메뉴 건너뛰기




Volumn 13, Issue 6, 2013, Pages 677-685

Biologic therapy for atopic asthma and beyond

Author keywords

Allergic pathway; Asthma; Biologics; MAbs

Indexed keywords

ALTRAKINCEPT; AMG 317; ANRUKINZUMAB; BENRALIZUMAB; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL PRODUCT; CORTICOSTEROID; DACLIZUMAB; DUPILUMAB; IMA 026; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; KELIXIMAB; LEBRIKIZUMAB; MEPOLIZUMAB; OMALIZUMAB; OXELUMAB; PASCOLIZUMAB; PITRAKINRA; PLACEBO; QAX 576; QGE 031; QUILIZUMAB; RESLIZUMAB; TRALOKINUMAB; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

EID: 84889883288     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0000000000000012     Document Type: Review
Times cited : (10)

References (70)
  • 1
    • 80052028124 scopus 로고    scopus 로고
    • Treatment of allergic asthma: Modulation of th2 cells and their responses
    • Bosnjak B, Stelzmueller B, Erb KJ, et al. Treatment of allergic asthma: modulation of Th2 cells and their responses. Respir Res 2011; 12:114.
    • (2011) Respir Res , vol.12 , pp. 114
    • Bosnjak, B.1    Stelzmueller, B.2    Erb, K.J.3
  • 2
    • 40049092917 scopus 로고    scopus 로고
    • Treatment strategies for allergy and asthma
    • Holgate ST, Polosa R. Treatment strategies for allergy and asthma. Nat Rev Immunol 2008; 8:218-230.
    • (2008) Nat Rev Immunol , vol.8 , pp. 218-230
    • Holgate, S.T.1    Polosa, R.2
  • 3
    • 79551505136 scopus 로고    scopus 로고
    • Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
    • Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011; 127:355-360.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 355-360
    • Lotvall, J.1    Akdis, C.A.2    Bacharier, L.B.3
  • 4
    • 70449649943 scopus 로고    scopus 로고
    • British thoracic society scottish intercollegiate guidelines network
    • BTS/SIGN British Guideline on Management of Asthma
    • British Thoracic Society Scottish Intercollegiate Guidelines network. BTS/SIGN British Guideline on Management of Asthma. Thorax 2008; 63 (Suppl 4):iv1-iv121.
    • (2008) Thorax , vol.63 , Issue.SUPPL. 4
  • 5
    • 0032480574 scopus 로고    scopus 로고
    • Randomised, dose-ranging, placebocontrolled study of chimeric antibody to cd4 (keliximab) in chronic severe asthma
    • Kon OM, Sihra BS, Compton CH, et al. Randomised, dose-ranging, placebocontrolled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet 1998; 352:1109-1113.
    • (1998) Lancet , vol.352 , pp. 1109-1113
    • Kon, O.M.1    Sihra, B.S.2    Compton, C.H.3
  • 6
    • 79960498901 scopus 로고    scopus 로고
    • Use of monoclonal antibodies in renal transplantation
    • van den Hoogen MW, Hilbrands LB. Use of monoclonal antibodies in renal transplantation. Immunotherapy 2011; 3:871-880.
    • (2011) Immunotherapy , vol.3 , pp. 871-880
    • Van Den Hoogen, M.W.1    Hilbrands, L.B.2
  • 7
    • 57349179165 scopus 로고    scopus 로고
    • Daclizumab asthma study group. Daclizumab improves asthma control in patients with moderate to severe persistent asthma: A randomized, controlled trial
    • Busse WW, Israel E, Nelson HS, et al., Daclizumab Asthma Study Group. Daclizumab improves asthma control in patients with moderate to severe persistent asthma: A randomized, controlled trial. Am J Respir Crit Care Med 2008; 178:1002-1008.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 1002-1008
    • Busse, W.W.1    Israel, E.2    Nelson, H.S.3
  • 8
    • 0033454115 scopus 로고    scopus 로고
    • Interleukin-4 receptor in moderate atopic asthma. A phase iii randomized placebo-controlled trial
    • Borish LC, Nelson HS, Lanz MJ, et al. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am J Respir Crit Care Med 1999; 160:1816-1823.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1816-1823
    • Borish, L.C.1    Nelson, H.S.2    Lanz, M.J.3
  • 9
    • 0034995872 scopus 로고    scopus 로고
    • Efficacy of soluble il-4 receptor for the treatment of adults with asthma
    • IL-4R Asthma Study Group
    • Borish LC, Nelson HS, Corren J, et al., IL-4R Asthma Study Group. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol 2001; 107:963-970.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 963-970
    • Borish, L.C.1    Nelson, H.S.2    Corren, J.3
  • 10
    • 84879401471 scopus 로고    scopus 로고
    • Dupilumab in persistent asthma with elevated eosinophil levels
    • Elegant work showing the efficacy of Dupilumab treatment in eosinophilic asthma
    • Wenzel S, Ford L, Pearlman D, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013; 368:2455-2466. Elegant work showing the efficacy of Dupilumab treatment in eosinophilic asthma.
