메뉴 건너뛰기




Volumn 36, Issue 8, 2012, Pages 1055-1062

HDAC6 as a target for antileukemic drugs in acute myeloid leukemia

Author keywords

Acute myeloid leukemia; Histone deacetylase inhibitors; Therapy

Indexed keywords

2 (7 HYDROXYCARBAMOYLHEPATNOYL AMINO) 3 [1,1':4',1'']TERPHENYL 4 YLPROPIONIC ACID METHYLESTER; 2 (9 HYDROXYCARBAMOYLNONANOYL AMINO) 3 PHENYLPROPIONIC ACID METHYLESTER; 4 [2 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)VINYL]BENZOIC ACID; [3 (4 FURAN 2 YLPHENYL) 2 7 HYDROXYCARBOMOYL HEPTANOYLAMINO] PROPIONIC ACID METHYLESTER; ALPHA TUBULIN; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HISTONE H4; ST 13; ST 34; UNCLASSIFIED DRUG;

EID: 84862548703     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.02.026     Document Type: Article
Times cited : (47)

References (35)
  • 1
    • 79956294708 scopus 로고    scopus 로고
    • Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
    • April 11 [Epub ahead of print]
    • Lübbert M., Suciu S., Baila L., Rüter B.H., Platzbecker U., Giagounidis A., et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol 2011, April 11 [Epub ahead of print].
    • (2011) J Clin Oncol
    • Lübbert, M.1    Suciu, S.2    Baila, L.3    Rüter, B.H.4    Platzbecker, U.5    Giagounidis, A.6
  • 2
    • 84857747740 scopus 로고    scopus 로고
    • A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy.Haematologica
    • Lübbert M, Rüter BH, Claus R, Schmoor C, Schmid M, Germing U et al. A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy. Haematologica 2011:97:393-401.
    • (2011) , vol.97 , pp. 393-401
    • Lübbert, M.1    Rüter, B.H.2    Claus, R.3    Schmoor, C.4    Schmid, M.5    Germing, U.6
  • 3
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P., Mufti G.J., Hellström-Lindberg E., Santini V., Gattermann N., Germing U., et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010, 28:562-569.
    • (2010) J Clin Oncol , vol.28 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellström-Lindberg, E.3    Santini, V.4    Gattermann, N.5    Germing, U.6
  • 4
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: implications for disease and therapy
    • Haberland M., Montgomery R.L., Olson E.N. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009, 10:32-42.
    • (2009) Nat Rev Genet , vol.10 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 7
    • 67349232749 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors that target tubulin
    • Schemies J., Sippl W., Jung M. Histone deacetylase inhibitors that target tubulin. Cancer Lett 2009, 280:222-232.
    • (2009) Cancer Lett , vol.280 , pp. 222-232
    • Schemies, J.1    Sippl, W.2    Jung, M.3
  • 8
    • 49649108912 scopus 로고    scopus 로고
    • Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion
    • Yang Y., Rao R., Shen J., Tang Y., Fiskus W., Nechtman J., et al. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Res 2008, 68:4833-4842.
    • (2008) Cancer Res , vol.68 , pp. 4833-4842
    • Yang, Y.1    Rao, R.2    Shen, J.3    Tang, Y.4    Fiskus, W.5    Nechtman, J.6
  • 9
    • 20844435806 scopus 로고    scopus 로고
    • Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
    • Hideshima T., Bradner J.E., Wong J., Chauhan D., Richardson P., Schreiber S.L., et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A 2005, 102:8567-8572.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8567-8572
    • Hideshima, T.1    Bradner, J.E.2    Wong, J.3    Chauhan, D.4    Richardson, P.5    Schreiber, S.L.6
  • 10
    • 0037925520 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
    • Krämer O.H., Zhu P., Ostendorff H.P., Golebiewski M., Tiefenbach J., Peters M.A., et al. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J 2003, 22:3411-3420.
    • (2003) EMBO J , vol.22 , pp. 3411-3420
    • Krämer, O.H.1    Zhu, P.2    Ostendorff, H.P.3    Golebiewski, M.4    Tiefenbach, J.5    Peters, M.A.6
  • 11
    • 34548075217 scopus 로고    scopus 로고
    • Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90
    • Fiskus W., Ren Y., Mohapatra A., Bali P., Mandawat A., Rao R., et al. Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90. Clin Cancer Res 2007, 13:4882-4890.
    • (2007) Clin Cancer Res , vol.13 , pp. 4882-4890
