-
1
-
-
0006171777
-
Supplemental ascorbate in the supportive treatment of cancer Prolongation of survival times in terminal human cancer
-
Cameron E, Pauling L: Supplemental ascorbate in the supportive treatment of cancer. Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 1976;73:3685-3689.
-
(1976)
Proc Natl Acad Sci USA
, vol.73
, pp. 3685-3689
-
-
Cameron, E.1
Pauling, L.2
-
2
-
-
0012375577
-
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
-
Cameron E, Pauling L: Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 1978;75:4538-4542.
-
(1978)
Proc Natl Acad Sci USA
, vol.75
, pp. 4538-4542
-
-
Cameron, E.1
Pauling, L.2
-
3
-
-
0018669229
-
Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial
-
Creagan ET, Moertel CG, O'Fallon JR, Schutt AJ, O'Connell MJ, RubinJ, Frytak S: Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 1979;301:687-690.
-
(1979)
N Engl J Med
, vol.301
, pp. 687-690
-
-
Creagan, E.T.1
Moertel, C.G.2
O'Fallon, J.R.3
Schutt, A.J.4
O'Connell, M.J.5
Rubinj Frytak, S.6
-
4
-
-
0021955675
-
High dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison
-
Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ, Ames MM: High dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med 1985;312:137-141.
-
(1985)
N Engl J Med
, vol.312
, pp. 137-141
-
-
Moertel, C.G.1
Fleming, T.R.2
Creagan, E.T.3
Rubin, J.4
O'Connell, M.J.5
Ames, M.M.6
-
5
-
-
26444521256
-
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
-
Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M: Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA 2005;102:13604-13609.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13604-13609
-
-
Chen, Q.1
Espey, M.G.2
Krishna, M.C.3
Mitchell, J.B.4
Corpe, C.P.5
Buettner, G.R.6
Shacter, E.7
Levine, M.8
-
6
-
-
34547429599
-
Ascorbate in pharmacological concentrations selectively generates ascor-bate radical and hydrogen peroxide in extracellular fluid in vivo
-
Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M: Ascorbate in pharmacological concentrations selectively generates ascor-bate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci USA 2007;104:8749-8754.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8749-8754
-
-
Chen, Q.1
Espey, M.G.2
Sun, A.Y.3
Lee, J.H.4
Krishna, M.C.5
Shacter, E.6
Choyke, P.L.7
Pooput, C.8
Kirk, K.L.9
Buettner, G.R.10
Levine, M.11
-
7
-
-
49649115940
-
Pharmacologic doses of ascorbate act as prooxidant and decrease growth of aggressive tumour xenografts in mice
-
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh BD, Drisko J, Levine M: Pharmacologic doses of ascorbate act as prooxidant and decrease growth of aggressive tumour xenografts in mice. Proc Natl Acad Sci USA 2008;105:11105-11109.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11105-11109
-
-
Chen, Q.1
Espey, M.G.2
Sun, A.Y.3
Pooput, C.4
Kirk, K.L.5
Krishna, M.C.6
Khosh, B.D.7
Drisko, J.8
Levine, M.9
-
8
-
-
1842435160
-
Vitamin C pharmacokinetics: Implications for oral and intravenous use
-
Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M: Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 2004;140:533-537.
-
(2004)
Ann Intern Med
, vol.140
, pp. 533-537
-
-
Padayatty, S.J.1
Sun, H.2
Wang, Y.3
Riordan, H.D.4
Hewitt, S.M.5
Katz, A.6
Wesley, R.A.7
Levine, M.8
-
9
-
-
49649109597
-
Vitamin C and cancer revisited
-
Frei B, Lawson S: Vitamin C and cancer revisited. Proc Natl Acad Sci USA 2008;105:11037-11038.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11037-11038
-
-
Frei, B.1
Lawson, S.2
-
10
-
-
67349235547
-
Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects
-
Verrax J, Calderon PB: Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects. Free Radic Biol Med 2009;47:32-40.
-
(2009)
Free Radic Biol Med
, vol.47
, pp. 32-40
-
-
Verrax, J.1
Calderon, P.B.2
-
11
-
-
58249141796
-
Oxalic acid excretion after intravenous ascorbic acid administration
-
Robitaille L, Mamer OA, Miller WH Jr, Levine M, Assouline S, Melnychuk D, Rousseau C, Hoffer LJ: Oxalic acid excretion after intravenous ascorbic acid administration. Metabolism 2009;58:263-269.