    • (2013) N Engl J Med , vol.368 , pp. 2455-2466
    • Wenzel, S.1    Ford, L.2    Pearlman, D.3
  • 11
    • 0036379740 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of pascolizumab (sb240683): A humanized antiinterleukin-4 antibody with therapeutic potential in asthma
    • Hart TK, Blackburn MN, Brigham-Burke M, et al. Preclinical efficacy and safety of pascolizumab (SB240683): A humanized antiinterleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol 2002; 130:93-100.
    • (2002) Clin Exp Immunol , vol.130 , pp. 93-100
    • Hart, T.K.1    Blackburn, M.N.2    Brigham-Burke, M.3
  • 12
    • 79954583416 scopus 로고    scopus 로고
    • Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
    • Gauvreau GM, Boulet L-P, Cockcroft DW, et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med 2011; 183:1007-1014.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1007-1014
    • Gauvreau, G.M.1    Boulet, L.-P.2    Cockcroft, D.W.3
  • 13
    • 71749097206 scopus 로고    scopus 로고
    • Effects of anti-il-13 (novartis qax576) on inflammatory responses following nasal allergen challenge (nac)
    • Kariyawasam HH, Nicholson GC, Tan AJ, et al. Effects of anti-IL-13 (Novartis QAX576) on inflammatory responses following nasal allergen challenge (NAC). Am J Respir Crit Care Med 2009; 179:A3642.
    • (2009) Am J Respir Crit Care Med , vol.179
    • Kariyawasam, H.H.1    Nicholson, G.C.2    Tan, A.J.3
  • 14
    • 76749141384 scopus 로고    scopus 로고
    • A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human il-13 antibody (cat-354) in subjects with asthma
    • Singh D, Kane B, Molfino NA, et al. A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma. BMC Pulm Med 2010; 10:3.
    • (2010) BMC Pulm Med , vol.10 , pp. 3
    • Singh, D.1    Kane, B.2    Molfino, N.A.3
  • 15
    • 84859720060 scopus 로고    scopus 로고
    • Preclinical development of cat-354, an il-13-neutralising antibody, for the treatment of severe uncontrolled asthma
    • May R, Monk P, Cohen E, et al. Preclinical development of CAT-354, an IL-13-neutralising antibody, for the treatment of severe uncontrolled asthma. Br J Pharmacol 2012; 166:177-193.
    • (2012) Br J Pharmacol , vol.166 , pp. 177-193
    • May, R.1    Monk, P.2    Cohen, E.3
  • 16
    • 84873389433 scopus 로고    scopus 로고
    • A phase ii placebo-controlled study of tralokinumab in moderate-to-severe asthma
    • A large phase II placebo-controlled study on tralokinumab in asthma evidencing the clinical effectiveness of this biologic drug
    • Piper E, Brightling C, Niven R, et al. A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma. Eur Respir J 2013; 41:330-338. A large phase II placebo-controlled study on tralokinumab in asthma evidencing the clinical effectiveness of this biologic drug.
    • (2013) Eur Respir J , vol.41 , pp. 330-338
    • Piper, E.1    Brightling, C.2    Niven, R.3
  • 17
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365:1088-1098.
    • (2011) N Engl J Med , vol.365 , pp. 1088-1098
    • Corren, J.1    Lemanske, R.F.2    Hanania, N.A.3
  • 18
    • 79960415853 scopus 로고    scopus 로고
    • Il-13 antibodies influence il-13 clearance in humans by modulating scavenger activity of il-13ra2
    • Kasaian MT, Raible D, Marquette K, et al. IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Ra2. J Immunol 2011; 187:561-569.
