Control of autophagy with small molecules

Archives of Pharmacal Research

Volumn 33, Issue 12, 2010, Pages 1881-1889

  Cho, Yoon Sun ^a   Kwon, Ho Jeong ^a  

^a Yonsei University   (South Korea)

Author keywords

Autophagy; Chemical genomics; Small molecules

Indexed keywords

BAFILOMYCIN A1; CURCUMIN; IMIQUIMOD; RAPAMYCIN; SAPONIN DERIVATIVE; TACROLIMUS; TEMOZOLOMIDE; TIMOSAPONIN A III; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AUTOPHAGY; DRUG ACTIVITY; DRUG DESIGN; DRUG ISOLATION; DRUG MECHANISM; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENOMICS; HUMAN; HUNTINGTON CHOREA; NONHUMAN; PARKINSON DISEASE; REVIEW;

ALZHEIMER DISEASE; AUTOPHAGY; CELL DEATH; HUMANS; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; PROTEINS; PYRIMIDINONES; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 78751545090     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-1201-6     Document Type: Review

References (44)

1. H. Aoki Y. Takada S. Kondo R. Sawaya B. B. Aggarwal Y. Kondo 2007 Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways Mol. Pharmacol. 72 29 39 1:CAS:528:DC%2BD2sXnsVyjs7Y%3D 10.1124/mol.106.033167 17395690
2. G. Bellot R. Garcia-Medina P. Gounon J. Chiche D. Roux J. Pouyssegur N. M. Mazure 2009 Hypoxia-induced autophagy is mediated through Hypoxia-Inducible Factor induction of BNIP3 and BNIP3L via their BH3 domains Mol. Cell. Biol. 29 2570 2581 1:CAS:528:DC%2BD1MXlvFSqu70%3D 10.1128/MCB.00166-09 19273585
3. E. F. C. Blommaart U. Krause J. P. M. Schellens H. Vreeling-Sindelarova A. J. Meijer 1997 The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes Eur. J. Biochem. 243 240 246 1:CAS:528:DyaK2sXhtVWitL4%3D 10.1111/j.1432-1033.1997.0240a.x 9030745
4. L. Cerioni L. Palomba O. Cantoni 2003 The Raf/MEK inhibitor PD98059 enhances ERK1/2 phosphorylation mediated by peroxynitrite via enforced mitochondrial formation of reactive oxygen species FEBS Lett. 547 92 96 1:CAS:528:DC%2BD3sXlsVaiurk%3D 10.1016/S0014-5793(03)00675-6 12860392
5. Y. Chen E. McMillan-Ward J. Kong S. J. Israels S. B. Gibson 2008 Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells Cell Death Differ. 15 171 182 1:CAS:528: DC%2BD2sXhsVegurrM 10.1038/sj.cdd.4402233 17917680
6. I. -K. Choi Y. S. Cho H. J. Jung H. J. Kwon 2010 Autophagonizer, a novel synthetic small molecule, induces autophagic cell death Biochem. Biophys. Res. Commun. 393 849 854 1:CAS:528:DC%2BC3cXjs1Onurw%3D 10.1016/j.bbrc.2010.02.097 20171180
7. T. Hara K. Nakamura M. Masui A. Yamamoto Y. Nakahara R. Suzuki-Migishima M. Yokoyama K. Mishima I. Saito H. Okano N. Mizushima 2006 Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Nature 441 885 889 1:CAS:528:DC%2BD28XlvVGlsbc%3D 10.1038/nature04724 16625204
8. T. Hara N. Mizushima 2009 Role of ULK-FIP200 complex in mammalian autophagy. FIP200, a counterpart of yeast Atg17? Autophagy 5 85 87 1:CAS:528:DC%2BD1MXnvFCksLw%3D 10.4161/auto.5.1.7180 18981720
9. G. Jia G. Cheng D. K. Agrawal 2007 Autophagy of vascular smooth muscle cells in atherosclerotic lesions Autophagy 3 63 64 1:CAS:528:DC%2BD2sXhtVeqsLfO 17172800
10. M. Katayama T. Kawaguchi M. S. Berger R. O. Pieper 2007 DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells Cell Death Differ. 14 548 558 1:CAS:528: DC%2BD2sXhslWhtr8%3D 10.1038/sj.cdd.4402030 16946731
11. T. Kino H. Hatanaka S. Miyata N. Inamura M. Nishiyama T. Yajima T. Goto M. Okuhara M. Kohsaka H. Aoki H. Imanaka 1987 FK-506, a novel immunosuppressant isolated from a Streptomyces J. Antibiot. 40 1256 1265 1:CAS:528: DyaL2sXmtFWmu7g%3D 2445722
