Steroid profiling in preeclamptic women: Evidence for aromatase deficiency

American Journal of Obstetrics and Gynecology

Volumn 203, Issue 5, 2010, Pages 477.e1-477.e9

  Hertig, Alexandre ^a,b   Liere, Philippe ^c   Chabbert Buffet, Nathalie ^a,b   Fort, Julie ^e   Pianos, Antoine ^c   Eychenne, Bernard ^c   Cambourg, Annie ^c   Schumacher, Michael ^c   Berkane, Nadia ^a   Lefevre, Guillaume ^a   Uzan, Serge ^a,b   Rondeau, Eric ^a,b   Rozenberg, Patrick ^e   Rafestin Oblin, Marie Edith ^d  

^a HÔPITAL TENON   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c Universite Paris Sud   (France)

^d CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^e CENTRE HOSPITALIER INTERCOMMUNAL   (France)

Author keywords

2 methoxyoestradiol; aromatase; estradiol; preeclampsia

Indexed keywords

2 METHOXYESTRADIOL; AROMATASE; BETAMETHASONE; ESTRADIOL; ESTRONE; GLUCOCORTICOID; STEROID; STEROID HORMONE;

ADULT; ARTICLE; BLOOD SALVAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ESTRONE BLOOD LEVEL; FEMALE; FETUS DISEASE; HELLP SYNDROME; HUMAN; MASS FRAGMENTOGRAPHY; PLACENTA; PREECLAMPSIA; PREGNANCY OUTCOME; PREGNANT WOMAN; PRIORITY JOURNAL; STEROID BLOOD LEVEL;

EID: 78149281128     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2010.06.011     Document Type: Article

References (43)