    • (2011) J Immunol , vol.187 , pp. 561-569
    • Kasaian, M.T.1    Raible, D.2    Marquette, K.3
  • 19
    • 69549129344 scopus 로고    scopus 로고
    • Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma
    • Burmeister Getz E, Fisher DM, Fuller R. Human pharmacokinetics/ pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma. J Clin Pharmacol 2009; 49:1025-1036.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1025-1036
    • Burmeister Getz, E.1    Fisher, D.M.2    Fuller, R.3
  • 20
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
    • Wenzel S, Wilbraham D, Fuller R, et al. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007; 370:1422-1431.
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3
  • 21
    • 77953039047 scopus 로고    scopus 로고
    • A randomized, controlled, phase 2 study of amg 317, an il-4ralpha antagonist, in patients with asthma
    • Corren J, Busse W, Meltzer EO, et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med 2010; 181:788-796.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 788-796
    • Corren, J.1    Busse, W.2    Meltzer, E.O.3
  • 23
    • 64549087965 scopus 로고    scopus 로고
    • A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: A study by analytical ultracentrifugation
    • Demeule B, Shire SJ, Liu J, et al. A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: A study by analytical ultracentrifugation. Anal Biochem 2009; 388:279-287.
    • (2009) Anal Biochem , vol.388 , pp. 279-287
    • Demeule, B.1    Shire, S.J.2    Liu, J.3
  • 24
    • 4444332507 scopus 로고    scopus 로고
    • Omalizumab-induced reductions in mast cell fce psilon ri expression and function
    • Beck LA, Marcotte GV, MacGlashan D, et al.Omalizumab-induced reductions in mast cell Fce psilon RI expression and function. J Allergy Clin Immunol 2004; 114:527-530.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 527-530
    • Beck, L.A.1    Marcotte, G.V.2    MacGlashan, D.3
  • 25
    • 77950296391 scopus 로고    scopus 로고
    • Decreases in human dendritic cell-dependent t(h)2-like responses after acute in vivo ige neutralization
    • Schroeder JT, Bieneman AP, Chichester KL, et al. Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J Allergy Clin Immunol 2010; 125:896-901.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 896-901
    • Schroeder, J.T.1    Bieneman, A.P.2    Chichester, K.L.3
  • 26
    • 84889881955 scopus 로고    scopus 로고
    • [Accessed on June 2013]
    • EMA Xolair SmPC. http://www.ema.europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/human/000606/WC500057298.pdf [Accessed on June 2013]
    • EMA Xolair SmPC
  • 27
    • 84889885292 scopus 로고    scopus 로고
    • US Food and Drug Administration [Accessed on June 2013]
    • US Food and Drug Administration. Omalizumab (Xolair) prescribing information. http://www.fda.gov/Drugs/DrugSafety/ PostmarketDrugSafetyInformationforPatientsandProviders/ucm103291.htm [Accessed on June 2013]
    • Omalizumab (Xolair) Prescribing Information
  • 29
    • 78650324258 scopus 로고    scopus 로고
    • Omalizumab in the management of oral corticosteroid-dependent ige-mediated asthma patients
    • Domingo C, Moreno A, AmengualMJ, et al.Omalizumab in the management of oral corticosteroid-dependent IGE-mediated asthma patients. Curr Med Res Opin 2011; 27:45-53.
    • (2011) Curr Med Res Opin , vol.27 , pp. 45-53
    • Domingo, C.1    Moreno, A.2    Amengual, M.J.3
  • 30
    • 84871716411 scopus 로고    scopus 로고
    • Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    • A demonstration of effectiveness of omalizumab in nonallergic asthma oening new horizon to the molecular activity of this humanized Ab
    • Gevaert P, Calus L, Van Zele T, et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol 2013; 131:110-116. A demonstration of effectiveness of omalizumab in nonallergic asthma, opening new horizon to the molecular activity of this humanized Ab.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 110-116
    • Gevaert, P.1    Calus, L.2    Van Zele, T.3
  • 31
    • 34249799929 scopus 로고    scopus 로고
    • Predicting and evaluating response to omalizumab in patients with severe allergic asthma
    • Bousquet J, Rabe K, Humbert M, et al. Predicting and evaluating response to omalizumab in patients with severe allergic asthma. Respir Med 2007; 101:1483-1492.
    • (2007) Respir Med , vol.101 , pp. 1483-1492
    • Bousquet, J.1    Rabe, K.2    Humbert, M.3
  • 32
    • 58149119978 scopus 로고    scopus 로고
    • Omalizumab therapy: Patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis
    • Humbert M, Boulet LP, Niven RM, et al. Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis. Allergy 2009; 64:81-84.
