-
1
-
-
77953923379
-
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
-
Alvarez, S. E., Harikumar, K. B., Hait, N. C., Allegood, J., Strub, G. M., Kim, E. Y., Maceyka, M., Jiang, H., Luo, C., Kordula, T. et al. (2010). Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465, 1084-1088.
-
(2010)
Nature
, vol.465
, pp. 1084-1088
-
-
Alvarez, S.E.1
Harikumar, K.B.2
Hait, N.C.3
Allegood, J.4
Strub, G.M.5
Kim, E.Y.6
McEyka, M.7
Jiang, H.8
Luo, C.9
Kordula, T.10
-
2
-
-
84866487978
-
S1P1 inhibits sprouting angiogenesis during vascular development
-
Ben Shoham, A., Malkinson, G., Krief, S., Shwartz, Y., Ely, Y., Ferrara, N., Yaniv, K. and Zelzer, E. (2012). S1P1 inhibits sprouting angiogenesis during vascular development. Development 139, 3859-3869.
-
(2012)
Development
, vol.139
, pp. 3859-3869
-
-
Ben Shoham, A.1
Malkinson, G.2
Krief, S.3
Shwartz, Y.4
Ely, Y.5
Ferrara, N.6
Yaniv, K.7
Zelzer, E.8
-
3
-
-
80054052730
-
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors
-
Blaho, V. A. and Hla, T. (2011). Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem. Rev. 111, 6299-6320.
-
(2011)
Chem. Rev.
, vol.111
, pp. 6299-6320
-
-
Blaho, V.A.1
Hla, T.2
-
4
-
-
79958257954
-
Lipid phosphate phosphatase 3 enables efficient thymic egress
-
Bréart, B., Ramos-Perez, W. D., Mendoza, A., Salous, A. K., Gobert, M., Huang, Y., Adams, R. H., Lafaille, J. J., Escalante-Alcalde, D., Morris, A. J. et al. (2011). Lipid phosphate phosphatase 3 enables efficient thymic egress. J. Exp. Med. 208, 1267-1278.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1267-1278
-
-
Bréart, B.1
Ramos-Perez, W.D.2
Mendoza, A.3
Salous, A.K.4
Gobert, M.5
Huang, Y.6
Adams, R.H.7
Lafaille, J.J.8
Escalante-Alcalde, D.9
Morris, A.J.10
-
5
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E., Baumruker, T., Hiestand, P. et al. (2002). The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277, 21453-21457.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
-
6
-
-
84860498826
-
Sphingosine-1-phosphate signaling in neural progenitors
-
Callihan, P. and Hooks, S. B. (2012). Sphingosine-1-phosphate signaling in neural progenitors. Methods Mol. Biol. 874, 193-200.
-
(2012)
Methods Mol. Biol.
, vol.874
, pp. 193-200
-
-
Callihan, P.1
Hooks, S.B.2
-
7
-
-
1942422176
-
Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis
-
Chae, S. S., Paik, J. H., Allende, M. L., Proia, R. L. and Hla, T. (2004a). Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev. Biol. 268, 441-447.
-
(2004)
Dev. Biol.
, vol.268
, pp. 441-447
-
-
Chae, S.S.1
Paik, J.H.2
Allende, M.L.3
Proia, R.L.4
Hla, T.5
-
8
-
-
1842610141
-
Constitutive expression of the S1P1 receptor in adult tissues
-
Chae, S. S., Proia, R. L. and Hla, T. (2004b). Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat. 73, 141-150.
-
(2004)
Prostaglandins Other Lipid Mediat.
