Standard recommendations for the application of Chinese clinical cell therapy for neurorestoration (2012)

Cell Transplantation

Volumn 22, Issue SUPPL.1, 2013, Pages

  Huang, Hongyun ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Cell therapy; China; Clinical application; Neurorestoration; Standard

Indexed keywords

BONE MARROW MONONUCLEAR CELL; CELL DIFFERENTIATION; CELL POPULATION; CELL SUSPENSION; CELL VIABILITY; COMPUTER ASSISTED TOMOGRAPHY; CORD BLOOD MONONUCLEAR CELL; DEMYELINATION; DEPRESSED BLOOD PRESSURE; DYSPNEA; ELEVATED BLOOD PRESSURE; EMBRYONIC STEM CELL; FEVER; GLIA CELL; HEADACHE; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IN VITRO STUDY; INFECTION; LIQUORRHEA; MENTAL DETERIORATION; MESENCHYMAL STEM CELL; MONONUCLEAR CELL; MOTOR DYSFUNCTION; NERVE DEGENERATION; NERVE INJURY; NERVOUS SYSTEM INJURY; NEURAL STEM CELL; NEUROLOGIC DISEASE; NEUROPATHIC PAIN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RASH; REVIEW; SCHWANN CELL; SENSORY DYSFUNCTION; STEM CELL TRANSPLANTATION; THERAPY EFFECT; TREATMENT OUTCOME; UMBILICAL CORD MESENCHYMAL STEM CELL; WOUND HEALING;

CELL- AND TISSUE-BASED THERAPY; CENTRAL NERVOUS SYSTEM; CHINA; HUMANS; NERVE REGENERATION; NERVOUS SYSTEM DISEASES; NEUROLOGY; PRACTICE GUIDELINES AS TOPIC; REGENERATIVE MEDICINE;

EID: 84890424639     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368913X672082     Document Type: Review

References (86)

1. Amoh, Y.; Li, L.; Katsuoka, K.; Hoffman, R. M. Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function. Cell Cycle 7(12):1865-1869; 2008.
2. Appel, S. H.; Engelhardt, J. I.; Henkel, J. S.; Siklos, L.; Beers, D. R.; Yen, A. A.; Simpson, E. P.; Luo, Y.; Carrum, G.; Heslop, H. E.; Brenner, M. K.; Popat, U. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology 71(17):1326-1334; 2008.
3. Attar, A.; Ayten, M.; Ozdemir, M.; Ozgencil, E.; Bozkurt, M.; Kaptanoglu, E.; Beksac, M.; Kanpolat, Y. An attempt to treat patients who have injured spinal cords with intralesional implantation of concentrated autologous bone marrow cells. Cytotherapy 13(1):54-60; 2011.
4. Bonner, J. F.; Connors, T. M.; Silverman, W. F.; Kowalski, D. P.; Lemay, M. A.; Fischer, I. Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord. J. Neurosci. 31(12):4675-4686; 2011.
5. Brown, S. A.; Levi, B.; Lequeux, C.; Wong, V. W.; Mojallal, A.; Longaker, M. T. Basic science review on adipose tissue for clinicians. Plast. Reconstr. Surg. 126(6):1936-1946; 2010.
6. Caiazzo, M.; Dell'anno, M. T.; Dvoretskova, E.; Lazarevic, D.; Taverna, S.; Leo, D.; Sotnikova, T. D.; Menegon, A.; Roncaglia, P.; Colciago, G.; Russo, G.; Carninci, P.; Pezzoli, G.; Gainetdinov, R. R.; Gustincich, S.; Dityatev, A.; Broccoli, V. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476(7359):224-227; 2011.
7. Chang, Y. K.; Chen, M. H.; Chiang, Y. H.; Chen, Y. F.; Ma, W. H.; Tseng, C. Y.; Soong, B. W.; Ho, J. H.; Lee, O. K. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells. J. Biomed. Sci. 18(1):54; 2011.
8. Chen, L.; Chen, D.; Xi, H. T.; Wang, Q. M.; Liu, Y. C.; Zhang, F.; Wang, H. M.; Ren, Y. S.; Xiao, J.; Wang, Y. C.; Huang, H. Y. Olfactory ensheathing cell neurorestorotherapy for amyotrophic lateral sclerosis patients: Benefits from multiple transplantations. Cell Transplant. 21(Suppl 1):S65-S77; 2012.
