B cells from common variable immunodeficiency patients fail to differentiate to antibody secreting cells in response to TLR9 ligand (CpG-ODN) or anti-CD40+IL21

Cellular Immunology

Volumn 268, Issue 1, 2011, Pages 9-15

  Clemente, Antonio ^a   Pons, Jaime ^a   Matamoros, Nuria ^a   Iglesias, Julio ^a   Ferrer, Joana M ^a  

^a HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

B lymphocytes; Common variable immunodeficiency; CpG ODN; IL21; TLRs

Indexed keywords

ANTIBODY; B LYMPHOCYTE RECEPTOR; CD40 ANTIBODY; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 21; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; HUMAN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADULT; AGED; ANTIBODIES; ANTIBODY-PRODUCING CELLS; B-LYMPHOCYTES; CD40 LIGAND; CELL DIFFERENTIATION; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; HUMANS; IMMUNOGLOBULINS; INTERLEUKINS; MALE; MIDDLE AGED; OLIGODEOXYRIBONUCLEOTIDES; TOLL-LIKE RECEPTOR 9;

EID: 79952487025     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.01.004     Document Type: Article

References (44)

1. Wood P., Stanworth S., Burton J., et al. Recognition, clinical diagnosis and management of patients with primary antibody deficiencies: a systematic review. Clin. Exp. Immunol. 2007, 149:410-423.
2. Cunningham-Rundles C., Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin. Immunol. 1999, 92:34-48.
3. Bacchelli C., Buckridge S., Thrasher A.J., Gaspar H.B. Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency. Clin. Exp. Immunol. 2007, 149:401-409.
4. Kuijpers T.W., Bende R.J., Baars P.A., et al. CD20 deficiency in humans results in impaired T cell-independent antibody responses. J. Clin. Invest. 2010, 120:214-222.
5. Van Zelm M.C., Smet J., Adams B., et al. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J. Clin. Invest. 2010, 120:1265-1274.
6. Iglesias J., Matamoros N., Raga S., Ferrer J.M., Mila J. CD95 expression and function on lymphocyte subpopulations in common variable immunodeficiency (CVID); related to increased apoptosis. Clin. Exp. Immunol. 1999, 117:138-146.
7. North M.E., Webster A.D., Farrant J. Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C. Clin. Exp. Immunol. 1991, 85:198-201.
8. Ferrer J.M., Iglesias J., Hernandez M., Matamoros N. Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients. Clin. Exp. Immunol. 1995, 102:286-289.
9. Rezaei N., Wing J.B., Aghamohammadi A., et al. B-cell-T-cell activation and interaction in common variable immunodeficiency. Hum. Immunol. 2010, 71:355-362.
10. Martinez-Pomar N., Raga S., Ferrer J.M., et al. Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-gamma gene. Clin. Exp. Immunol. 2006, 144:233-238.
11. Wehr C., Kivioja T., Schmitt C., et al. The EURO class trial: defining subgroups in common variable immunodeficiency. Blood 2008, 111:77-85.
12. Carsetti R., Rosado M.M., Donnanno S., et al. The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency. J. Allergy Clin. Immunol. 2005, 115:412-417.
13. Punnonen J., Kainulainen L., Ruuskanen O., Nikoskelainen J., Arvilommi H. IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency. Scand. J. Immunol. 1997, 45:203-212.
14. Zielen S., Bauscher P., Hofmann D., Meuer S.C. Interleukin 10 and immune restoration in common variable immunodeficiency. Lancet 1993, 342:750-751.
15. Eisenstein E.M., Chua K., Strober W. B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10. J. Immunol. 1994, 152:5957-5968.
16. Coffman R.L., Lebman D.A., Rothman P. Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 1993, 54:229-270.
17. Konforte D., Simard N., Paige C.J. IL-21: an executor of B cell fate. J. Immunol. 2009, 182:1781-1787.
