Transplantation of autologous activated schwann cells in the treatment of spinal cord injury: Six cases, more than five years of follow-up

Cell Transplantation

Volumn 21, Issue SUPPL. 1, 2012, Pages

  Zhou, Xian Hu ^a   Ning, Guang Zhi ^a   Feng, Shi Qing ^a   Kong, Xiao Hong ^b   Chen, Jia Tong ^b   Zheng, Yong Fa ^a   Ban, De Xiang ^a   Liu, Tao ^a   Li, Hui ^a   Wang, Pei ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

Autologous activated schwann cells (AASCs); Cell transplantation; Humans; Spinal cord injury (SCI)

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTOTRANSPLANTATION; CELL TRANSPLANTATION; CHILD; CLINICAL ARTICLE; CLINICAL EXAMINATION; EVOKED MUSCLE RESPONSE; EVOKED SOMATOSENSORY RESPONSE; FEMALE; FOLLOW UP; FUNCTIONAL INDEPENDENCE MEASURE; HUMAN; IN VITRO STUDY; LAMINECTOMY; MALE; NERVE LIGATION; PRIORITY JOURNAL; SCHOOL CHILD; SCHWANN CELL; SPINAL CORD INJURY; SURAL NERVE; URODYNAMICS;

EID: 84930483498     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368912X633752     Document Type: Article

References (32)

