Phenotypic profiling of mycobacterium tuberculosis espa point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence

Journal of Bacteriology

Volumn 195, Issue 24, 2013, Pages 5421-5430

  Chen, Jeffrey M ^a   Zhang, Ming ^a   Rybniker, Jan ^a   Basterra, Laetitia ^a   Dhar, Neeraj ^a   Tischler, Anna D ^b   Pojer, Florence ^a   Cole, Stewart T ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ARGININE; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; ESCHERICHIA COLI SECRETED PROTEIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; IN VITRO STUDY; MICROBIAL ATTENUATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN SECRETION; SITE DIRECTED MUTAGENESIS; TUBERCULOSIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; MACROPHAGES; MEMBRANE TRANSPORT PROTEINS; MICE; MUTANT PROTEINS; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; VIRULENCE;

EID: 84890210825     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00967-13     Document Type: Article

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