Single subject designs in biomedicine

Single Subject Designs in Biomedicine

Volumn , Issue , 2009, Pages 1-124

  Janosky, Janine E ^a   Libkuman, Terry M ^a   Leininger, Shelley L ^a   Hoerger, Michael P ^a  

^a CENTRAL MICHIGAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84889845129     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-2444-2     Document Type: Book

References (372)

1. Edgington ES. Statistics and single case analysis. Progress in Behavior Modification. 1984;16:83-119.
2. Barlow DH, Hersen M. Single case experimental designs: Strategies for studying behavior change. New York: Pergamon, 1984.
3. Guyatt GH, Heyting A, Jaeschke R, et al. N of 1 randomized trials for investigating new drugs. Controlled Clinical Trials. 1990;11:88-100.
4. Woolf GM, Townsend M, Guyatt GH. Treatment of cryptosporidiosis with spiramycin in AIDS: An "N of 1" trial. Journal of Clinical Gastroenterology. 1987;9:632-634.
5. Balestra DJ, Balestra ST, Wasson JH. Ulcerative colitis and steriod-responsive, diffuse interstitial lung disease: A trial of N = 1. Journal of the American Medical Association. 1988;260:62-64.
6. Langer JC, Wintrop AL, Issenman RM. The single-subject randomized trial: Useful clinical tool for assessing therapeutic efficacy in pediatric practice. Clinical Pediatrics. 1993;32:654-657.
7. Jaeschke R, Cook D, Sackett DL. The potential role of single-patient randomized controlled trials (N-of-1 RCTs) in clinical practice. Journal of the American Board of Family Practice. 1992;5:227-229.
8. Janosky JE. Use of the single subject design for practice based primary care research. Postgraduate Medical Journal. 2005;81(959):549-551.
9. Robin ED, Burke CM. Single-patient randomized clinical trial: Opiates for intractable dyspnea. Chest. 1986;90:888-892.
10. Wagner JL, Winett R. Prompting one low-fat, high-fiber selection in a fast food restaurant. Journal of Applied Behavior Analysis. 1988;21:179-185.
11. Guyatt GH, Keller JL, Jaeschke R, et al. The n-of-1 randomized controlled trial: Clinical usefulness. Annals of Internal Medicine. 1990;112:293-299.
12. Larson EB, Ellsworth AJ, Oas J. Randomized clinical trials in single patients during a 2-year period. Journal of the American Medical Association. 1993;270:2708-2712.
13. Guyatt G, Sackett D, Taylor DQ, et al. Determining optimal therapy-randomized trials in individual patients. New England Journal of Medicine. 1986;314:889-892.
14. Thompson CK. Single subject controlled experiments in aphasia: The science and the state of the science. Journal of Common Disorders. 2006;39(4):266-291.
15. Zhang H, Luo WL, Nichols TE. Diagnosis of single-subject and group fMRI data with SPMd. Human Brain Mapping. 2006;27(5):442-451.
16. Goebel R, Esposito F, Formisano E. Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: From single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis. Human Brain Mapping. 2006;27(5):392-401.
17. Chen X, Pereira F, LeeW, Strother S, Mitchell T. Exploring predictive and reproducible modeling with the single-subject FIAC dataset. Human Brain Mapping. 2006;27(5):452-461.
18. Rio DE, Rawlings RR, Woltz LA, Salloum JB, Hommer DW. Single subject image analysis using the complex general linear model - An application to functional magnetic resonance imaging with multiple inputs. Computer Methods and Programs in Biomedicine. 2006;82(1):10-19.
19. Michaud TC, Nawoczenski DA. The influence of two different types of foot orthoses on first metatarsophalangel joint kinematics during gait in a single subject. Journal of Manipulative and Physiological Therapeutics. 2006;29(1):60-65.
20. Tankersley M, McGoey KE, Dalton D, Rumrill Jr. PD, Balan CM. Single subject research methods in rehabilitation. Work (Reading, MA). 2006;26(1):85-92.
21. Schlosser RW, Sigfoos J. Augmentative and alternative communication interventions for persons with elemental disabilities: Narrative review of comparative single-subject experimental studies. Research in Developmental Disabilities. 2006;27(1):1-29.
