Optimization of a surfactant-free antioxidant formulation using response surface methodology

Drug Development and Industrial Pharmacy

Volumn 40, Issue 1, 2014, Pages 120-125

  Almeida, Isabel F ^a   Costa, Paulo C ^a   Fernanda Bahia, M ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Castanea sativa; Formulation; Hydrogels; Physical stability; Response surface methodology

Indexed keywords

ANTIOXIDANT; CARBOPOL 940; CASTANEA SATIVA EXTRACT; GLYCEROL; LIQUID PARAFFIN; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; CASTANEA SATIVA; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; DRUG FORMULATION; DRUG MIXTURE; DRUG STABILITY; DRUG STORAGE; EMULSION; IC 50; OXIDATIVE STRESS; PLANT LEAF; PROCESS OPTIMIZATION; RESPONSE SURFACE METHOD; STORAGE TEMPERATURE;

ACRYLIC RESINS; ANTIOXIDANTS; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; FAGACEAE; FREE RADICAL SCAVENGERS; GLYCEROL; MINERAL OIL; PLANT EXTRACTS; PLANT LEAVES; REACTIVE OXYGEN SPECIES; TEMPERATURE;

EID: 84890450642     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.750666     Document Type: Article

References (25)

1. Herrling T, Jung K, Fuchs J. Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin. Spectrochim Acta A Mol Biomol Spectrosc 2006;63:840-5.
2. Sakurai H, Yasui H, Yamada Y, et al. Detection of reactive oxygen species in the skin of live mice and rats exposed to UVA light: a research review on chemiluminescence and trials for UVA protection. Photochem Photobiol Sci 2005;4:715-20.
3. Nishigori C, Hattori Y, Arima Y, et al. Photoaging and oxidative stress. Exp Dermatol 2003;12:18-21.
4. Burke KE. Photodamage of the skin: protection and reversal with topical antioxidants. J Cosmet Dermatol. 2004;3:149-55.
5. Lin JY, Selim MA, Shea CR, et al. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J Am Acad Dermatol 2003;48:866-74.
6. Almeida IF, Costa PC, Bahia MF. Evaluation of functional stability and batch-to-batch reproducibility of a castanea sativa leaf extract with antioxidant activity. AAPS PharmSciTech 2010;11:120-5.
7. Schwarz K, Huang SW, German JB, et al. Activities of antioxidants are affected by colloidal properties of oil-in-water and water-in-oil emulsions and bulk oils. J Agric Food Chem 2000;48:4874-82.
8. Loden M, Wessman W. The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties. Int J Cosmet Sci 2001;23:115-19.
9. Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol 2008;159:23-34.
10. Fernandez-Montes EA. Tecnicas y procedimientos em formulac?on magistral e dermatologica. Madrid: E. Alia; 2005.
11. Box GEP, Wilson KB. On the experimental attainment of optimum conditions. J R Stat Soc Ser B 1951;13:1-45.
12. Nazzal S, Khan MA. Response surface methodology for the optimization of ubiquinone self-nanoemulsified drug delivery system. AAPS PharmSciTech 2002;3:E3.
13. Chopra S, Motwani SK, Iqbal Z, et al. Optimisation of polyherbal gels for vaginal drug delivery by Box-Behnken statistical design. Eur J Pharm Biopharm 2007;67:120-31.
14. Moulai Mostefa N, Hadj Sadok A, Sabri N, et al. Determination of optimal cream formulation from long-term stability investigation using a surface response modelling. Int J Cosmet Sci 2006;28: 211-18.
15. Fukumoto LR, Mazza G. Assessing antioxidant and prooxidant activities of phenolic compounds. J Agric Food Chem 2000;48: 3597-604.
16. Vicentini FT, Vaz MM, Fonseca YM, et al. Characterization and stability study of a water-in-oil microemulsion incorporating quercetin. Drug Dev Ind Pharm 2011;37:47-55.
17. Georgetti SR, Casagrande R, Moura-de-Carvalho Vicentini FT, et al. Evaluation of the antioxidant activity of soybean extract by different in vitro methods and investigation of this activity after its incorporation in topical formulations. Eur J Pharm Biopharm 2006;64:99-106.
18. Di Mambro VM, Fonseca MJ. Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts. J Pharm Biomed Anal 2005;37:287-95.
19. Almeida IF, Valentao P, Andrade PB, et al. In vivo skin irritation potential of a Castanea sativa (Chestnut) leaf extract, a putative natural antioxidant for topical application. Basic Clin Pharmacol Toxicol 2008;103:461-7.
20. Jones DS, Lawlor MS, Woolfson AD. Examination of the flow rheological and textural properties of polymer gels composed of poly(methylvinylether-co-maleic anhydride) and poly(vinylpyrrolidone): rheological and mathematical interpretation of textural parameters. J Pharm Sci 2002;91:2090-101.
21. Jones DS, Muldoon BC, Woolfson AD, et al. An examination of the rheological and mucoadhesive properties of poly(acrylic acid) organogels designed as platforms for local drug delivery to the oral cavity. J Pharm Sci 2007;96:2632-46.
22. Baby AR, Migliato KF, Maciel CPM, et al. Accelerated chemical stability data of O/W fluid emulsions containing the extract of Trichilia catigua Adr. Juss (and) Ptychopetalum olacoides Bentham. Rev Bras Cienc Farm 2007;43:405-12.
23. Ofori-Kwakye K, Kwapong AA, Adu F. Antimicrobial activity of extracts and topical products of the stem bark of Spathodea campanulata for wound healing. Afr J Tradit Complement Altern Med 2009;6:168-174.
24. Bouftira I, Abdelly C, Sfar S. Characterization of cosmetic cream with Mesembryanthemum crystallinum plant extract: influence of formulation composition on physical stability and anti-oxidant activity. Int J Cosmet Sci 2008;30:443-52.
25. Sakai T. Surfactant-free emulsions. Curr Opin Colloid Interface Sci 2008;13:228-35.