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Volumn 13, Issue 6, 2013, Pages 639-645

B-cell memory and primary immune deficiencies: Interleukin-21 related defects

Author keywords

B cell memory; Common variable immune deficiency; Humoral immune response; Interleukin 21; Primary immune deficiency

Indexed keywords

B CELL MATURATION ANTIGEN; CD38 ANTIGEN; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; JANUS KINASE 3; STAT3 PROTEIN;

EID: 84889886947     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0000000000000009     Document Type: Review
Times cited : (18)

References (52)
  • 1
    • 0032976666 scopus 로고    scopus 로고
    • Common variable immunodeficiency: Clinical and immunological features of 248 patients
    • Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 1999; 92:34-48.
    • (1999) Clin Immunol , vol.92 , pp. 34-48
    • Cunningham-Rundles, C.1    Bodian, C.2
  • 2
    • 84875700335 scopus 로고    scopus 로고
    • B-cell biology and development
    • A review discussing critical stages in B-cell develoment on the basis of characterized genetic defects associated with rimary immune deficiencies
    • Pieper K, Grimbacher B, Eibel H. B-cell biology and development. J Allergy Clin Immunol 2013; 131:959-971. A review discussing critical stages in B-cell development on the basis of characterized genetic defects associated with primary immune deficiencies.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 959-971
    • Pieper, K.1    Grimbacher, B.2    Eibel, H.3
  • 3
    • 42049084134 scopus 로고    scopus 로고
    • Common variable immunodeficiency: An update on etiology and management
    • Yong PF, Tarzi M, Chua I, et al. Common variable immunodeficiency: An update on etiology and management. Immunol Allergy Clin North Am 2008; 28:367-386.
    • (2008) Immunol Allergy Clin North Am , vol.28 , pp. 367-386
    • Yong, P.F.1    Tarzi, M.2    Chua, I.3
  • 4
    • 77950195424 scopus 로고    scopus 로고
    • Clinical consequences of defects in b-cell development
    • Vale AM, Schroeder HW. Clinical consequences of defects in B-cell development. J Allergy Clin Immunol 2010; 125:778-787.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 778-787
    • Vale, A.M.1    Schroeder, H.W.2
  • 5
    • 51749093932 scopus 로고    scopus 로고
    • Flowcytometric phenotyping of common variable immunodeficiency
    • Warnatz K, Schlesier M. Flowcytometric phenotyping of common variable immunodeficiency. Clin Cytometry 2008; 74B:261-271.
    • (2008) Clin Cytometry , vol.74 , pp. 261-271
    • Warnatz, K.1    Schlesier, M.2
  • 6
    • 38049105639 scopus 로고    scopus 로고
    • The euroclass trial: Defining subgroups in common variable immunodeficiency
    • Wehr C, Kivioja T, Schmitt C, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 2008; 111:77-85.
    • (2008) Blood , vol.111 , pp. 77-85
    • Wehr, C.1    Kivioja, T.2    Schmitt, C.3
  • 7
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for il-21 in regulating immunoglobulin production
    • Ozaki K, Spolski R, Feng CG, et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002; 298:1630-1634.
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1    Spolski, R.2    Feng, C.G.3
  • 8
    • 84255197284 scopus 로고    scopus 로고
    • A descrition of the abnormal signalling through a mutated common gamma-chain of the il-21 recetor and its association with ersistent humoral abnormalities found after bone marrow translantation of x-linked and jak3 scid atients with incomlete chimerism Il-21 is the primary common y chainbinding cytokine required for human b-cell differentiation in vivo
    • Recher M, Berglund LJ, Avery DT, et al. IL-21 is the primary common y chainbinding cytokine required for human B-cell differentiation in vivo. Blood 2011; 118:6824-6835. A description of the abnormal signalling through a mutated common gamma-chain of the IL-21 receptor and its association with persistent humoral abnormalities found after bone marrow transplantation of X-linked and JAK3 SCID patients with incomplete chimerism.