22. Powers SW, Piazza-Waggoner C, Jones JF, Ferguson KS, Dianes C, Acton JD. Examining clinical trial results with single-subject analysis: An example involving behavioral and nutrition treatment for young children with cystic fibrosis. Journal of Pediatric Psychology. 2006;31(6):574-581.
23. Ownsworth T, Fleming J, Desbois J, Strong J, Kuipers P. A metacognitive contextual intervention to enhance error awareness and functional outcome following traumatic brain injury: A single-case experimental design. Journal of the International Neuropsychological Society. 2006;12(1):54-63.
24. Betker AL, Szturm T, Moussavi ZK, Nett C. Video game-based exercise for balance rehabilitation: A single-subject design. Archives of Physical Medicine & Rehabilitation. 2006;87(8):1141-1149.
25. Nikles CJ, Mitchell GK, Del Mar. CB, Clavarino A, McNairn N. An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics. 2006;117(6):2040-2046.
26. Winslow E, Hutchison R. Placebo use in the N-Of-1 Trial. [Department Letter]. American Journal of Nursing. 2006;106(9):16.
27. Smith JF, Chen K, Johnson S, Morrone-Strupinsky J, Reiman EM, Nelson A, Moeller JR, Alexander GE.. Network analysis of single-subject fMRI during a finger opposition task. NeuroImage. 2006;32(1):325-332.
28. Ma HH. An Alternative method for quantitative synthesis of single-subject researches: Percentage of data points exceeding the median. Behavior Modification. 2006;30(5):598-617.
29. Didden R, Korzilius H, Van Oorsouw W, Sturmey P. Behavioral treatment of challenging behaviors in individuals with mild mental retardation: Meta-analysis of single-subject research. American Journal of Mental Retardation. 2006;111(4):290-298.
30. Marklund I, Klassbo M. Effects of lower limb intensive mass practice in poststroke patients: Single-subject experimental design with long-term follow-up. Clinical Rehabilitation. 2006;20(7):568-576.
31. Wehmeyer ML, Palmer SB, Smith SJ, ParentW, Davies DK, Stock S. Technology use by people with intellectual and developmental disabilities to support employment actives: A singlesubject design meta-analysis. Journal of Vocational Rehabilitation. 2006;24(2):81-86.
32. Avins AL, Bent S, Neuhaus JM. Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study. Contemporary Clinical Trial. 2005;26(3):397-401.
33. Cook TD, Campbell, DT. Quasi-experimentation: Design & analysis issues for field settings. Boston, MA: Houghton Mifflin Company, 1979.
34. Gay, LR. Educational research: Competencies for analysis and application. Columbus, OH: Merrill Publishing Company, 1987.
35. Hersen M, Barlow DH. Single case experimental designs: Strategies for studying behavioral change, New York: Pergamon, 1976.
36. Janosky JE. Use of the nonparametric smoother for examination of data from a single-subject design. Behavior Modification. 1992;16(3):387-399.
37. Kazdin, AE. Single case research designs: Methods for clinical and applied settings. New York: Oxford, 1982.
38. Kratochwill T, Alden K, Demuth D, et al. A further consideration in the application of an analysis-of-variance model for the intrasubject design. Journal of Applied Behavior Analysis. 1974;7:629-634.
39. McLaughlin, TF. An examination and evaluation of single subject designs used in behavior analysis research in school settings. Educational Research Quarterly. 1983;7:35-42.
40. McReynolds LV, Thompson CK. Flexibility of single-subject experimental designs. Part 1: Review of the basics of single-subject designs. Journal of Speech and Hearing Disorders. 1986;51:194-203.
41. Sidman M. Tactics of scientific research. New York: Basic Books, 1960.
42. Larson EB. N-of-1 clinical trials: A technique for improving medical therapeutics. Western Journal of Medicine. 1990;152:52-56.
43. Edgington ES. Statistics and single case analysis. Program in Behavior Modification. 1984;16:83-119.
44. Hartmann DP, Gottman JM, Jones RR, Gardner W, Kazdin AE, Vaught R. Interrupted timeseries analysis and its application to behavioral data. Journal of Applied Behavior Analysis. 1980;13:543-559.