9. Chen, L.; Huang, H.; Xi, H.; Xie, Z.; Liu, R.; Jiang, Z.; Zhang, F.; Liu, Y.; Chen, D.; Wang, Q.; Wang, H.; Ren, Y.; Zhou, C. Intracranial transplant of olfactory ensheathing cells in children and adolescents with cerebral palsy: A randomized controlled clinical trial. Cell Transplant. 19(2):185-91; 2010.
10. Chinese Branch of the International Association of Neurorestoratology (IANR) and the Preparatory Committee of Chinese Association of Neurorestoratology. Standard recommendations (2011) for the application of Chinese clinical cell therapy for neurorestoration. Chin. J. Clinicians (Electronic Edition) 5(19):5710-5714; 2011.
11. Choi, J. H.; Chung, J. Y.; Yoo, D. Y.; Hwang, I. K.; Yoo, K. Y.; Lee, C. H.; Yan, B. C.; Ahn, J. O.; Youn, H. Y.; Won, M. H. Cell proliferation and neuroblast differentiation in the rat dentate gyrus after intrathecal treatment with adiposederived mesenchymal stem cells. Cell. Mol. Neurobiol. 31(8):1271-1280; 2011.
12. Cipriani, S.; Bonini, D.; Marchina, E.; Balgkouranidou, I.; Caimi, L.; Grassi Zucconi, G.; Barlati, S. Mesenchymal cells from human amniotic fluid survive and migrate after transplantation into adult rat brain. Cell. Biol Int. 31(8):845-850; 2007.
13. Cox, Jr., C. S.; Baumgartner, J. E.; Harting, M. T.; Worth, L. L.; Walker, P. A.; Shah, S. K.; Ewing-Cobbs, L.; Hasan, K. M.; Day, M. C.; Lee, D.; Jimenez, F.; Gee, A. Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children. Neurosurgery 68(3):588-600; 2011.
14. Davies, S. J.; Shih, C. H.; Noble, M.; Mayer-Proschel, M.; Davies, J. E.; Proschel, C. Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury. PLoS One 6(3):e17328; 2011.
15. Döbrössy, M.; Busse, M.; Piroth, T.; Rosser, A.; Dunnett S.; Nikkhah G. Neurorehabilitation with neural transplantation. Neurorehabil. Neural. Repair 24(8):692-701; 2010.
16. Dongmei, H.; Jing, L.; Mei, X.; Ling, Z.; Hongmin, Y.; Zhidong, W.; Li, D.; Zikuan, G.; Hengxiang, W. Clinical analysis of the treatment of spinocerebellar ataxia and multiple system atrophy-cerebellar type with umbilical cord mesenchymal stromal cells. Cytotherapy 13(8):913-917; 2011.
17. Dyson, S. C.; Barker, R. A. Cell-based therapies for Parkinson's disease. Expert Rev. Neurother. 11(6):831-844; 2011.
18. Eaton, M. J.; Widerström-Noga, E.; Wolfe, S. Q. Subarachnoid transplant of the human neuronal hNT2.19 serotonergic cell line attenuates behavioral hypersensitivity without affecting motor dysfunction after severe contusive spinal cord injury. Neurol. Res. Int. 2011:891605; 2011.
19. Forthofer, M.; Wirth, 3rd., E. D. Coordination of a neural tissue transplantation study in patients with posttraumatic syringomyelia. SCI Nurs. 18(1):19-29; 2001.
20. Freedman, M. S.; Bar-Or, A.; Atkins, H. L.; Karussis, D.; Frassoni, F.; Lazarus, H.; Scolding, N.; Slavin, S.; Le, Blanc, K.; Uccelli, A; MSCT Study Group. The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: Consensus report of the International MSCT Study Group. Mult. Scler. 16(4):503-510; 2010.
21. Gaspard, N.; Vanderhaeghen, P. From stem cells to neural networks: Recent advances and perspectives for neurodevelopmental disorders. Dev. Med. Child. Neurol. 53(1): 13-17; 2011.
22. Ghanizadeh, A. Non-neuronal cell transplantation as a possible therapeutic approach for epilepsy treatment. Brain Res. Bull. 83(5):194-195; 2010.
23. Gobbel, G. T.; Kondziolka, D.; Fellows-Mayle, W.; Uram, M. Cellular transplantation for the nervous system: Impact of time after preparation on cell viability and survival. J. Neurosurg. 113(3):666-672; 2010.
