EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis

Journal of Bacteriology

Volumn 194, Issue 4, 2012, Pages 884-893

  Chen, Jeffrey M ^a   Boy Röttger, Stefanie ^a   Dhar, Neeraj ^a   Sweeney, Nathan ^b   Buxton, Roger S ^b   Pojer, Florence ^a   Rosenkrands, Ida ^c   Cole, Stewart T ^a  

^a EPFL   (Switzerland)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; EARLY SECRETORY ANTIGENIC TARGET 6; ESCHERICHIA COLI SECRETED PROTEIN A; ESPC PROTEIN; ESPD PROTEIN; ESXA PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BACTERIAL VIRULENCE; CELL LEVEL; CONTROLLED STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SECRETION; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; TYPE I SECRETION SYSTEM;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL SECRETION SYSTEMS; MYCOBACTERIUM TUBERCULOSIS; SIGNAL TRANSDUCTION;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84863116545     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.06417-11     Document Type: Article

References (31)

1. Bange FC, Collins FM, Jacobs WR, Jr. 1999. Survival of mice infected with Mycobacterium smegmatis containing large DNA fragments from Mycobacterium tuberculosis. Tuber. Lung Dis. 79:171-180.
2. Bitter W, et al. 2009. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog. 5:e1000507.
3. Bottai D, et al. 2011. ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. J. Infect. Dis. 203:1155-1164.
4. Brodin P, et al. 2005. Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity. J. Biol. Chem. 280:33953-33959.
5. Brodin P, et al. 2006. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 74:88-98.
6. Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS. 2006. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 313:1632-1636.
7. Dhar N, McKinney JD. 2010. Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice. Proc. Natl. Acad. Sci. U. S. A. 107:12275-12280.
8. DiGiuseppe Champion PA, Champion MM, Manzanillo P, Cox JS. 2009. ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria. Mol. Microbiol. 73: 950-962.
9. Donnelly-Wu MK, Jacobs WR, Jr, Hatfull GF. 1993. Superinfection immunity of mycobacteriophage L5: applications for genetic transformation of mycobacteria. Mol. Microbiol. 7:407-417.
10. Fisher MA, Plikaytis BB, Shinnick TM. 2002. Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. J. Bacteriol. 184:4025-4032.
11. Fortune SM, et al. 2005. Mutually dependent secretion of proteins required for mycobacterial virulence. Proc. Natl. Acad. Sci. U. S. A. 102: 10676-10681.
12. Frigui W, et al. 2008. Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog. 4:e33.
13. Garces A, et al. 2010. EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. PLoS Pathog. 6:e1000957.
14. Guinn KM, et al. 2004. Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol. Microbiol. 51:359-370.
15. Hsu T, et al. 2003. The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc. Natl. Acad. Sci. U. S. A. 100:12420-12425.
16. Lewis KN, et al. 2003. Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guerin attenuation. J. Infect. Dis. 187:117-123.
17. MacGurn JA, Raghavan S, Stanley SA, Cox JS. 2005. A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis. Mol. Microbiol. 57:1653-1663.
18. Meher AK, Bal NC, Chary KV, Arora A. 2006. Mycobacterium tuberculosis H37Rv ESAT-6-CFP-10 complex formation confers thermodynamic and biochemical stability. FEBS J. 273:1445-1462.
19. Meher AK, Lella RK, Sharma C, Arora A. 2007. Analysis of complex formation and immune response of CFP-10 and ESAT-6 mutants. Vaccine 25:6098-6106.
20. Millington KA, et al. 2011. Rv3615c is a highly immunodominant RD1 (region of difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. U. S. A. 108:5730-5735.
21. Ohol YM, et al. 2010. Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host Microbe 7:210-220.
22. Pym AS, Brodin P, Brosch R, Huerre M, Cole ST. 2002. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol. Microbiol. 46: 709-717.
23. Raghavan S, Manzanillo P, Chan K, Dovey C, Cox JS. 2008. Secreted transcription factor controls Mycobacterium tuberculosis virulence. Nature 454:717-721.
24. Rickman L, et al. 2005. A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor. Mol. Microbiol. 56:1274-1286.
25. Rohde KH, Abramovitch RB, Russell DG. 2007. Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues. Cell Host Microbe 2:352-364.
26. Simeone R, Bottai D, Brosch R. 2009. ESX/type VII secretion systems and their role in host-pathogen interaction. Curr. Opin. Microbiol. 12:4-10.
27. Stanley SA, Raghavan S, Hwang WW, Cox JS. 2003. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc. Natl. Acad. Sci. U. S. A. 100:13001-13006.
28. Stover CK, et al. 1991. New use of BCG for recombinant vaccines. Nature 351:456-460.
29. van Kessel JC, Hatfull GF. 2008. Mycobacterial recombineering. Methods Mol. Biol. 435:203-215.
30. Walters SB, et al. 2006. The Mycobacterium tuberculosis PhoPR twocomponent system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 60:312-330.
31. Wards BJ, Collins DM. 1996. Electroporation at elevated temperatures substantially improves transformation efficiency of slow-growing mycobacteria. FEMS Microbiol. Lett. 145:101-105.