Optimisation of polyherbal gels for vaginal drug delivery by Box-Behnken statistical design

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 67, Issue 1, 2007, Pages 120-131

  Chopra, Shruti ^a   Motwani, Sanjay K ^a   Iqbal, Zeenat ^a   Talegaonkar, Sushma ^a   Ahmad, Farhan J ^a   Khar, Roop K ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Box Behnken design; Formulation; Mucoadhesion; Optimisation; Polyherbal gels

Indexed keywords

AEROSIL; AZADIRACHTA INDICA EXTRACT; CARBOPOL 974P; CICHORIUM INTYBUS EXTRACT; CURCUMA LONGA EXTRACT; HERBACEOUS AGENT; TRIGONELLA FOENUM GRAECUM EXTRACT; UNCLASSIFIED DRUG;

ADHESION; ARTICLE; DRUG DELIVERY SYSTEM; DRUG STABILITY; FLOW KINETICS; GEL; RESPONSE SURFACE METHOD; STATISTICAL ANALYSIS;

ADHESIVENESS; ADMINISTRATION, INTRAVAGINAL; ALGORITHMS; ANTI-INFECTIVE AGENTS, LOCAL; AZADIRACHTA; CHEMISTRY, PHARMACEUTICAL; CURCUMA; DRUG DELIVERY SYSTEMS; DRUG STABILITY; GELS; HYDROGEN-ION CONCENTRATION; MODELS, STATISTICAL; MUCOUS MEMBRANE; PLANT PREPARATIONS; RHEOLOGY; TRIGONELLA; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 34250862710     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.12.013     Document Type: Article

References (54)

