Suppressive effects of a novel CC chemokine receptor 4 antagonist on Th2 cell trafficking in ligand- and antigen-induced mouse models

European Journal of Pharmacology

Volumn 720, Issue 1-3, 2013, Pages 335-343

  Komiya, Takaki ^a   Sugiyama, Tetsuya ^a   Takeda, Kazuhiko ^a   Watanabe, Noriki ^a   Imai, Masamichi ^a   Kokubo, Masaya ^a   Tokuda, Natsuko ^a   Ochiai, Hiroshi ^a   Habashita, Hiromu ^a   Shibayama, Shiro ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Allergic disease; CCR4 antagonist; Chemokine; Chemokine receptor; Th2 cell trafficking

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR4; E 0001 163; INTERLEUKIN 4; MACROPHAGE DERIVED CHEMOKINE; N [5 BROMO 3 [[3 [2 (DIMETHYLAMINO) ETHOXY] 4 METHOXYBENZYL]OXY] 2 PYRAZINYL] 4 METHYLBENZENESULFONAMIDE; OVALBUMIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMOKINESIS; CHEMOTAXIS; CONTROLLED STUDY; CROSS REACTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MIGRATION INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVALBUMIN-INDUCED AIRWAY INFLAMMATION; PRIORITY JOURNAL; SPLEEN CELL; TH2 CELL;

ALLERGIC DISEASE; CCR4 ANTAGONIST; CHEMOKINE; CHEMOKINE RECEPTOR; TH2 CELL TRAFFICKING;

ADOPTIVE TRANSFER; ANIMALS; ANTI-ALLERGIC AGENTS; ANTIGENS; CELL LINE; CELL MOVEMENT; CHEMOKINE CCL22; HEK293 CELLS; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; OVALBUMIN; PNEUMONIA; RECEPTORS, CCR4; SPLEEN; SULFANILAMIDES; TH2 CELLS;

EID: 84890124544     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.10.006     Document Type: Article

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