Evaluation of 6Β-hydroxycortisol, 6β-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo

Clinical Pharmacology and Therapeutics

Volumn 89, Issue 6, 2011, Pages 888-895

  Peng, C C ^a   Templeton, I ^a   Thummel, K E ^a   Davis, C ^b   Kunze, K L ^a   Isoherranen, N ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6BETA HYDROXYHYDROCORTISOL; 6BETA HYDROXYHYDROCORTISONE; CYTOCHROME P450 3A4; HYDROCORTISONE; ITRACONAZOLE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CATALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HUMAN; HYDROXYLATION; IC 50; IN VIVO STUDY; LIVER MICROSOME; MALE; METABOLITE; PRIORITY JOURNAL; SINGLE DRUG DOSE;

CORTISONE; CYTOCHROME P-450 CYP3A; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; HUMANS; HYDROCORTISONE; ITRACONAZOLE; MICROSOMES, LIVER; MOLECULAR PROBES; REPRODUCIBILITY OF RESULTS;

EID: 79956321178     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.53     Document Type: Article

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