Heterozygosity for Ptenpromotes Tumorigenesis in a Mouse Model of Medulloblastoma

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Castellino, Robert C ^a   Barwick, Benjamin G ^a   Schniederjan, Matthew ^a   Buss, Meghan C ^a   Becher, Oren ^b   Hambardzumyan, Dolores ^b   Macdonald, Tobey J ^a   Brat, Daniel J ^a   Durden, Donald L ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMOA1 PROTEIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3 KINASE; PTEN PROTEIN, MOUSE; SHH PROTEIN, MOUSE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; GENE EXPRESSION; GENE LOSS; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEDULLOBLASTOMA; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; OVERALL SURVIVAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; TUMOR VASCULARIZATION; WESTERN BLOTTING; ANIMAL; CELL DIFFERENTIATION; DISEASE MODEL; DOWN REGULATION; ENZYMOLOGY; GENETICS; HETEROZYGOTE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NERVE CELL; PATHOLOGY; SURVIVAL; UPREGULATION; VASCULARIZATION;

ERINACEIDAE; MUS;

ALLELES; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HEDGEHOG PROTEINS; HETEROZYGOTE; HUMANS; MEDULLOBLASTOMA; MICE; NEOVASCULARIZATION, PATHOLOGIC; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASES; PROGNOSIS; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; UP-REGULATION;

EID: 77956549578     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010849     Document Type: Article

References (41)

1. Rood BR, Macdonald TJ, Packer RJ (2004) Current treatment of medulloblas-toma: recent advances and future challenges. Semin Oncol 31: 666-675.
2. Giangaspero F BS, Giordana MT, Kleihues P, Trojanowski JQ (2000) Medulloblastoma; Kleihues PCW, ed. Lyon, France: International Agency for Research of Cancer. pp 96-103.
3. Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, et al. (2005) Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 352: 978-986.
4. Garre ML, Cama A, Bagnasco F, Morana G, Giangaspero F, et al. (2009) Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome-a new clinical perspective. Clin Cancer Res 15: 2463-2471.
5. Packer RJ, Rood BR, MacDonald TJ (2003) Medulloblastoma: present concepts of stratification into risk groups. Pediatr Neurosurg 39: 60-67.
6. Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, et al. (2002) Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415: 436-442.
7. Griffin CA, Hawkins AL, Packer RJ, Rorke LB, Emanuel BS (1988) Chromosome abnormalities in pediatric brain tumors. Cancer Res 48: 175-180.
8. Castellino RC, Durden DL (2007) Mechanisms of disease: the PI3K-Akt-PTEN signaling node-an intercept point for the control of angiogenesis in brain tumors. Nat Clin Pract Neurol 3: 682-693.
9. Hartmann W, Digon-Sontgerath B, Koch A, Waha A, Endl E, et al. (2006) Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res 12: 3019-3027.
10. Hatton BA, Villavicencio EH, Tsuchiya KD, Pritchard JI, Ditzler S, et al. (2008) The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res 68: 1768-1776.
11. Kanehisa M (2002) The KEGG database. Novartis Found Symp 247: 91-101; discussion 101-103, 119-128, 244-152.
12. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29.
13. Soroceanu L, Kharbanda S, Chen R, Soriano RH, Aldape K, et al. (2007) Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A 104: 3466-3471.
14. Wee S, Wiederschain D, Maira SM, Loo A, Miller C, et al. (2008) PTEN-deficient cancers depend on PIK3CB. Proc Natl Acad Sci U S A 105: 13057-13062.
15. Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, et al. (2009) mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 15: 148-159.
16. Blaess S, Corrales JD, Joyner AL (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/ hindbrain region. Development 133: 1799-1809.
17. Delgado-Esteban M, Martin-Zanca D, Andres-Martin L, Almeida A, Bolanos JP (2007) Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway. J Neurochem 102: 194-205.
18. Lin CH, Stoeck J, Ravanpay AC, Guillemot F, Tapscott SJ, et al. (2004) Regulation of neuroD2 expression in mouse brain. Dev Biol 265: 234-245.
19. Nagase T, Nagase M, Machida M, Fujita T (2008) Hedgehog signalling in vascular development. Angiogenesis 11: 71-77.
20. Iijima M, Nakazato Y (1997) Pale islands in medulloblastoma consist of differentiated cells with low growth potential. Pathol Int 47: 25-30.
21. Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, et al. (2004) Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 23: 6156-6162.
22. Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, et al. (2008) Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth. Cancer Res 68: 7838-7845.
23. Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, et al. (2008) PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev 22: 436-448.
24. Ellison D (2002) Classifying the medulloblastoma: insights from morphology and molecular genetics. Neuropathol Appl Neurobiol 28: 257-282.
25. Vajkoczy P, Farhadi M, Gaumann A, Heidenreich R, Erber R, et al. (2002) Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2. J Clin Invest 109: 777-785.
26. Longo R, Gasparini G (2008) Anti-VEGF therapy: the search for clinical biomarkers. Expert Rev Mol Diagn 8: 301-314.
27. Ongusaha PP, Kwak JC, Zwible AJ, Macip S, Higashiyama S, et al. (2004) HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res 64: 5283-5290.
28. Leon SP, Folkerth RD, Black PM (1996) Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 77: 362-372.
29. Li VW, Folkerth RD, Watanabe H, Yu C, Rupnick M, et al. (1994) Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet 344: 82-86.
30. Grotzer MA, Wiewrodt R, Janss AJ, Zhao H, Cnaan A, et al. (2001) High microvessel density in primitive neuroectodermal brain tumors of childhood. Neuropediatrics 32: 75-79.
31. Huber H, Eggert A, Janss AJ, Wiewrodt R, Zhao H, et al. (2001) Angiogenic profile of childhood primitive neuroectodermal brain tumours/medulloblasto-mas. Eur J Cancer 37: 2064-2072.
32. Backlund LM, Nilsson BR, Goike HM, Schmidt EE, Liu L, et al. (2003) Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN. Clin Cancer Res 9: 4151-4158.
33. Frappart PO, Lee Y, Lamont J, McKinnon PJ (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. Embo J 26: 2732-2742.
34. Mayo LD, Donner DB (2002) The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci 27: 462-467.
35. McCall TD, Pedone CA, Fults DW (2007) Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice. Cancer Res 67: 5179-5185.
36. Marone R, Cmiljanovic V, Giese B, Wymann MP (2008) Targeting phosphoinositide 3-kinase: moving towards therapy. Biochim Biophys Acta 1784: 159-185.
37. Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, et al. (2001) PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci U S A 98: 4622-4627.
38. Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, et al. (2003) Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol 263: 50-66.
39. Castellino RC, De Bortoli M, Lin LL, Skapura DG, Rajan JA, et al. (2007) Overexpressed TP73 induces apoptosis in medulloblastoma. BMC Cancer 7: 127.
40. Tusher VG, Tibshirani R, Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98: 5116-5121.
41. Team RDC (2008) R: A Language and Environment for Statistical Computing. ViennaAustria: R Foundation for Statistical Computing.