Effect of CC chemokine receptor 4 antagonism on the evolution of experimental autoimmune encephalomyelitis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 37, 2012, Pages

  Othy, Shivashankar ^a,b   Topcu̧, Selma ^a,b   Kaveri, Srini V ^a,b,c   Bayry, Jagadeesh ^a,b,c  

^a INSERM   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c NATIONAL INSTITUTE OF IMMUNOHAEMATOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 BENZOFURAN 2 YL CARBONYL) 1 [5 [4 CHLOROBENZYL)SULFANYL] 1,3,4 THIADIAZOL 2 YL] 3 HYDROXY 5 (2 THIENYL) 1,5 DIHYDRO 2H PYRROL 2 ONE; AF 18025; AF 399; AF 420; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR4; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; CD4+ CD25+ T LYMPHOCYTE; CELL MIGRATION; DISEASE SEVERITY; EVOLUTION; GENE DELETION; INJECTION; LETTER; LYMPHOCYTE DIFFERENTIATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PATHOGENESIS; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SCORING SYSTEM; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ANIMALS; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-23; RECEPTORS, CCR4;

EID: 84866277908     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1209124109     Document Type: Letter

References (5)

1. Poppensieker K, et al. (2012) CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci USA 109:3897-3902.
2. Bayry J, et al. (2008) In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination. Proc Natl Acad Sci USA 105:10221-10226.
3. Newhouse B, et al. (2004) Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists. Bioorg Med Chem Lett 14:5537-5542.
4. Pere H, et al. (2011) A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens. Blood 118:4853-4862.
5. Iellem A, et al. (2001) Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 194:847-853.