    • (2011) Blood , vol.118 , pp. 6824-6835
    • Recher, M.1    Berglund, L.J.2    Avery, D.T.3
  • 9
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in nk cell expansion and regulation of lymphocyte fonction
    • Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte fonction. Nature 2000; 408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3
  • 10
    • 0034633734 scopus 로고    scopus 로고
    • Cloning of a type i cytokine receptor most related to the il-2 receptor beta chain
    • Ozaki K, Kikly K, Michalovich D, et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A 2000; 97:11439-11444.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11439-11444
    • Ozaki, K.1    Kikly, K.2    Michalovich, D.3
  • 11
    • 84877614089 scopus 로고    scopus 로고
    • First study of homozygotous loss-of-function mutations of the il-21 recetor gene found in two unrelated kindreds affected by crytosoridial-related cholangitis eving to severe liver disease Loss-of-function mutations in the il-21 receptor gene cause a primary immunodeficiency syndrome
    • Kotlarz D, Zietara N, Uzel G, et al. Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J Exp Med 2013; 210:433-443. First study of homozygotous loss-of-function mutations of the IL-21 receptor gene found in two unrelated kindreds affected by cryptosporidial- related cholangitis evolving to severe liver disease.
    • (2013) J Exp Med , vol.210 , pp. 433-443
    • Kotlarz, D.1    Zietara, N.2    Uzel, G.3
  • 13
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: The common gammachain is an indispensable subunit of the il-21 receptor complex
    • Asao H, Okuyama C, Kumaki S, et al. Cutting edge: the common gammachain is an indispensable subunit of the IL-21 receptor complex. J Immunol 2001; 167:1-5.
    • (2001) J Immunol , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3
  • 14
    • 76149139419 scopus 로고    scopus 로고
    • B cell-intrinsic signaling through il-21 receptor and stat3 is required for establishing long-lived antibody responses in humans
    • A descrition of the critical and nonredundant role of STAT3 in B-cell roduction of high-affinity secific antibodies and differentiation into immunoglobulin-secreting cells
    • Avery DT, Deenick EK, Ma CS, et al. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 2010; 207:155-171. A description of the critical and nonredundant role of STAT3 in B-cell production of high-affinity specific antibodies and differentiation into immunoglobulin-secreting cells.
    • (2010) J Exp Med , vol.207 , pp. 155-171
    • Avery, D.T.1    Deenick, E.K.2    Ma, C.S.3
  • 15
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether il-21 induces b cell costimulation, growth arrest, or bim-dependent apoptosis
    • Jin H, Carrrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 2004; 173:657-665.
    • (2004) J Immunol , vol.173 , pp. 657-665
    • Jin, H.1    Carrrio, R.2    Yu, A.3    Malek, T.R.4
  • 16
    • 84886943331 scopus 로고    scopus 로고
    • A review discussing the autocrine and aracrine functions of il-21 as a regulatory cytokine and a cytokine that romotes b-cell differentiation into immunoglobulinsecreting cells deending on the secific costimulation alied Why do human b cells secrete granzyme b?
    • Hagn M, Jahrsdo rfer B. Why do human B cells secrete granzyme B? Oncoimmunology 2012; 1:1368-1375. A review discussing the autocrine and paracrine functions of IL-21 as a regulatory cytokine and a cytokine that promotes B-cell differentiation into immunoglobulinsecreting cells depending on the specific costimulation applied.
    • (2012) Oncoimmunology , vol.1 , pp. 1368-1375
    • Hagn, M.1    Jahrsdorfer, B.2
  • 17
    • 68149099548 scopus 로고    scopus 로고
    • Human b cells secrete granzyme b when recognizing viral antigens in the context of the acute phase cytokine il-21
    • Hagn M, Schwesinger E, Ebel V, et al. Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J Immunol 2009; 183:1838-1845.
    • (2009) J Immunol , vol.183 , pp. 1838-1845
    • Hagn, M.1    Schwesinger, E.2    Ebel, V.3
  • 18
    • 84859947465 scopus 로고    scopus 로고
    • Human b cells differentiate into granzyme b-secreting cytotoxic b lymphocytes upon incomplete t-cell help
    • Hagn M, Sontheimer K, Dahlke K, et al. Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help. Immunol Cell Biol 2012; 90:457-467.