    • (2009) Allergy , vol.64 , pp. 81-84
    • Humbert, M.1    Boulet, L.P.2    Niven, R.M.3
  • 33
    • 77950297895 scopus 로고    scopus 로고
    • Regulation of syk kinase and fcrbeta expression in human basophils during treatment with omalizumab
    • Zaidi AK, Saini SS, MacglashanDWJr. Regulation of Syk kinase and FcRbeta expression in human basophils during treatment with omalizumab. J Allergy Clin Immunol 2010; 125:902-908.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 902-908
    • Zaidi, A.K.1    Saini, S.S.2    Macglashan Jr., D.W.3
  • 34
    • 84866152237 scopus 로고    scopus 로고
    • Omalizumab in patients with severe asthma: The xclusive study
    • Schumann C, Kropf C, Wibmer T, et al. Omalizumab in patients with severe asthma: the XCLUSIVE study. Clin Respir J 2012; 6:215-227.
    • (2012) Clin Respir J , vol.6 , pp. 215-227
    • Schumann, C.1    Kropf, C.2    Wibmer, T.3
  • 35
    • 0141570710 scopus 로고    scopus 로고
    • Pharmacodynamics of omalizumab: Implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma
    • Hochhaus G, Brookman L, Fox H, et al. Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma. Curr Med Res Opinion 2003; 19:491-498.
    • (2003) Curr Med Res Opinion , vol.19 , pp. 491-498
    • Hochhaus, G.1    Brookman, L.2    Fox, H.3
  • 36
    • 77953195601 scopus 로고    scopus 로고
    • Antibodies specific for a segment of human membrane ige deplete ige-producing b cells in humanized mice
    • Brightbill HD, Jeet S, Lin Z, et al. Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. J Clin Invest 2010; 120:2218-2229.
    • (2010) J Clin Invest , vol.120 , pp. 2218-2229
    • Brightbill, H.D.1    Jeet, S.2    Lin, Z.3
  • 37
    • 84870640867 scopus 로고    scopus 로고
    • Effect of an anti-m1 prime monoclonal antibody, memp1972a, in a phase ii proof-of-activity allergen challenge study in patients with mild asthma
    • First roof of concet using a strategy aimed at inhibiting switched B cells
    • Gauvreau G, Boulet L-P, Cockcroft DW, et al. Effect of an anti-m1 prime monoclonal antibody, Memp1972a, in a phase II proof-of-activity allergen challenge study in patients with mild asthma. Am J Resp Crit Care Med 2012; 185:A6793. First proof of concept using a strategy aimed at inhibiting switched B cells.
    • (2012) Am J Resp Crit Care Med , vol.185
    • Gauvreau, G.1    Boulet, L.-P.2    Cockcroft, D.W.3
  • 38
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • Flood-Page P, Swenson C, Faiferman I, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007; 176:1062-1071.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3
  • 39
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as antiinterleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page PT, Menzies-Gow AN, Kay AB, et al. Eosinophil's role remains uncertain as antiinterleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003; 167:199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3
  • 40
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, Ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356:2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3
  • 41
    • 0037869321 scopus 로고    scopus 로고
    • Eosinophils and interleukin-5: The debate continues
    • Kay AB, Menzies-Gow A. Eosinophils and interleukin-5: the debate continues. Am J Respir Crit Care Med 2003; 167:1586-1587.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1586-1587
    • Kay, A.B.1    Menzies-Gow, A.2
  • 42
    • 0037393468 scopus 로고    scopus 로고
    • Anti-il-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    • Menzies-Gow AN, Flood-Page PT, Robinson DS, et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol 2003; 111:714-719.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 714-719
    • Menzies-Gow, A.N.1    Flood-Page, P.T.2    Robinson, D.S.3
  • 43
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisonedependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisonedependent asthma with sputum eosinophilia. N Engl J Med 2009; 360:985-993.