, vol.73
, pp. 141-150
-
-
Chae, S.S.1
Proia, R.L.2
Hla, T.3
-
9
-
-
79959340773
-
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
-
Christoffersen, C., Obinata, H., Kumaraswamy, S. B., Galvani, S., Ahnström, J., Sevvana, M., Egerer-Sieber, C., Muller, Y. A., Hla, T., Nielsen, L. B. et al. (2011). Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc. Natl. Acad. Sci. USA 108, 9613-9618.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 9613-9618
-
-
Christoffersen, C.1
Obinata, H.2
Kumaraswamy, S.B.3
Galvani, S.4
Ahnström, J.5
Sevvana, M.6
Egerer-Sieber, C.7
Muller, Y.A.8
Hla, T.9
Nielsen, L.B.10
-
10
-
-
0036266101
-
International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
-
Chun, J., Goetzl, E. J., Hla, T., Igarashi, Y., Lynch, K. R., Moolenaar, W., Pyne, S. and Tigyi, G. (2002). International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54, 265-269.
-
(2002)
Pharmacol. Rev.
, vol.54
, pp. 265-269
-
-
Chun, J.1
Goetzl, E.J.2
Hla, T.3
Igarashi, Y.4
Lynch, K.R.5
Moolenaar, W.6
Pyne, S.7
Tigyi, G.8
-
11
-
-
78650141494
-
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
-
Chun, J., Hla, T., Lynch, K. R., Spiegel, S. and Moolenaar, W. H. (2010). International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 62, 579-587.
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 579-587
-
-
Chun, J.1
Hla, T.2
Lynch, K.R.3
Spiegel, S.4
Moolenaar, W.H.5
-
12
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
TRANSFORMS Study Group
-
Cohen, J. A., Barkhof, F., Comi, G., Hartung, H. P., Khatri, B. O., Montalban, X., Pelletier, J., Capra, R., Gallo, P., Izquierdo, G. et al.; TRANSFORMS Study Group (2010). Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N. Engl. J. Med. 362, 402-415.
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
Hartung, H.P.4
Khatri, B.O.5
Montalban, X.6
Pelletier, J.7
Capra, R.8
Gallo, P.9
Izquierdo, G.10
-
13
-
-
84859385704
-
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
-
Cyster, J. G. and Schwab, S. R. (2012). Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. Annu. Rev. Immunol. 30, 69-94.
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 69-94
-
-
Cyster, J.G.1
Schwab, S.R.2
-
14
-
-
16844375322
-
Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme
-
Edsbagge, J., Johansson, J. K., Esni, F., Luo, Y., Radice, G. L. and Semb, H. (2005). Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development 132, 1085-1092.
-
(2005)
Development
, vol.132
, pp. 1085-1092
-
-
Edsbagge, J.1
Johansson, J.K.2
Esni, F.3
Luo, Y.4
Radice, G.L.5
Semb, H.6
-
15
-
-
0142074397
-
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning
-
Escalante-Alcalde, D., Hernandez, L., Le Stunff, H., Maeda, R., Lee, H. S., Sciorra, V. A., Daar, I., Spiegel, S., Morris, A. J. et al. (2003). The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development 130, 4623-4637.
-
(2003)
Development
, vol.130
, pp. 4623-4637
-
-
Escalante-Alcalde, D.1
Hernandez, L.2
Le Stunff, H.3
Maeda, R.4
Lee, H.S.5
Sciorra, V.A.6
Daar, I.7
Spiegel, S.8
Morris, A.J.9
-
16
-
-
84859727262
-
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
-
Fukuhara, S., Simmons, S., Kawamura, S., Inoue, A., Orba, Y., Tokudome, T., Sunden, Y., Arai, Y., Moriwaki, K., Ishida, J. et al. (2012). The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122, 1416-1426.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1416-1426
-
-
Fukuhara, S.1
Simmons, S.2
Kawamura, S.3
Inoue, A.4
Orba, Y.5
Tokudome, T.6
Sunden, Y.7
Arai, Y.8
Moriwaki, K.9
Ishida, J.10
-
17
-
-
84866044722
-
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
-
Gaengel, K., Niaudet, C., Hagikura, K., Laviña, B., Muhl, L., Hofmann, J. J., Ebarasi, L., Nyström, S., Rymo, S., Chen, L. L. et al. (2012). The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev. Cell 23, 587-599.
