Gas chromatography-mass spectrometry-based profiling of serum fatty acids in acetaminophen-induced liver injured rats

Journal of Applied Toxicology

Volumn 34, Issue 2, 2014, Pages 149-157

  Xiong, Yin Hua ^a,b,c   Xu, Ying ^b   Yang, Li ^b   Wang, Zheng Tao ^a,b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c JIANGXI SCIENCE AND TECHNOLOGY NORMAL UNIVERSITY   (China)

Author keywords

Acetaminophen; Fatty acids; GC MS; Liver injury; Metabolic profile

Indexed keywords

ALANINE AMINOTRANSFERASE; ARACHIDONIC ACID; ASPARTATE AMINOTRANSFERASE; DOCOSAHEXAENOIC ACID; ESTERIFIED FATTY ACID; FATTY ACID; LINOLEIC ACID; OLEIC ACID; PARACETAMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOMETRIC ANALYSIS; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; HISTOPATHOLOGY; LIMIT OF DETECTION; LIVER INJURY; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; METHODOLOGY; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ACETAMINOPHEN; FATTY ACIDS; GC-MS; LIVER INJURY; METABOLIC PROFILE;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; DISCRIMINANT ANALYSIS; DRUG-INDUCED LIVER INJURY; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LINEAR MODELS; LIVER; MALE; METABOLOME; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84890340320     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2844     Document Type: Article

References (25)

1. Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ. 2009. Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARα activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem. Res. Toxicol. 22: 699-707.
2. Das UN. 2006. Biological significance of essential fatty acids. J. Assoc. Physicians India 54: 309-331.
3. Devi KP, Sreepriya M, Balakrishna K, Veluchamy G, Devaki T. 2004. Assessment of the protective potential of Premna tomentosa (L. Verbenaceae) extract on lipid profile and lipid-metabolizing enzymes in acetaminophen-intoxicated rats. J. Altern. Complement. Med. 10: 540-546.
4. EI-Badry AM, Graf R, Clavien PA. 2007. Omega 3 - Omega 6: What is right for the liver? J. Hepatol. 47: 718-725.
5. Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L. 2009. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury. Lab. Invest. 89: 222-230.
6. Hauff S, Vetter W. 2010. Exploring the fatty acids of vernix caseosa in form of their methyl esters by off-line coupling of non-aqueous reversed phase high performance liquid chromatography and gas chromatography coupled to mass spectrometry. J. Chromatog., A. 1217: 8270-8278.
7. Hinson JA, Bucci TJ, Irwin LK, Michael SL, Mayeux PR. 2002. Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric Oxide 6: 160-167.
8. James LP, Mayeux RP, Hinson JA. 2003. Acetaminophen-induced hepatotoxicity. Drug Metab. Dispos. 31: 1499-1506.
9. Jiang J, Nilsson-Ehle P, Xu N. 2006. Influence of liver cancer on lipid and lipoprotein metabolism. Lipids Health Dis. 5: 4.
10. Jump DB. 2004. Fatty acid regulation of gene transcription. Crit. Rev. Clin. Lab. Sci. 41: 41-78.
11. Kim HK, Choi S, Choi H. 2004. Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. J. Nutr. Biochem. 15: 485-492.
12. Kondo Y, Nishiumi S, Shinohara M, Hatano N, Ikeda A, Yoshie T, Kobayashi T, Shiomi Y, Irino Y, Takenawa T, Azuma T, Yoshida M. 2011. Serum fatty acid profiling of colorectal cancer by gas chromatography/mass spectrometry. Biomark. Med. 5: 451-460.
13. Meng Z, Wen D, Sun D, Gao F, Li W, Liao Y, Liu H. 2007. Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography. J. Sep. Sci. 30: 1537-1543.
14. Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K. 2011. Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. J. Hepatol. 54: 432-438.
15. Mjøs SA. 2004. The prediction of fatty acid structure from selected ions in electron impact mass spectra of fatty acid methyl ester. Eur. J. Lipid Sci. Technol. 106: 550-560.
16. Oster RT, Tishinsky JM, Yuan Z, Robinson LE. 2010. Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARγ mRNA, in 3T3-L1 adipocyte. Appl. Physiol. Nutr. Metab. 35: 783-789.
17. Sánchez-Avila N, Mata-Granados JM, Ruiz-Jiménez J, Luque de Castro MD. 2009. Fast, sensitive and highly discriminant gas chromatography-mass spectrometry method for profiling analysis of fatty acids in serum. J. Chromatogr. A 1216: 6864-6872.
18. Schmöcker C, Weylandt KH, Kahlke L, Wang J, Lobeck H, Tiegs G, Berg T, Kang JX. 2007. Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. Hepatology 45: 864-869.
19. Sun J, Schnackenberg LK, Holland RD, Schmitt TC, Cantor GH, Dragan YP, Beger RD. 2008. Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 871: 328-340.
20. Tan BB, Liang YZ, Yi LZ, Li HD, Zhou ZG, Ji XY, Deng JH. 2009. Identification of free fatty acids profiling of type 2 diabetes mellitus and exploring possible biomarkers by GC-MS coupled with chemometrics. Metabolomics. 6(2): 219-228.
21. Tuazon MA, Henderson GC. 2012. Fatty acid profile of skeletal muscle phospholipid is altered in mdx mice and is predictive of disease markers. Metabolism 61 (6): 801-811.
22. Tujios S, Fontana RJ. 2011. Mechanisms of drug-induced liver injury: from bedside to bench. Nat. Rev. Gastroenterol. Hepatol. 8: 202-211.
23. Wu HQ, Huang XL, Lin XS, Huang F, Zhu ZX, Ma YF. 2007. Gas chromatographic retention time rule and mass spectrometric fragmentation rule of fatty acids and its application in food. Chin. J. Anal. Chem. 35: 998-1003.
24. Xu Y, Yang L, Yang F, Xiong YH, Wang ZT. 2012. Metabolic profiling of fifteen amino acids in serum of chemical-induced liver injured rats by hydrophilic interaction liquid chromatograph coupled with tandem mass spectrometry. Metabolomics 8: 475-483.
25. Yi L, He J, Liang Y, Yuan D, Gao H, Zhou H. 2007. Simultaneously quantitative measurement of comprehensive profiles of esterified and non-esterified fatty acid in plasma of type 2 diabetic patients. Chem. Phys. Lipids 150: 204-216.