-
(2009)
Metabolism
, vol.58
, pp. 263-269
-
-
Robitaille, L.1
Mamer, O.A.2
Miller Jr., W.H.3
Levine, M.4
Assouline, S.5
Melnychuk, D.6
Rousseau, C.7
Hoffer, L.J.8
-
13
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O: On the origin of cancer cells. Science 1956;123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
15
-
-
1642453771
-
A systematic review of molecular and biological tumor markers in neuroblastoma
-
Riley RD, Heney D, Jones DR, Sutton AJ, Lambert PC, Abrams KR, Young B, Wailoo AJ, Burchill SA: A systematic review of molecular and biological tumor markers in neuroblastoma. Clin Cancer Res 2004;10:4-12.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4-12
-
-
Riley, R.D.1
Heney, D.2
Jones, D.R.3
Sutton, A.J.4
Lambert, P.C.5
Abrams, K.R.6
Young, B.7
Wailoo, A.J.8
Burchill, S.A.9
-
16
-
-
0018837540
-
Serum ferritin as a guide to therapy in neurob-lastoma
-
Hann HW, Levy HM, Evans AE: Serum ferritin as a guide to therapy in neurob-lastoma. Cancer Res 1980;40:1411-1413.
-
(1980)
Cancer Res
, vol.40
, pp. 1411-1413
-
-
Hann, H.W.1
Levy, H.M.2
Evans, A.E.3
-
17
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
-
(1983)
J Immunol Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
18
-
-
0015298529
-
Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase
-
Thurman R G, Ley HG, Scholz, R: Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Eur J Biochem 1972;25:420-430.
-
(1972)
Eur J Biochem
, vol.25
, pp. 420-430
-
-
Thurman, R.G.1
Ley, H.G.2
Scholz, R.3
-
20
-
-
0027273037
-
Ferritin production and desferrioxamine cytotoxic-ity in human neuroblastoma cell lines
-
Selig RA, Madafiglio J, Haber M, Norris MD, White L, Stewart BW: Ferritin production and desferrioxamine cytotoxic-ity in human neuroblastoma cell lines. Anticancer Res 1993;13:721-725.
-
(1993)
Anticancer Res
, vol.13
, pp. 721-725
-
-
Selig, R.A.1
Madafiglio, J.2
Haber, M.3
Norris, M.D.4
White, L.5
Stewart, B.W.6
-
21
-
-
0021993608
-
Ferritin and superoxid-dependent lipid peroxidation
-
Thomas CE, Morehouse LA, Aust SD: Ferritin and superoxid-dependent lipid peroxidation. J Biol Chem 1985;260:3275-3280.
-
(1985)
J Biol Chem
, vol.260
, pp. 3275-3280
-
-
Thomas, C.E.1
Morehouse, L.A.2
Aust, S.D.3
-
22
-
-
0022982227
-
Superoxide-dependent and-independent mechanisms of iron mobolization from ferritin by xanthine oxidase Implications for oxygen-free-radical-induced tissue desrtuction during ischemia and inflammation
-
Biemond P, Swaak AJ, Beindorff CM, Koster JF: Superoxide-dependent and-independent mechanisms of iron mobolization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue desrtuction during ischemia and inflammation. Biochem J 1986;239:169-173.
-
(1986)
Biochem J
, vol.239
, pp. 169-173
-
-
Biemond, P.1
Swaak, A.J.2
Beindorff, C.M.3
Koster, J.F.4
-
24
-
-
0028247159
-
Ascorbic acid mediated iron release from cellular ferritin and its relation to DNA strand break formation in neuroblastoma cells
-
Baader SL, Bruchelt G, Carmine TC, Lode HN, Rieth AG, Niethammer D: Ascorbic acid mediated iron release from cellular ferritin and its relation to DNA strand break formation in neuroblastoma cells. J Cancer Res Clin Oncol 1994;120:415-421.
-
(1994)
J Cancer Res Clin Oncol
, vol.120
, pp. 415-421
-
-
Baader, S.L.1
Bruchelt, G.2
Carmine, T.C.3
Lode, H.N.4
Rieth, A.G.5
Niethammer, D.6
-
25
-
-
0030032753
-
Mobilization of iron from cellular ferritin by ascorbic acid in neu-roblastoma SK-N-SH cells: An EPR study
-
Baader SL, Bill E, Trautwein AX, Bruchelt G, Matzanke B: Mobilization of iron from cellular ferritin by ascorbic acid in neu-roblastoma SK-N-SH cells: an EPR study. FEBS Lett 1996;381:131-134.
-
(1996)
FEBS Lett
, vol.381
, pp. 131-134
-
-
Baader, S.L.1
Bill, E.2
Trautwein, A.X.3
Bruchelt, G.4
Matzanke, B.5
-
26
-
-
0029868538
-
Vitamin C-driven free radical generation from iron
-
Herbert V, Shaw S, Jayatilleke E: Vitamin C-driven free radical generation from iron. J Nutr 1996;126:1213-1220.