-
(2012)
Dev. Cell
, vol.23
, pp. 587-599
-
-
Gaengel, K.1
Niaudet, C.2
Hagikura, K.3
Laviña, B.4
Muhl, L.5
Hofmann, J.J.6
Ebarasi, L.7
Nyström, S.8
Rymo, S.9
Chen, L.L.10
-
18
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait, N. C., Allegood, J., Maceyka, M., Strub, G. M., Harikumar, K. B., Singh, S. K., Luo, C., Marmorstein, R., Kordula, T., Milstien, S. et al. (2009). Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325, 1254-1257.
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
McEyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
-
19
-
-
51749096383
-
The vascular S1P gradient-cellular sources and biological significance
-
Hla, T., Venkataraman, K. and Michaud, J. (2008). The vascular S1P gradient-cellular sources and biological significance. Biochim. Biophys. Acta 1781, 477-482.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 477-482
-
-
Hla, T.1
Venkataraman, K.2
Michaud, J.3
-
20
-
-
84866025219
-
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development
-
Jung, B., Obinata, H., Galvani, S., Mendelson, K., Ding, B. S., Skoura, A., Kinzel, B., Brinkmann, V., Rafii, S., Evans, T. et al. (2012). Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev. Cell 23, 600-610.
-
(2012)
Dev. Cell
, vol.23
, pp. 600-610
-
-
Jung, B.1
Obinata, H.2
Galvani, S.3
Mendelson, K.4
Ding, B.S.5
Skoura, A.6
Kinzel, B.7
Brinkmann, V.8
Rafii, S.9
Evans, T.10
-
21
-
-
57149146056
-
Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation
-
Kai, M., Heisenberg, C. P. and Tada, M. (2008). Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation. Development 135, 3043-3051.
-
(2008)
Development
, vol.135
, pp. 3043-3051
-
-
Kai, M.1
Heisenberg, C.P.2
Tada, M.3
-
22
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
FREEDOMS Study Group
-
Kappos, L., Radue, E. W., O'Connor, P., Polman, C., Hohlfeld, R., Calabresi, P., Selmaj, K., Agoropoulou, C., Leyk, M., Zhang-Auberson, L. et al.; FREEDOMS Study Group (2010). A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N. Engl. J. Med. 362, 387-401.
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
Polman, C.4
Hohlfeld, R.5
Calabresi, P.6
Selmaj, K.7
Agoropoulou, C.8
Leyk, M.9
Zhang-Auberson, L.10
-
23
-
-
58849083220
-
The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
-
Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A. and Mochizuki, N. (2009). The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science 323, 524-527.
-
(2009)
Science
, vol.323
, pp. 524-527
-
-
Kawahara, A.1
Nishi, T.2
Hisano, Y.3
Fukui, H.4
Yamaguchi, A.5
Mochizuki, N.6
-
24
-
-
0344011597
-
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
-
Kingsbury, M. A., Rehen, S. K., Contos, J. J., Higgins, C. M. and Chun, J. (2003). Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nat. Neurosci. 6, 1292-1299.
-
(2003)
Nat. Neurosci.
, vol.6
, pp. 1292-1299
-
-
Kingsbury, M.A.1
Rehen, S.K.2
Contos, J.J.3
Higgins, C.M.4
Chun, J.5
-
25
-
-
3142744111
-
The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis
-
Kono, M., Mi, Y., Liu, Y., Sasaki, T., Allende, M. L., Wu, Y. P., Yamashita, T. and Proia, R. L. (2004). The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J. Biol. Chem. 279, 29367-29373.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 29367-29373
-
-
Kono, M.1
Mi, Y.2
Liu, Y.3
Sasaki, T.4
Allende, M.L.5
Wu, Y.P.6
Yamashita, T.7
Proia, R.L.8
-
26
-
-
0034644150
-
A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development
-
Kupperman, E., An, S., Osborne, N., Waldron, S. and Stainier, D. Y. (2000). A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. Nature 406, 192-195.
