Ethanolic extracts of A. paniculata (Burm. F.) nees and its active compound, andrographolide, decrease the expression of glucose transporters (Glut 4) in high fuctose-fat fed rats

International Journal of Phytomedicine

Volumn 3, Issue 4, 2011, Pages 486-497

  Nugroho, Agung Endro ^a   Andrie, Mohamad ^a   Susilowati, Rina ^a   Nurrochmad, Arief ^a   Lukitaningsih, Endang ^a   Pramono, Suwijiyo ^a  

^a GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

Andrographis paniculata (Burm. f.) Nees; Andrographolide; GLUT 4; Insulin resistance

Indexed keywords

ALCOHOL; ANDROGRAPHIS PANICULATA EXTRACT; ANDROGRAPHOLIDE; GLIBENCLAMIDE; GLUCOSE; GLUCOSE TRANSPORTER 4; METFORMIN;

ANDROGRAPHIS PANICULATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; LIPID DIET; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; RAT; SOLEUS MUSCLE;

EID: 84875181437     PISSN: None     EISSN: 09750185     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Greenspan FS, Strewler GJ. Basic and Clinical Endocrinology. 5th Ed. Prentice-Hall International Inc. Sydney. 1997;605-609.
2. Rang HP, Dale MM, Ritte JM. Pharmacology. 4th Ed. Churchill Livingstone. Melbourne. 2003;385-340.
3. Tisch R, McDevitt H. Insulin-Dependent Diabetes Mellitus. Cell, 1996;85:291-297.
4. Bastaki S. Diabetes Mellitus and Its Treatment. Int J Diabetes & Metabolism. 2005;13:111-134
5. Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care, 1989;12(8):553-564.
6. Srinivasan K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr. 2005;56(6):399-414.
7. Niranjan A, Tewari S, Lehri A. Biological activities of Kalmegh (Andrograpis paniculata Nees. Indian J Nat Proc Resour, 2010;1(2):125-135.
8. Zhang XF, Tan BK, Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats. Acta Pharmacol Sin, 2000;1(12):1157-1164.
9. Dandu AM, Inamdar NM. Evaluation of beneficial effects of antioxidant properties of aqueous leaf extract of Andrographis paniculata in STZ-induced diabetes. Pak J Pharm Sci, 2009;22(1):49-52.
10. Cheung HY, Cheung CS, Kong CK. Determination of bioactive diterpenoids from Andrographis paniculata by micellar electrokinetic chromatography. J Chromatogr A 2001;930(1-2):171-176.
11. Pholphana N, Rangkadilok N, Thongnest S, Ruchirawat S, Ruchirawat M, Satayavivad J. Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f.) Nees. Phytochem Anal, 2004;15(6):365-371.
12. Burgos RA, Caballero EE, Sánchez NS, Schroeder RA, Wikman GK, Hancke JL. Testicular toxicity assessment of Andrographis paniculata dried extract in rats. J Ethnopharmacol, 1997;58(3):219-224.
13. Yu BC, Hung CR, Chen WC, Cheng JT. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med, 2003;69(12):1075-1079.
14. Subramanian R, Asmawi MZ, Sadikun A. In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide. Acta Biochim Pol, 2008;55(2):391-398.
15. Suga A, Hirano T, Kageyama H, Osaka T, Namba Y, Tsuji M, Miura M, Adachi M, Inoue. Effects of fructose and glucose on plasma leptin, insulin, and insulin resistance in lean and VMH-lesioned obese rats. Am J Physiol Endocrinol Metab, 2000;278:E677-E683.
16. Pooranaperundevi M, Sumiyabanu MS, Viswanathan P, Sundarapandiyan R, Anuradha CV. Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. Singapore Med, 2010;J51(5):389-398.
17. Chi TC, Liu IM, Cheng JT. Less of insulin desensitization in sympathetic nerve terminals from wistar rats with insulin resistance. J Auton Nerv Syst, 2000;80(1-2):80-84.
18. Katja CZ, Mario S, Artur-Aron W, Franz B, Helmut EG, Karsten S. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res, 1999;59:98-204.
19. Akiba T, Yaguchi K, Tsutsumi K, Nishioka T, Koyama I, Nomura M, Yokogawa K, Moritani S, Miyamoto K. Inhibitory mechanism of caffeine on insulin-stimulated glucose uptake in adipose cells. Biochem Pharmacol, 2004; 68(10):1929-1937.
20. Bessesen DH. The role of carbohydrates in insulin resistance. J Nutr, 2001;131(10):2782S-2786S.
21. Malinauskas BM, Aeby VG, Overton RF, Carpenter-Aeby T, Barber-Heidal K. A survey of energy drink consumption patterns among college students. Nutr J, 2007;6:35.
22. Patel JV, Cummings DE, Girod JP, Mascarenhas AV, Hughes EA, Gupta M, Lip GY, Reddy S, Brotman DJ. Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment. J Negat Results Biomed, 2006;5:4.
23. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest, 2000;106(2):171-176.
24. Marette A, Burdett E, Douen A, Vranic M, Klip A. Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle. Diabetes, 1992;41(12):1562-1569.
25. Watson RT, Pessin JE. Intracellular organization of insulin signaling and GLUT4 translocation. Recent Prog Horm Res, 2001;56:175-193.
26. Mueckler M. Insulin resistance and the disruption of Glut4 trafficking in skeletal muscle. J Clin Invest, 2001;107(10):1211-1213.
27. Fernandez-Veledo S, Nieto-Vazquez I, de Castro J, Ramos MP, Brüderlein S, Möller P, Lorenzo M. Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: paracrine interaction with myocytes. J Clin Endocrinol Metab, 2008;93(7):2866-2876.
28. D'Angelo G, Elmarakby AA, Pollock DM, Stepp DW. Fructose Feeding Increases Insulin Resistance but Not Blood Pressure in Sprague-Dawley Rats. Hypertension, 2005;46:806-811.
29. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr, 2002;76:911-922.
30. Henquin JC. Pathways in t-Cell Stimulus-Secretion Coupling as Targets for Therapeutic Insulin Secretagogues. Diabetes, 2004;53 (Suppl. 3):S48-S58.
31. Klip A, Leiter L. Cellular Mechanism of Action of Metformin. Diabetes Care, 1990;13(6):696-704.
32. Widyawati T. Aspek Farmakologi Sambiloto (Andrographis paniculata Nees). Majalah Kedokteran Nusantara, 2007;40(3):216-222.
33. Rao YK, Vimalamma G, Rao CV, Tzeng YM. Flavonoids and andrographolides from Andrographis paniculata. Phytochemistry, 2004;65:2317-2321.
34. Chao WW, Lin BF. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chinese Medicine, 2010;5:17
35. Yu BC, Chang CK, Su CF, Cheng JT. Mediation of beta-endorphin in andrographolide-induced plasma glucoselowering action in type I diabetes-like animals. Naunyn Schmiedebergs Arch Pharmacol, 2008;377(4-6):529-540.