    • Fiskus, W.1    Ren, Y.2    Mohapatra, A.3    Bali, P.4    Mandawat, A.5    Rao, R.6
  • 12
    • 65549166880 scopus 로고    scopus 로고
    • HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling
    • Kekatpure V.D., Dannenberg A.J., Subbaramaiah K. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J Biol Chem 2009, 284:7436-7445.
    • (2009) J Biol Chem , vol.284 , pp. 7436-7445
    • Kekatpure, V.D.1    Dannenberg, A.J.2    Subbaramaiah, K.3
  • 13
    • 34548416641 scopus 로고    scopus 로고
    • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
    • Boyault C., Zhang Y., Fritah S., Caron C., Gilquin B., Kwon S.H., et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev 2007, 21:2172-2181.
    • (2007) Genes Dev , vol.21 , pp. 2172-2181
    • Boyault, C.1    Zhang, Y.2    Fritah, S.3    Caron, C.4    Gilquin, B.5    Kwon, S.H.6
  • 14
    • 71049117160 scopus 로고    scopus 로고
    • Function of Histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR
    • Palijan A., Fernandes I., Bastien Y., Tang L., Verway M., Kourelis M., et al. Function of Histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR. J Biol Chem 2009, 284:30275-30287.
    • (2009) J Biol Chem , vol.284 , pp. 30275-30287
    • Palijan, A.1    Fernandes, I.2    Bastien, Y.3    Tang, L.4    Verway, M.5    Kourelis, M.6
  • 15
    • 51649126046 scopus 로고    scopus 로고
    • Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6
    • Scott G.K., Marx C., Berger C.E., Saunders L.R., Verdin E., Schäfer S., et al. Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6. Mol Cancer Res 2008, 6:1250-1258.
    • (2008) Mol Cancer Res , vol.6 , pp. 1250-1258
    • Scott, G.K.1    Marx, C.2    Berger, C.E.3    Saunders, L.R.4    Verdin, E.5    Schäfer, S.6
  • 16
    • 0344640906 scopus 로고    scopus 로고
    • Domain-selective small molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
    • Haggarty S.J., Koeller K.M., Wong J.C., Grozinger C.M., Schreiber S.L. Domain-selective small molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A 2003, 100:4389-4394.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4389-4394
    • Haggarty, S.J.1    Koeller, K.M.2    Wong, J.C.3    Grozinger, C.M.4    Schreiber, S.L.5
  • 17
    • 77955355838 scopus 로고    scopus 로고
    • Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
    • Butler K.V., Kalin J., Brochier C., Vistoli G., Langley B., Kozikowski A.P., et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc 2010, 132:10842-10846.
    • (2010) J Am Chem Soc , vol.132 , pp. 10842-10846
    • Butler, K.V.1    Kalin, J.2    Brochier, C.3    Vistoli, G.4    Langley, B.5    Kozikowski, A.P.6
  • 18
    • 38949141196 scopus 로고    scopus 로고
    • Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)
    • Schäfer S., Saunders L., Eliseeva E., Velena A., Jung M., Schwienhorst A., et al. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg Med Chem 2008, 16:2011-2033.
    • (2008) Bioorg Med Chem , vol.16 , pp. 2011-2033
    • Schäfer, S.1    Saunders, L.2    Eliseeva, E.3    Velena, A.4    Jung, M.5    Schwienhorst, A.6
  • 19
    • 0037405043 scopus 로고    scopus 로고
    • Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
    • Dryden S.C., Nahhas F.A., Nowak J.E., Goustin A.S., Tainsky M.A. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol 2003, 23:3173-3185.
    • (2003) Mol Cell Biol , vol.23 , pp. 3173-3185
    • Dryden, S.C.1    Nahhas, F.A.2    Nowak, J.E.3    Goustin, A.S.4    Tainsky, M.A.5
  • 20
    • 20044379059 scopus 로고    scopus 로고
    • Review: tubulin function, action of antitubulin drugs, and new drug development
    • Pellegrini F., Budman D.R. Review: tubulin function, action of antitubulin drugs, and new drug development. Cancer Invest 2005, 23:264-273.
    • (2005) Cancer Invest , vol.23 , pp. 264-273
    • Pellegrini, F.1    Budman, D.R.2
  • 22
    • 27144475816 scopus 로고    scopus 로고
    • Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
    • Bradbury C.A., Khanim F.L., Hayden R., Bunce C.M., White D.A., Drayson M.T., et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 2006, 19:1751-1759.
    • (2006) Leukemia , vol.19 , pp. 1751-1759
    • Bradbury, C.A.1    Khanim, F.L.2    Hayden, R.3    Bunce, C.M.4    White, D.A.5    Drayson, M.T.6
