NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Li, Hui ^a,b,c   Han, Wei ^b   Polosukhin, Vasilly ^b   Yull, Fiona E ^b   Segal, Brahm H ^d,e   Xie, Can Mao ^a   Blackwell, Timothy S ^b,f  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; 4(2' AMINOETHYL)AMINO 1,8 DIMETHYLIMIDAZO(1,2 A)QUINOXALINE; 4(2'-AMINOETHYL)AMINO-1,8-DIMETHYLIMIDAZO(1,2-A)QUINOXALINE; I KAPPA B KINASE; IMIDAZOLE DERIVATIVE; QUINOXALINE DERIVATIVE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COUNT; BACTERIUM COLONY; BLOOD ANALYSIS; CECAL LIGATION AND PUNCTURE; CELL PHAGOCYTOSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; HISTOPATHOLOGY; HOST RESISTANCE; IN VIVO STUDY; INTESTINE SURGERY; LEUKOCYTE COUNT; LIGATION; LUNG ALVEOLITIS; LUNG LAVAGE; LUNG PARENCHYMA; MACROPHAGE; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEAL FLUID; PERITONEUM CELL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PUNCTURE; REPEAT PROCEDURE; SEPSIS; SURVIVAL; WESTERN BLOTTING; ANIMAL; BACTERIAL INFECTION; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; PHAGOCYTOSIS;

BACTERIA (MICROORGANISMS); MUS;

ACUTE LUNG INJURY; ANIMALS; BACTERIAL INFECTIONS; CELLS, CULTURED; I-KAPPA B KINASE; IMIDAZOLES; LIGATION; MACROPHAGES; MICE; NEUTROPHILS; NF-KAPPA B; PHAGOCYTOSIS; QUINOXALINES; SEPSIS;

EID: 84890079105     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/503213     Document Type: Article

References (27)