-
(2000)
Nature
, vol.406
, pp. 192-195
-
-
Kupperman, E.1
An, S.2
Osborne, N.3
Waldron, S.4
Stainier, D.Y.5
-
27
-
-
31544447428
-
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization
-
LaMontagne, K., Littlewood-Evans, A., Schnell, C., O'Reilly, T., Wyder, L., Sanchez, T., Probst, B., Butler, J., Wood, A., Liau, G. et al. (2006). Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. 66, 221-231.
-
(2006)
Cancer Res.
, vol.66
, pp. 221-231
-
-
LaMontagne, K.1
Littlewood-Evans, A.2
Schnell, C.3
O'Reilly, T.4
Wyder, L.5
Sanchez, T.6
Probst, B.7
Butler, J.8
Wood, A.9
Liau, G.10
-
28
-
-
14644391944
-
Generation and metabolism of bioactive sphingosine-1-phosphate
-
Le Stunff, H., Milstien, S. and Spiegel, S. (2004). Generation and metabolism of bioactive sphingosine-1-phosphate. J. Cell. Biochem. 92, 882-899.
-
(2004)
J. Cell. Biochem.
, vol.92
, pp. 882-899
-
-
Le Stunff, H.1
Milstien, S.2
Spiegel, S.3
-
29
-
-
0033615537
-
Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
-
Lee, M. J., Thangada, S., Claffey, K. P., Ancellin, N., Liu, C. H., Kluk, M., Volpi, M., Sha'afi, R. I. and Hla, T. (1999). Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99, 301-312.
-
(1999)
Cell
, vol.99
, pp. 301-312
-
-
Lee, M.J.1
Thangada, S.2
Claffey, K.P.3
Ancellin, N.4
Liu, C.H.5
Kluk, M.6
Volpi, M.7
Sha'afi, R.I.8
Hla, T.9
-
30
-
-
17944363486
-
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
-
Lee, M. J., Thangada, S., Paik, J. H., Sapkota, G. P., Ancellin, N., Chae, S. S., Wu, M., Morales-Ruiz, M., Sessa, W. C., Alessi, D. R. et al. (2001). Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol. Cell 8, 693-704.
-
(2001)
Mol. Cell
, vol.8
, pp. 693-704
-
-
Lee, M.J.1
Thangada, S.2
Paik, J.H.3
Sapkota, G.P.4
Ancellin, N.5
Chae, S.S.6
Wu, M.7
Morales-Ruiz, M.8
Sessa, W.C.9
Alessi, D.R.10
-
31
-
-
0033783522
-
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
-
Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C. X., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S. S., Lee, M. J. et al. (2000). Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106, 951-961.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 951-961
-
-
Liu, Y.1
Wada, R.2
Yamashita, T.3
Mi, Y.4
Deng, C.X.5
Hobson, J.P.6
Rosenfeldt, H.M.7
Nava, V.E.8
Chae, S.S.9
Lee, M.J.10
-
32
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
Mandala, S., Hajdu, R., Bergstrom, J., Quackenbush, E., Xie, J., Milligan, J., Thornton, R., Shei, G. J., Card, D., Keohane, C. et al. (2002). Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346-349.
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
Thornton, R.7
Shei, G.J.8
Card, D.9
Keohane, C.10
-
33
-
-
36248957063
-
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues
-
Massberg, S., Schaerli, P., Knezevic-Maramica, I., Köllnberger, M., Tubo, N., Moseman, E. A., Huff, I. V., Junt, T., Wagers, A. J., Mazo, I. B. et al. (2007). Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 131, 994-1008.
-
(2007)
Cell
, vol.131
, pp. 994-1008
-
-
Massberg, S.1
Schaerli, P.2
Knezevic-Maramica, I.3
Köllnberger, M.4
Tubo, N.5
Moseman, E.A.6
Huff, I.V.7
Junt, T.8
Wagers, A.J.9
Mazo, I.B.10
-
34
-
-
84873836098
-
Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning
-
Mendelson, K., Zygmunt, T., Torres-Vázquez, J., Evans, T. and Hla, T. (2013). Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning. J. Biol. Chem. 288, 2143-2156.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 2143-2156
-
-
Mendelson, K.1
Zygmunt, T.2
Torres-Vázquez, J.3
Evans, T.4
Hla, T.5
-
35
-
-
77949332336
-
Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
-
Michaud, J., Im, D. S. and Hla, T. (2010). Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J. Immunol. 184, 1475-1483.