    • (2012) Immunol Cell Biol , vol.90 , pp. 457-467
    • Hagn, M.1    Sontheimer, K.2    Dahlke, K.3
  • 19
    • 79952487025 scopus 로고    scopus 로고
    • B cells from common variable immunodeficiency patients fail to differentiate to antibody secreting cells in response to tlr9 ligand (cpg-odn) or anti-cd40 ; il21
    • A descrition of decreased B-cell differentiation into immunoglobulin-secreting cells and antibody roduction following IL-21 in-vitro stimulation in atients with CVID
    • Clemente A, Pons J, Matamoros N, et al. B cells from common variable immunodeficiency patients fail to differentiate to antibody secreting cells in response to TLR9 ligand (CpG-ODN) or anti-CD40 ; IL21. Cell Immunol 2011; 268:9-15. A description of decreased B-cell differentiation into immunoglobulin-secreting cells and antibody production following IL-21 in-vitro stimulation in patients with CVID.
    • (2011) Cell Immunol , vol.268 , pp. 9-15
    • Clemente, A.1    Pons, J.2    Matamoros, N.3
  • 20
    • 29144519767 scopus 로고    scopus 로고
    • Il-21 induces differentiation of human naive and memory b cells into antibody-secreting plasma cells
    • Ettinger E, Sims GP, Fairhurst A, et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005; 175:7867-7879.
    • (2005) J Immunol , vol.175 , pp. 7867-7879
    • Ettinger, E.1    Sims, G.P.2    Fairhurst, A.3
  • 21
    • 0037438633 scopus 로고    scopus 로고
    • Intrinsic differences in the proliferation of naive and memory human b cells as a mechanism for enhanced secondary immune responses
    • Tangye SG, Avery DT, Deenick EK, Hodgkin PD. Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J Immunol 2003; 170:686-694.
    • (2003) J Immunol , vol.170 , pp. 686-694
    • Tangye, S.G.1    Avery, D.T.2    Deenick, E.K.3    Hodgkin, P.D.4
  • 22
    • 38049101408 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of human b cell differentiation into ig-secreting cells: Predominant role of il-21 produced by cxcr5 ; t follicular helper cells
    • Bryant VL, Ma CS, Avery DT, et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5 ; T follicular helper cells. J Immunol 2007; 179:8180-8190.
    • (2007) J Immunol , vol.179 , pp. 8180-8190
    • Bryant, V.L.1    Ma, C.S.2    Avery, D.T.3
  • 23
    • 84874066172 scopus 로고    scopus 로고
    • A review discussing comlementary and sometimes synergistic effects of baff and il-21 on b-cell growth and differentiation The interplay of il-21 and baff in the formation and maintenance of human b cell memory
    • Karnell JL, Ettinger R. The interplay of IL-21 and BAFF in the formation and maintenance of human B cell memory. Front Immunol 2012; 3:1-9. A review discussing complementary and sometimes synergistic effects of BAFF and IL-21 on B-cell growth and differentiation.
    • (2012) Front Immunol , vol.3 , pp. 1-9
    • Karnell, J.L.1    Ettinger, R.2
  • 24
    • 35348960378 scopus 로고    scopus 로고
    • Stat3 mutations in the hyper-ige syndrome
    • Holland SM, DeLeo FR, Elloumi HD, et al. STAT3 mutations in the hyper-IgE syndrome. N Engl J Med 2007; 357:1608-1619.
    • (2007) N Engl J Med , vol.357 , pp. 1608-1619
    • Holland, S.M.1    DeLeo, F.R.2    Elloumi, H.D.3
  • 25
    • 34548317417 scopus 로고    scopus 로고
    • Dominant-negative mutations in dnabinding domain of stat3 cause hyper-ige syndrome
    • Minegishi Y, Saito M, Tsuchiya S, et al. Dominant-negative mutations in DNAbinding domain of STAT3 cause hyper-IgE syndrome. Nature 2007; 448:1058-1062.
