Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells

Molecular Cancer

Volumn 11, Issue , 2012, Pages

  Furukawa, Toru ^a   Tanji, Etsuko ^a   Kuboki, Yuko ^a   Hatori, Takashi ^a   Yamamoto, Masakazu ^a   Shimizu, Kyoko ^a   Shibata, Noriyuki ^a   Shiratori, Keiko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Cell cycle; MAPK; RNA interference; SON; Speckle

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; PROTEIN; SON PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER TISSUE; CARCINOGENICITY; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOLECULAR IMAGING; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PANCREAS CANCER; RNA INTERFERENCE;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CARCINOMA, PANCREATIC DUCTAL; CELL CYCLE CHECKPOINTS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; PANCREATIC NEOPLASMS; RNA INTERFERENCE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84874003117     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-11-88     Document Type: Article

References (36)

1. Cancer statistics in Japan 2008, National Cancer Center, Tokyo, Kato H, Sobue T, Katanoda K, Saito Y, Tsukuma H, Sakura N, Kitai A.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009, 59(4):225-249. 10.3322/caac.20006, 19474385.
3. Berrino F, De Angelis R, Sant M, Rosso S, Bielska-Lasota M, Coebergh JW, Santaquilani M. Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol 2007, 8(9):773-783. 10.1016/S1470-2045(07)70245-0, 17714991.
4. O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003, 348(11):994-1004. 10.1056/NEJMoa022457, 12637609.
5. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988, 53(4):549-554.
6. Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, Valentine V, Hempen PM, Hilgers W, Yeo CJ, Hruban RH, et al. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol 2003, 163(4):1255-1260. 10.1016/S0002-9440(10)63485-2, 1868306, 14507635.
7. Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A. Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am J Pathol 2003, 162(6):1807-1815. 10.1016/S0002-9440(10)64315-5, 1868131, 12759238.
8. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssegur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 1999, 18(3):664-674. 10.1093/emboj/18.3.664, 1171159, 9927426.
9. Furukawa T, Kanai N, Shiwaku HO, Soga N, Uehara A, Horii A. AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. Oncogene 2006, 25(35):4831-4839. 10.1038/sj.onc.1209494, 16532023.
10. Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A. RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. Cancer Res 2005, 65(7):2899-2905. 10.1158/0008-5472.CAN-04-3981, 15805292.
11. Sun C, Yamato T, Furukawa T, Ohnishi Y, Kijima H, Horii A. Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. Oncol Rep 2001, 8(1):89-92.
12. Furukawa T, Duguid WP, Rosenberg L, Viallet J, Galloway DA, Tsao MS. Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am J Pathol 1996, 148(6):1763-1770. 1861644, 8669463.
13. Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, et al. Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis. Lab Invest 2004, 84(10):1339-1351. 10.1038/labinvest.3700160, 15300227.
14. Lens SM, Voest EE, Medema RH. Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer 2010, 10(12):825-841. 10.1038/nrc2964, 21102634.
15. Verdaasdonk JS, Bloom K. Centromeres: unique chromatin structures that drive chromosome segregation. Nat Rev Mol Cell Biol 2011, 12(5):320-332. 10.1038/nrm3107, 3288958, 21508988.
16. Hirano Y, Ishii K, Kumeta M, Furukawa K, Takeyasu K, Horigome T. Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus. Genes Cells 2009, 14(2):155-166. 10.1111/j.1365-2443.2008.01262.x, 19170763.