1. B. Sibai, G. Dekker, and M. Kupferminc Pre-eclampsia Lancet 365 2005 785 799
2. A. Hertig, S. Watnick, H. Strevens, H. Boulanger, N. Berkane, and E. Rondeau How should women with pre-eclampsia be followed up? New insights from mechanistic studies Nat Clin Pract Nephrol 4 2008 503 509
3. S.E. Maynard, J.Y. Min, and J. Merchan Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia J Clin Invest 111 2003 649 658
4. A. Luttun, and P. Carmeliet Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered? J Clin Invest 111 2003 600 602
5. K. Kanasaki, and R. Kalluri The biology of preeclampsia Kidney Int 76 2009 831 837
6. E.R. Barnea, N.J. MacLusky, A.H. DeCherney, and F. Naftolin Catechol-o-methyl transferase activity in the human term placenta Am J Perinatol 5 1988 121 127
7. K. Kanasaki, K. Palmsten, and H. Sugimoto Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia Nature 453 2008 1117 1121
8. R.J. D'Amato, C.M. Lin, E. Flynn, J. Folkman, and E. Hamel 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site Proc Natl Acad Sci U S A 91 1994 3964 3968
9. T. Fotsis, Y. Zhang, and M.S. Pepper The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth Nature 368 1994 237 239
10. S.B. Lee, A.P. Wong, and K. Kanasaki Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions Am J Pathol 176 2010 710 720
11. P. Liere, Y. Akwa, and S. Weill-Engerer Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatography-mass spectrometry J Chromatogr B Biomed Sci Appl 739 2000 301 312
12. D. Meffre, A. Pianos, and P. Liere Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry Endocrinology 148 2007 2505 2517
13. Hertig A, Fort J, Lefevre G, et al. Soluble endoglin in preeclamptic women with or without HELLP syndrome. Am J Obstet Gynecol (in press).
14. J.N. Martin Jr, C.H. Rose, and C.M. Briery Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child Am J Obstet Gynecol 195 2006 914 934
15. A. Hertig, N. Berkane, and G. Lefevre Maternal serum sFlt1 concentration is an early and reliable predictive marker of preeclampsia Clin Chem 50 2004 1702 1703
16. A. Hertig, G. Lefevre, and K. Toumi Soluble endoglin levels during normotensive and hypertensive pregnancies Eur J Obstet Gynecol Reprod Biol 140 2008 138 140
17. F. Xue, and K.B. Michels Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence Lancet Oncol 8 2007 1088 1100
18. R. Troisi, N. Potischman, and J.M. Roberts Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies Int J Epidemiol 32 2003 455 460 (Pubitemid 36764107)
19. T. Ranta, U.H. Stenman, H.A. Unnerus, J. Rossi, and M. Seppala Maternal plasma prolactin levels in preeclampsia Obstet Gynecol 55 1980 428 430
20. S.P. Salas, G. Marshall, B.L. Gutierrez, and P. Rosso Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction Hypertension 47 2006 203 208
21. U. Rosing, and K. Carlstrom Serum levels of unconjugated and total oestrogens and dehydroepiandrosterone, progesterone and urinary oestriol excretion in pre-eclampsia Gynecol Obstet Invest 18 1984 199 205
22. B.C. Obiekwe, D. Sturdee, B.L. Cockrill, and T. Chard Human placental lactogen in pre-eclampsia BJOG 91 1984 1077 1080
23. J.T. Murai, E. Muzykanskiy, and R.N. Taylor Maternal and fetal modulators of lipid metabolism correlate with the development of preeclampsia Metabolism 46 1997 963 967
24. M.E. Hhnel, J.D. Martin, C.A. Michael, and R. Hhnel Metabolism of androstenedione by placental microsomes in pregnancy hypertension Clin Chim Acta 181 1989 103 108
25. L. Kragie Aromatase in primate pregnancy: a review Endocr Res 28 2002 121 128
26. E.R. Simpson, M.D. Michael, V.R. Agarwal, M.M. Hinshelwood, S.E. Bulun, and Y. Zhao Cytochromes P450 11: expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage Faseb J 11 1997 29 36
27. S.J. Zhu, Y. Li, and H. Li Retinoic acids promote the action of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17beta-estradiol in placental cells J Endocrinol 172 2002 31 43
28. L. Diaz, N. Noyola-Martinez, and D. Barrera Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts J Reprod Immunol 81 2009 17 24
29. R. Milczarek, E. Sokolowska, A. Hallmann, K. Kaletha, and J. Klimek NADPH- and iron-dependent lipid peroxidation inhibit aromatase activity in human placental microsomes J Steroid Biochem Mol Biol 110 2008 230 235
30. C. Zhang, M.A. Williams, and S.E. Sanchez Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women Am J Epidemiol 153 2001 572 580 (Pubitemid 32221712)
31. M.A. Williams, G.B. Woelk, I.B. King, L. Jenkins, and K. Mahomed Plasma carotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean women Am J Hypertens 16 2003 665 672
32. M. Cackovic, C.S. Buhimschi, and G. Zhao Fractional excretion of tumor necrosis factor-alpha in women with severe preeclampsia Obstet Gynecol 112 2008 93 100
33. G. Kaur, S. Mishra, A. Sehgal, and R. Prasad Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia Mol Cell Biochem 313 2008 37 44
34. B. Jiang, A. Kamat, and C.R. Mendelson Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture: potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian achaete-scute homologous protein-2) Mol Endocrinol 14 2000 1661 1673
35. T.Y. Aw, D.P. Jones, D.J. O'Shannessy, J.H. Priest, and R.E. Priest Oxygen dependence of oestrogen production by human placental microsomes and cultured choriocarcinoma cells J Steroid Biochem 22 1985 753 758
36. S. Zamudio, K.K. Leslie, M. White, D.D. Hagerman, and L.G. Moore Low serum estradiol and high serum progesterone concentrations characterize hypertensive pregnancies at high altitude J Soc Gynecol Investig 1 1994 197 205
37. E.D. Albrecht, G.W. Aberdeen, and G.J. Pepe The role of estrogen in the maintenance of primate pregnancy Am J Obstet Gynecol 182 2000 432 438
38. E. Svedas, H. Nisell, M.J. Vanwijk, Y. Nikas, and K.R. Kublickiene Endothelial dysfunction in uterine circulation in preeclampsia: can estrogens improve it? Am J Obstet Gynecol 187 2002 1608 1616
39. M.L. Johnson, A.T. Grazul-Bilska, D.A. Redmer, and L.P. Reynolds Effects of estradiol-17beta on expression of mRNA for seven angiogenic factors and their receptors in the endometrium of ovariectomized (OVX) ewes Endocrine 30 2006 333 342
40. J.T. Ho, J.G. Lewis, and P. O'Loughlin Reduced maternal corticosteroid-binding globulin and cortisol levels in pre-eclampsia and gamete recipient pregnancies Clin Endocrinol (Oxf) 66 2007 869 877
41. X.Y. Wang, Q. Xiong, and C. Wang Study of estradiol on treatment of preeclampsia in rat model [in Chinese] Zhonghua Fu Chan Ke Za Zhi 40 2005 739 742
42. N.Z. Djordjevic, G.M. Babic, S.D. Markovic, B.I. Ognjanovic, A.S. Stajn, and Z.S. Saicic The antioxidative effect of estradiol therapy on erythrocytes in women with preeclampsia Reprod Toxicol 29 2010 231 236
43. M.R. Reyes, A. Sifuentes-Alvarez, and B. Lazalde Estrogens are potentially the only steroids with an antioxidant role in pregnancy: in vitro evidence Acta Obstet Gynecol Scand 85 2006 1090 1093