1. Edsman K., Carlfors J., and Petersson R. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. Eur. J. Pharm. Sci. 6 (1998) 105-112
2. ®) in physiological conditions. Eur. J. Pharm. Sci. 9 (1999) 99-105
3. Rozier A., Mazuel C., Grove J., and Plazonnet B. Gelrite: a novel ion-activated, in situ gelling polymer for ophthalmic vehicles, Effect on bioavailability of timolol. Int. J. Pharm. 57 (1989) 163-168
4. Choi H.G., Jung J.H., Ryu J.M., Yoon S.J., Oh Y.K., and Kim C.K. Development of in situ gelling and mucoadhesive acetaminophen liquid suppository. Int. J. Pharm. 16 (1998) 533-544
5. Miller S.C., and Donovan M.D. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. Int. J. Pharm. 12 (1982) 147-152
6. Gilbert J.C., Richardson J.C., Davies M.C., Palin K.J., and Hadgraft J. The effect of solutes and polymers on the gelation properties of pluronic F-127 solutions for controlled drug delivery. J. Control. Release 5 (1987) 113-118
7. Sandri G., Rossi S., Ferrari F., Bonferoni M.C., Muzzarelli C., and Caramella C. Assessment of chitosan derivatives as buccal and vaginal penetration enhancers. Eur. J. Pharm. Sci. 21 (2004) 351-359
8. Veyries M.L., Couarraze G., Geiger S., Agnely F., Massias L., Kunzli B., Faurisson R., and Rouveix B. Controlled release of vancomycin from poloxamer 407 gels. Int. J. Pharm. 192 (1999) 183-193
9. Albertsson A.C., Carlfors J., and Sturesson C. Preparation and characterisation of poly (adipic anhydride) microspheres for ocular drug delivery. J. Appl. Polym. Sci. 62 (1996) 695-705
10. Desai S.D., and Blanchard J. Pluronic F127-based ocular delivery system containing biodegradable polyisobutylcyanoacrylate nanocapsules of pilocarpine. Drug Deliv. 7 (2000) 201-207
11. Bochot A., Fattal E., Grossiord J.L., Puisieux F., and Couvreur P. Characterisation of a new ocular delivery system based on a dispersion of liposomes in a thermo sensitive gel. Int. J. Pharm. 162 (1998) 119-127
12. Paavola A., Kilpelainen I., Yliruusi J., and Rosenberg P. Controlled release injectable liposomal gel of ibuprofen for epidural analgesia. Int. J. Pharm. 199 (2000) 85-93
13. Gao Z.H., Shukla A.J., Johnson J.R., and Crowley W.R. Controlled release of a contraceptive steroid from biodegradable and injectable gel formulations: in vitro evaluation. Pharm. Res. 12 (1995) 857-863
14. Smart J.D., Kellaway I.W., and Worthington H.E.C. An in vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol. 36 (1984) 295-299
15. Chen J.L., and Cyr G.N. In: Manly R.S. (Ed). Adhesion in Biological Systems (1970), Academic Press, New York 163-181
16. Park K., and Robinson J.R. Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion. Int. J. Pharm. 196 (1984) 107-127
17. Peppas N.A., and Buri P.A. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J. Control. Release 2 (1985) 257-275
18. R.N. Chopra, S.L. Nayer, I.C. Chopra, Glossary of Indian Medicinal Plants, third ed., New Delhi, Council of Scientific and Industrial Research, 1992, pp. 7-246.
19. J. Bruneton, Pharmacognosy, Phytochemistry, Medicinal Plants, France, Lavoisiler Publishing Co., 1995, pp. 265-380.
20. Murray M.T., and Pizzorno J.E. Textbook of Natural Medicine (1999), Churchill Living, China
21. Vermani K., and Garg S. Herbal medicines for sexually transmitted diseases and AIDS. J. Ethanopharmacol. 80 (2002) 49-66
22. Bhatt M.A., Khan M.T.J., Ahmed B., and Jamshaid M. Antibacterial activity of Trigonella foenum-graecum seeds. Fitoerapia (1996) 372-374
23. Subapriya R., and Nagini S. Medicinal properties of neem leaves: a review. Curr. Med. Chem. - Anti-Cancer Agents 5 (2005) 149-156
24. Petrovic J., Stanojkovic A., Comic Lj., and Curcic S. Antibacterial activity of Cichorium intybus. Fitoterapia 75 (2004) 737-739
25. Singh R., Chander R., Bose M., and Luthra P.M. Antibacterial activity of Curcuma longa rhizome extract on pathogenic bacteria. Curr. Sci. 83 (2002) 738-740
26. S. Chopra, F.J. Ahmad, R.K. Khar, S. Mahdi, Z. Iqbal, Screening of antibacterial activity of some medicinal plants, in: Proceedings of British Pharmaceutical Conference 2006, Manchester, September 4-6, 2006.
27. Carlfors J., Edsman K., Petersson R., and Jornving K. Rheological evaluation of Gelrite® in situ gels for ophthalmic use. Eur. J. Pharm. Sci. 6 (1998) 113-119