1. Bachelin, C.; Lachapelle, F.; Girard, C.; Moissonnier, P.; Serguera-Lagache, C.; Mallet, J.; Fontaine, D.; Chojnowski, A.; Le Guern, E.; Nait-Oumesmar, B.; Baron-Van Evercooren, A. Efficient myelin repair in the macaque spinal cord by autologous grafts of Schwann cells. Brain 128(Pt. 3):540-549; 2005.
2. Ban, D. X.; Kong, X. H.; Feng, S. Q.; Ning, G. Z.; Chen, J. T.; Guo, S. F. Intraspinal cord graft of autologous acti-vated Schwann cells efficiently promotes axonal regeneration and functional recovery after rat's spinal cord injury. Brain Res. 1256:149-161; 2009.
3. Brock, J. H.; Rosenzweig, E. S.; Blesch, A.; Moseanko, R.; Havton, L. A.; Edgerton, V. R.; Tuszynski, M. H. Local and remote growth factor effects after primate spinal cord injury. J. Neurosci. 30(29):9728-9737; 2010.
4. Bunge, R. P. The role of the Schwann cell in trophic support and regeneration. J. Neurol. 242(1 Suppl. 1):S19-21; 1994.
5. Chen, Y. Y.; McDonald, D.; Cheng, C.; Magnowski, B.; Durand, J.; Zochodne, D. W. Axon and Schwann cell partnership during nerve regrowth. J. Neuropathol. Exp. Neurol. 64(7):613-622; 2005.
6. Curt, A.; Dietz, V. Ambulatory capacity in spinal cord injury: Significance of somatosensory evoked potentials and ASIA protocol in predicting outcome. Arch. Phys. Med. Rehabil. 78:39-43; 1997.
7. Curt, A.; Keck, M. E.; Dietz, V. Functional outcome following spinal cord injury: Significance of motor-evoked potentials and ASIA scores. Arch. Phys. Med. Rehabil. 79:81-86; 1998.
8. Eftekharpour, E.; Karimi-Abdolrezaee, S.; Fehlings, M. G. Current status of experimental cell replacement approaches to spinal cord injury. Neurosurg. Focus 24(3-4):E19; 2008.
9. Feng, S. Q.; Kong, X. H.; Guo, S. F.; Wang, P.; Li, L.; Zhong, J. H.; Zhou, X. F. Treatment of spinal cord injury with co-grafts of genetically modified Schwann cells and fetal spinal cord cell suspension in the rat. Neurotox. Res. 7(1-2):169-177; 2005.
10. Feng, S. Q.; Zhou, X. F.; Rush, R. A.; Ferguson, I. A. Graft of pre-injured sural nerve promotes regeneration of corticospinal tract and functional recovery in rats with chronic spinal cord injury. Brain Res. 1209:40-48; 2008.
11. Filbin, M. T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat. Rev. Neurosci. 4(9):703-713; 2003.
12. Funakoshi, H.; Frisen, J.; Barbany, G.; Timmusk, T.; Zachrisson, O.; Verge, V. M.; Persson, H. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123(2):455-465; 1993.
13. Hammarberg, H.; Risling, M.; Hkfelt, T.; Cullheim, S.; Piehl, F. Expression of insulin-like growth factors and corresponding binding proteins (IGFBP 1-6) in rat spinal cord and peripheral nerve after axonal injuries. J. Comp. Neurol. 400(1):57-72; 1998.
14. Hoke, A.; Redett, R.; Hameed, H.; Jari, R.; Zhou, C.; Li, Z. B.; Griffin, J. W.; Brushart, T. M. Schwann cells express motor and sensory phenotypes that regulate axon regeneration. J. Neurosci. 26(38):9646-9655; 2006.
15. Ide, C. Peripheral nerve regeneration. Neurosci. Res. 25(2):101-121; 1996.
16. Jessen, K. R.; Mirsky, R. Why do Schwann cells survive in the absence of axons? Ann. NY Acad. Sci. 883:109-115; 1999.
17. Jessen, K. R.; Mirsky, R. The origin and development of glial cells in peripheral nerves. Nat. Rev. Neurosci. 6(9): 671-682; 2005.
18. Li, R. Culture methods for selective growth of normal rat and human Schwann cells. Methods Cell Biol. 57:167-186; 1998.
19. Li, X.; Gonias, S. L.; Campana, W. M. Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury. Glia 51(4):254-265; 2005.
20. Lima, C.; Escada, P.; Pratas-Vital, J.; Branco, C.; Arcangeli, C. A.; Lazzeri, G.; Maia, C. A.; Capucho, C.; Hasse-Ferreira, A.; Peduzzi, J. D. Olfactory mucosal auto-grafts and rehabilitation for chronic traumatic spinal cord injury. Neurorehabil. Neural Repair 24(1):10-22; 2010.
21. Maynard, Jr., F. M.; Bracken, M. B.; Creasey, G.; Gitunno, Jr., J. F.; Donovan, W. H.; Ducker, T. B.; Garber, S. L.; Marino, R. J.; Stover, S. L.; Tator, C. H.; Waters, R. L.; Wilberger, J. E.; Young, W. International Standards for Neurological and functional classification of spinal cord injury. American Spinal Injury Association. Spinal Cord 35:266-274; 1997.
22. Meyer, M.; Matsuoka, I.; Wetmore, C.; Olson, L.; Thoenen, H. Enhanced synthesis of brain-derived neuro-trophic factor in the lesioned peripheral nerve: Different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol. 119(1):45-54; 1992.
23. Park, D. H.; Lee, J. H.; Borlongan, C. V.; Sanberg, P. R.; Chung, Y. G.; Cho, T. H. Transplantation of umbilical cord blood stem cells for treating spinal cord injury. Stem Cell Rev. 7(1):181-194; 2011.
24. Ribeiro-Resende, V. T.; Koenig, B.; Nichterwitz, S.; Oberhoffner, S.; Schlosshauer, B. Strategies for inducing the formation of bands of Bungner in peripheral nerve regeneration. Biomaterials 30(29):5251-5259; 2009.
25. Rosenbluth, J.; Schiff, R.; Liang, W. L.; Dou, W. Anti-body-mediated CNS demyelination II. Focal spinal cord lesions induced by implantation of an IgM antisulfatide-secreting hybridoma. J. Neurocytol. 32(3):265-276; 2003.
26. Saberi, H.; Moshayedi, P.; Aghayan, H. R.; Arjmand, B.; Hosseini, S. K.; Emami-Razavi, S. H.; Rahimi-Movaghar, V.; Raza, M.; Firouzi, M. Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: An interim report on safety considerations and possible outcomes. Neurosci. Lett. 443(1):46-50; 2008.
27. Schwab, J. M.; Brechtel, K.; Mueller, C. A.; Failli, V.; Kaps, H. P.; Tuli, S. K.; Schluesener, H. J. Experimental strategies to promote spinal cord regeneration-an inte-grative perspective. Prog. Neurobiol. 78(2):91-116; 2006.
28. Taylor, J. S.; Bampton, E. T. Factors secreted by Schwann cells stimulate the regeneration of neonatal retinal gan-glion cells. J. Anat. 204(1):25-31; 2004.
29. Terenghi, G. Peripheral nerve regeneration and neuro-trophic factors. J. Anat. 194(Pt. 1):1-14; 1999.
30. Tetzlaff, W.; Okon, E. B.; Karimi-Abdolrezaee, S.; Hill, C. E.; Sparling, J. S.; Plemel, J. R.; Plunet, W. T.; Tsai, E. C.; Baptiste, D.; Smithson, L. J.; Kawaja, M. D.; Fehlings, M. G.; Kwon, B. K. A systematic review of cellular transplantation therapies for spinal cord injury. J. Neurotrauma 28(8):1611-1682; 2011.
31. Tsunoda, I.; Tanaka, T.; Saijoh, Y.; Fujinami, R. S. Tar-geting inflammatory demyelinating lesions to sites of Wallerian degeneration. Am. J. Pathol. 171(5):1563-1575; 2007.
32. Wang, G.; Ao, Q.; Gong, K.; Gong, Y.; Zhang, X. Syner-gistic effect of neural stem cells and olfactory ensheathing cells on repair of adult rat spinal cord injury. Cell Trans-plant. 19(10):1325-1337; 2010.