The central administration of C75, a fatty acid synthase inhibitor, activates sympathetic outflow and thermogenesis in interscapular brown adipose tissue

Pflugers Archiv European Journal of Physiology

Volumn 465, Issue 12, 2013, Pages 1687-1699

  Cassolla, Priscila ^a   Uchoa, Ernane Torres ^a   Mansur Machado, Frederico Sander ^b   Guimarães, Juliana Bohnen ^b   Rissato Garófalo, Maria Antonieta ^a   De Almeida Brito, Nilton ^c   Kagohara Elias, Lucila Leico ^a   Coimbra, Cândido Celso ^b   Do Carmo Kettelhut, Isis ^a   Carvalho Navegantes, Luiz Carlos ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Brown adipose tissue; Fatty acid synthase inhibitors; Sympathetic activation; Thermogenesis

Indexed keywords

ANTIOBESITY AGENT; C 75; CERULENIN; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; MESSENGER RNA; PROTEIN FOS; TRANS 4 CARBOXY 5 OCTYL 3 METHYLENEBUTYROLACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC DENERVATION; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; CORE TEMPERATURE; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; DRUG DOSE COMPARISON; DRUG EFFECT; FOOD INTAKE; HEAT LOSS; HYPERTHERMIA; HYPOPHAGIA; INTERSCAPULAR BROWN ADIPOSE TISSUE; MALE; NONHUMAN; NUCLEUS RAPHE PALLIDUS; PARAVENTRICULAR THALAMIC NUCLEUS; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SINGLE DRUG DOSE; SYMPATHETIC INNERVATION; THALAMUS VENTRAL NUCLEUS; THERMOGENESIS; THERMOREGULATION; WEIGHT CONTROL; WEIGHT REDUCTION;

4-BUTYROLACTONE; ADIPOSE TISSUE, BROWN; ANIMALS; EATING; FATTY ACID SYNTHASE, TYPE I; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; SKIN TEMPERATURE; SYMPATHECTOMY; THERMOGENESIS;

EID: 84890427742     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-013-1301-5     Document Type: Article

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