-
(2010)
J. Immunol.
, vol.184
, pp. 1475-1483
-
-
Michaud, J.1
Im, D.S.2
Hla, T.3
-
36
-
-
28544437478
-
Essential role for sphingosine kinases in neural and vascular development
-
Mizugishi, K., Yamashita, T., Olivera, A., Miller, G. F., Spiegel, S. and Proia, R. L. (2005). Essential role for sphingosine kinases in neural and vascular development. Mol. Cell. Biol. 25, 11113-11121.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 11113-11121
-
-
Mizugishi, K.1
Yamashita, T.2
Olivera, A.3
Miller, G.F.4
Spiegel, S.5
Proia, R.L.6
-
37
-
-
84859701240
-
Sphingosine 1-phosphate in coagulation and inflammation
-
Obinata, H. and Hla, T. (2012). Sphingosine 1-phosphate in coagulation and inflammation. Semin. Immunopathol. 34, 73-91.
-
(2012)
Semin. Immunopathol.
, vol.34
, pp. 73-91
-
-
Obinata, H.1
Hla, T.2
-
38
-
-
34247874512
-
Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
-
Oo, M. L., Thangada, S., Wu, M. T., Liu, C. H., Macdonald, T. L., Lynch, K. R., Lin, C. Y. and Hla, T. (2007). Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J. Biol. Chem. 282, 9082-9089.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9082-9089
-
-
Oo, M.L.1
Thangada, S.2
Wu, M.T.3
Liu, C.H.4
McDonald, T.L.5
Lynch, K.R.6
Lin, C.Y.7
Hla, T.8
-
39
-
-
79957925060
-
Engagement of S1P-degradative mechanisms leads to vascular leak in mice
-
Oo, M. L., Chang, S. H., Thangada, S., Wu, M. T., Rezaul, K., Blaho, V., Hwang, S. I., Han, D. K. and Hla, T. (2011). Engagement of S1P-degradative mechanisms leads to vascular leak in mice. J. Clin. Invest. 121, 2290-2300.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2290-2300
-
-
Oo, M.L.1
Chang, S.H.2
Thangada, S.3
Wu, M.T.4
Rezaul, K.5
Blaho, V.6
Hwang, S.I.7
Han, D.K.8
Hla, T.9
-
40
-
-
57149134062
-
The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish
-
Osborne, N., Brand-Arzamendi, K., Ober, E. A., Jin, S. W., Verkade, H., Holtzman, N. G., Yelon, D. and Stainier, D. Y. (2008). The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Curr. Biol. 18, 1882-1888.
-
(2008)
Curr. Biol.
, vol.18
, pp. 1882-1888
-
-
Osborne, N.1
Brand-Arzamendi, K.2
Ober, E.A.3
Jin, S.W.4
Verkade, H.5
Holtzman, N.G.6
Yelon, D.7
Stainier, D.Y.8
-
41
-
-
0035853689
-
Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3-and beta1-containing integrins
-
Paik, J. H., Chae SS, Lee, M. J., Thangada, S. and Hla, T. (2001). Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3-and beta1-containing integrins. J. Biol. Chem. 276, 11830-11837.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11830-11837
-
-
Paik, J.H.1
Chae, S.S.2
Lee, M.J.3
Thangada, S.4
Hla, T.5
-
42
-
-
4644269059
-
Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization
-
Paik, J. H., Skoura, A., Chae, S. S., Cowan, A. E., Han, D. K., Proia, R. L. and Hla, T. (2004). Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 18, 2392-2403.
-
(2004)
Genes Dev.
