The active centres of agelastatin A, a strongly cytotoxic alkaloid of the Coral Sea axinellid sponge Agelas dendromorpha, as determined by comparative bioassays with semisynthetic derivatives

Helvetica Chimica Acta

Volumn 79, Issue 3, 1996, Pages 727-735

  D'Ambrosio, Michele ^a   Guerriero, Antonio ^a   Ripamonti, Marina ^b   Debitus, Cécile ^c   Waikedre, Jean ^c   Pietra, Francesco ^a  

^a UNIVERSITY OF TRENTO   (Italy)

^b PFIZER INC   (United States)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGILASTATIN A; ALKALOID; CYTOTOXIC AGENT; DOXORUBICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BIOASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKEMIA L 1210; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SPONGE; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

EID: 0029904176     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.19960790315     Document Type: Article

References (2)

1. M. D'Ambrosio, A. Guerriero, C. Debitus, O. Ribes, J. Pusset, S. Leroy, F. Pietra, J. Chem Soc., Chem. Commun. 1993, 1305,
2. M. D'Ambrosio, A. Guerriero, G. Chiasera, F. Pietra, Helv. Chim. Acta 1994, 77, 1895.