    • (2007) Nature , vol.448 , pp. 1058-1062
    • Minegishi, Y.1    Saito, M.2    Tsuchiya, S.3
  • 26
    • 46049106939 scopus 로고    scopus 로고
    • Novel signal transducer and activator of transcription 3 (stat3) mutations, reduced th17 cells numbers, and variably defective stat3 phosphorylation in hyper-ige syndrome
    • Renner ED, Rylaarsdam S, Anover-Sombke S, et al. Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced TH17 cells numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol 2008; 122:181-187.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 181-187
    • Renner, E.D.1    Rylaarsdam, S.2    Anover-Sombke, S.3
  • 27
    • 0023917156 scopus 로고
    • Impaired antibody responses in the hyperimmunoglobulin e syndrome
    • Leung DY, Ambrosino DM, Arbeit RD, et al. Impaired antibody responses in the hyperimmunoglobulin E syndrome. J Allergy Clin Immunol 1988; 81: 1082-1087.
    • (1988) J Allergy Clin Immunol , vol.81 , pp. 1082-1087
    • Leung, D.Y.1    Ambrosino, D.M.2    Arbeit, R.D.3
  • 28
    • 0036732753 scopus 로고    scopus 로고
    • Dcs induce cd40-independent immunoglobulin class switching through blys and april
    • Litinskiy MB, Nardelli DM, Hilbert B, et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 2002; 3:822-829.
    • (2002) Nat Immunol , vol.3 , pp. 822-829
    • Litinskiy, M.B.1    Nardelli, D.M.2    Hilbert, B.3
  • 29
    • 47949102460 scopus 로고    scopus 로고
    • Viral double-stranded rna triggers ig class switching by activating upper respiratory mucosa b cells through an innate tlr3 pathway involving baff
    • Xu W, Santini PA, Matthews AJ, et al. Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF. J Immunol 2008; 181:276-287.
    • (2008) J Immunol , vol.181 , pp. 276-287
    • Xu, W.1    Santini, P.A.2    Matthews, A.J.3
  • 30
    • 33847273161 scopus 로고    scopus 로고
    • Unique maturation program of the ige response in vivo
    • Erazo A, Kutchukhidze N, Leung M, et al. Unique maturation program of the IgE response in vivo. Immunity 2007; 26:191-203.
    • (2007) Immunity , vol.26 , pp. 191-203
    • Erazo, A.1    Kutchukhidze, N.2    Leung, M.3
  • 31
    • 0033929090 scopus 로고    scopus 로고
    • An il13 coding region variant is associated with a high total serum ige level and atopic dermatitis in the german multicenter atopy study (mas-90)
    • Liu X, Nickel R, Beyer K, et al. An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German Multicenter Atopy Study (MAS-90). J Allergy Clin Immunol 2000; 106:167-170.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 167-170
    • Liu, X.1    Nickel, R.2    Beyer, K.3
  • 32
    • 84862909005 scopus 로고    scopus 로고
    • Immature b cells preferentially switch to ige with increased direct smu to sepsilon recombination
    • Wesemann DR, Magee JM, Boboila C, et al. Immature B cells preferentially switch to IgE with increased direct Smu to Sepsilon recombination. JEM 2011; 208:2733-2746.
    • (2011) JEM , vol.208 , pp. 2733-2746
    • Wesemann, D.R.1    Magee, J.M.2    Boboila, C.3
  • 33
    • 73949133111 scopus 로고    scopus 로고
    • Long-term clinical outcome of patients with severe combined immunodeficiency who received related donor bone marrow transplants without pretransplant chemotherapy or posttransplant gvhd prophylaxis
    • Railey MD, Lokhnygina Y, Buckley RH. Long-term clinical outcome of patients with severe combined immunodeficiency who received related donor bone marrow transplants without pretransplant chemotherapy or posttransplant GVHD prophylaxis. J Pediatr 2009; 155:834-840.
    • (2009) J Pediatr , vol.155 , pp. 834-840
    • Railey, M.D.1    Lokhnygina, Y.2    Buckley, R.H.3
  • 34
    • 79952698207 scopus 로고    scopus 로고
    • Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: Longterm outcomes
    • Buckley RH. Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: longterm outcomes. Immunol Res 2011; 49: 25-43.
    • (2011) Immunol Res , vol.49 , pp. 25-43
    • Buckley, R.H.1
  • 35
    • 37349017582 scopus 로고    scopus 로고
    • Cryptosporidium infection in patients with primary immunodeficiencies
    • Wolska-Kusnierz B, Bajer A, Caccio S, et al. Cryptosporidium infection in patients with primary immunodeficiencies. J Pediatr Gastroenterol Nutr 2007; 45:458-464.