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 44
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973-984.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 45
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (dream): A multicentre, double-blind, placebo-controlled trial
    • The first large confirmatory study of mepolizumab in eosinophilic asthma
    • Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380:651-659. The first large confirmatory study of mepolizumab in eosinophilic asthma.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3
  • 46
    • 80055080497 scopus 로고    scopus 로고
    • Mepolizumab, a humanized anti-il-5 mab, as a treatment option for severe nasal polyposis
    • Gevaert P, Van Bruaene N, Cattaert T, et al. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol 2011; 128:989-995.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 989-995
    • Gevaert, P.1    Van Bruaene, N.2    Cattaert, T.3
  • 47
    • 0038643527 scopus 로고    scopus 로고
    • Effect of sch55700, a humanized antihuman interleukin-5 antibody, in severe persistent asthma: A pilot study
    • Kips JC, O'Connor BJ, Langley SJ, et al. Effect of SCH55700, a humanized antihuman interleukin-5 antibody, in severe persistent asthma: A pilot study. Am J Respir Crit Care Med 2003; 167:1655-1659.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1655-1659
    • Kips, J.C.1    O'Connor, B.J.2    Langley, S.J.3
  • 48
    • 81455155725 scopus 로고    scopus 로고
    • Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo controlled study
    • Castro M, Mathur S, Hargreave F, et al. Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo controlled study. Am J Respir Crit Care Med 2011; 184:1125-1132.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3
  • 49
    • 33750508779 scopus 로고    scopus 로고
    • Nasal il-5 levels determine the response to anti-il-5 treatment in patients with nasal polyps
    • Gevaert P, Lang-Loidolt D, Lackner A, et al. Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol 2006; 118:1133-1141.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 1133-1141
    • Gevaert, P.1    Lang-Loidolt, D.2    Lackner, A.3
  • 50
    • 77952733788 scopus 로고    scopus 로고
    • Medi-563, a humanized anti-il-5 receptor alpha mab with enhanced antibody-dependent cell-mediated cytotoxicity function
    • Kolbeck R, Kozhich A, Koike M, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol 2010; 125:1344-1353.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1344-1353
    • Kolbeck, R.1    Kozhich, A.2    Koike, M.3
  • 51
    • 77952683218 scopus 로고    scopus 로고
    • Safety profile, pharmacokinetics, and biologic activity of medi-563, an anti-il-5 receptor alpha antibody, in a phase i study of subjects with mild asthma
    • Busse WW, Katial R, Gossage D, et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol 2010; 125:1237-1244.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1237-1244
    • Busse, W.W.1    Katial, R.2    Gossage, D.3
  • 52
    • 84870645524 scopus 로고    scopus 로고
    • Reduction in the number and severity of exacerbations following acute severe asthma: Results of a placebocontrolled, randomized clinical trial with benralizumab
    • Molfino NA, Novak R, Silverman RA, et al. Reduction in the number and severity of exacerbations following acute severe asthma: results of a placebocontrolled, randomized clinical trial with benralizumab. Am J Respir Crit Care Med 2012; 185:A2753.
    • (2012) Am J Respir Crit Care Med , vol.185
    • Molfino, N.A.1    Novak, R.2    Silverman, R.A.3
  • 53
    • 30744466671 scopus 로고    scopus 로고
    • The role of t lymphocytes in asthma
    • Kay AB. The role of T lymphocytes in asthma. Chem Immunol Allergy 2006; 91:59-75.
    • (2006) Chem Immunol Allergy , vol.91 , pp. 59-75
    • Kay, A.B.1
  • 54
    • 14744294833 scopus 로고    scopus 로고
    • Costimulation: Critical pathways in the immunologic regulation of asthma
    • Bellou A, Finn PW. Costimulation: critical pathways in the immunologic regulation of asthma. Curr Allergy Asthma Rep 2005; 5:149-154.
    • (2005) Curr Allergy Asthma Rep , vol.5 , pp. 149-154
    • Bellou, A.1    Finn, P.W.2
  • 55
    • 77649198441 scopus 로고    scopus 로고
    • Investigational therapeutics targeting the il-4/il-13/stat-6 pathway for the treatment of asthma
    • Oh CK, Geba GP, Molfino N. Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur Respir Rev 2010; 19:46-54.
    • (2010) Eur Respir Rev , vol.19 , pp. 46-54
    • Oh, C.K.1    Geba, G.P.2    Molfino, N.3
  • 56
    • 80051707109 scopus 로고    scopus 로고
    • Allergic inflammation: Role of cytokines with special emphasis on il-4
    • Saggini A, Maccauro G, Tripodi D, et al. Allergic inflammation: role of cytokines with special emphasis on IL-4. Int J Immunopathol Pharmacol 2011; 24:305-311.
