New discoveries of old SON: A link between RNA splicing and cancer

Journal of Cellular Biochemistry

Volumn 115, Issue 2, 2014, Pages 224-231

  Hickey, Christopher J ^a   Kim, Jung Hyun ^a   Ahn, Eun Young Erin ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Cancer; Gene Expression; RNA Splicing; SON; Transcription

Indexed keywords

ADENOSINE DEAMINASE; ARGININE; AURORA B KINASE; CELL PROTEIN; COMPLEMENTARY DNA; DNA BINDING PROTEIN; DNA METHYLTRANSFERASE 1; GAMMA TUBULIN; GAMMA TUBULIN COMPLEX PROTEIN 2; HISTONE DEACETYLASE 6; KATANIN P80; PERICENTRIN; RNA BINDING PROTEIN; RNA POLYMERASE II; SC35 PROTEIN; SERINE ARGININE RICH PROTEIN; SON PROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; APOPTOSIS; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL TRANSFORMATION; CHROMOSOMAL INSTABILITY; CHROMOSOME 16; DNA LIBRARY; EPITHELIUM CELL; EXON; GENE LOCUS; GENE OVEREXPRESSION; GENE SILENCING; GENE STRUCTURE; GENOMIC INSTABILITY; HUMAN; INTRON; LEUKEMIA; METAPHASE; MICROTUBULE; MITOSIS; MITOSIS INHIBITION; NEOPLASM; NONHUMAN; PANCREAS ADENOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; RNA INTERFERENCE; RNA METABOLISM; RNA PROCESSING; RNA SPLICING; TANDEM REPEAT; TRANSCRIPTION REGULATION;

CANCER; GENE EXPRESSION; RNA SPLICING; SON; TRANSCRIPTION;

APOPTOSIS; CARCINOGENESIS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMIC INSTABILITY; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; RNA SPLICING; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84890531975     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24672     Document Type: Review

References (46)

