Synthesis and anticancer activity of all known (-)-agelastatin alkaloids

Journal of Organic Chemistry

Volumn 78, Issue 23, 2013, Pages 11970-11984

  Han, Sunkyu ^a   Siegel, Dustin S ^a   Morrison, Karen C ^b   Hergenrother, Paul J ^b   Movassaghi, Mohammad ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER ACTIVITIES; BIOSYNTHETIC PRECURSORS; CROSS COUPLING REACTIONS; ENANTIOSELECTIVE TOTAL SYNTHESIS; NATURALLY OCCURRING; STRUCTURE ACTIVITY RELATIONSHIPS; SYNTHETIC INTERMEDIATES; SYSTEMATIC ANALYSIS;

ALKALOIDS; CELL CULTURE; CELL DEATH; METABOLITES;

NITROGEN COMPOUNDS;

AGELASTATIN; AGELASTATIN A; AGELASTATIN B; AGELASTATIN C; AGELASTATIN D; AGELASTATIN E; AGELASTATIN F; ANTINEOPLASTIC ALKALOID; COLCHICINE; COPPER; GUANIDINE; HETEROCYCLIC COMPOUND; IMIDAZOLE DERIVATIVE; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS COUPLING REACTION; CYCLIZATION; DRUG POTENCY; DRUG SYNTHESIS; ERYTHROCYTE; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; IC 50; MOLECULAR DYNAMICS; OXIDATION; RING OPENING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HL-60 CELLS; HUMANS; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

EID: 84890215732     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo4020112     Document Type: Article

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