    • (2011) Int J Immunopathol Pharmacol , vol.24 , pp. 305-311
    • Saggini, A.1    Maccauro, G.2    Tripodi, D.3
  • 57
    • 0032881604 scopus 로고    scopus 로고
    • Differential responses of human monocytes and macrophages to il-4 and il-13
    • Hart P, Bonder C, Balogh J, et al. Differential responses of human monocytes and macrophages to IL-4 and IL-13. J Leukoc Biol 1999; 66:575-578.
    • (1999) J Leukoc Biol , vol.66 , pp. 575-578
    • Hart, P.1    Bonder, C.2    Balogh, J.3
  • 58
    • 0037393323 scopus 로고    scopus 로고
    • Il-13 receptors and signaling pathways: An evolving web
    • Hershey GK. IL-13 receptors and signaling pathways: An evolving web. J Allergy Clin Immunol 2003; 111:677-690.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 677-690
    • Hershey, G.K.1
  • 59
    • 40049101678 scopus 로고    scopus 로고
    • Ige in allergy and asthma today
    • Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol 2008; 8:205-217.
    • (2008) Nat Rev Immunol , vol.8 , pp. 205-217
    • Gould, H.J.1    Sutton, B.J.2
  • 60
    • 82955233553 scopus 로고    scopus 로고
    • The role of mast cells in allergic inflammation
    • Amin K. The role of mast cells in allergic inflammation. Respir Med 2012; 106:9-14.
    • (2012) Respir Med , vol.106 , pp. 9-14
    • Amin, K.1
  • 61
    • 38149126990 scopus 로고    scopus 로고
    • Staphylococcus aureus enterotoxin b, protein a, and lipoteichoic acid stimulations in nasal polyps
    • Patou J, Gevaert P, Van Zele T, et al. Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps. J Allergy Clin Immunol 2008; 121:110-115.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 110-115
    • Patou, J.1    Gevaert, P.2    Van Zele, T.3
  • 62
    • 69949123296 scopus 로고    scopus 로고
    • Off-label use of omalizumab in nonasthma conditions: New opportunities
    • Morjaria JB, Polosa R. Off-label use of omalizumab in nonasthma conditions: new opportunities. Expert Rev Resp Med 2009; 3:299-308.
    • (2009) Expert Rev Resp Med , vol.3 , pp. 299-308
    • Morjaria, J.B.1    Polosa, R.2
  • 64
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160:1001-1008.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3
  • 65
    • 85047693849 scopus 로고    scopus 로고
    • Anti-il-5 treatment reduces deposition of ecm proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    • Flood-Page P, Menzies-Gow A, Phipps S, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003; 112:1029-1036.
    • (2003) J Clin Invest , vol.112 , pp. 1029-1036
    • Flood-Page, P.1    Menzies-Gow, A.2    Phipps, S.3
  • 66
    • 3042714189 scopus 로고    scopus 로고
    • Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice
    • Tanaka H, Komai M, Nagao K, et al. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol 2004; 31:62-68.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 62-68
    • Tanaka, H.1    Komai, M.2    Nagao, K.3
  • 67
    • 84860010929 scopus 로고    scopus 로고
    • Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor
    • A comprehensive review of the rationale of targeting IL-5
    • Molfino NA, Gossage D, Kolbeck R, et al. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin Exp Allergy 2012; 42:712-737. A comprehensive review of the rationale of targeting IL-5.
    • (2012) Clin Exp Allergy , vol.42 , pp. 712-737
    • Molfino, N.A.1    Gossage, D.2    Kolbeck, R.3
  • 68
    • 0030969430 scopus 로고    scopus 로고
    • Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization
    • Hamelmann E, Oshiba A, Loader J, et al. Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. Am J Respir Crit Care Med 1997; 155:819-825.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 819-825
    • Hamelmann, E.1    Oshiba, A.2    Loader, J.3
  • 69
    • 0029371991 scopus 로고
    • Involvement of il-5 in a murine model of allergic pulmonary inflammation: Prophylactic and therapeutic effect of an anti-il-5 antibody
    • Kung TT, Stelts DM, Zurcher JA, et al. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody. Am J Respir Cell Mol Biol 1995; 13:360-365.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 360-365
    • Kung, T.T.1    Stelts, D.M.2    Zurcher, J.A.3
  • 70
    • 0000965148 scopus 로고    scopus 로고
    • Trfk-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma
    • Mathur M, Herrmann K, Li X, et al. TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma. Am J Respir Crit Care Med 1999; 159:580-587.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 580-587
    • Mathur, M.1    Herrmann, K.2    Li, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.