17. Conchon S, Cao X, Barlowe C, Pelham HR. Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex. EMBO J 1999, 18(14):3934-3946. 10.1093/emboj/18.14.3934, 1171469, 10406798.
18. Valentine MT, Gilbert SP. To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5. Curr Opin Cell Biol 2007, 19(1):75-81. 10.1016/j.ceb.2006.12.011, 2270473, 17188855.
19. Gao S, Alarcon C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massague J. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 2009, 36(3):457-468. 10.1016/j.molcel.2009.09.043, 2796330, 19917253.
20. Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G. Control of Aurora-A stability through interaction with TPX2. J Cell Sci 2011, 124(Pt 1):113-122. 3001410, 21147853.
21. Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD. WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell 2005, 121(6):859-872. 10.1016/j.cell.2005.03.036, 15960974.
22. Addepalli MK, Ray KB, Kumar B, Ramnath RL, Chile S, Rao H. RNAi-mediated knockdown of AURKB and EGFR shows enhanced therapeutic efficacy in prostate tumor regression. Gene Ther 2010, 17(3):352-359. 10.1038/gt.2009.155, 19956271.
23. Li Y, Zhu Z, Zhang S, Yu D, Yu H, Liu L, Cao X, Wang L, Gao H, Zhu M. ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. PLoS One 2011, 6(3):e17794. 10.1371/journal.pone.0017794, 3058037, 21423629.
24. Liu M, Yu H, Huo L, Liu J, Li M, Zhou J. Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor. Biochem Pharmacol 2008, 76(2):169-178. 10.1016/j.bcp.2008.04.018, 18539263.
25. Li B, Qi XQ, Chen X, Huang X, Liu GY, Chen HR, Huang CG, Luo C, Lu YC. Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma. Brain Res 2010, 1352:200-207.
26. Mattioni T, Hume CR, Konigorski S, Hayes P, Osterweil Z, Lee JS. A cDNA clone for a novel nuclear protein with DNA binding activity. Chromosoma 1992, 101(10):618-624. 10.1007/BF00360539, 1424986.
27. Sun CT, Lo WY, Wang IH, Lo YH, Shiou SR, Lai CK, Ting LP. Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON. J Biol Chem 2001, 276(26):24059-24067. 10.1074/jbc.M101330200, 11306577.
28. Ahn EY, Yan M, Malakhova OA, Lo MC, Boyapati A, Ommen HB, Hines R, Hokland P, Zhang DE. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. Proc Natl Acad Sci U S A 2008, 105(44):17103-17108. 10.1073/pnas.0802696105, 2579385, 18952841.
29. Sharma A, Takata H, Shibahara K, Bubulya A, Bubulya PA. Son is essential for nuclear speckle organization and cell cycle progression. Mol Biol Cell 2010, 21(4):650-663. 10.1091/mbc.E09-02-0126, 2820428, 20053686.
30. Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, Pandit S, Fu XD, Zhang DE. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell 2011, 42(2):185-198. 10.1016/j.molcel.2011.03.014, 3137374, 21504830.
31. Leser GP, Fakan S, Martin TE. Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters. Eur J Cell Biol 1989, 50(2):376-389.
32. Prasanth KV, Sacco-Bubulya PA, Prasanth SG, Spector DL. Sequential entry of components of the gene expression machinery into daughter nuclei. Mol Biol Cell 2003, 14(3):1043-1057. 10.1091/mbc.E02-10-0669, 151578, 12631722.
33. Bubulya PA, Prasanth KV, Deerinck TJ, Gerlich D, Beaudouin J, Ellisman MH, Ellenberg J, Spector DL. Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei. J Cell Biol 2004, 167(1):51-63. 10.1083/jcb.200404120, 2172523, 15479736.
34. Lamond AI, Spector DL. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 2003, 4(8):605-612. 10.1038/nrm1172, 12923522.
35. Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010, 464(7291):1067-1070. 10.1038/nature08956, 2855406, 20305636.
36. Kuboki Y, Shiratori K, Hatori T, Fujita I, Kimijima A, Yamamoto M, Kobayashi M, Furukawa T. Association of epidermal growth factor receptor and mitogen-activated protein kinase with cystic neoplasms of the pancreas. Mod Pathol 2010, 23(8):1127-1135. 10.1038/modpathol.2010.97, 20495538.