45. Jones RR, Vaught RS, Weinrott M. Time-series analysis in operant research. Journal of Applied Behavior Analysis. 1977;10:151-166.
46. Kazdin AE. Statistical analyses for single-case experimental designs. In DH Barlow, M Hersen (Eds.). Single-case experimental designs: Strategies for studying behavior change (2nd ed., pp. 285-324). New York: Pergamon Press, 1984.
47. Blumberg CJ. Comments on "A simplified time-series analysis for evaluating treatment interventions". Journal of Applied Behavior Analysis. 1984;17(4):539-542.
48. Bock RD. Multivariate statistical methods in behavioral research. New York: McGraw-Hill, 1975.
49. Chatfield C. The analysis of time series: An introduction. New York: Chapman and Hall, 1982.
50. Conover WJ. Practical nonparametric statistics. New York: Wiley, 1971.
51. DeProspero A, Cohen S. Inconsistent visual analysis of intrasubject data. Journal of Applied Behavior Analysis. 1979;12:573-579.
52. Draper NR, Smith H. Applied regression analysis. New York: John Wiley and Sons, 1981.
53. Franklin RD, Allison DB, Gorman BS. Design and analysis of single-case research. Mahwah, NJ: Erlbaum, 1996.
54. Glass G, Willson V, Gottman J. Designs and analysis of time-series experiments. Boulder, CO: Associated University Press, 1975.
55. Gottman JM, Glass GV. Analysis of interrupted time-series experiments. In TR Kratochwill (Ed.). Single-subject research: Strategies for evaluating change (pp. 197-237) New York: Academic Press, 1978.
56. Institute of Medicine. Committee on strategies for small-number- participant clinical research trials. Washington, DC: Institute of Medicine, 2001.
57. Gottman JM, McFall RM, Barnett JT. Design and analysis of research using time series. Psychological Bulletin. 1969;72(4):299-306.
58. Holtzman WH. Statistical models for the study of change in the single case. In C Harris (Ed.) Problems in measuring change. Madison, WI: University of Wisconsin Press, 1967.
59. TryonWW. A simplified time-series analysis for evaluating treatment interventions: A rejoiner toBlumberg. Journal of Applied Behavior Analysis. 1984;17:543-544.
60. Tryon WW. Digital filters in behavioral research. Journal of the Experimental Analysis of Behavior. 1983;39:185-190.
61. TryonWW. A simplified time-series for evaluating treatment interventions. Journal of Applied Behavior Analysis. 1982;15:423-429.
62. Tufte ER. The visual display of quantitative information. Cheshire, CT: Graphics Press, 1983.
63. Tukey JW. Exploratory data analysis. Reading, MA: Addison-Wesley Publishing Company, 1977.
64. Velleman PF. Definition and comparison of robust nonlinear data smoothing algorithms. Journal of the American Statistical Association. 1980;75:609-615.
65. White OR. A glossary of behavioral terminology. Champaign, IL: Research Press, 1971.
66. White OR. A manual for the calculation and use of the median slope: A technique of progress estimation and prediction in the single case. Eugene, OR: University of Oregon, Regional Resource Center for Handicapped Children, 1972.
67. White OR. The "split-middle". A "quickie" method of trend estimation. Seattle, WA: University of Washington, Experimental Education Unit, Child Development and Mental Retardation Center, 1974.
68. Edgington ES. Validity of randomization tests for one-subject experiments. Journal of Educational Statistics. 1980;5:235-251.
69. Mood AF. Introduction to the theory of statistics. New York: McGraw-Hill, 1950.
70. Ninness HA, Newton R, Saxon J, et al. Small group statistics: A Monte Carlo comparison of parametric and randomization tests. Behavioral and Social Issues. 2002;12:53-63.
71. Ottenbacher KJ. Reliability and accuracy of visually analyzing graphed data from singlesubject designs. The American Journal of Occupational Therapy. 1986;40:464-469.
72. Barlow DH, Hersen M. Single case experimental designs: Strategies for studying behavior change (2nd ed.). New York: Pergamon Press, 1984.
73. Kazdin A. Single-case research designs: Methods for clinical and applied settings. NewYork: Oxford University Press, 1982.