-
(1996)
J Nutr
, vol.126
, pp. 1213-1220
-
-
Herbert, V.1
Shaw, S.2
Jayatilleke, E.3
-
28
-
-
0028598722
-
Ascorbic acid induces lipid peroxidation on neuroectodermal SK-N-LO cells with high endogeneous ferritin content and loaded with Mab-ferritin immunoconjugates
-
Lode HL, Bruchelt G, Zinsser D, Baader SL, Rieth AG, Schade UF, Niethammer D: Ascorbic acid induces lipid peroxidation on neuroectodermal SK-N-LO cells with high endogeneous ferritin content and loaded with Mab-ferritin immunoconjugates. Anticancer Res 1994;14:1903-1906.
-
(1994)
Anticancer Res
, vol.14
, pp. 1903-1906
-
-
Lode, H.L.1
Bruchelt, G.2
Zinsser, D.3
Baader, S.L.4
Rieth, A.G.5
Schade, U.F.6
Niethammer, D.7
-
29
-
-
65549134351
-
Inhibition of constitutively activated nuclear factor-κB induces reactive oxygen species-and iron-dependent cell death in cutaneous T-cell lymphoma
-
Kiessling M-K, Klemke CD, Kamiñski MM, Galani IE, Krammer PH, Gülow K: Inhibition of constitutively activated nuclear factor-κB induces reactive oxygen species-and iron-dependent cell death in cutaneous T-cell lymphoma. Cancer Res 2009;69:2365-2374.
-
(2009)
Cancer Res
, vol.69
, pp. 2365-2374
-
-
Kiessling, M.-K.1
Klemke, C.D.2
Kamiñski, M.M.3
Galani, I.E.4
Krammer, P.H.5
Gülow, K.6
-
30
-
-
11444261260
-
Energy boost: The Warburg effect returns in a new theory of cancer
-
Garber K: Energy boost: the Warburg effect returns in a new theory of cancer. J Natl Cancer Inst 2004;96:1805-1806.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1805-1806
-
-
Garber, K.1
-
31
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
Kim JW, Dang CV: Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 2006;66:8927-8930.
-
(2006)
Cancer Res
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
32
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB: Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
33
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ: Why do cancers have high aerobic glycolysis? Nature Rev Cancer 2004;4:891-899.
-
(2004)
Nature Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
34
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007;11:37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
Lee, C.T.7
Lopaschuk, G.D.8
Puttagunta, L.9
Bonnet, S.10
Harry, G.11
Hashimoto, K.12
Porter, C.J.13
Andrade, M.A.14
Thebaud, B.15
Michelakis, E.D.16
-
36
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le A, Cooper ChR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang ChiV: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 2010; 107:2037-2042.
-
Proc Natl Acad Sci USA
, vol.2010
, Issue.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, Ch.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
Deck, L.M.6
Royer, R.E.7
Vander Jagt, D.L.8
Semenza, G.L.9
Chiv, D.10
-
37
-
-
70349956364
-
Pharmacokinetics of vitamin C: Insights into the oral and intravenous administration of ascorbate
-
Duconge J, Miranda-Massari JR, Gonzales MJ, Jackson JA, Warnock W, Riordan NH: Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate. P R Health Sci J 2008;27:7-19.
-
(2008)
P R Health Sci J
, vol.27
, pp. 7-19
-
-
Duconge, J.1
Miranda-Massari, J.R.2
Gonzales, M.J.3
Jackson, J.A.4
Warnock, W.5
Riordan, N.H.6
-
38
-
-
67349203545
-
Losing and finding a way at C: New promise for pharmacologic ascorbate in cancer treatment
-
Levine M, Espey MG, Chen Q: Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment. Free Radic Biol Med 2009;47:27-29.
-
(2009)
Free Radic Biol Med
, vol.47
, pp. 27-29
-
-
Levine, M.1
Espey, M.G.2
Chen, Q.3
-
39
-
-
57749108330
-
Mega-dose vitamin C as therapy for human cancer?
-
Borst P: Mega-dose vitamin C as therapy for human cancer? Proc Natl Acad Sci USA 2008;105:E95.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
-
-
Borst, P.1
-
40
-
-
57749084637
-
Reply to Borst: Randomized clinical trials of high dose intravenous vitamin C in cancer patients are warranted
-
Frei B, Lawson S, Levine M, Chen Q, Espey MG: Reply to Borst: Randomized clinical trials of high dose intravenous vitamin C in cancer patients are warranted. Proc Natl Acad Sci USA 2008;105:E96.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
-
-
Frei, B.1
Lawson, S.2
Levine, M.3
Chen, Q.4
Espey, M.G.5
-
41
-
-
66449133323
-
A change of strategy in the war of cancer
-
Gatenby RA: A change of strategy in the war of cancer. Nature 2009;459:508-509.
-
(2009)
Nature
, vol.459
, pp. 508-509
-
-
Gatenby, R.A.1
|