Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes

PLoS Genetics

Volumn 7, Issue 9, 2011, Pages

  Lu, Huimei ^a   Huang, Yi Yuan ^a   Mehrotra, Sonam ^a   Droz Rosario, Roberto ^a   Liu, Jingmei ^a   Bhaumik, Mantu ^a   White, Eileen ^a,b   Shen, Zhiyuan ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; RAD51 PROTEIN; BCCIP PROTEIN, MOUSE; BRCA2 PROTEIN; BRCA2 PROTEIN, MOUSE; CDKN1A PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

ANAPHASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BCCIP GENE; BLASTOCYST; CELL PROLIFERATION; CHROMATID ABERRATION; CHROMOSOMAL INSTABILITY; CHROMOSOME BREAKAGE; CHROMOSOME IDENTIFICATION; CHROMOSOME REPLICATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; FEMALE; FIBROBLAST; GENE DELETION; GENE FUNCTION; GENE SILENCING; IN VIVO STUDY; INTRAUTERINE GROWTH RETARDATION; IONIZING RADIATION; MOUSE; NEWBORN; NONHUMAN; REGULATOR GENE; RNA INTERFERENCE; SISTER CHROMATID EXCHANGE; TUMOR SUPPRESSOR GENE; ANIMAL; CHROMOSOME SEGREGATION; CYTOLOGY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GENETIC RECOMBINATION; GENETICS; METABOLISM; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; BRCA2 PROTEIN; CELL CYCLE PROTEINS; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; EMBRYONIC DEVELOPMENT; FIBROBLASTS; MICE; MICE, TRANSGENIC; RAD51 RECOMBINASE; RECOMBINATION, GENETIC; SISTER CHROMATID EXCHANGE;

EID: 80053439726     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002291     Document Type: Article

References (48)

