Dosimetric anchoring of In vivo and In vitro studies for perfluorooctanoate and perfluorooctanesulfonate

Toxicological Sciences

Volumn 136, Issue 2, 2013, Pages 308-327

  Wambaugh, John F ^a   Setzer, R Woodrow ^a   Pitruzzello, Ann M ^b   Liu, Jie ^a   Reif, David M ^a   Kleinstreuer, Nicole C ^a   Wang, Nina Ching Y ^a   Sipes, Nisha ^a   Martin, Matthew ^a   Das, Kaberi ^c   DeWitt, Jamie C ^d   Strynar, Mark ^a   Judson, Richard ^a   Houck, Keith A ^a   Lau, Christopher ^c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b RTI INTERNATIONAL   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Bayesian analysis; Compartment model; In vitro in vivo extrapolation; Perfluorooctanesulfonate; Perfluorooctanesulfonic acid; Perfluorooctanoate; Perfluorooctanoic acid; Pharmacokinetics; Saturable resorption model; Statistical analysis; ToxCast

Indexed keywords

PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID;

AC50; AREA UNDER THE CURVE; ARTICLE; AVERAGE SERUM CONCENTRATION; BAYES THEOREM; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; COMPARATIVE TOXICOLOGY; CONCENTRATION RESPONSE; DEVELOPMENTAL TOXICITY; DOSE LIVER FUNCTION RELATION; DOSE TIME EFFECT RELATION; DOSIMETRY; EMAX; EXPERIMENTAL MONKEY; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; IMMUNOCYTOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MACACA FASCICULARIS; MAXIMUM PLASMA CONCENTRATION; MEAN SERUM CONCENTRATION; META ANALYSIS; NONHUMAN; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PLASMA HALF LIFE; REPRODUCTIVE TOXICITY; SEX DIFFERENCE; SPECIES COMPARISON; SPECIES DIFFERENCE; STRAIN DIFFERENCE; SYSTEMATIC REVIEW; THYROID GLAND TOXICITY; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS; VETERINARY TOXICOLOGY;

BAYESIAN ANALYSIS; COMPARTMENT MODEL; IN VITRO-IN VIVO EXTRAPOLATION.; PERFLUOROOCTANESULFONATE; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOATE; PERFLUOROOCTANOIC ACID; PHARMACOKINETICS; SATURABLE RESORPTION MODEL; STATISTICAL ANALYSIS; TOXCAST;

ALKANESULFONIC ACIDS; ANIMALS; CAPRYLATES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOROCARBONS; MACACA FASCICULARIS; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84890409624     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft204     Document Type: Article

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