18. Coffman R.L., Lebman D.A., Shrader B. Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Immunol. 2009, 182:8-13.
19. Poulsen L.K., Hummelshoj L. Triggers of IgE class switching and allergy development. Ann. Med. 2007, 39:440-456.
20. Ruprecht C.R., Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur. J. Immunol. 2006, 36:810-816.
21. Spolski R., Leonard W.J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 2008, 26:57-79.
22. Ettinger R., Sims G.P., Fairhurst A.M., et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J. Immunol. 2005, 175:7867-7879.
23. Tangye S.G., Avery D.T., Deenick E.K., Hodgkin P.D. Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J. Immunol. 2003, 170:686-694.
24. Ettinger R., Sims G.P., Robbins R., et al. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J. Immunol. 2007, 178:2872-2882.
25. Bryant V.L., Ma C.S., Avery D.T., et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J. Immunol. 2007, 179:8180-8190.
26. Borte S., Pan-Hammarstrom Q., Liu C., et al. Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency. Blood 2009, 114:4089-4098.
27. Perez-Andres M., Paiva B., Nieto W.G., et al. Human peripheral blood B-cell compartments: a crossroad in B-cell traffic. Cytometry part B. 2010, 78B(suppl. 1):S47-S60.
28. Snapper C.M., Mond J.J. Towards a comprehensive view of immunoglobulin class switching. Immunol. Today 1993, 14:15-17.
29. Jefferis R., Kumararatne D.S. Selective IgG subclass deficiency: quantification and clinical relevance. Clin. Exp. Immunol. 1990, 81:357-367.
30. Smith T.F. IgG subclasses. Adv. Pediatr. 1992, 39:101-126.
31. Hammarstrom L., Vorechovsky I., Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin. Exp. Immunol. 2000, 120:225-231.
32. Durandy A., Revy P., Imai K., Fischer A. Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects. Immunol. Rev. 2005, 203:67-79.
33. Di Renzo M., Pasqui A.L., Auteri A. Common variable immunodeficiency: a review. Clin. Exp. Med. 2004, 3:211-217.
34. Cunningham-Rundles C., Ponda P.P. Molecular defects in T- and B-cell primary immunodeficiency diseases. Nat. Rev. Immunol. 2005, 5:880-892.
35. Landers C.D., Bondada S. CpG oligodeoxynucleotides stimulate cord blood mononuclear cells to produce immunoglobulins. Clin. Immunol. 2005, 116:236-245.
36. Hanten J.A., Vasilakos J.P., Riter C.L., et al. Comparison of human B cell activation by TLR7 and TLR9 agonists. BMC Immunol. 2008, 9:39.
37. Huggins J., Pellegrin T., Felgar R.E., et al. CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells. Blood 2007, 109:1611-1619.
38. Rui L., Vinuesa C.G., Blasioli J., Goodnow C.C. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat. Immunol. 2003, 4:594-600.
39. Henn A.D., Rebhahn J., Brown M.A., et al. Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division. J. Immunol. 2009, 183:3177-3187.
40. Pozzi N., Gaetaniello L., Martire B., et al. Defective surface expression of attracting on T cells in patients with common variable immunodeficiency (CVID). Clin. Exp. Immunol. 2001, 123:99-104.
41. Giovannetti A., Pierdominici M., Mazzetta F., et al. Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. J. Immunol. 2007, 178:3932-3943.
42. Avery D.T., Bryant V.L., Ma C.S., de Waal M.R., Tangye S.G. IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4. J. Immunol. 2008, 181:1767-1779.
43. Escobar D., Pons J., Clemente A., et al. Defective B cell response to TLR9 ligand (CpG-ODN), Streptococcus pneumoniae and Haemophilus influenzae extracts in common variable immunodeficiency patients. Cell. Immunol. 2010, 262:105-111.
44. Yu J.E., Knight A.K., Radigan L., et al. Toll-like receptor 7 and 9 defects in common variable immunodeficiency. J. Allergy Clin. Immunol. 2009, 124:349-356.