74. Kratochwill TR (Ed.). Single subject research: Strategies for evaluating change. New York: Academic Press, 1978.
75. Hawkins RP. Developing a behavior code. In DP Harmann (Ed.), Using observers to study behavior: New direction for methodology of social and behavioral science (pp. 21-35). San Francisco, CA: Jossey-Bass, 1982.
76. Brown-Chidsey R, Steege MW. Response to intervention: Principles and strategies for effective practice. New York: The Guilford Press, 2005.
77. Haynes SN, Wilson CC. Behavioral assessment: Recent advances in methods, concepts, and applications. San Francisco, CA: Jossey-Bass, 1979.
78. Richards SB, Taylor RL, Ramasamy R, Richards RY. Single subject research: Applications in educational and clinical settings. San Diego, CA: Singular Publishing Group, 1999.
79. Janosky JE, Al-Shboul QM, Pellitieri TR. Validation of the use of a nonparametric smoother for the examination of data from a single-subject design. Behavior Modification. 1995;19(3):307-324.
80. Campbell DT, Stanley JC. Experimental and quasi-experimental designs for research. Chicago, IL: Rand McNally, 1966.
81. Cook TD, Campbell DT (Eds.). Quasi-experimentation: Design and analysis issues for field settings. Boston, MA: Houghton Mifflin Company, 1979.
82. Krishef CH. Fundamental approaches to single subject design and analysis. Malabar, FL: Krieger Publishing Company, 1991.
83. Leitenburg H. The use of single-case methodology in psychotherapy research. Journal of Abnormal Psychology. 1973;82(1):87-101.
84. Baer DM, Wolf MM, Risley RR. Some current dimensions of applied behavior analysis. Journal of Applied Behavior Analysis. 1968;1:91-97.
85. Tawney JW, Gast DL. Single subject research in special education. Columbus, OH: Merrill, 1984.
86. Cooper JO, Heron TE, Heward WL. Applied behavior analysis. Columbus, OH: Merrill Publishing Company, 1987.
87. Hersen M, Barlow DH. Single case experimental design: Strategies for studying behavior change. New York: Pergamon, 1976.
88. Ullman J, Sulzer-Azaroff B. Multielement baseline design in educational research. In E Ramp, G Semb (Eds.), Behavior analysis: Areas of research and application (pp. 371-391). Englewood Cliffs, NJ: Prentice-Hall, 1975.
89. Alberto P, Troutman A. Applied behavior analysis for teachers (5th ed.). Columbus, OH: Merrill, 1999.
90. Neuman S. Alternating treatments designs. In S Neuman, S McCormick (Eds.), Single subject experimental research: Applications for literacy (pp. 64-83). Neward, DE: International Reading Association, 1995.
91. Barlow DH, Hayes SC. Alternating treatments design: One strategy for comparing the effects of two treatments in a single subject. Journal of Applied Behavior Analysis. 1979;12:199-210.
92. Poling, A, Methot L, LeSage M. Fundamentals of behavior analytic research. New York: Plenum Press, 1995.
93. Hartmann DP, Hall RV. The changing criterion design. Journal of Applied Behavior Analysis. 1976;9(4):527-532.
94. Hall RV. Behavior modification: The measurement of behavior. Lawrence, KS: H & H Enterprises, 1971.
95. Janosky JE, Leininger SL, Hoerger M. The use of single-subject methodology for research reported in biomedical journals. White Paper, Central Michigan University, 2009.
96. Forbes J. The British and Foreign Medical Review or Quarterly Journal of Practical Medicine and Surgery. 1840;10 (3).
97. Broca P. Remarks on the seat of the faculty of articulate language followed by an observation of aphemia. In G von Bonin (Ed.), Some papers on the cerebral cortex (pp. 49-72). Springfield, IL: C. C. Thomas, 1861/1960.
98. Fechner T. Elements of psychophysics. In H Langfeld (Ed.), The classical psychologists (pp. 562-572). Boston, MA: Houghton Mifflin, 1860/1912.
99. Ebbinghaus H. Memory: A contribution to experimental psychology, (HA Ruger, CE Bussenius, Trans.). New York: Columbia University Press, 1885/1913.
