Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice

European Journal of Pharmacology

Volumn 624, Issue 1-3, 2009, Pages 38-44

  Nakagami, Yasuhiro ^a   Kawashima, Kayo ^b   Yonekubo, Kazuki ^a   Etori, Maki ^a   Jojima, Takaaki ^d   Miyazaki, Shojiro ^d   Sawamura, Ryoko ^c   Hirahara, Kazuki ^a   Nara, Futoshi ^b   Yamashita, Makoto ^a  

^a Biological Research Laboratories   (Japan)

^b Exploratory Research Laboratories   (Japan)

^c Drug Metabolism and Pharmacokinetics Research Laboratories   (Japan)

^d DAIICHI SANKYO CO   (Japan)

Author keywords

Atopic dermatitis; CCL17; CCL22; CCR4; Ear swelling

Indexed keywords

3 [2 [2 PHENYL 4 (4 PYRIDIN 4 YLBENZYL)MORPHOLIN 2 YL]ETHYL]QUINAZOLINE 2,4 (1H,3H)DIONE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR4; INTERLEUKIN 4; OVALBUMIN; RS 1154; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOPIC DERMATITIS; CELL MIGRATION; CHO CELL; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH2 CELL;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL ASSAY; CHO CELLS; CRICETINAE; CRICETULUS; DERMATITIS, ATOPIC; DERMATOLOGIC AGENTS; EAR DISEASES; INHIBITORY CONCENTRATION 50; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MORPHOLINES; OVALBUMIN; QUINAZOLINONES; RECEPTORS, CCR4; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 70350738223     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.09.058     Document Type: Article

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