12. D. J. Klionsky J. M. Cregg W. A. Dunn Jr. S. D. Emr Y. Sakai I. V. Sandoval A. Sibirny S. Subramani M. Thumm M. Veenhuis Y. Ohsumi 2003 A unified nomenclature for yeast autophagy-related genes Dev. Cell 5 539 545 1:CAS:528:DC%2BD3sXotlSqu7o%3D 10.1016/S1534-5807(03)00296-X 14536056
13. Y. Kondo T. Kanzawa R. Sawaya S. Kondo 2005 The role of autophagy in cancer development and response to therapy Nat. Rev. Cancer 5 726 734 1:CAS:528:DC%2BD2MXpsleksL4%3D 10.1038/nrc1692 16148885
14. H. J. Kwon 2006 Discovery of new small molecules and targets towards angiogenesis via chemical genomics approach Curr. Drug Targets 7 397 405 1:CAS:528:DC%2BD28Xjt1Sitb4%3D 10.2174/138945006776359377 16611028
15. B. Levine D. J. Klionsky 2004 Development by self-digestion: molecular mechanisms and biological functions of autophagy Dev. Cell 6 463 477 1:CAS:528:DC%2BD2cXjsFeqsbs%3D 10.1016/S1534-5807(04)00099-1 15068787
16. R. S. Lokey 2003 Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia Curr. Opin. Chem. Biol. 7 91 96 1:CAS:528:DC%2BD3sXltlejsw%3D%3D 10.1016/S1367-5931(02)00002-9 12547432
17. W. Martinet S. Verheye G. R. Y. De Meyer 2007 Everolimus-induced mTOR inhibition selectively depletes macrophages in atherosclerotic plaques by autophagy Autophagy 3 241 244 1:CAS:528:DC%2BD2sXhtVGrtLjL 17224626
18. W. Martinet G. R. Y. De Meyer 2009 Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential Circ. Res. 104 304 317 1:CAS:528:DC%2BD1MXhsV2jsLk%3D 10.1161/CIRCRESAHA.108.188318 19213965
19. M. Martinez-Vicente Z. Talloczy E. Wong G. Tang H. Koga S. Kaushik R. de Vries E. Arias S. Harris D. Sulzer A. M. Cuervo 2010 Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease Nat. Neurosci. 13 567 576 1:CAS:528:DC%2BC3cXksFarsr4%3D 10.1038/nn.2528 20383138
20. R. Mathew V. Karantza-Wadsworth E. White 2007 Role of autophagy in cancer Nat. Rev. Cancer 7 961 967 1:CAS:528:DC%2BD2sXhtlCrsLbJ 10.1038/nrc2254 17972889
21. N. Matsuda K. Tanaka 2010 Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's Disease? J. Alzheimers Dis. 19 1 9 1:CAS:528:DC%2BC3cXitlKqtA%3D%3D 20061621
22. N. Matsuda S. Sato K. Shiba K. Okatsu K. Saisho C. A. Gautier Y. S. Sou S. Saiki S. Kawajiri F. Sato M. Kimura M. Komatsu N. Hattori K. Tanaka 2010 PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy J. Cell Biol. 189 211 221 1:CAS:528:DC%2BC3cXlt1Khu7c%3D 10.1083/jcb.200910140 20404107
23. A. Meléndez Z. Tallóczy M. Seaman E. L. Eskelinen D. H. Hall B. Levine 2003 Autophagy genes are essential for dauer development and life-span extension in C. elegans Science 301 1387 1391 10.1126/science.1087782 12958363
24. N. Mizushima T. Yoshimori B. Levine 2010 Methods in mammalian autophagy research Cell 140 313 326 1:CAS:528:DC%2BC3cXlt1KlsLc%3D 10.1016/j.cell.2010.01. 028 20144757
25. T. Noda Y. Ohsumi 1998 Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast J. Biol. Chem. 273 3963 3966 1:CAS:528: DyaK1cXht1ahsr8%3D 10.1074/jbc.273.7.3963 9461583
26. M. Oh I. -K. Choi H. J. Kwon 2008 Inhibition of histone deacetylase1 induces autophagy Biochem. Biophys. Res. Commun. 369 1179 1183 1:CAS:528:DC%2BD1cXksVeis7g%3D 10.1016/j.bbrc.2008.03.019 18342621
27. F. Reggiori D. J. Klionsky 2002 Autophagy in the eukaryotic cell Eukaryot. Cell 1 11 21 1:CAS:528:DC%2BD38XitVSls74%3D 10.1128/EC.01.1.11-21.2002 12455967
28. A. Saito T. Yanashita Y. Mariki Y. Nosaka K. Tsuchiya T. Ando 1999 A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors Proc. Natl. Acad. Sci. U.S.A. 96 4592 4597 1:CAS:528:DyaK1MXjs1ylsbk%3D 10.1073/pnas.96.8.4592 10200307