100. Pavlov IP. Lectures on conditioned reflexes. New York: International Publishers, 1928/1963.
101. Jay V. The legacy of Jean-Martin Charcot. Archives of Pathology and Laboratory Medicine. 2000;124:10-11.
102. Darwin C. On the origin of species by means of natural selection, or the preservation of favoured races in the struggle for life. London: John Murray, 1859.
103. Stilson DW. Probability and statistics in psychological research and theory. San Francisco, CA: Holden-Day, 1966.
104. Boring E. A History of psychology (2nd ed.). New York: Appleton-Century-Crofts, 1950.
105. Box J. Guinness, Gosset, Fisher, and small samples. Statistical Science. 1987;2:45-52.
106. Fisher RA. Statistical methods for research workers. Edinburgh: Oliver & Boyd, 1925.
107. Boring E. The nature and history of experimental control. American Journal of Psychology. 1954;67:573-589.
108. Dukes W. N = 1. Psychological Bulletin. 1965;64:74-79.
109. Barlow D, Hersen M. Single case experimental designs: Strategies for studying behavior change (2nd ed.). New York: Pergamon, 1984.
110. Healy D. Let them eat Prozac. New York: New York University Press, 2004.
111. Skinner BF. On the conditions for elicitation of certain eating reflexes. Proceedings of the National Academy of Sciences. 1930;16:433-438.
112. Skinner BF. Science and human behavior. New York: Macmillan, 1953.
113. Skinner BF. Behaviorism at fifty. Science. 1963;140:951-958.
114. Catania AC. Learning: Interim (4th ed.) New York: Sloan, 2007.
115. Avins AL, Bent S, Neuhaus JM. Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study. Contemporary Clinical Trials. 2005;26:397-401.
116. Institute of Medicine. Committee on strategies for small-number- participant clinical research trials, 2001.
117. Janosky JE. Use of the single subject design for practice based primary care research. Postgraduate Medical Journal. 2005;81:549-551.
118. Rapoff M, Stark L. Editorial: Journal of Pediatric Psychology statement of purpose: Section on single-subject studies. Journal of Pediatric Psychology. 2008;33:16-21.
119. Hume D. An enquiry concerning human understanding. New York: Bobbs-Merril Co., 1784/1984.
120. Janosky JE. Statistical testing alone and estimation plus testing: Reporting study outcomes in biomedical journals. Statistics and Probability Letters. 2008;78:2327-2331.
121. Hill AB. The environment and disease: Association or causation? Proceedings of the Royal Society of Medicine. 1965;58:295-300.
122. Susser M. What is a cause and how do we know one? A grammar for pragmatic epidemiology. American Journal of Epidemiology. 1991;133:635-648.
123. Weed D. Causal and preventive inference. In P Greenwald, B Kramer, DWeed (Eds.), Cancer prevention and control (pp. 285-302). New York: Marcel Dekker, 1995.
124. Weed D, Gorelic L. The practice of causal inference in cancer epidemiology. Cancer Epidemiology, Biomarkers & Prevention. 1996;5:303-311.
125. Kazdin A. Single-case research designs: Methods for clinical and applied settings. NewYork: Oxford University Press, 1982.
126. Richards S, Taylor R, Ramasamy R, Richards R. Single subject research: Applications in educational and clinical settings. Belmont, CA: Wadsworth, 1999.
127. TrochimW, Donnelly JP. The research methods knowledge base (3rd ed.). Mason, OH: Thomson Publishing, 2007.
128. Dimidjian S, Hollon S, Dobson K, et al. Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression. Journal of Consulting and Clinical Psychology. 2006;74:658-670.
129. Breggin P, Cohen D. Your drug may be your problem. New York: Perseus Books, 1999.
130. Reiss S, Aman M. Psychotropic medications & developmental disabilities: The international consensus handbook. Columbus, OH: The Ohio State University, Nisonger Center Publisher, 1997.
131. Johnson C, Handen B, Lubetsky M, Sacco K. Efficacy of methylphenidate and behavioral intervention on classroom behavior in children with ADHD and mental retardation. Behavior Modification. 1994;18:470-487.
132. Nikles C, Mitchell G, Del Mar. C, Clavarino A, McNairn N. An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics. 2006;117:2040-2046.
133. Benson H, Friedman R. Harnessing the power of the placebo effect and renaming it "remembered wellness". Annual Review of Medicine. 1996;47:193-199.