24. Hernándeza, J.; Torres-Espína, A.; Navarro, X. Adult stem cell transplants for spinal cord injury repair: Current state in preclinical research. Curr. Stem Cell Res. Ther. 6(3):273-287; 2011.
25. Hilfiker, A.; Kasper, C.; Hass, R.; Haverich, A. Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: Is there a future for transplantation? Langenbecks Arch. Surg. 396(4):489-497; 2011.
26. Huang, H.; Chen, L.; Sanberg, P. R. Cell therapy from bench to bedside translation in CNS neurorestoratology era. Cell Med. 1(1):15-46; 2010.
27. Huang, H.; Chen, L.; Sanberg, P. R. Clinical achievements, obstacles, falsehoods, and future directions of cell-based neurorestoratology. Cell Transplant. 21(S1):S3-S11; 2012.
28. Huang, H.; Chen, L.; Wang, H.; Xiu, B. Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury. Chin. Med. J. 116(10):1488-1491; 2003.
29. Huang, H.; Chen, L.; Xi, H.; Wang, H.; Zhang, J.; Zhang, F.; Liu, Y. Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: A controlled pilot study. Clin. Transplant. 22:710-718; 2008.
30. Huang, H.; Xi, H.; Chen, L.; Zhang, F.; Liu, Y. Long-term outcome of olfactory ensheathing cell therapy for patients with complete chronic spinal cord injury. Cell Transplant. 21(S1):S23-S31; 2012.
31. Hunt, C. J. Cryopreservation of human stem cells for clinical application: A review. Transfus. Med. Hemother. 38(2):107-123; 2011.
32. Ikegame, Y.; Yamashita, K.; Hayashi, S.; Mizuno, H.; Tawada, M.; You, F.; Yamada, K.; Tanaka, Y.; Egashira, Y.; Nakashima, S.; Yoshimura, S.; Iwama, T. Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Cytotherapy 13(6):675-685; 2011.
33. International Association of Neurorestoratology. Beijing Declaration of International Association of Neurorestoratology (IANR). Cell Transplant. 18(4):487; 2009.
34. Karussis, D.; Karageorgiou, C.; Vaknin-Dembinsky, A.; Gowda-Kurkalli, B.; Gomori, J. M.; Kassis, I.; Bulte, J. W.; Petrou, P.; Ben-Hur, T.; Abramsky, O.; Slavin, S. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch. Neurol. 67(10):1187-1194; 2010.
35. Lasala, G. P.; Minguell, J. J. Vascular disease and stem cell therapies. Br. Med. Bull. 98:187-197; 2011.
36. Lee, J. M.; Bae, J. S.; Jin, H. K. Intracerebellar transplantation of neural stem cells into mice with neurodegeneration improves neuronal networks with functional synaptic transmission. J. Vet. Med. Sci. 72(8):999-1009; 2010.
37. Lima, C.; Escada, P.; Pratas-Vital, J.; Branco, C.; Arcangeli, C. A.; Lazzeri, G.; Maia, C. A.; Capucho, C.; Hasse-Ferreira, A.; Peduzzi, J. D. Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury. Neurorehabil. Neural Repair. 24(1):10-22; 2010.
38. Lin, Y. C.; Ko, T. L.; Shih, Y. H.; Lin, M. Y.; Fu, T. W.; Hsiao, H. S.; Hsu, J. Y.; Fu, Y. S. Human umbilical mesenchymal stem cells promote recovery after ischemic stroke. Stroke 42(7):2045-2053; 2011.
39. Loewenbrück, K.; Storch, A. Stem cell-based therapies in Parkinson's disease: Future hope or current treatment option? J. Neurol. 258(Suppl 2):S346-S353; 2011.
40. Loftis, J. M. Sertoli cell therapy: A novel possible treatment strategy for treatment-resistant major depressive disorder. Med. Hypotheses 77(1):35-42; 2011.
41. Lopatina, T.; Kalinina, N.; Karagyaur, M.; Stambolsky, D.; Rubina, K.; Revischin, A.; Pavlova, G.; Parfyonova, Y.; Tkachuk, V. Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One 6(3):e17899; 2011.
42. López-Lozano, J. J.; Bravo, G.; Brera, B.; Dargallo, J.; Salmeán, J.; Uría, J.; Insausti, J.; Millán, I. Long-term follow-up in 10 Parkinson's disease patients subjected to fetal brain grafting into a cavity in the caudate nucleus: The Clinica Puerta de Hierro experience. CPH Neural Transplantation Group. Transplant. Proc. 27(1):1395-1400; 1995.