1. Ahn EY, Yan M, Malakhova OA, Lo MC, Boyapati A, Ommen HB, Hines R, Hokland P, Zhang DE,. 2008. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. Proc Natl Acad Sci USA 105: 17103-17108.
2. Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, Pandit S, Fu XD, Zhang DE,. 2011. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell 42: 185-198.
3. Ahn EE, Higashi T, Yan M, Matsuura S, Hickey CJ, Lo MC, Shia WJ, DeKelver RC, Zhang DE,. 2013. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a∼27a∼24-2 cluster. J Biol Chem 288: 5381-5388.
4. Aldana-Masangkay GI, Sakamoto KM,. 2011. The role of HDAC6 in cancer. J Biomed Biotechnol 2011: 875824.
5. Aravind L, Koonin EV,. 1999. G-patch: A new conserved domain in eukaryotic RNA-processing proteins and type D retroviral polyproteins. Trends Biochem Sci 24: 342-344.
6. Berdichevskii FB, Chumakov IM, Kiselev LL,. 1988. [Decoding of the primary structure of the son3 region in human genome: Identification of a new protein with unusual structure and homology with DNA-binding proteins]. Mol Biol (Mosk) 22: 794-801.
7. Birney E, Kumar S, Krainer AR,. 1993. Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res 21: 5803-5816.
8. Bliskovskii VV, Berdichevskii FB, Tkachenko AV, Belova ME, Chumankov IM,. 1992. Coding part of the son gene small transcript contains four areas of complete tandem repeats. Mol Biol (Mosk) 26: 793-806.
9. Chen T, Hevi S, Gay F, Tsujimoto N, He T, Zhang B, Ueda Y, Li E,. 2007. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet 39: 391-396.
10. Chumakov IM, Berdichevskii FB, Sokolova NV, Reznikov MV, Prasolov VS,. 1991. Identification of a protein product of a novel human gene SON and the biological effect upon administering a changed form of this gene into mammalian cells. Mol Biol (Mosk) 25: 731-739.
11. DeKelver RC, Yan M, Ahn EY, Shia WJ, Speck NA, Zhang DE,. 2013. Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential. Blood 121: 3714-3717.
12. Faustino NA, Cooper TA,. 2003. Pre-mRNA splicing and human disease. Genes Dev 17: 419-437.
13. Furukawa T, Tanji E, Kuboki Y, Hatori T, Yamamoto M, Shimizu K, Shibata N, Shiratori K,. 2012. Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells. Mol Cancer 11: 88.
14. Garcia-Blanco MA, Baraniak AP, Lasda EL,. 2004. Alternative splicing in disease and therapy. Nat Biotechnol 22: 535-546.
15. Giorgi C, Moore MJ,. 2007. The nuclear nurture and cytoplasmic nature of localized mRNPs. Semin Cell Dev Biol 18: 186-193.
16. Graveley BR,. 2000. Sorting out the complexity of SR protein functions. RNA 6: 1197-1211.
17. Greenhalf W, Lee J, Chaudhuri B,. 1999. A selection system for human apoptosis inhibitors using yeast. Yeast 15: 1307-1321.
18. Gudikote JP, Imam JS, Garcia RF, Wilkinson MF,. 2005. RNA splicing promotes translation and RNA surveillance. Nat Struct Mol Biol 12: 801-809.
19. Hackanson B, Rimmele L, Benkisser M, Abdelkarim M, Fliegauf M, Jung M, Lubbert M,. 2012. HDAC6 as a target for antileukemic drugs in acute myeloid leukemia. Leuk Res 36: 1055-1062.
20. Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD,. 2008. Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol 9: R99.
21. Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J,. 2010. SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle 9: 2679-2685.
22. Khan IM, Fisher RA, Johnson KJ, Bailey ME, Siciliano MJ, Kessling AM, Farrer M, Carritt B, Kamalati T, Buluwela L,. 1994. The SON gene encodes a conserved DNA binding protein mapping to human chromosome 21. Ann Hum Genet 58: 25-34.
23. Komori T, Doi A, Furuta H, Wakao H, Nakao N, Nakazato M, Nanjo K, Senba E, Morikawa Y,. 2010. Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. J Biol Chem 285: 37884-37894.
24. Kornblihtt AR, Schor IE, Allo M, Dujardin G, Petrillo E, Munoz MJ,. 2013. Alternative splicing: A pivotal step between eukaryotic transcription and translation. Nat Rev Mol Cell Biol 14: 153-165.
25. Le Hir H, Izaurralde E, Maquat LE, Moore MJ,. 2000. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J 19: 6860-6869.
26. Ma XM, Yoon SO, Richardson CJ, Julich K, Blenis J,. 2008. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133: 303-313.
27. Masliah G, Barraud P, Allain FH,. 2013. RNA recognition by double-stranded RNA binding domains: A matter of shape and sequence. Cell Mol Life Sci 70: 1875-1895.
28. Mattioni T, Hume CR, Konigorski S, Hayes P, Osterweil Z, Lee JS,. 1992. A cDNA clone for a novel nuclear protein with DNA binding activity. Chromosoma 101: 618-624.
29. Moore MJ, Wang Q, Kennedy CJ, Silver PA,. 2010. An alternative splicing network links cell-cycle control to apoptosis. Cell 142: 625-636.
30. Nott A, Le Hir H, Moore MJ,. 2004. Splicing enhances translation in mammalian cells: An additional function of the exon junction complex. Genes Dev 18: 210-222.
31. Nousiainen M, Sillje HH, Sauer G, Nigg EA, Korner R,. 2006. Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci USA 103: 5391-5396.
32. Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA,. 2009. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell 35: 228-239.
33. Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE,. 2001. From PREDs and open reading frames to cDNA isolation: Revisiting the human chromosome 21 transcription map. Genomics 78: 46-54.
34. Sacco-Bubulya P, Spector DL,. 2002. Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. J Cell Biol 156: 425-436.
35. Saitoh N, Spahr CS, Patterson SD, Bubulya P, Neuwald AF, Spector DL,. 2004. Proteomic analysis of interchromatin granule clusters. Mol Biol Cell 15: 3876-3890.
36. Saunders LR, Barber GN,. 2003. The dsRNA binding protein family: Critical roles, diverse cellular functions. FASEB J 17: 961-983.
37. Sharma A, Takata H, Shibahara K, Bubulya A, Bubulya PA,. 2010. Son is essential for nuclear speckle organization and cell cycle progression. Mol Biol Cell 21: 650-663.
38. Sharma A, Markey M, Torres-Munoz K, Varia S, Kadakia M, Bubulya A, Bubulya PA,. 2011. Son maintains accurate splicing for a subset of human pre-mRNAs. J Cell Sci 124: 4286-4298.
39. Singh G, Kucukural A, Cenik C, Leszyk JD, Shaffer SA, Weng Z, Moore MJ,. 2012. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Cell 151: 750-764.
40. Sun CT, Lo WY, Wang IH, Lo YH, Shiou SR, Lai CK, Ting LP,. 2001. Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON. J Biol Chem 276: 24059-24067.
41. Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faca VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM,. 2011. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 20: 289-299.
42. Takawa M, Cho HS, Hayami S, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Maejima K, Ueda K, Masuda A, Dohmae N, Field HI, Tsunoda T, Kobayashi T, Akasu T, Sugiyama M, Ohnuma S, Atomi Y, Ponder BA, Nakamura Y, Hamamoto R,. 2012. Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Res 72: 3217-3227.
43. Tange TO, Nott A, Moore MJ,. 2004. The ever-increasing complexities of the exon junction complex. Curr Opin Cell Biol 16: 279-284.
44. Tran AD, Marmo TP, Salam AA, Che S, Finkelstein E, Kabarriti R, Xenias HS, Mazitschek R, Hubbert C, Kawaguchi Y, Sheetz MP, Yao TP, Bulinski JC,. 2007. HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci 120: 1469-1479.
45. Wynn SL, Fisher RA, Pagel C, Price M, Liu QY, Khan IM, Zammit P, Dadrah K, Mazrani W, Kessling A, Lee JS, Buluwela L,. 2000. Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. Genomics 68: 57-62.
46. Zhong XY, Wang P, Han J, Rosenfeld MG, Fu XD,. 2009. SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell 35: 1-10.