Anti-diabetic effect of a combination of andrographolide-enriched extract of andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats

Indian Journal of Experimental Biology

Volumn 51, Issue 12, 2013, Pages 1101-1108

  Nugroho, Agung Endro ^a   Lindawati, Novena Yety ^a   Herlyanti, Kyky ^a   Widyastuti, Lina ^a   Pramono, Suwidjiyo ^a  

^a GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

Andrographis paniculata; Centella asiatica; Diabetes mellitus; High fructose fat diet; Hyperlipidemia

Indexed keywords

ANDROGRAPHOLIDE; ANTIDIABETIC AGENT; ASIATICOSIDE; DITERPENE; FRUCTOSE; HMPL 004; HMPL-004; PLANT EXTRACT; TRITERPENE;

ANIMAL; ARTICLE; CENTELLA; CHEMISTRY; DRUG COMBINATION; DRUG POTENTIATION; EXPERIMENTAL DIABETES MELLITUS; HUMAN; LIPID DIET; PATHOLOGY; PHYTOTHERAPY; RAT;

ANIMALS; CENTELLA; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; DITERPENES; DRUG COMBINATIONS; DRUG SYNERGISM; FRUCTOSE; HUMANS; HYPOGLYCEMIC AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; TRITERPENES;

EID: 84889852983     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Triplitt CL, Reasner CA & Isley WL, Diabetes mellitus, in Pharmacotherapy, A pathofisiologic approach, edited by JT. Dipiro RL, Talbert GC, Yee GR, Matzke BG and Wells LM, 6th ed. (McGraw-Hill Co USA) 2004, 1333.
2. Greenspan FS & Strewler GJ, Basic and clinical endocrinology. 5th ed. (Prentice-Hall International Inc Sidney Australia) 1997, 605.
3. Rang HP, Dale MM & Ritte JM, Pharmacology. 4th ed. (Churchill Livingstone Melbourne) 2003, 385.
4. Tisch R & McDevitt H, Insulin-dependent diabetes mellitus, Cell, 85 (1996) 291.
5. Bastaki S, Diabetes Mellitus and its treatment, Int J Diabetes Metabolism, 13 (2005) 111.
6. Koh-Banerjee P, Wang Y, Hu FB, Spiegelman D, Willett WC & Rimm EB, Changes in body weight and body fat distribution as risk factors for clinical diabetes in US Men, Am. J. Epidemiol, 159 (2004) 1150.
7. Misra A, Singhal N & Khurana L, Obesity, The metabolic syndrome, and type 2 diabetes in developing countries: Role of dietary fats and oils, J Am Coll Nutr, 29 (2010) 289S.
8. Sears DD, Hsiao G, Hsiao A, Yu JG, Courtney DH, Ofrecio JM, Chapman J & Subramanian S, Mechanism of human insulin resistance and thiazolidinedione-mediated insulin sensitization, Proceedings of The National Academy of Sciences, 106 (2009) 18745.
9. Zhang XF & Tan BK, Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats, Acta Pharmacol Sin, 21 (2000) 1157.
10. Nugroho AE, Andrie M, Warditiani NK, Siswanto E, Pramono S & Lukitaningsih E, Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats, Indian J Pharmacol, 44 (2012) 377.
11. Wibudi A, Kiranadi B, Manalu W, Winarto A & Suyono S, The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro, Acta Med Indones, 40 (2008) 63.
12. Cheung HY, Cheung CS & Kong CK, Determination of bioactive diterpenoids from Andrographis paniculata by micellar electrokinetic chromatography, J Chromatogr A, 930 (2001) 171.
13. Pholphana N, Rangkadilok N, Thongnest S, Ruchirawat S, Ruchirawat M & Satayavivad J, Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f.) Nees, Phytochem Anal, 15 (2004) 365.
14. Yu BC, Hung CR, Chen WC & Cheng JT, Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats, Planta Med, 69 (2003) 1075.
15. Zhang Z, Jiang J, Yu P, Zeng X, Larrick JW & Wang Y, Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment, J Transl Med, 7 (2009) 62.
16. Nugroho AE, Andrie M, Susilowati R, Nurrochmad A, Lukitaningsih E & Pramono S, Ethanolic extracts of A. paniculata (Burm. f.) nees and its active compound, andrographolide, decrease the expression of glucose transporters (GLUT 4) in high fuctose-fat fed rats, Intl J Phytomed, 3 (2011) 486.
17. Ayyanar M & Ignacimuthu S, Herbal medicines for wound healing among tribal people in Southern India, ethnobotanical and scientific evidences, Int J Applied Res in Natural Products, 2 (2009) 29.
18. Paocharoen V, The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients, J Med Assoc Thai, 93 (2010) S166.
19. Babish JG, Pacioretty LM, Bland JS, Minich DM, Hu J & Tripp ML, Antidiabetic screening of commercial botanical products in 3T3-L1 adipocytes and db/db mice, J Med Food, 13 (2010) 535.
20. Kobayashi K, Forte TM, Taniguchi S, Ishida BY, Oka K & Chan L, The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding, Metabolism, 49 (2000) 22.
21. Shukla A, Rasik AM & Dhawan BN, Asiaticoside-induced elevation of antioxidant levels in healing wounds, Phytother Res, 13 (1999) 50.
22. Zhang LN, Zheng JJ, Zhang L, Gong X, Huang H, Wang CD, Wang B, Wu MJ, Li XH, Sun WJ, Liu YJ & Wan JY, Protective effects of asiaticoside on septic lung injury in mice, Exp Toxicol Pathol, 63 (2011) 519.
23. Rangwala SM, Peroxisome proliferator-activated receptor gamma in diabetes and metabolism, Trends Pharmacol Sci, 25 (2004) 331.
24. Singh B & Rastogi RP, A reinvestigation of the triterpenes of Centella asiatica, Phytochem, 8 (1969) 917.
25. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW & Olefsky JM, Brain PPAR- γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones, Nat Med, 17 (2011) 618.
26. Suga A, Hirano T, Kageyama H, Osaka T, Namba Y, Tsuji M, et al, Effects of fructose and glucose on plasma leptin, insulin, and insulin resistance in lean and VMH-lesioned obese rats, Am J Physiol Endocrinol Metab, 278 (2000) E677.
27. Pooranaperundevi M, Sumiyabanu MS, Viswanathan P, Sundarapandiyan R & Anuradha CV, Insulin resistance induced by a high- fructose diet potentiates thioacetamide hepatotoxicity, Singapore Med J, 51 (2010) 389.
28. D'Angelo G, Elmarakby AA, Pollock DM & Stepp DW, Fructose feeding increases insulin resistance but not blood pressure in sprague-dawley rats, Hypertension, 46 (2005) 806.
29. Fernandez-Veledo S, Nieto-Vazquez I, de Castro J, Ramos MP, Bruderlein S, Moller P, et al, Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: Paracrine interaction with myocytes, J Clin Endocrinol Metab, 93 (2008) 2866.
30. Basciano H, Miller AE, Naples M, Baker C, Kohen R, Xu E, et al, Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis, Am J Physiol Endocrinol Metab, 297 (2008) E462.
31. Kozka IJ & Holman GD, Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin Treatment of rat adipocytes, Diabetes, 42 (1993) 1159.
32. Yu BC, Chang CK, Su CF & Cheng JT, Mediation of beta- endorphin in andrographolide-induced plasma glucoselowering action in type I diabetes-like animals, Naunyn Schmiedebergs Arch Pharmacol, 377 (2008) 529.