  • 23
    • 58149089923 scopus 로고    scopus 로고
    • Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases
    • Chou C.J., Herman D., Gottesfeld J.M. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem 2008, 283:35402-36359.
    • (2008) J Biol Chem , vol.283 , pp. 35402-36359
    • Chou, C.J.1    Herman, D.2    Gottesfeld, J.M.3
  • 24
    • 34547094822 scopus 로고    scopus 로고
    • Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group
    • Beckers T., Burkhardt C., Wieland H., Gimmnich P., Ciossek T., Maier T., et al. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int J Cancer 2007, 121:1138-1148.
    • (2007) Int J Cancer , vol.121 , pp. 1138-1148
    • Beckers, T.1    Burkhardt, C.2    Wieland, H.3    Gimmnich, P.4    Ciossek, T.5    Maier, T.6
  • 26
    • 52649133274 scopus 로고    scopus 로고
    • HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells
    • Rao R., Fiskus W., Yang Y., Lee P., Joshi R., Fernandez P., et al. HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells. Blood 2008, 112:1886-1893.
    • (2008) Blood , vol.112 , pp. 1886-1893
    • Rao, R.1    Fiskus, W.2    Yang, Y.3    Lee, P.4    Joshi, R.5    Fernandez, P.6
  • 27
    • 22844432021 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors
    • Bali P., Pranpat M., Bradner J., Balasis M., Fiskus W., Guo F., et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 2005, 280:26729-26734.
    • (2005) J Biol Chem , vol.280 , pp. 26729-26734
    • Bali, P.1    Pranpat, M.2    Bradner, J.3    Balasis, M.4    Fiskus, W.5    Guo, F.6
  • 29
    • 67650090545 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: potential in cancer therapy
    • Marks P.A., Xu W.S. Histone deacetylase inhibitors: potential in cancer therapy. J Cell Biochem 2009, 107:600-608.
    • (2009) J Cell Biochem , vol.107 , pp. 600-608
    • Marks, P.A.1    Xu, W.S.2
  • 30
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci S., Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006, 6:38-51.
    • (2006) Nat Rev Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 31
    • 34447509697 scopus 로고    scopus 로고
    • Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-Cell lymphoma
    • Duvic M., Vu J. Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-Cell lymphoma. Expert Opin Invest Drugs 2007, 16:1111-1120.
    • (2007) Expert Opin Invest Drugs , vol.16 , pp. 1111-1120
    • Duvic, M.1    Vu, J.2
  • 32
    • 77749309291 scopus 로고    scopus 로고
    • Romidepsin for the treatment of cutaneous T-cell lymphoma
    • Campas-Moya C. Romidepsin for the treatment of cutaneous T-cell lymphoma. Drugs Today 2009, 45:787-795.
    • (2009) Drugs Today , vol.45 , pp. 787-795
    • Campas-Moya, C.1
  • 33
    • 84862570265 scopus 로고    scopus 로고
    • Tubacin, an inhibitor of HDAC6, induces apoptosis of acute lymphoblastic leukemia cells in vitro and in vivo through a Na+/K+ATPase-dependent pathway
    • (abstract)
    • Rodriguez-Gonzalez A., Simms-Waldrip T., Ikeda A.K., Lin T., Lomenick B., Aldana Masangkay G., et al. Tubacin, an inhibitor of HDAC6, induces apoptosis of acute lymphoblastic leukemia cells in vitro and in vivo through a Na+/K+ATPase-dependent pathway. Blood 2008, 112:1923. (abstract).
    • (2008) Blood , vol.112 , pp. 1923
    • Rodriguez-Gonzalez, A.1    Simms-Waldrip, T.2    Ikeda, A.K.3    Lin, T.4    Lomenick, B.5    Aldana Masangkay, G.6
  • 34
    • 34547684065 scopus 로고    scopus 로고
    • HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
    • Boyault C., Sadoul K., Pabion M., Khochbin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 2007, 26:5468-5476.
    • (2007) Oncogene , vol.26 , pp. 5468-5476
    • Boyault, C.1    Sadoul, K.2    Pabion, M.3    Khochbin, S.4
  • 35
    • 58149330694 scopus 로고    scopus 로고
    • Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor
    • Bazzaro M., Lin Z., Santillan A., Lee M.K., Wang M.C., Chan K.C., et al. Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor. Clin Cancer Res 2008, 14:7340-7347.
    • (2008) Clin Cancer Res , vol.14 , pp. 7340-7347
    • Bazzaro, M.1    Lin, Z.2    Santillan, A.3    Lee, M.K.4    Wang, M.C.5    Chan, K.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.