29. R. C. Scott O. Schuldiner T. P. Neufeld 2004 Role and regulation of starvation-induced autophagy in the Drosophila fat body Dev. Cell 7 167 178 1:CAS:528:DC%2BD2cXnsVKntr0%3D 10.1016/j.devcel.2004.07.009 15296714
30. P. O. Seglen P. B. Gordon 1982 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes Proc. Natl. Acad. Sci. U.S.A. 79 1889 1892 1:CAS:528:DyaL38Xhslykurc%3D 10.1073/pnas.79.6.1889 6952238
31. J. S. Shim J. H. Kim H. Y. Cho Y. N. Yum S. H. Kim H. J. Park B. S. Shim S. H. Choi H. J. Kwon 2003 Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin Chem. Biol. 10 695 704 1:CAS:528: DC%2BD3sXmvFSisbw%3D 10.1016/S1074-5521(03)00169-8 12954328
32. 2+/Calmodulin function Chem. Biol. 11 1455 1463 1:CAS:528:DC%2BD2cXos1Chs7Y%3D 10.1016/j.chembiol.2004.08.015 15489172
33. B. R. Stockwell S. J. Haggarty S. L. Schreiber 1999 High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications Chem. Biol. 6 71 83 1:CAS:528:DyaK1MXhs1yru7o%3D 10.1016/S1074-5521(99)80004-0 10021420
34. K. Suzuki Y. Ohsumi 2007 Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae FEBS Lett. 581 2156 2161 1:CAS:528: DC%2BD2sXlt1Chs7k%3D 10.1016/j.febslet.2007.01.096 17382324
35. L. -K. Sy S. -C. Yan C. -N. Lok R. Y. K. Man C. -M. Che 2008 Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells Cancer Res. 68 10229 10237 1:CAS:528:DC%2BD1cXhsV2itL7J 10.1158/0008-5472.CAN-08-1983 19074891
36. M. Tsukada Y. Ohsumi 1993 Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae FEBS Lett. 333 169 174 1:CAS:528:DyaK3sXms1Kht7w%3D 10.1016/0014-5793(93)80398-E 8224160
37. T. Vellai K. Takacs-Vellai M. Sass D. J. Klionsky 2009 The regulation of aging: does autophagy underlie longevity? Trends Cell Biol. 19 487 494 1:CAS:528:DC%2BD1MXhtFygsrrP 10.1016/j.tcb.2009.07.007 19726187
38. I. Vergne V. Deretic 2010 The role of PI3P phosphatases in the regulation of autophagy FEBS Lett. 584 1313 1318 1:CAS:528:DC%2BC3cXjs12nu70%3D 10.1016/j.febslet.2010.02.054 20188094
39. S. Verheye W. Martinet M. M. Kockx M. W. M. Knaapen K. Salu J. -P. Timmermans J. T. Ellis D. L. Kilpatrick G. R. Y. De Meyer 2007 Selective clearance of macrophages in atherosclerotic plaques by autophagy J. Am. Coll. Cardiol. 49 706 715 1:CAS:528:DC%2BD2sXhs1Slt7Y%3D 10.1016/j.jacc.2006.09.047 17291937
40. A. L. Wang T. J. Lukas M. Yuan N. Du M. O. Tso A. H. Neufeld 2009 Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration PLoS ONE 4 e4160 10.1371/journal.pone.0004160 19129916
41. A. Williams S. Sarkar P. Cuddon E. K. Ttofi S. Saiki F. H. Siddiqui L. Jahreiss A. Fleming D. Pask P. Goldsmith C. J. O'Kane R. A. Floto D. C. Rubinsztein 2008 Novel targets for Huntington's disease in an mTOR-independent autophagy pathway Nat. Chem. Biol. 4 295 305 1:CAS:528:DC%2BD1cXkvVSmt7c%3D 10.1038/nchembio.79 18391949
42. M. P. Wymann G. Bulgarelli-Leva M. J. Zvelebil L. Pirola B. Vanhaesebroeck M. D. Waterfield G. Panayotou 1996 Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction Mol. Cell. Biol. 16 1722 1733 1:CAS:528:DyaK28XhvVags7s%3D 8657148
43. J. Y. Yi Y.-J. Jung S. S. Choi J. Hwang E. Chung 2009 Autophagy-mediated anti-tumoral activity of imiquimod in Caco-2 cells Biochem. Biophys. Res. Commun. 386 455 458 1:CAS:528:DC%2BD1MXosVyitL8%3D 10.1016/j.bbrc.2009.06.046 19527683
44. +-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells J. Biol. Chem. 266 17707 17712 1:CAS:528:DyaK3MXltFWhs78%3D 1832676