NF-κB and P38 MAPK Inhibition Improve Survival in Endotoxin Shock and in a Cecal Ligation and Puncture Model of Sepsis in Combination With Antibiotic Therapy

Journal of Surgical Research

Volumn 152, Issue 1, 2009, Pages 46-53

  O'Sullivan, Adrian W ^a   Wang, Jiang Huai ^a   Redmond, Henry P ^a  

^a University College Cork and INFANT Centre   (Ireland)

Author keywords

antibiotics; cecal ligation and puncture; cytokines; sepsis; signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMOXICILLIN PLUS CLAVULANIC ACID; CYTOPLASM PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; SN 50; TUMOR NECROSIS FACTOR ALPHA; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; ANTIINFECTIVE AGENT; ENDOTOXIN; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PEPTIDE; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BLOOD SAMPLING; CECUM; COLONY FORMING UNIT; CONTROLLED STUDY; DISEASE MODEL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; FATALITY; IN VIVO STUDY; LIGATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN ISOLATION; PUNCTURE; SALMONELLA TYPHIMURIUM; SEPSIS; SEPTIC SHOCK; SPLEEN; STAPHYLOCOCCUS AUREUS; SURVIVAL RATE; TISSUE SECTION; TRANSLATION REGULATION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; INJURY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOTTING, WESTERN; CECUM; DRUG THERAPY, COMBINATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTOXINS; ENZYME ACTIVATION; ENZYME INHIBITORS; IMIDAZOLES; INTERLEUKIN-6; LIGATION; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; PYRIDINES; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 63149188224     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.04.030     Document Type: Article

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