Cytochrome P450-mediated metabolic alterations in preeclampsia evaluated by quantitative steroid signatures

Journal of Steroid Biochemistry and Molecular Biology

Volumn 139, Issue , 2014, Pages 182-191

  Moon, Ju Yeon ^a,b   Moon, Myeong Hee ^b   Kim, Ki Tae ^c   Jeong, Dae Hoon ^c   Kim, Young Nam ^c   Chung, Bong Chul ^a   Choi, Man Ho ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Yonsei University   (South Korea)

^c Inje University   (South Korea)

Author keywords

Cytochrome P450; GC MS; Preeclampsia; Steroid oxidation; Steroid signatures

Indexed keywords

26 HYDROXYCHOLESTEROL; ANDROGEN; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CORTICOSTEROID; CYTOCHROME P450; CYTOCHROME P450 3A4; CYTOCHROME P450 46A1; OXYSTEROL; STEROID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HUMAN; HYDROXYLATION; MATERNAL HYPERTENSION; OXIDATION; PREECLAMPSIA; PREGNANT WOMAN; STEREOCHEMISTRY; STEROID METABOLISM;

CYTOCHROME P450; GC-MS; PREECLAMPSIA; STEROID OXIDATION; STEROID SIGNATURES;

ADULT; CALIBRATION; CASE-CONTROL STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GONADAL STEROID HORMONES; HUMANS; HYDROXYSTEROIDS; PRE-ECLAMPSIA; PREGNANCY; REFERENCE STANDARDS; YOUNG ADULT;

EID: 84889882462     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.02.014     Document Type: Article

References (36)