134. Guess H, Kleinman A, Kusek J, Engel L. S cience of the placebo: Toward an interdisciplinary research agenda. London: BMJ Books, 2002.
135. Vitiello B, Davis M, Greenhill L, Pine D. Blindness of clinical evaluators, parents, and children in a placebo-controlled trial of fluvoxamine. Journal of Child and Adolescent Psychopharmacology. 2006;16:219-225.
136. McKay K, Imel Z, Wampold B. Psychiatrist effects in the psychopharmacological treatment of depression. Journal of Affective Disorders. 2006;92:287-290.
137. Kirsch I. Are drug and placebo effects in depression additive? Biological Psychiatry. 2000;47:733-735.
138. Newcombe R. Should the single subject design be regarded as a valid alternative to the randomised controlled trial? Postgraduate Medical Journal. 2005;81:546-547.
139. Madden GJ. A behavioral-economics primer. In. WK Bickel, R Vuchinich (Eds.), Reframing health behavior change with behavioral economics (pp. 3-26). Mahwah, NJ: Lawrence Erlbaum & Associates, 2000.
140. Edgington ES. Statistics and single case analysis. Progress in Behavior Modification. 1984;16:83-119.
141. Kazdin AE. Single-case research designs: Methods for clinical and applied settings. New York: Oxford, 1982.
142. Bernard, C. An introduction to the study of experimental medicine. New York: Dover, 1957.
143. Barlow D, Nock M, Hersen M. Single-case experimental designs: Strategies for studying behavior for change. New York: Pearson, 2009.
144. ShadishWR, Cook TD, Campbell DT. Experimental and quasi-experimental designs for generalized causal inference. Boston, MA: Houghton Mifflin, 2001.
145. Ittenbach RF, Lawhead WF. Historical and philosophical foundations of single-case research. In RD Franklin, DB Allison, BS Gorman (Eds.). Design and analysis of single-case research (pp. 13-39). Mahwah, NJ: Lawrence Erlbaum, 1997.
146. McGuigan FJ. Experimental psychology: Methods of research. Englewood Cliffs, NJ: Prentice Hall, 1997.
147. Gresham FM. Treatment integrity in single-subject research. In RD Franklin, DB Allison, BS Gorman (Eds.). Design and analysis of single-case research (pp. 93-117). Mahwah, NJ: Lawrence Erlbaum, 1997.
148. Kazdin AE. Comparative outcome studies of psychotherapy: Methodological issues and strategies. Journal of Consulting and Clinical Psychology. 1986;54:95-105.
149. Cone J. Psychometric considerations. In M Hersen, A Bellack (Eds.). Behavioral assessment: A practical handbook (pp. 38-70). New York: Pergamon, 1981.
150. Johnston J, Pennypacker J. Strategies and tactics of human behavioral research. Hillsdale, NJ: Lawrence Erlbaum, 1980.
151. Brennen R, Kane, M. An index of dependability for mastery tests. Journal of Educational Measurement. 1977;14:277-289.
152. Suen HK. Principles of test theories. Hillsdale, NJ: Lawrence Erlbaum, 1990.
153. Kazdin AE. Statistical analyses for single-case experimental designs. In DH Barlow, M. Hersen. Single case experimental designs: Strategies for studying behavior change (pp. 285-324). Boston, MA: Allyn and Bacon, 1984.
154. Cooper JO, Heron, TE, Heward, WL. Applied behavior analysis. Upper Saddle River, NJ: Pearson, 2007.
155. Richards SB, Taylor RL, Ramasamy R, Richards, RY. Single subject research: Applications in educational and clinical settings. Belmont, CA: Wadsworth, 1999.
156. Primavera LH, Allison DB, Alfonso VC. Measurement of dependent variables. In RD Franklin, DB Allison, BS Gorman. (Eds.). Design and analysis of single-case research. Mahwah, NJ Lawrence Erlbaum, 1997.
157. Edgington ES. Response-guided experimentation. Contemporary Psychology. 1983;28:64-65.
158. Barlow DH, Hersen M. Single case experimental designs: Strategies for studying behavior change. Boston, MA: Allyn and Bacon, 1984.