, vol.18
, pp. 2392-2403
-
-
Paik, J.H.1
Skoura, A.2
Chae, S.S.3
Cowan, A.E.4
Han, D.K.5
Proia, R.L.6
Hla, T.7
-
43
-
-
34247379074
-
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
-
Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y. W., Huang, Y., Cyster, J. G. et al. (2007). Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316, 295-298.
-
(2007)
Science
, vol.316
, pp. 295-298
-
-
Pappu, R.1
Schwab, S.R.2
Cornelissen, I.3
Pereira, J.P.4
Regard, J.B.5
Xu, Y.6
Camerer, E.7
Zheng, Y.W.8
Huang, Y.9
Cyster, J.G.10
-
44
-
-
37849033437
-
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress
-
Pham, T. H., Okada, T., Matloubian, M., Lo, C. G. and Cyster, J. G. (2008). S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity 28, 122-133.
-
(2008)
Immunity
, vol.28
, pp. 122-133
-
-
Pham, T.H.1
Okada, T.2
Matloubian, M.3
Lo, C.G.4
Cyster, J.G.5
-
45
-
-
76149126108
-
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
-
Pham, T. H., Baluk, P., Xu, Y., Grigorova, I., Bankovich, A. J., Pappu, R., Coughlin, S. R., McDonald, D. M., Schwab, S. R. and Cyster, J. G. (2010). Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J. Exp. Med. 207, 17-27.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 17-27
-
-
Pham, T.H.1
Baluk, P.2
Xu, Y.3
Grigorova, I.4
Bankovich, A.J.5
Pappu, R.6
Coughlin, S.R.7
McDonald, D.M.8
Schwab, S.R.9
Cyster, J.G.10
-
46
-
-
77952150595
-
Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila
-
Renault, A. D., Kunwar, P. S. and Lehmann, R. (2010). Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila. Development 137, 1815-1823.
-
(2010)
Development
, vol.137
, pp. 1815-1823
-
-
Renault, A.D.1
Kunwar, P.S.2
Lehmann, R.3
-
47
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
-
Rosen, H. and Goetzl, E. J. (2005). Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. 7, 560-570.
-
(2005)
Nat. Rev. Immunol.
, vol.7
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
48
-
-
0037155058
-
Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells
-
Ryu, Y., Takuwa, N., Sugimoto, N., Sakurada, S., Usui, S., Okamoto, H., Matsui, O. and Takuwa, Y. (2002). Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. Circ. Res. 90, 325-332.
-
(2002)
Circ. Res.
, vol.90
, pp. 325-332
-
-
Ryu, Y.1
Takuwa, N.2
Sugimoto, N.3
Sakurada, S.4
Usui, S.5
Okamoto, H.6
Matsui, O.7
Takuwa, Y.8
-
49
-
-
1842455323
-
Point-counterpoint of sphingosine 1-phosphate metabolism
-
Saba, J. D. and Hla, T. (2004). Point-counterpoint of sphingosine 1-phosphate metabolism. Circ. Res. 94, 724-734.
-
(2004)
Circ. Res.
, vol.94
, pp. 724-734
-
-
Saba, J.D.1
Hla, T.2
-
50
-
-
15444373513
-
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
-
Sanchez, T., Thangada, S., Wu, M. T., Kontos, C. D., Wu, D., Wu, H. and Hla, T. (2005). PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 102, 4312-4317.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 4312-4317
-
-
Sanchez, T.1
Thangada, S.2
Wu, M.T.3
Kontos, C.D.4
Wu, D.5
Wu, H.6
Hla, T.7
-
51
-
-
83255192195
-
G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis
-
Serafimidis, I., Heximer, S., Beis, D. and Gavalas, A. (2011). G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. Mol. Cell. Biol. 31, 4442-4453.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 4442-4453
-
-
Serafimidis, I.1
Heximer, S.2
Beis, D.3
Gavalas, A.4
-
52
-
-
34047251154
-
Functions of the multifaceted family of sphingosine kinases and some close relatives
-
Spiegel, S. and Milstien, S. (2007). Functions of the multifaceted family of sphingosine kinases and some close relatives. J. Biol. Chem. 282, 2125-2129.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2125-2129
-
-
Spiegel, S.1
Milstien, S.2
-
53
-
-
79551648970
-
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration
-
Strub, G. M., Paillard, M., Liang, J., Gomez, L., Allegood, J. C., Hait, N. C., Maceyka, M., Price, M. M., Chen, Q., Simpson, D. C. et al. (2011). Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J. 25, 600-612.