1. Martin G. S., Mannino D. M., Eaton S., Moss M., The epidemiology of sepsis in the United States from 1979 through 2000. The New England Journal of Medicine 2003 348 16 1546 1554 2-s2.0-0037451929 10.1056/NEJMoa022139 (Pubitemid 36437931)
2. Angus D. C., Linde-Zwirble W. T., Lidicker J., Clermont G., Carcillo J., Pinsky M. R., Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical Care Medicine 2001 29 7 1303 1310 2-s2.0-0034958947 (Pubitemid 32641789)
3. Mayr F. B., Yende S., Linde-Zwirble W. T., Peck-Palmer O. M., Barnato A. E., Weissfeld L. A., Angus D. C., Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. Journal of the American Medical Association 2010 303 24 2495 2503 2-s2.0-77953860883 10.1001/jama.2010.851
4. Liu S. F., Malik A. B., NF- B activation as a pathological mechanism of septic shock and inflammation. American Journal of Physiology-Lung Cellular and Molecular Physiology 2006 290 4 L622 L645 2-s2.0-33645116785 10.1152/ajplung.00477.2005 (Pubitemid 43738989)
5. Böhrer H., Qiu F., Zimmermann T., Role of NF- B in the mortality of sepsis. Journal of Clinical Investigation 1997 100 5 972 985
6. Everhart M. B., Han W., Sherrill T. P., Arutiunov M., Polosukhin V. V., Burke J. R., Sadikot R. T., Christman J. W., Yull F. E., Blackwell T. S., Duration and intensity of NF- B activity determine the severity of endotoxin-induced acute lung injury. The Journal of Immunology 2006 176 8 4995 5005 2-s2.0-33645769722
7. Ye X., Ding J., Zhou X., Chen G., Shu F. L., Divergent roles of endothelial NF- B in multiple organ injury and bacterial clearance in mouse models of sepsis. Journal of Experimental Medicine 2008 205 6 1303 1315 2-s2.0-45149121950 10.1084/jem.20071393 (Pubitemid 351831488)
8. Ding J., Song D., Ye X., Liu S. F., A pivotal role of endothelial-specific NF- B signaling in the pathogenesis of septic shock and septic vascular dysfunction. The Journal of Immunology 2009 183 6 4031 4038 2-s2.0-70349307058 10.4049/jimmunol.0900105
9. Cheng D. S., Han W., Chen S. M., Airway epithelium controls lung inflammation and injury through the NF- B pathway. The Journal of Immunology 2007 178 10 6504 6513 (Pubitemid 46717434)
10. Su J., Li X., Cui X., Li Y., Fitz Y., Hsu L., Mani H., Quezado M., Eichacker P. Q., Ethyl pyruvate decreased early nuclear factor- B levels but worsened survival in lipopolysaccharide-challenged mice. Critical Care Medicine 2008 36 4 1059 1067 2-s2.0-41649094479 10.1097/CCM.0B013E318164403B (Pubitemid 351482719)
11. Li X., Cui X., Li Y., Fitz Y., Hsu L., Eichacker P. Q., Parthenolide has limited effects on nuclear factor- B increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice. Cytokine 2006 33 6 299 308 2-s2.0-33744533883 10.1016/j.cyto.2006.03.002 (Pubitemid 43816306)
12. O'Sullivan A. W., Wang J. H., Redmond H. P., NF- B and P38 MAPK inhibition improve survival in endotoxin shock and in a cecal ligation and puncture model of sepsis in combination with antibiotic therapy. Journal of Surgical Research 2009 152 1 46 53 2-s2.0-63149188224 10.1016/j.jss.2008.04.030
13. Sadikot R. T., Zeng H., Joo M., Everhart M. B., Sherrill T. P., Li B., Cheng D.-S., Yull F. E., Christman J. W., Blackwell T. S., Targeted immunomodulation of the NF- B pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. The Journal of Immunology 2006 176 8 4923 4930 2-s2.0-33645796654
14. Lavon I., Goldberg I., Amit S., Landsman L., Jung S., Tsuberi B.-Z., Barshack I., Kopolovic J., Galun E., Bujard H., Ben-Neriah Y., High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF- B activation. Nature Medicine 2000 6 5 573 577 2-s2.0-17144449583 10.1038/75057 (Pubitemid 30305909)
15. Craciun F. L., Schuller E. R., Remick D. G., Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival. The Journal of Immunology 2010 185 11 6930 6938 2-s2.0-78650630315 10.4049/jimmunol.1002300
16. Burke J. R., Pattoli M. A., Gregor K. R., Brassil P. J., MacMaster J. F., McIntyre K. W., Yang X., Iotzova V. S., Clarke W., Strnad J., Qiu Y., Zusi F. C., BMS-345541 is a highly selective inhibitor of I B kinase that binds at an allosteric site of the enzyme and blocks NF- B-dependent transcription in mice. Journal of Biological Chemistry 2003 278 3 1450 1456 2-s2.0-0037449711 10.1074/jbc.M209677200 (Pubitemid 36801370)
17. Rittirsch D., Huber-Lang M. S., Flierl M. A., Ward P. A., Immunodesign of experimental sepsis by cecal ligation and puncture. Nature Protocols 2009 4 1 31 36 2-s2.0-61449154547 10.1038/nprot.2008.214
18. Lagranderie M., Nahori M.-A., Balazuc A.-M., Kiefer-Biasizzo H., Lapa E Silva J.-R., Milon G., Marchal G., Vargaftig B. B., Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production. Immunology 2003 108 3 352 364 2-s2.0-0037339779 10.1046/j.1365-2567.2003.01609.x (Pubitemid 36332394)
19. Ebong S., Call D., Nemzek J., Bolgos G., Newcomb D., Remick D., Immunopathologic alterations in murine models of sepsis of increasing severity. Infection and Immunity 1999 67 12 6603 6610 2-s2.0-0032728317
20. Xiao H., Siddiqui J., Remick D. G., Mechanisms of mortality in early and late sepsis. Infection and Immunity 2006 74 9 5227 5235 2-s2.0-33748072117 10.1128/IAI.01220-05 (Pubitemid 44300441)
21. Hollenberg S. M., Dumasius A., Easington C., Colilla S. A., Neumann A., Parrillo J. E., Characterization of a hyperdynamic murine model of resuscitated sepsis using echocardiography. The American Journal of Respiratory and Critical Care Medicine 2001 164 5 891 895 2-s2.0-0035447007 (Pubitemid 32881930)
22. Dejager L., Pinheiro I., Dejonckheere E., Libert C., Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends in Microbiology 2011 19 4 198 208 2-s2.0-79953292076 10.1016/j.tim.2011.01.001
23. Courtine E., Pène F., Cagnard N., Toubiana J., Fitting C., Brocheton J., Rousseau C., Gerondakis S., Chiche J.-D., Ouaaz F., Mira J.-P., Critical role of cRel subunit of NF- B in sepsis survival. Infection and Immunity 2011 79 5 1848 1854 2-s2.0-79955638078 10.1128/IAI.00021-11
24. Weiss Y. G., Maloyan A., Tazelaar J., Raj N., Deutschman C. S., Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. Journal of Clinical Investigation 2002 110 6 801 806 2-s2.0-0036738485 10.1172/JCI200215888
25. Weiss Y. G., Bromberg Z., Raj N., Raphael J., Goloubinoff P., Ben-Neriah Y., Deutschman C. S., Enhanced heat shock protein 70 expression alters proteasomal degradation of I B kinase in experimental acute respiratory distress syndrome. Critical Care Medicine 2007 35 9 2128 2138 2-s2.0-34548292474 10.1097/01.CCM.0000278915.78030.74 (Pubitemid 47326450)
26. Singleton K. D., Wischmeyer P. E., Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. The American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2007 292 5 R1839 R1845 2-s2.0-34248184997 10.1152/ajpregu.00755.2006 (Pubitemid 46708539)
27. McIntyre K. W., Shuster D. J., Gillooly K. M., Dambach D. M., Pattoli M. A., Lu P., Zhou X.-D., Qiu Y., Zusi F. C., Burke J. R., A highly selective inhibitor of I B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis & Rheumatism 2003 48 9 2652 2659 2-s2.0-0141676361 10.1002/art.11131 (Pubitemid 37129443)