28. Mortazavi S.A., Carpenter B.G., and Smart J.D. An investigation of the rheological behaviour of the mucoadhesive/mucosal interface. Int. J. Pharm. 83 (1992) 221-225
29. Caramella C., Rossi S., Bonferoni M.C., and La Manna A. A rheometric method for the assessment of polymer-mucin interaction. Proc. Int. Symp. Control. Release Bioact. Mater. 19 (1992) 90-91
30. S. Rossi, F. Ferrari, M.C. Bonferoni, M. Bertoni, C. Caramella, Comparative evaluation of two in vitro approaches for testing bioadhesion, in: Minutes -European Symposium In Vitro and Ex Vivo Test Systems to Rationalize Drug Design and Delivery, Editions de Santr, Paris, 1993, pp. 232-237.
31. Dyvik K., and Graffner C. Investigation of the applicability of a tensile testing machine for measuring mucoadhesive strength. Acta Pharm. Nord. 4 (1992) 79-84
32. de Vries M.E., and Boddr H.E. Hydrogels for buccal drug delivery: properties relevant for muco-adhesion. J. Biomed. Mater. Res. 22 (1988) 1023-1032
33. Tamburic S., and Craig D.Q.M. An investigation into the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems. J. Control. Release 37 (1995) 59-68
34. Knuth K., Amiji M., and Robinson J. Hydrogel delivery systems for vaginal and oral applications. Adv. Drug Deliv. Rev. 11 (1993) 137-167
35. Aerosil: Invented to improve, product overview, 2006 (www.aerosil.com).
36. Dittgen M., Durrani M., and Lehmann K. Acrylic polymers: a review of pharmaceutical applications. STP Pharma Sci. 7 (1997) 403-437
37. B.F. Goodrich, The science of rheology: pharmaceutically applied, Technical note (1992).
38. Owen D.H., and Katz D.F. A vaginal fluid simulant. Contraception 59 (1999) 91-95
39. Govender S., Pillay V., Chetty D.J., Essack S.Y., Dangor C.M., and Govender T. Optimisation and characterisation of bioadhesive controlled release tetracycline microspheres. Int. J. Pharm. 306 (2005) 24-40
40. S. Chopra, G.V. Patil, S.K. Motwani, Release modulating hydrophilic matrix systems of losartan potassium: optimisation of formulation using statistical experimental design, Eur. J. Pharm. Biopharm. (doi:10.1016/j.ejpb.2006.09.001).
41. Box G.E.P., and Behnken D.W. Some new three level designs for the study of quantitative variables. Technometrics 2 (1960) 455-475
42. Ferry J.D. Viscoelastic Properties of Polymers. second ed. (1970), Wiley, New York
43. Ross-Murphy S.B., and McEvoy H. Br. Polym. J. 18 (1986) 2
44. Bremecker K.D. Tromethamine-an alternative in carbomer gels containing amines. Pharm. Ind. 51 (1989) 199-202
45. Gu J.-M., and Robinson J.R. Binding of acrylic polymers to mucin/epithelial surfaces: structure-property relationships. CRC Crit. Rev. Ther. Drug Carrier Syst. 5 (1988) 21-67
46. Bonacucina G., Martelli S., and Palmieri G.F. Rheological, mucoadhesive and release properties of Carbopol gels in hydrophilic cosolvents. Int. J. Pharm. 282 (2004) 115-130
47. Taberner T.S., Martin-Villodre A., Pla-Delfina J.M., and Herráez J.V. Consistency of Carbopol 971-P NF gels and influence of soluble and cross-linked PVP. Int. J. Pharm. 233 (2002) 43-50
48. Hernández M.J., Pellicer J., Delegido J., and Dolz M. Rheological characterisation of easy to disperse (ETD) Carbopol hydrogels. J. Disper. Sci. Technol. 19 (1998) 31-42
49. Herráez J.V., Dolz M., Sobrino P., Belda R., and González F. Modification of rheological behavior of cellulose gels with NaCl concentration. Application of Ostwald's model. Pharmazie 48 (1993) 359-362
50. Delegido J., Dolz M., Hernández M.J., and Pellicer J. Pseudoplasticity and thixotropy of different types of starch hydrogels prepared with microcrystalline cellulose-sodium carboxymethyl cellulose. J. Disper. Sci. Technol. 3-4 (1995) 283-294
51. Hassan E.E., and Gallo J.M. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res. 7 (1990) 491-495
52. Caillouette J.C., Sharp C.F., Zimmerman G.J., and Roy S. Vaginal pH as a marker for bacterial pathogens and menopausal status. Am. J. Obstet. Gynecol. 176 (1997) 1270-1277
53. Pavelić Z., Škalko-Basnet N., and Jalšenjak I. Liposomes for vaginal drug delivery. J. Liposome Res. 8 (1998) 94-95
54. Pham A.T., and Lee P.I. Probing the mechanism of drug release from hydroxypropylmethyl cellulose matrices. Pharm. Res. 11 (1994) 1379-1385