    • (2007) J Pediatr Gastroenterol Nutr , vol.45 , pp. 458-464
    • Wolska-Kusnierz, B.1    Bajer, A.2    Caccio, S.3
  • 36
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by il-21 in the generation of inflammatory t cells
    • Nurieva R, Yang RO, Martinez G, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007; 448:480-483.
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, R.O.2    Martinez, G.3
  • 37
    • 77949813614 scopus 로고    scopus 로고
    • Role of b cells in common variable immune deficiency
    • Ahn S, Cunningham-Rundles C. Role of B cells in common variable immune deficiency. Expert Rev Clin Immunol 2009; 5:557-564.
    • (2009) Expert Rev Clin Immunol , vol.5 , pp. 557-564
    • Ahn, S.1    Cunningham-Rundles, C.2
  • 38
    • 48649085583 scopus 로고    scopus 로고
    • Common variable immunodeficiency: A new look at an old disease
    • Park M, Li J, Hagan J, et al. Common variable immunodeficiency: A new look at an old disease. Lancet 2008; 372:489-502.
    • (2008) Lancet , vol.372 , pp. 489-502
    • Park, M.1    Li, J.2    Hagan, J.3
  • 39
    • 36348946296 scopus 로고    scopus 로고
    • Common variable immunodeficiency in children
    • Glocker E, Ehl S, Grimbacher B. Common variable immunodeficiency in children. Curr Opin Pediatr 2007; 19:685-692.
    • (2007) Curr Opin Pediatr , vol.19 , pp. 685-692
    • Glocker, E.1    Ehl, S.2    Grimbacher, B.3
  • 40
    • 33646066801 scopus 로고    scopus 로고
    • Molecular basis of common variable immunodeficiency
    • Castigli E, Geha RS. Molecular basis of common variable immunodeficiency. J Allergy Clin Immunol 2006; 117:740-746.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 740-746
    • Castigli, E.1    Geha, R.S.2
  • 41
    • 0036493366 scopus 로고    scopus 로고
    • Severe deficiency of switched memory b cells (cd27( ;)igm(-)igd(-)) in subgroups of patients with common variable immunodeficiency: A new approach to classify a heterogeneous disease
    • Warnatz K, Denz A, Drager R, et al. Severe deficiency of switched memory B cells (CD27( ;)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: A new approach to classify a heterogeneous disease. Blood 2002; 99:1544-1551.
    • (2002) Blood , vol.99 , pp. 1544-1551
    • Warnatz, K.1    Denz, A.2    Drager, R.3
  • 42
    • 0042332029 scopus 로고    scopus 로고
    • Common variable immunodeficiency patient classification based on impaired b cell memory differentiation correlates with clinical aspects
    • Piqueras B, Lavenu-Bombled C, Galicier L, et al. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J Clin Immunol 2003; 23:385-400.
    • (2003) J Clin Immunol , vol.23 , pp. 385-400
    • Piqueras, B.1    Lavenu-Bombled, C.2    Galicier, L.3
  • 43
    • 41149164360 scopus 로고    scopus 로고
    • Screening of functional and positional candidate genes in families with common variable immunodeficiency
    • Salzer U, Neumann C, Thiel J, et al. Screening of functional and positional candidate genes in families with common variable immunodeficiency. BMC Immunol 2008; 9:3.
    • (2008) BMC Immunol , vol.9 , pp. 3
    • Salzer, U.1    Neumann, C.2    Thiel, J.3
  • 44
    • 84889888754 scopus 로고    scopus 로고
    • Impaired in vitro capacity to undergo iggisotype classswitching (ics) in response to interleukin-21 (il21) stimulation in common variable immunodeficiency (cvid)
    • Desjardins M,MazerBD.Impaired in vitro capacity to undergo IgGisotype classswitching (ICS) in response to interleukin-21 (IL21) stimulation in common variable immunodeficiency (CVID). J Allergy Clin Immunol 2013; 131:AB70.
