메뉴 건너뛰기




Volumn 73, Issue 23, 2013, Pages 7122-7133

BCCIP suppresses tumor initiation but is required for tumor progression

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN;

EID: 84890282285     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-1766     Document Type: Article
Times cited : (27)

References (50)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 79951482450 scopus 로고    scopus 로고
    • Genomic instability and cancer: An introduction
    • Shen Z. Genomic instability and cancer: an introduction. J Mol Cell Biol. 2011;3:1-3.
    • (2011) J Mol Cell Biol , vol.3 , pp. 1-3
    • Shen, Z.1
  • 3
    • 0030932869 scopus 로고    scopus 로고
    • Cancer-susceptibility genes. Gatekeepers and caretakers
    • Kinzler KW, Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997;386:761, 763.
    • (1997) Nature , vol.386
    • Kinzler, K.W.1    Vogelstein, B.2
  • 4
    • 0035905743 scopus 로고    scopus 로고
    • Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2
    • Liu J, Yuan Y, Huan J, Shen Z. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Oncogene 2001;20:336-45.
    • (2001) Oncogene , vol.20 , pp. 336-345
    • Liu, J.1    Yuan, Y.2    Huan, J.3    Shen, Z.4
  • 5
    • 14044251525 scopus 로고    scopus 로고
    • The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair
    • Lu H, et al. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol Cell Biol 2005;25:1949-57.
    • (2005) Mol Cell Biol , vol.25 , pp. 1949-1957
    • Lu, H.1
  • 6
    • 37549005555 scopus 로고    scopus 로고
    • BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage
    • Lu H, Yue J, Meng X, Nickoloff JA, Shen Z. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Nucleic Acids Res 2007;35:7160-70.
    • (2007) Nucleic Acids Res , vol.35 , pp. 7160-7170
    • Lu, H.1    Yue, J.2    Meng, X.3    Nickoloff, J.A.4    Shen, Z.5
  • 7
    • 80053439726 scopus 로고    scopus 로고
    • Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes
    • Lu H, et al. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet 2011;7:e1002291.
    • (2011) PLoS Genet , vol.7
    • Lu, H.1
  • 8
    • 34648823097 scopus 로고    scopus 로고
    • Roles of BCCIP in chromosome stability and cytokinesis
    • Meng X, Fan J, Shen Z. Roles of BCCIP in chromosome stability and cytokinesis. Oncogene 2007;26:6253-60.
    • (2007) Oncogene , vol.26 , pp. 6253-6260
    • Meng, X.1    Fan, J.2    Shen, Z.3
  • 9
    • 0037413675 scopus 로고    scopus 로고
    • Genomic structure of the human BCCIP gene and its expression in cancer
    • Meng X, Liu J, Shen Z. Genomic structure of the human BCCIP gene and its expression in cancer. Gene 2003;302:139-46.
    • (2003) Gene , vol.302 , pp. 139-146
    • Meng, X.1    Liu, J.2    Shen, Z.3
  • 10
    • 14044266503 scopus 로고    scopus 로고
    • Inhibition of G1 to S cell cycle progression by BCCIP beta
    • Meng X, Liu J, Shen Z. Inhibition of G1 to S cell cycle progression by BCCIP beta. Cell Cycle 2004;3:343-8.
    • (2004) Cell Cycle , vol.3 , pp. 343-348
    • Meng, X.1    Liu, J.2    Shen, Z.3
  • 11
    • 14044258059 scopus 로고    scopus 로고
    • BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1
    • Meng X, Lu H, Shen Z. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Cell Cycle 2004;3:1457-62.
    • (2004) Cell Cycle , vol.3 , pp. 1457-1462
    • Meng, X.1    Lu, H.2    Shen, Z.3
  • 12
    • 33847261611 scopus 로고    scopus 로고
    • Abrogation of the transactivation activity of p53 by BCCIP down-regulation
    • Meng X, Yue J, Liu Z, Shen Z. Abrogation of the transactivation activity of p53 by BCCIP down-regulation. J Biol Chem 2007;282:1570-6.
    • (2007) J Biol Chem , vol.282 , pp. 1570-1576
    • Meng, X.1    Yue, J.2    Liu, Z.3    Shen, Z.4
  • 13
    • 70349278429 scopus 로고    scopus 로고
    • BCCIP is required for the nuclear localization of the p21 protein
    • Fan J, Wray J, Meng X, Shen Z. BCCIP is required for the nuclear localization of the p21 protein. Cell Cycle 2009;8:3019-24.
    • (2009) Cell Cycle , vol.8 , pp. 3019-3024
    • Fan, J.1    Wray, J.2    Meng, X.3    Shen, Z.4
  • 14
    • 84856177783 scopus 로고    scopus 로고
    • Requirement of mouse BCCIP for neural development and progenitor proliferation
    • Huang YY, Lu H, Liu S, Droz-Rosario R, Shen Z. Requirement of mouse BCCIP for neural development and progenitor proliferation. PLoS ONE 2012;7:e30638.
    • (2012) PLoS ONE , vol.7
    • Huang, Y.Y.1    Lu, H.2    Liu, S.3    Droz-Rosario, R.4    Shen, Z.5
  • 15
    • 35348966282 scopus 로고    scopus 로고
    • Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis
    • Mao N, Zhou Q, Kojic M, Perez-Martin J, Holloman WK. Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis. DNA Repair (Amst) 2007;6:1651-60.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 1651-1660
