Pubitemid 38987896)
52. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7:847-854. (Pubitemid 38989508)
53. Molaro A, Hodges E, Fang F, Song Q, McCombie WR, Hannon GJ, Smith AD. Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell. 2011;146:1029-1041.
54. Gervin K, Vigeland MD, Mattingsdal M, Hammer M, Nygaord H, Olsen AO, Brandt I, Harris JR, Undlien DE, Lyle R. DNA methylation and gene expression changes in monzygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes. PLoS Genetics. 2012;8: e1002454.