Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

Genes and Development

Volumn 26, Issue 24, 2012, Pages 2749-2762

  Dhar, Shilpa S ^a   Lee, Sung Hun ^a   Kan, Pu Yeh ^a   Voigt, Philipp ^b   Ma, Li ^a   Shi, Xiaobing ^a   Reinberg, Danny ^b   Lee, Min Gyu ^a,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Epigenetics; Histone modification; HOX genes; Neuronal differentiation; PHD domains; PRMT7

Indexed keywords

HISTONE H3; HISTONE H4; HOMEODOMAIN PROTEIN; HOX PROTEIN; HOXA PROTEIN; HOXB PROTEIN; METHYLTRANSFERASE; MIXED LINEAGE LEUKEMIA 4 PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; NUCLEOSOMAL METHYLTRANSFERASE; PLANT HOMEODOMAIN PROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; PROTEIN ARGININE METHYLTRANSFERASE 7; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; GENE MUTATION; GENE TARGETING; HISTONE METHYLATION; HUMAN; HUMAN CELL; KABUKI MAKEUP SYNDROME; PRIORITY JOURNAL; STEM CELL; UPREGULATION;

CELL DIFFERENTIATION; CELL LINE, TUMOR; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; METHYLATION; NERVE TISSUE PROTEINS; NEURONS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-ARGININE N-METHYLTRANSFERASES; STEM CELLS;

EID: 84871568905     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.203356.112     Document Type: Article

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