43. Luan, Z.; Liu, W. P.; Qu, S. Q.; Du, K.; He, S.; Wang, Z. Y.; Yang, Y. X.; Wang, C. Y.; Gong, X. J. Effects of neural progenitor cell transplantation in children with severe cerebral palsy. Cell Transplant. 21(Suppl 1):S91-S98; 2012.
44. Lunn, J. S.; Sakowski, S. A.; Federici, T.; Glass, J. D.; Boulis, N. M.; Feldman, E. L. Stem cell technology for the study and treatment of motor neuron diseases. Regen. Med. 6(2):201-213; 2011.
45. Mackay-Sim, A.; Féron, F.; Cochrane, J.; Bassingthwaighte, L.; Bayliss, C.; Davies, W.; Fronek, P.; Gray, C.; Kerr, G.; Licina, P.; Nowitzke, A.; Perry, C.; Silburn, P. A.; Urquhart, S.; Geraghty, T. Autologous olfactory ensheathing cell transplantation in human paraplegia: A 3-year clinical trial. Brain 131(Pt 9):2376-2386; 2008.
46. Mendez, I.; Dagher, A.; Hong, M.; Gaudet, P.; Weerasinghe, S.; McAlister, V.; King, D.; Desrosiers, J.; Darvesh, S.; Acorn, T.; Robertson, H. Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: A pilot study. Report of three cases. J. Neurosurg. 96(3):589-596; 2002.
47. Michel-Monigadon, D.; Brachet, P.; Neveu, I.; Naveilhan, P. Immunoregulatory properties of neural stem cells. Immunotherapy 3(4 Suppl):39-41; 2011.
48. Minnerup, J.; Kim, J. B.; Schmidt, A.; Diederich, K.; Bauer, H.; Schilling, M.; Strecker, J. K.; Ringelstein, E. B.; Sommer, C.; Schöler, H. R.; Schäbitz, W. R. Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke. Stroke 42(6):1757-1763; 2011.
49. Mizuno, H. Adipose-derived stem and stromal cells for cellbased therapy: Current status of preclinical studies and clinical trials. Curr. Opin. Mol. Ther. 12(4):442-449; 2010.
50. Nagai, N.; Kawao, N.; Okada, K.; Okumoto, K.; Teramura, T.; Ueshima, S.; Umemura, K.; Matsuo, O. Systemic transplantation of embryonic stem cells accelerates brain lesion decrease and angiogenesis. Neuroreport 21(8):575-579; 2010.
51. Narantuya, D.; Nagai, A.; Sheikh, A. M.; Wakabayashi, K.; Shiota, Y.; Watanabe, T.; Masuda, J.; Kobayashi, S.; Kim, S. U.; Yamaguchi, S. Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition. Brain Res. 1316:145-152; 2010.
52. Novikova, L. N.; Lobov, S.; Wiberg, M.; Novikov, L. N. Efficacy of olfactory ensheathing cells to support regeneration after spinal cord injury is influenced by method of culture preparation. Exp. Neurol. 229(1):132-142; 2011.
53. Obenaus, A.; Dilmac, N.; Tone, B.; Tian, H. R.; Hartman, R.; Digicaylioglu, M.; Snyder, E. Y.; Ashwal, S. Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury. Ann. Neurol. 69(2):282-291; 2011.
54. Park, B. W.; Kang, D. H.; Kang, E. J.; Byun, J. H.; Lee, J. S.; Maeng, G. H.; Rho, G. J. Peripheral nerve regeneration using autologous porcine skin-derived mesenchymal stem cells. J. Tissue Eng. Regen. Med. 6(2):113-124; 2012.
55. Pellegrini, K. L.; Beilharz, M. W. The survival of myoblasts after intramuscular transplantation is improved when fewer cells are injected. Transplantation 91(5):522-526; 2011.
56. Raisman, G.; Carlstedt, T.; Choi, D.; Li, Y. Clinical prospects for transplantation of OECs in the repair of brachial and lumbosacral plexus injuries: Opening a door. Exp. Neurol. 229(1):168-173; 2011.