    • Mao, N.1    Zhou, Q.2    Kojic, M.3    Perez-Martin, J.4    Holloman, W.K.5
  • 16
    • 70049086787 scopus 로고    scopus 로고
    • Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas
    • Liu J, Lu H, Ohgaki H, Merlo A, Shen Z. Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas. BMC Cancer 2009;9:268.
    • (2009) BMC Cancer , vol.9 , pp. 268
    • Liu, J.1    Lu, H.2    Ohgaki, H.3    Merlo, A.4    Shen, Z.5
  • 17
    • 33644835805 scopus 로고    scopus 로고
    • Identifi cation of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines
    • Roversi G, et al. Identifi cation of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines. Oncogene 2006;25:1571-83.
    • (2006) Oncogene , vol.25 , pp. 1571-1583
    • Roversi, G.1
  • 18
    • 59649109382 scopus 로고    scopus 로고
    • BCCIP as a prognostic marker for radiotherapy of laryngeal cancer
    • Rewari A, et al. BCCIP as a prognostic marker for radiotherapy of laryngeal cancer. Radiother Oncol 2009;90:183-8.
    • (2009) Radiother Oncol , vol.90 , pp. 183-188
    • Rewari, A.1
  • 19
    • 33746879125 scopus 로고    scopus 로고
    • Patched2 modulates tumorigenesis in patched1 heterozygous mice
    • Lee Y, et al. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res 2006;66:6964-71.
    • (2006) Cancer Res , vol.66 , pp. 6964-6971
    • Lee, Y.1
  • 20
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 2000;14:994-1004.
    • (2000) Genes Dev , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    Van Der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 21
    • 0035170704 scopus 로고    scopus 로고
    • hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo
    • Zhuo L, et al. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 2001;31:85-94.
    • (2001) Genesis , vol.31 , pp. 85-94
    • Zhuo, L.1
  • 22
    • 60549090233 scopus 로고    scopus 로고
    • Recurrent genomic alterations characterize medullo-blastoma arising from DNA double-strand break repair deficiency
    • Frappart PO, et al. Recurrent genomic alterations characterize medullo-blastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci USA 2009;106:1880-5.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1880-1885
    • Frappart, P.O.1
  • 23
    • 0028256226 scopus 로고
    • GFAP promoter directs astrocyte-specific expression in transgenic mice
    • Brenner M, Kisseberth WC, Su Y, Besnard F, Messing A. GFAP promoter directs astrocyte-specific expression in transgenic mice. J Neurosci 1994;14:1030-7.
    • (1994) J Neurosci , vol.14 , pp. 1030-1037
    • Brenner, M.1    Kisseberth, W.C.2    Su, Y.3    Besnard, F.4    Messing, A.5
  • 24
    • 0028064477 scopus 로고
    • Structure and transcriptional regulation of the GFAP gene
    • Brenner M. Structure and transcriptional regulation of the GFAP gene. Brain Pathol 1994;4:245-57.
    • (1994) Brain Pathol , vol.4 , pp. 245-257
    • Brenner, M.1
  • 25
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of brain tumors
    • Wechsler-Reya R, Scott MP. The developmental biology of brain tumors. Annu Rev Neurosci 2001;24:385-428.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 26
    • 34047263220 scopus 로고    scopus 로고
    • Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors
    • Zindy F, et al. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 2007;67:2676-84.
    • (2007) Cancer Res , vol.67 , pp. 2676-2684
    • Zindy, F.1
  • 27
    • 41749098048 scopus 로고    scopus 로고
    • The origins of medulloblastoma subtypes
    • Gilbertson RJ, Ellison DW. The origins of medulloblastoma subtypes. Annu Rev Pathol 2008;3:341-65.
    • (2008) Annu Rev Pathol , vol.3 , pp. 341-365
    • Gilbertson, R.J.1    Ellison, D.W.2
  • 28
    • 11844301282 scopus 로고    scopus 로고
    • Medulloblastoma: Developmental mechanisms out of control
    • Marino S. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 2005;11:17-22.
    • (2005) Trends Mol Med , vol.11 , pp. 17-22
    • Marino, S.1
  • 29
    • 78650811198 scopus 로고    scopus 로고
    • Subtypes of medulloblastoma have distinct developmental origins
    • Gibson P, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 2010;468:1095-9.
    • (2010) Nature , vol.468 , pp. 1095-1099
    • Gibson, P.1
  • 30
    • 23444437373 scopus 로고    scopus 로고
    • Ruiz i Altaba A Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors
    • Stecca B, Ruiz i Altaba A Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors. J Neurobiol 2005;64:476-90.
    • (2005) J Neurobiol , vol.64 , pp. 476-490
    • Stecca, B.1
  • 32
  • 33
    • 0033990220 scopus 로고    scopus 로고
    • Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma
    • Zurawel RH, et al. Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma. Genes Chromosomes Cancer 2000;27:44-51.
