Atorvastatin ameliorates contrast medium-induced renal tubular cell apoptosis in diabetic rats via suppression of Rho-kinase pathway

European Journal of Pharmacology

Volumn 723, Issue 1, 2014, Pages 15-22

  Su, Jinzi ^a   Zou, Wenbo ^a,d   Cai, Wenqin ^a   Chen, Xiuping ^a   Wang, Fangbing ^a   Li, Shuizhu ^a   Ma, Wenwen ^b   Cao, Yangming ^c  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Yichang Central People's Hospital   (China)

Author keywords

Apoptosis; Atorvastatin; Contrast induced acute kidney injury; Diabetic rat; ROCK 1

Indexed keywords

ATORVASTATIN; CASPASE 3; CONTRAST MEDIUM; IOPROMIDE; MYOSIN; PROTEIN BAX; PROTEIN BCL 2; RHO FACTOR; RHO KINASE; STREPTOZOCIN;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTRAST MEDIUM INDUCED ACUTE KIDNEY INJURY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME REPRESSION; HISTOLOGY; HISTOPATHOLOGY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TUBULE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION;

APOPTOSIS; ATORVASTATIN; CONTRAST-INDUCED ACUTE KIDNEY INJURY; DIABETIC RAT; ROCK-1;

ACUTE KIDNEY INJURY; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CONTRAST MEDIA; DIABETES MELLITUS, EXPERIMENTAL; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IOHEXOL; KIDNEY TUBULES; MALE; PROTEIN PHOSPHATASE 1; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES;

EID: 84890462390     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.10.025     Document Type: Article

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