-
(2011)
FASEB J.
, vol.25
, pp. 600-612
-
-
Strub, G.M.1
Paillard, M.2
Liang, J.3
Gomez, L.4
Allegood, J.C.5
Hait, N.C.6
McEyka, M.7
Price, M.M.8
Chen, Q.9
Simpson, D.C.10
-
54
-
-
0037370012
-
Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
-
Sugimoto, N., Takuwa, N., Okamoto, H., Sakurada, S. and Takuwa, Y. (2003). Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol. Cell. Biol. 23, 1534-1545.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 1534-1545
-
-
Sugimoto, N.1
Takuwa, N.2
Okamoto, H.3
Sakurada, S.4
Takuwa, Y.5
-
55
-
-
33746897677
-
Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient
-
Venkataraman, K., Thangada, S., Michaud, J., Oo, M. L., Ai, Y., Lee, Y. M., Wu, M., Parikh, N. S., Khan, F., Proia, R. L. et al. (2006). Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem. J. 397, 461-471.
-
(2006)
Biochem. J.
, vol.397
, pp. 461-471
-
-
Venkataraman, K.1
Thangada, S.2
Michaud, J.3
Oo, M.L.4
Ai, Y.5
Lee, Y.M.6
Wu, M.7
Parikh, N.S.8
Khan, F.9
Proia, R.L.10
-
56
-
-
0033600839
-
Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins
-
Windh, R. T., Lee, M. J., Hla, T., An, S., Barr, A. J. and Manning, D. R. (1999). Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. J. Biol. Chem. 274, 27351-27358.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27351-27358
-
-
Windh, R.T.1
Lee, M.J.2
Hla, T.3
An, S.4
Barr, A.J.5
Manning, D.R.6
-
57
-
-
84873138442
-
S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence
-
Ye, D. and Lin, F. (2013). S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence. Development 140, 789-799.
-
(2013)
Development
, vol.140
, pp. 789-799
-
-
Ye, D.1
Lin, F.2
-
58
-
-
84865260845
-
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
-
Yu, F. X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H. et al. (2012). Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780-791.
-
(2012)
Cell
, vol.150
, pp. 780-791
-
-
Yu, F.X.1
Zhao, B.2
Panupinthu, N.3
Jewell, J.L.4
Lian, I.5
Wang, L.H.6
Zhao, J.7
Yuan, H.8
Tumaneng, K.9
Li, H.10
-
59
-
-
80052595682
-
Lysophosphatidic acid signaling may initiate fetal hydrocephalus
-
Yung, Y. C., Mutoh, T., Lin, M. E., Noguchi, K., Rivera, R. R., Choi, J. W., Kingsbury, M. A. and Chun, J. (2011). Lysophosphatidic acid signaling may initiate fetal hydrocephalus. Sci. Transl. Med. 3, 99ra87.
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Yung, Y.C.1
Mutoh, T.2
Lin, M.E.3
Noguchi, K.4
Rivera, R.R.5
Choi, J.W.6
Kingsbury, M.A.7
Chun, J.8
-
60
-
-
0033135378
-
Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway
-
Zhang, Q., Peyruchaud, O., French, K. J., Magnusson, M. K. and Mosher, D. F. (1999). Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. Blood 93, 2984-2990.
-
(1999)
Blood
, vol.93
, pp. 2984-2990
-
-
Zhang, Q.1
Peyruchaud, O.2
French, K.J.3
Magnusson, M.K.4
Mosher, D.F.5
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