1. E.A. Steegers, P. von Dadelszen, J.J. Duvekot, and R. Pijnenborg Pre-eclampsia Lancet 376 2010 631 644
2. D.W. Nebert, and D.W. Russell Clinical importance of the cytochromes P450 Lancet 360 2002 1155 1162 (Pubitemid 35246494)
3. A.H. Payne, and D.B. Hales Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones Endocrine Reviews 25 2004 947 970 (Pubitemid 39657774)
4. Y.Y. Zhang, and L. Yang Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications Expert Opinion on Drug Metabolism and Toxicology 5 2009 621 629
5. I.A. Pikuleva Cholesterol-metabolizing cytochromes P450 Drug Metabolism and Disposition 34 2006 513 520
6. K.K. Miller, J. Cai, S.L. Ripp Jr., W.M. Pierce, T.H. Rushmore, and R.A. Prough Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450 Drug Metabolism and Disposition 32 2004 305 313 (Pubitemid 38263888)
7. C.C. Peng, I. Templeton, K.E. Thummel, C. Davis, K.L. Kunze, and N. Isoherranen Evaluation of 6 beta-hydroxycortisol, 6 beta-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo Clinical Pharmacology and Therapeutics 89 2011 888 895
8. A.K. Goodenough, J.M. Onorato, Z. Ouyang, S. Chang, A.D. Rodrigues, S. Kasichayanula, S. Huang, W. Turley, R. Burrell, M. Bifano, M. Jemal, F. LaCreta, A. Tymiak, and D. Wang-Iverson Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis Chemical Research in Toxicology 24 2011 1575 1585
9. D.W. Nebert, and T.P. Dalton The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis Nature Reviews Cancer 6 2006 947 960 (Pubitemid 44862679)
10. T. Wong, C.H. Shackleton, T.R. Covey, and G. Ellis Identification of the steroids in neonatal plasma that interfere with 17a-hydroxyprogesterone radioimmunoassays Clinical Chemistry 38 1992 1830 1837
11. A.W. Hsing, F.Z. Stanczyk, A. Bélanger, P. Schroeder, L. Chang, R.T. Falk, and T.R. Fears Reproducibility of serum sex steroid assays in men by RIA and mass spectrometry Cancer Epidemiology Biomarkers and Prevention 16 2007 1004 1008 (Pubitemid 46910104)
12. O.J. Semmes Defining the role of mass spectrometry in cancer diagnostics Cancer Epidemiology Biomarkers and Prevention 13 2004 1555 1557 (Pubitemid 39331874)
13. W.J. Griffiths, T. Koal, Y. Wang, M. Kohl, D.P. Enot, and H.P. Deigner Targeted metabolomics for biomarker discovery Angewandte Chemie-International Edition 49 2010 5426 5445
14. N.B. Krone, A. Hughes, G.G. Lavery, P.M. Stewart, W. Arlt, and C.H. Shackleton Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS) Journal of Steroid Biochemistry and Molecular Biology 121 2010 496 504
15. J.-Y. Moon, H.-J. Jung, M.H. Moon, B.C. Chung, and M.H. Choi Heat-map visualization of gas chromatography-mass spectrometry based quantitative signatures on steroid metabolism Journal of the American Society for Mass Spectrometry 20 2009 1626 1637
16. Y.W. Ha, J.-Y. Moon, H.-J. Jung, B.C. Chung, and M.H. Choi Evaluation of plasma enzyme activities using gas chromatography-mass spectrometry based steroid signatures Journal of Chromatography B 877 2009 4125 4132
17. J.-Y. Moon, K.J. Kim, M.H. Moon, B.C. Chung, and M.H. Choi A novel GC-MS method in urinary estrogen analysis from postmenopausal women with osteoporosis Journal of Lipid Research 52 2011 1595 1603
18. N.C. Van de Merbel Quantitative determination of endogenous compounds in biological samples using chromatographic techniques Trends in Analytical Chemistry 27 2008 924 933
19. R. Tamimi, P. Lagiou, L.J. Vatten, L. Mucci, D. Trichopoulos, S. Hellerstein, A. Ekbom, H.O. Adami, and C.C. Hsieh Pregnancy hormones, pre-eclampsia, and implications for breast cancer risk in the offspring Cancer Epidemiology Biomarkers and Prevention 12 2003 647 650 (Pubitemid 36899846)
20. S.W. Walsh Progesterone and estradiol production by normal and preeclamptic placentas Obstetrics and Gynecology 71 1988 222 226 (Pubitemid 18053484)
21. S.W. Walsh, and S. Coulter Increased placental progesterone may cause decreased placental prostacyclin production in preeclampsia American Journal of Obstetrics and Gynecology 161 1989 1586 1592 (Pubitemid 20024037)
22. S.W. Walsh Eicosanoids in preeclampsia Prostaglandins Leukotrienes and Essential Fatty Acids 70 2004 223 232 (Pubitemid 38141908)
23. M.T. Acromite, C.S. Mantzoros, R.E. Leach, J. Hurwitz, and L.G. Dorey Androgens in preeclampsia American Journal of Obstetrics and Gynecology 180 1999 60 63 (Pubitemid 29088390)
24. R. Troisi, N. Potischman, J.M. Roberts, R. Ness, W. Crombleholme, D. Lykins, P. Siiteri, and R.N. Hoover Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies International Journal of Epidemiology 32 2003 455 460 (Pubitemid 36764107)
25. N.R. Miller, D. Garry, H.W. Cohen, and R. Figueroa Serum androgen markers in preeclampsia Journal of Reproductive Medicine 48 2003 225 229 (Pubitemid 36514621)
26. R. Troisi, N. Potischman, C.N. Johnson, J.M. Roberts, D. Lykins, G. Harger, N. Markovic, P. Siiteri, and R.N. Hoover Estrogen and androgen concentrations are not lower in the umbilical cord serum of pre-eclamptic pregnancies Cancer Epidemiology Biomarkers and Prevention 12 2003 1268 1270 (Pubitemid 37499456)
27. A. Hertig, P. Liere, N. Chabbert-Buffet, J. Fort, A. Pianos, B. Eychenne, A. Cambourg, M. Schumacher, N. Berkane, G. Lefevre, S. Uzan, E. Rondeau, P. Rozenberg, and M.E. Rafestin-Oblin Steroid profiling in preeclamptic women: evidence for aromatase deficiency American Journal of Obstetrics and Gynecology 203 477 2010 e1 e9
28. J.T. Ho, J.G. Lewis, P. O'Loughlin, C.J. Bagley, R. Romero, G.A. Dekker, and D.J. Torpy Reduced maternal corticosteroid-binding globulin and cortisol levels in pre-eclampsia and gamete recipient pregnancies Clinical Endocrinology (Oxf) 66 2007 869 877 (Pubitemid 47028417)
29. S.P. Salas, G. Marshall, B.L. Gutiérrez, and P. Rosso Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction Hypertension 47 2006 203 208 (Pubitemid 43189764)
30. J.T. Murai, E. Muzykanskiy, and R.N. Taylor Maternal and fetal modulators of lipid metabolism correlate with the development of preeclampsia Metabolism: Clinical and Experimental 46 1997 963 967 (Pubitemid 27339925)
31. A.G. Frantz, F.H. Katz, and J. W Jailer, 6 beta-hydroxy-cortisol: high levels in human urine in pregnancy and toxemia Proceedings of the Society for Experimental Biology and Medicine 105 1960 41 43
32. C.O. Watlington, L.B. Kramer, E.G. Schuetz, J. Zilai, W.M. Grogan, P. Guzelian, F. Gizek, and A.C. Schoolwerth Corticosterone 6 beta-hydroxylation correlates with blood pressure in spontaneously hypertensive rats American Journal of Physiology 262 1992 F927 F931
33. I.L. Aye, B.J. Waddell, P.J. Mark, and J.A. Keelan Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors Placenta 32 2011 183 191
34. I.L. Aye, B.J. Waddell, P.L. Mark, and J.A. Keelan Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-?B Molecular Human Reproduction 18 2012 341 353
35. P. Bodzek, B. Janoszka, T. Wielkoszynski, D. Bodzek, and A. Sieron Concentration of chosen oxycholesterols in plasma of pregnant women with pregnancy-induced hypertension Biomedical Chromatography 16 2002 13 18 (Pubitemid 34121389)
36. H.N. Hodis, S. Hashimoto, W.J. Mack, and A. Sevanian Probucol reduces oxysterol formation in hypertensive rabbits Hypertention 36 2000 436 441