Response surface methodology for the optimization of ubiquinone self-nanoemulsified drug delivery system

AAPS PharmSciTech

Volumn 3, Issue 1, 2002, Pages

  Nazzal, Sami ^a   Khan, Mansoor A ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Coenzyme Q10; Optimization; Response surface methodology; Self nanoemulsified drug delivery; Turbidimetry

Indexed keywords

COSURFACTANT; CREMOPHOR; LEMON OIL; OCTANOIN; SURFACTANT; UBIDECARENONE; CASTOR OIL; DIACYLGLYCEROL; DRUG DERIVATIVE; UBIQUINONE; VEGETABLE OIL;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; EMULSION; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PRECIPITATION; PREDICTION; PROCESS OPTIMIZATION; REGRESSION ANALYSIS; RELIABILITY; RESPONSE SURFACE METHOD; TURBIDITY; CHEMISTRY; DELAYED RELEASE FORMULATION; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; PHARMACEUTICS; PHOTOMETRY;

CASTOR OIL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIGLYCERIDES; DRUG DELIVERY SYSTEMS; EMULSIONS; NANOTECHNOLOGY; NEPHELOMETRY AND TURBIDIMETRY; PLANT OILS; TECHNOLOGY, PHARMACEUTICAL; UBIQUINONE;

EID: 0141798535     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt030103     Document Type: Article

References (29)

1. Perng CH, Kearney AS, Patel K, Palepu NR, Zuber, G. Investigation of formulation approaches to improve the disolution of SB-210661, a poorly water soluble 5-lipoxygenase inhibitor. Int J Pharm. 1998;176:31-38.
2. Nazzal S, Guven N, Reddy IK, Khan MA. Preparation and characterization of Coenzyme Q10 - Eudragit© solid dispersion. Drug Dev Ind Pharm. 2002;28(1):49-57.
3. Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and "self-microemulsifying" drug delivery systems. Eur J Pharm Sci. 2000;Suppl 2:S93-8.
4. Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko FJ, Pouton CW. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm Res. 1992;9(1):87-93.
5. Craig DQM, Lievens HSR, Pitt KG, Storey DE. An investigation into the physico-chemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and article size analysis. Int J Pharm. 1993;96:147-155.
6. Gao ZG, Choi HG, Shin HJ, Park KM, Lim SJ, Hwang KJ, Kim CK. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A. Int J Pharm. 1998;161:75-86.
7. Groves MJ, de Galindez DA. Rheological characterization of self-emulsifying oil/surfactant systems. Acta Pharm Suecica. 1976;13:353-360.
8. Yalabik-Kas HS, Groves MJ. Zeta potential of droplets prepared from a self-emulsifying oil. Drug Dev Ind Pharm. 1984;10(2):211-223.
9. Craig DQ, Barker SA, Banning D, Booth SW. Investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm. 1995;114:103-110.
10. Kim CK, Ryuu SA, Park KM, Lim SJ, Hwang SJ. Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A. Int J Pharm. 1997;147:131-134.
11. Cortesi R, Esposito E, Maietti A, Menegatti E, Nastruzzi C. Formulation study for the antitumor drug camptothecin: ilposomes, micellar solutions and a microemulsion. Int J Pharm. 1997;159:95-103.
12. Prinderre P, Piccerelle P, Cauture E, Kalantzis G, Joachim J. Formulation and evaluation of o/w emulsions using experimental design. Int J Pharm. 1998;163:73-79.
13. Gullapalli RP, Sheth BB. Influence of an optimized nonionic emulsifier blend on properties of oil in water emulsions. Eur J Pharm Biopharm. 1999;48(3):233-238.
14. Kommuru TR, Gurley B, Khan MA, Reddy IK. Selfe-mulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm. 2001;212:233-46.
15. Karachi AA, Khan MA. Box-Behnken design for the optimization of formulation variables of indomethacin coprecipitates with polymer mixtures. Int J Pharm. 1996;131:9-17.
16. Singh SK, Reddy IK, Khan MA. Optimization and characterization of controlled release pellets coated with an experimental latex: II. Cationic drug. Int J Pharm. 1996;141:179-195.
17. Sastry SV, Reddy IK, Khan MA. Atenolol gastrointestinal therapeutic system: optimization of formulation variables using response surface methodology. J Cont Rel. 1997;45:121-130.
18. Wehrle P, Korner D, Benita S. Sequential statistical optimization of a positively charged submicron emulsion of miconazole. Pharm Dev Tech. 1996;1(1):97-111.
19. Box GEP, Behnken DW. Some new three level designs for the study of quantitative variables. Technometrics. 1960;2:455-475.
20. Nazzal S, Smalyukh II, Lavrentovich OD, Khan MA. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of Ubiquinone: Mechanism and progress of emulsion formation. Int J Pharm. In press.
21. Groves MJ, Mustafa RMA. Measurement of the "spontaneity" of self-emulsifiable oils. J Pharm Pharmac. 1974;26:671-681.
22. Pouton CW. Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification. Int J Pharm. 1985;27:335-348.
23. 10) aqueous samples using reversed phase liquid chromatography. Pharmazie. 2001;56(5):394-396.
24. Reiss H. Entropy-induced dispersion of bulk liquids. J Colloid Interface Sci. 1975;53(1):61-70.
25. Iranloye TA, Pilpel N, Groves MJ. Some factors affecting the droplet size and charge of dilute oil-inwater emulsions prepared by self-emulsification. J Disp Sci and Technology. 1983;4(2):109-121.
26. Constantinides PP, Scalart JP. Formulation and physical characterization of water-in-oil microemulsions containing long- versus medium-chain glycerides. Int J Pharm. 1997;158:57-68.
27. Halbaut L, Berbe C, del Pozo A. An investigation into physical and chemical properties of semi-solid self-emulsifying systems for hard gelatin capsules. Int J Pharm. 1996;130:203-212.
28. Bachynsky MO, Shah NH, Patel CI, Malick AW. Factors affecting the efficiency of a self-emulsifying oral delivery system. Drug Dev Ind Pharm. 1997;23(8):809-816.
29. Shah NH, Carvajal MT, Patel I, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm. 1994;106:15-23.