57. Rhee, Y. H.; Ko, J. Y.; Chang, M. Y.; Yi, S. H.; Kim, D.; Kim, C. H.; Shim, J. W.; Jo, A. Y.; Kim, B. W.; Lee, H.; Lee, S. H.; Suh, W.; Park, C. H.; Koh, H. C.; Lee, Y. S.; Lanza, R.; Kim, K. S.; Lee, S. H. Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J. Clin. Invest. 121(6):2326-2335; 2011.
58. Richardson, R. M.; Freed, C. R.; Shimamoto, S. A.; Starr, P. A. Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft. J. Neurol. Neurosurg. Psychiatry 82(3):266-271; 2011.
59. Ronaghi, M.; Erceg, S.; Moreno-Manzano, V.; Stojkovic, M. Challenges of stem cell therapy for spinal cord injury: Human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells? Stem Cells 28(1):93-99; 2010.
60. Rosenkranz, K.; Meier, C. Umbilical cord blood cell transplantation after brain ischemia-From recovery of function to cellular mechanisms. Ann. Anat. 193(4):371-379; 2011.
61. Roshal, L. M.; Tzyb, A. F.; Pavlova, L. N.; Soushkevitch, G. N.; Semenova, J. B.; Javoronkov, L. P.; Kolganova, O. I.; Konoplyannikov, A. G.; Shevchuk, A. S.; Yujakov, V. V.; Karaseva, O. V.; Ivanova, T. F.; Chernyshova, T. A.; Konoplyannikova, O. A.; Bandurko, L. N.; Marey, M. V.; Sukhikh, G. T. Effect of cell therapy on recovery of cognitive functions in rats during the delayed period after brain injury. Bull. Exp. Biol. Med. 148(1):140-147; 2009.
62. Salehi, M.; Pasbakhsh, P.; Soleimani, M.; Abbasi, M.; Hasanzadeh, G.; Modaresi, M. H.; Sobhani, A. Repair of spinal cord injury by co-transplantation of embryonic stem cell-derived motor neuron and olfactory ensheathing cell. Iran. Biomed. J. 13(3):125-135; 2009.
63. Sanberg, P. R.; Eve, D. J.; Willing, A. E.; Garbuzova-Davis, S.; Tan, J.; Sanberg, C. D.; Allickson, J. G.; Cruz, L. E.; Borlongan, C. V. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells. Cell Transplant. 20(1):85-94; 2011.
64. Schwartz, M. "Tissue-repairing" blood-derived macrophages are essential for healing of the injured spinal cord: From skin-activated macrophages to infiltrating blood-derived cells? Brain Behav. Immun. 24(7):1054-1057; 2010.
65. Schwarz, S. C.; Schwarz, J. Translation of stem cell therapy for neurological diseases. Transl. Res. 156(3):155-160; 2010.
66. Sotelo, C.; Alvarado-Mallart, R. M. Reconstruction of the defective cerebellar circuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic implants. Neuroscience 20(1):1-22; 1987.
67. Su, L.; Xu, J.; Ji, B. X.; Wan, S. G.; Lu, C. Y.; Dong, H. Q.; Yu, Y. Y.; Lu, D. P. Autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Int. J. Hematol. 84(3):276-281; 2006.
68. Tomaskovic-Crook, E.; Crook, J. M. Human embryonic stem cell therapies for neurodegenerative diseases. CNS Neurol. Disord. Drug Targets 10(4):440-448; 2011.
69. Vaquero, J.; Zurita, M. Functional recovery after severe CNS trauma: Current perspectives for cell therapy with bone marrow stromal cells. Prog. Neurobiol. 93(3):341-349; 2011.
70. Vertès, A. 2010 world stem cell summit-Part 2. IDrugs 13(12):822-824; 2010.
71. Waldau, B.; Hattiangady, B.; Kuruba, R.; Shetty, A. K. Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy. Stem Cells 28(7):1153-1164; 2010.
72. Walker, P. A.; Harting, M. T.; Shah, S. K.; Day, M. C.; El, Khoury, R.; Savitz, S. I.; Baumgartner, J.; Cox, C. S. Progenitor cell therapy for the treatment of central nervous system injury: A review of the state of current clinical trials. Stem Cells Int. 2010:369578; 2010.
73. Wang, R.; Zhang, J.; Guo, Z.; Shen, L.; Shang, A.; Chen, Y.; Yao, S.; He, T.; Yin, D.; Tian, J. In-vivo PET imaging of implanted human retinal pigment epithelium cells in a Parkinson's disease rat model. Nucl. Med. Commun. 29(5):455-461; 2008.