1. Shen Z, (2011) Genomic instability and cancer: an introduction. J Mol Cell Biol 3: 1-3.
2. Shen Z, Nickoloff J, (2007) Mammalian Homologous Recombination and Cancer Intervention. In: Wei Q, Li L, Chen DJ, editors. DNA Repair, Genetic Instability, and Cancer Singapore World Scientific Publishing Co. Pte. Ltd pp. 119-156.
3. Allen C, Ashley AK, Hromas R, Nickoloff JA, (2011) More forks on the road to replication stress recovery. J Mol Cell Biol 3: 4-12.
4. Jensen RB, Carreira A, Kowalczykowski SC, (2010) Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 467: 678-683.
5. Liu J, Doty T, Gibson B, Heyer WD, (2010) Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol 17: 1260-1262.
6. Couzin J, (2003) The twists and turns in BRCA's path. Science 302: 591-593.
7. Liu J, Yuan Y, Huan J, Shen Z, (2001) Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Oncogene 20: 336-345.
8. Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, et al. (2000) TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J Biol Chem 275: 31145-31154.
9. Meng X, Liu J, Shen Z, (2003) Genomic structure of the human BCCIP gene and its expression in cancer. Gene 302: 139-146.
10. Lu H, Guo X, Meng X, Liu J, Allen C, et al. (2005) The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol Cell Biol 25: 1949-1957.
11. Fan J, Wray J, Meng X, Shen Z, (2009) BCCIP is required for the nuclear localization of the p21 protein. Cell Cycle 8: 3019-3024.
12. Meng X, Liu J, Shen Z, (2004) Inhibition of G1 to S cell cycle progression by BCCIP beta. Cell Cycle 3: 343-348.
13. Liu J, Lu H, Ohgaki H, Merlo A, Shen Z, (2009) Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas. BMC Cancer 9: 268.
14. Roversi G, Pfundt R, Moroni RF, Magnani I, van Reijmersdal S, et al. (2006) Identification of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines. Oncogene 25: 1571-1583.
15. Meng X, Lu H, Shen Z, (2004) BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Cell Cycle 3: 1457-1462.
16. Lu H, Yue J, Meng X, Nickoloff JA, Shen Z, (2007) BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Nucleic Acids Res 35: 7160-7170.
17. Meng X, Fan J, Shen Z, (2007) Roles of BCCIP in chromosome stability and cytokinesis. Oncogene 26: 6253-6260.
18. Meng X, Yue J, Liu Z, Shen Z, (2007) Abrogation of the transactivation activity of p53 by BCCIP down-regulation. J Biol Chem 282: 1570-1576.
19. Mao N, Zhou Q, Kojic M, Perez-Martin J, Holloman WK, (2007) Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis. DNA Repair (Amst) 6: 1651-1660.
20. Rewari A, Lu H, Parikh R, Yang Q, Shen Z, et al. (2009) BCCIP as a prognostic marker for radiotherapy of laryngeal cancer. Radiother Oncol 90: 183-188.
21. Coumoul X, Deng CX, (2006) RNAi in mice: a promising approach to decipher gene functions in vivo. Biochimie 88: 637-643.
22. Shukla V, Coumoul X, Deng CX, (2007) RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector. Int J Biol Sci 3: 91-99.
23. Coumoul X, Shukla V, Li C, Wang RH, Deng CX, (2005) Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res 33: e102.
24. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, et al. (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93: 5860-5865.
25. Theiler K, (1989) The House Mouse, Atlas of Embryo Development New York Springer-Verlag.
26. Kaufmann MH, (1994 (reprinted 2008)) The Atlas of Mouse Development (revised edition) London, UK Elsevier Ltd.
27. Inman KE, Downs KM, (2006) Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation. Gene Expr Patterns 6: 783-793.
28. Xue Y, Wang X, Li Z, Gotoh N, Chapman D, et al. (2001) Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development 128: 1559-1572.
29. Norris DP, Brennan J, Bikoff EK, Robertson EJ, (2002) The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development 129: 3455-3468.
30. Wray J, Liu J, Nickoloff JA, Shen Z, (2008) Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress. Cancer Res 68: 2699-2707.
31. Wilson DM 3rd, Thompson LH, (2007) Molecular mechanisms of sister-chromatid exchange. Mutat Res 616: 11-23.
32. Hu Y, Lu X, Barnes E, Yan M, Lou H, et al. (2005) Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol Cell Biol 25: 3431-3442.
33. Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, et al. (2007) RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev 21: 3073-3084.
34. Kaufmann BP, Bate RC, (1938) An X-Ray Induced Intercalary Duplication in Drosophila Involving Union of Sister Chromatids. Proc Natl Acad Sci U S A 24: 368-371.
35. Evers B, Jonkers J, (2006) Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene 25: 5885-5897.
36. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, et al. (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol 4: 1-7.
37. Chan KL, Palmai-Pallag T, Ying S, Hickson ID, (2009) Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol 11: 753-760.
38. Branzei D, Foiani M, (2005) The DNA damage response during DNA replication. Curr Opin Cell Biol 17: 568-575.
39. Godthelp BC, van Buul PP, Jaspers NG, Elghalbzouri-Maghrani E, van Duijn-Goedhart A, et al. (2006) Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2. Mutat Res 601: 191-201.
40. Nagasawa H, Wilson PF, Chen DJ, Thompson LH, Bedford JS, et al. (2008) Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination. DNA Repair (Amst) 7: 515-522.
41. Roos WP, Nikolova T, Quiros S, Naumann SC, Kiedron O, et al. (2009) Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs. DNA Repair (Amst) 8: 72-86.
42. Shen Z, Peterson SR, Comeaux JC, Zastrow D, Moyzis RK, et al. (1996) Self-association of human RAD52 protein. Mutat Res 364: 81-89.
43. Shen Z, Cloud KG, Chen DJ, Park MS, (1996) Specific interactions between the human RAD51 and RAD52 proteins. J Biol Chem 271: 148-152.
44. Yue J, Wang Q, Lu H, Brenneman M, Fan F, et al. (2009) The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair. Cancer Res 69: 7978-7985.
45. Hertzog PJ, (2001) Isolation of Embryonic Fibroblasts and Their use in the In Vitro Characterization of Gene Function. In: Tymms MJ, Kola I, editors. Gene Knockout Protocols Totowa, New Jersey Humana Press pp. 205-215.
46. Williams ES, Klingler R, Ponnaiya B, Hardt T, Schrock E, et al. (2009) Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res 69: 2100-2107.
47. Williams ES, Bailey SM, (2009) Chromosome orientation fluorescence in situ hybridization (CO-FISH). Cold Spring Harb Protoc 2009: pdb prot5269.
48. Wang W, Seki M, Narita Y, Sonoda E, Takeda S, et al. (2000) Possible association of BLM in decreasing DNA double strand breaks during DNA replication. Embo J 19: 3428-3435.