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 44-51
    • Zurawel, R.H.1
  • 34
    • 0037232580 scopus 로고    scopus 로고
    • Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
    • Kenney AM, Cole MD, Rowitch DH. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 2003;130:15-28.
    • (2003) Development , vol.130 , pp. 15-28
    • Kenney, A.M.1    Cole, M.D.2    Rowitch, D.H.3
  • 36
    • 33750492325 scopus 로고    scopus 로고
    • Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation
    • Pogoriler J, Millen K, Utset M, Du W. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development 2006;133:3929-37.
    • (2006) Development , vol.133 , pp. 3929-3937
    • Pogoriler, J.1    Millen, K.2    Utset, M.3    Du, W.4
  • 37
    • 0141816821 scopus 로고    scopus 로고
    • A molecular fingerprint for medulloblastoma
    • Lee Y, et al. A molecular fingerprint for medulloblastoma. Cancer Res 2003;63:5428-37.
    • (2003) Cancer Res , vol.63 , pp. 5428-5437
    • Lee, Y.1
  • 38
    • 77956549578 scopus 로고    scopus 로고
    • Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma
    • Castellino RC, et al. Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. PLoS One 2010;5:e10849.
    • (2010) PLoS One , vol.5
    • Castellino, R.C.1
  • 39
    • 33744827377 scopus 로고    scopus 로고
    • Phosphatidylinositol 3′-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN
    • Hartmann W, et al. Phosphatidylinositol 3′-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res 2006;12:3019-27.
    • (2006) Clin Cancer Res , vol.12 , pp. 3019-3027
    • Hartmann, W.1
  • 41
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • Vazquez F, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 2000;20:5010-8.
    • (2000) Mol Cell Biol , vol.20 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 42
    • 84873123369 scopus 로고    scopus 로고
    • Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: A novel mechanism of PTEN inactivation
    • Yang Z, et al. Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: a novel mechanism of PTEN inactivation. Clin Res Hepatol Gastroenterol 2013;37:72-9.
    • (2013) Clin Res Hepatol Gastroenterol , vol.37 , pp. 72-79
    • Yang, Z.1
  • 43
    • 44949178279 scopus 로고    scopus 로고
    • Mouse models of DNA double-strand break repair and neurological disease
    • Frappart PO, McKinnon PJ. Mouse models of DNA double-strand break repair and neurological disease. DNA Repair (Amst) 2008;7:1051-60.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1051-1060
    • Frappart, P.O.1    McKinnon, P.J.2
  • 44
    • 34250001115 scopus 로고    scopus 로고
    • BRCA2 is required for neurogenesis and suppression of medulloblastoma
    • Frappart PO, Lee Y, Lamont J, McKinnon PJ. BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 2007;26:2732-42.
    • (2007) EMBO J , vol.26 , pp. 2732-2742
    • Frappart, P.O.1    Lee, Y.2    Lamont, J.3    McKinnon, P.J.4
  • 45
    • 18844394291 scopus 로고    scopus 로고
    • An essential function for NBS1 in the prevention of ataxia and cerebellar defects
    • Frappart PO, et al. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med 2005;11:538-44.
    • (2005) Nat Med , vol.11 , pp. 538-544
    • Frappart, P.O.1
  • 46
    • 0032842478 scopus 로고    scopus 로고
    • Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    • Tronche F, et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 1999;23:99-103.
    • (1999) Nat Genet , vol.23 , pp. 99-103
    • Tronche, F.1
  • 47
    • 77951599543 scopus 로고    scopus 로고
    • Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma
    • Huse JT, Holland EC. Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer 2010;10:319-31.
    • (2010) Nat Rev Cancer , vol.10 , pp. 319-331
    • Huse, J.T.1    Holland, E.C.2
  • 48
    • 79955010717 scopus 로고    scopus 로고
    • Hedgehogs, flies, Wnts and MYCs: The time has come for many things in medulloblastoma
    • Monje M, Beachy PA, Fisher PG. Hedgehogs, flies, Wnts and MYCs: the time has come for many things in medulloblastoma. J Clin Oncol 2011;29:1395-8.
    • (2011) J Clin Oncol , vol.29 , pp. 1395-1398
    • Monje, M.1    Beachy, P.A.2    Fisher, P.G.3
  • 49
    • 79955034739 scopus 로고    scopus 로고
    • Medulloblastoma comprises four distinct molecular variants
    • Northcott PA, et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011;29:1408-14.
    • (2011) J Clin Oncol , vol.29 , pp. 1408-1414
    • Northcott, P.A.1
  • 50
    • 79954991010 scopus 로고    scopus 로고
    • Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    • Cho YJ, et al. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol 2011;29:1424-30.
    • (2011) J Clin Oncol , vol.29 , pp. 1424-1430
    • Cho, Y.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.