74. Wang, Y.; Piao, J. H.; Larsen, E. C.; Kondo, Y.; Duncan, I. D. Migration and remyelination by oligodendrocyte progenitor cells transplanted adjacent to focal areas of spinal cord inflammation. J. Neurosci. Res. 89(11):1737-1746; 2011.
75. Wetzig, A.; Mackay-Sim, A.; Murrell, W. Characterization of olfactory stem cells. Cell Transplant. 20(11-12):1673-1691; 2011.
76. Wu, J.; Sun, T. S.; Ye, C. Q.; Yao, J. H.; Zhu, B.; He, H. Y. Clinical observation of fetal olfactory ensheathing glia transplantation(OEGT) in patients with complete chronic spinal cord injury. Cell Transplant. 21(Suppl 1):S33-S37; 2012.
77. Xiong, N.; Cao, X.; Zhang, Z.; Huang, J.; Chen, C.; Zhang, Z.; Jia, M.; Xiong, J.; Liang, Z.; Sun, S.; Lin, Z.; Wang, T. Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats. Biol. Blood Marrow Transplant. 16(11):1519-1529; 2010.
78. Xu, X.; Geremia, N.; Bao, F.; Pniak, A.; Rossoni, M.; Brown, A. Schwann cell co-culture improves the therapeutic effect of bone marrow stromal cells on recovery in spinal cord-injured mice. Cell Transplant. 20(7):1065-1086; 2011.
79. Xu, X. X.; Shao, X. M.; Yu, F.; Liu, L. M.; Zhang, M. X.; Gao, X. L. Effects of tanycytes transplantation on the motor function score and rubrospinal motor evoked potentials of adult rats after spinal cord completely transected. Zhongguo Ying Yong Sheng Li Xue Za Zhi 26(4):433-435; 2010.
80. Yalvac, M. E.; Rizvanov, A. A.; Kilic, E.; Sahin, F.; Mukhamedyarov, M. A.; Islamov, R. R.; Palotás, A. Potential role of dental stem cells in the cellular therapy of cerebral ischemia. Curr. Pharm. Des. 15(33):3908-3916; 2009.
81. Yang, W. Z.; Zhang, Y.; Wu, F.; Zhang, M.; Cho, S. C.; Li, C. Z.; Li, S. H.; Shu, G. J.; Sheng, Y. X.; Zhao, N.; Tang, Y.; Jiang, S.; Jiang, S.; Gandjian, M.; Ichim, T. E.; Hu, X. Human umbilical cord blood-derived mononuclear cell transplantation: Case series of 30 subjects with hereditary ataxia. J. Transl. Med. 9:65; 2011.
82. Yang, X.; Song, L.; Wu, N.; Liu, Z.; Xue, S.; Hui, G. An experimental study on intracerebroventricular transplantation of human amniotic epithelial cells in a rat model of Parkinson's disease. Neurol. Res. 32(10):1054-1059; 2010.
83. Yang, Y. C.; Liu, B. S.; Shen, C. C.; Lin, C. H.; Chiao, M. T.; Cheng, H. C. Transplantation of adipose tissue-derived stem cells for treatment of focal cerebral ischemia. Curr. Neurovasc. Res. 8(1):1-13; 2011.
84. Yarygin, K. N.; Kholodenko, I. V.; Konieva, A. A.; Burunova, V. V.; Tairova, R. T.; Gubsky, L. V.; Cheglakov, I. B.; Pirogov, Y. A.; Yarygin, V. N.; Skvortsova, V. I. Mechanisms of positive effects of transplantation of human placental mesenchymal stem cells on recovery of rats after experimental ischemic stroke. Bull. Exp. Biol. Med. 148(6):862-868; 2009.
85. Zhang, Y.; Wang, D.; Chen, M.; Yang, B.; Zhang, F.; Cao, K. Intramyocardial transplantation of undifferentiated rat induced pluripotent stem cells causes tumorigenesis in the heart. PLoS One 6(4):e19012; 2011.
86. Zhou, X. H.; Ning, G. Z.; Feng, S. Q.; Kong, X. H.; Chen, J. T.; Zheng, Y. F.; Ban, D. X.; Liu, T.; Li, H.; Wang, P. Transplantation of autologous activated Schwann cells in the treatment of spinal cord injury: Six cases, more than five years of follow-up. Cell Transplant. 21(Suppl 1):S39-S47; 2012.