An attempt to treat patients who have injured spinal cords with intralesional implantation of concentrated autologous bone marrow cells

Cytotherapy

Volumn 13, Issue 1, 2011, Pages 54-60

  Attar, Ayhan ^a   Ayten, Murat ^b   Ozdemir, Mevci ^c   Ozgencil, Enver ^a   Bozkurt, Melih ^d   Kaptanoglu, Erkan ^d   Beksac, Meral ^a   Kanpolat, Yucel ^e  

^a ANKARA UNIVERSITY   (Turkey)

^b Trabzon Public Hospital   (Turkey)

^c Ergani Public Hospital   (Turkey)

^d ANKARA NUMUNE HOSPITAL   (Turkey)

^e Turkish Academy of Sciences   (Turkey)

Author keywords

Mononuclear cell; Regeneration; Spinal cord; Trauma

Indexed keywords

ADULT; ANESTHESIA; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW CELL; CASE REPORT; CLINICAL TRIAL; DECOMPRESSION; EDEMA; EVOKED MUSCLE RESPONSE; EVOKED SOMATOSENSORY RESPONSE; FEMALE; FOLLOW UP; HUMAN; INJURY; LAMINECTOMY; MALE; MONONUCLEAR CELL; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOSIS; PARAPLEGIA; PRIORITY JOURNAL; SPINAL CORD INJURY; SPINE FRACTURE; SPINE STABILIZATION; SPINE SURGERY; THORACIC SPINE; TRAFFIC ACCIDENT;

EID: 78650393929     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2010.510506     Document Type: Article

References (23)

1. Lima C, Pratas-Vital J, Escada P, Hasse-Ferreira A, Capucho C, Peduzzi JD. Olfactory mucosa autografts in human spinal cord injury: a pilot clinical study. J Spinal Cord Med. 2006;29:191-203.
2. Tator CH. Phase 1 trial of oscillating fi eld stimulation for complete spinal cord injury in humans. J Neurosurg Spine. 2005;2:1.
3. Yüceer N, Tuna H, Attar A, Sargon M, Egemen N. The effects of topical L-arginine and Ng-nitro-L-arginine methyl ester after experimental acute spinal cord injury. A light and electron microscopic study. Neurosurg Rev. 2002;25:184-90.
4. Tator CH. Strategies for recovery and regeneration after brain and spinal cord injury. Inj Prev. 2002;8(Suppl 4):33-6.
5. Tsai EC, Tator CH. Neuroprotection and regeneration strategies for spinal cord repair. Curr Pharm Des. 2005;11: 1211-22.
6. Bergmark BA, Winograd CH, Koopman C. Residence and quality of life determinants for adults with tetraplegia of traumatic spinal cord injury etiology. Spinal Cord. 2008; 46:684-9.
7. Bregman BS, Coumans JV, Dai HN, Kuhn PL, Lynskey J, McAtee M, Sandhu F. Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury. Prog Brain Res. 2002;137:257-73.
8. Cardenas DD, Hoffman JM, Kirshblum S, McKinley W. Etiology and incidence of rehospitalization after traumatic spinal cord injury: a multicenter analysis. Arch Phys Med Rehabil. 2004;85:1757-63.
9. Carter RE Jr. Etiology of traumatic spinal cord injury: statistics of more than 1,100 cases. Tex Med. 1977;73:61-5.
10. Attar A, Kaptanoglu E, Aydin Z, Ayten M, Sargon MF. Electron microscopic study of the progeny of ependymal stem cells in the normal and injured spinal cord. Surg Neurol. 2005;64(Suppl 2):28-32.
11. Kaptanoglu E, Solaroglu I, Surucu HS, Akbiyik F, Beskonakli E. Blockade of sodium channels by phenytoin protects ultrastructure and attenuates lipid peroxidation in experi mental spinal cord injury. Acta Neurochir (Wien). 2005;147:405-12.
12. Ahn H, Fehlings MG. Prevention, identifi cation, and treatment of perioperative spinal cord injury. Neurosurg Focus. 2008;25:E15.
13. Furlan JC, Fehlings MG. Cardiovascular complications after acute spinal cord injury: pathophysiology, diagnosis, and management. Neurosurg Focus. 2008;25:E13.
14. Ziv Y, Avidan H, Pluchino S, Martino G, Schwartz M. Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc Natl Acad Sci USA. 2006;103:13174-9.
15. Schultz SS. Adult stem cell application in spinal cord injury. Curr Drug Targets. 2005;6:63-73.
16. Wu S, Suzuki Y, Ejiri Y, Noda T, Bai H, Kitada M, et al. Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J Neurosci Res. 2003;72:343-51.
17. Chu K, Kim M, Jeong SW, Kim SU, Yoon BW. Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia. Neurosci Lett. 2003;343:129-33.
18. Copray JC. Restoring the brain with neural stem cells. Acta Neurochir (Wien). 2003;145:425-7.
19. Coskun K, Attar A, Tuna H, Sargun M, Turker K, Egemen N. Early protective effects of Iloprost after experimental spinal cord ischemia in rabbits. Acta Neurochir (Wien). 2000;142: 1135-42.
20. Satake K, Lou J, Lenke LG. Migration of mesenchymal stem cells through cerebrospinal fl uid into injured spinal cord tissue. Spine. 2004;29:1971-9.
21. Phinney DG, Isakova I. Review. Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system. Curr Pharm Des. 2005;11:1255-65.
22. Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 1999;283:534-7.
23. Chopp M, Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol. 2002;1:92-100.