    • (2013) J Allergy Clin Immunol , vol.131
    • Desjardins, M.1    Mazer, B.D.2
  • 45
    • 77249109584 scopus 로고    scopus 로고
    • Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective iga deficiency
    • Borte S, Pan-Hammarstrom Q, Liu C, et al. Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency. Blood 2009; 114:4089-4098.
    • (2009) Blood , vol.114 , pp. 4089-4098
    • Borte, S.1    Pan-Hammarstrom, Q.2    Liu, C.3
  • 46
    • 84861210702 scopus 로고    scopus 로고
    • Il-21 inhibits t cell il-2 production and impairs treg homeostasis
    • A descrition of the overlaing role between IL-2 and IL-21 in suorting conventional T-cell exansion but their distinct caacity to suort regulatory T cells homeostasis
    • Attridge K, Wang CJ, Wardzinski L, et al. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood 2012; 119:4656-4664. A description of the overlapping role between IL-2 and IL-21 in supporting conventional T-cell expansion, but their distinct capacity to support regulatory T cells homeostasis.
    • (2012) Blood , vol.119 , pp. 4656-4664
    • Attridge, K.1    Wang, C.J.2    Wardzinski, L.3
  • 47
    • 84865790795 scopus 로고    scopus 로고
    • Interleukin 21 correlates with t cell and b cell subset alterations in systemic lupus erythematosus
    • Terrier B, Costedoat-Chalumeau N, Garrido M, et al. Interleukin 21 correlates with T cell and B cell subset alterations in systemic lupus erythematosus. J Rheumatol 2012; 39:1819-1828.
    • (2012) J Rheumatol , vol.39 , pp. 1819-1828
    • Terrier, B.1    Costedoat-Chalumeau, N.2    Garrido, M.3
  • 48
    • 80052198125 scopus 로고    scopus 로고
    • Critical role of il-21 in modulating th17 and regulatory t cells in behçet disease
    • Geri G, Terrier B, Rosenzwajg M, et al. Critical role of IL-21 in modulating TH17 and regulatory T cells in Behçet disease. J Allergy Clin Immunol 2011; 128:655-664.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 655-664
    • Geri, G.1    Terrier, B.2    Rosenzwajg, M.3
  • 49
    • 84865637800 scopus 로고    scopus 로고
    • Association between interleukin 21 and graves' disease
    • Jia HY, Zhang ZG, Gu XJ, et al. Association between interleukin 21 and Graves' disease. Genet Mol Res 2011; 10:3338-3346.
    • (2011) Genet Mol Res , vol.10 , pp. 3338-3346
    • Jia, H.Y.1    Zhang, Z.G.2    Gu, X.J.3
  • 50
    • 84856790983 scopus 로고    scopus 로고
    • Generation and characterization of human antihuman il-21 neutralizing monoclonal antibodies
    • Maurer MF, Garrigues U, Jaspers SR, et al. Generation and characterization of human antihuman IL-21 neutralizing monoclonal antibodies. MABs 2012; 4:69-83.
    • (2012) MABs , vol.4 , pp. 69-83
    • Maurer, M.F.1    Garrigues, U.2    Jaspers, S.R.3
  • 51
    • 84857786741 scopus 로고    scopus 로고
    • A phase i trial of recombinant human il-21 in combination with cetuximab in patients with metastatic colorectal cancer
    • Steele N, Anthony A, Saunders M, et al. A phase I trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer. Br J Cancer 2012; 106:793-798.
    • (2012) Br J Cancer , vol.106 , pp. 793-798
    • Steele, N.1    Anthony, A.2    Saunders, M.3
  • 52
    • 84867524002 scopus 로고    scopus 로고
    • A phase i dose-finding trial of recombinant interleukin-21 and rituximab in relapsed and refractory low grade b-cell lymphoproliferative disorders
    • Timmerman JM, Byrd JC, Andorsky DJ, et al. A phase I dose-finding trial of recombinant interleukin-21 and rituximab in relapsed and refractory low grade B-cell lymphoproliferative disorders. Clin Cancer Res 2012; 18: 5752-5760.
    • (2012) Clin Cancer Res , vol.18 , pp. 5752-5760
    • Timmerman, J.M.1    Byrd, J.C.2    Andorsky, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.