159. Krishef CH. Fundamental approaches to single subject design and analysis. Malabar, FL: Krieger Publishing Company, 1991.
160. Houle TT. Statistical analyses for single-case experimental designs. In D Barlow, M Nock, M Hersen. Single-case experimental designs: Strategies for studying behavior for change (pp. 271-305). New York: Pearson, 2009.
161. Gigerenzer G, Gaissmaier W, Kurz-Milcke E., Schwartz LM, Woloshin S. Helping doctors and patientsmake sense of health statistics. Psychological Science in the Public Interest. 2008:8: 53-96.
162. Franklin RD, Allison DB, Gorman BS. Design and analysis of single-case research. Mahwah, NJ: Lawrence Erlbaum, 1997.
163. Parsonson BS, Baer DM. The analysis and presentation of graphic data. In TR Kratochwill (Ed.). Single subject research: Strategies for evaluating change (pp. 101-165). New York: Academic Press, 1978.
164. Carr JE, Burkholder EO. Creating single subject design graphs with Microsoft excel. Journal of Applied Behavior Analysis. 1998;31:245-251.
165. Komaki JI, Coombs T, Redding Jr. TP, Schepman S. A rich and rigorous examination of applied behavior analysis research in the world of work. In CL Cooper, IT Robertson (Eds.). International review of industrial and organization psychology. Sussex: John Wiley, 2000.
166. Kazdin AE. Statistical analysis for single-case experimental designs. In M Hersen, DH Barlow (Eds.). Single-case experimental designs: Strategies for studying behavior change New York: Pergamon, 1976.
167. Janosky JE. Use of the single subject design for practice based primary care research. Post Graduate Medicine Journal, 2005;81:549-551.
168. Matyas TA, Greenwood KM. The effect of serial dependence on visual judgment in singlecase charts: An addendum. Occupational Therapy Journal. 1990;10:208-220.
169. Matyas TA, Greenwood KM. Visual analysis of single-case time-series: Effects of variability, serial dependence and magnitude of intervention effects. Journal of Applied Behavior Analysis. 1990;23:341-351.
170. Huff D. How to lie with statistics. New York: W. W. Norton, 1993.
171. Kazdin AE. Research design in clinical psychology. Boston, MA: Allyn & Bacon, 1992.
172. Johnson CM. Validating case studies in family medicine: Single-subject research designs. Family Practice Research Journal. 1984;4:27-35.
173. Onghena P. Edgington PS. Customization of pain treatments: Single-case design and analysis. Clinical Journal of Pain. 2005;21:56-68.
174. Bulté I, Onghena P. An R package for single-case randomization tests. Behavior Research Methods. 2008;40:467-478.
175. Todman J, Dugard P. Single-case and small n experimental designs: A practical guide to randomization tests. Mahwah, NJ: Lawrence Erlbaum, 2001.
176. Janosky JE. Use of the nonparametric smoother for examination of data from a single-subject design. Behavior Modification. 1992;16:387-399.
177. Janosky JE, Al-Shboul QM, Pellitieri TR. Validation of the use of a nonparametric smoother for the examination of data from a single-subject design. Behavior Modification. 1995;19:307-24.
178. Janosky JE, Pellitieri TR, Al-Shboul QM. The need for a revised lower limit for the nonparametric smoother. Statistics and Probability Letters. 1997;32:269-72.
179. Janosky, JE, Al-shboul, Q. Statistical analysis of single-subject designs. Physical Therapy. 1995;75:157-8.
180. Pittenger, DJ. Behavioral research: Design and analysis. New York: McGraw-Hill, 2003.
181. Kirk, RE. Statistics: An introduction. Fort Worth, TX: Holt, Rinehart and Winston, 1990.
182. Revusky, SH. Some statistical treatments compatible with individual organism methodology. Journal of Experimental Analysis of Behavior. 1967;10:319-330.
183. Jones, PW. Single-case time series with Bayesian analysis: A practitioner's guide. Measurement and Evaluationin Counseling and Development. 2008;36:28-39.
184. Kratochwill TR. (Ed.). Single subject research: Strategies for evaluating change. New York: Academic press, 1978.
185. Furedy JJ. Commentary: On the limited role of the "single- subject" design in psychology: Hypothesis generating but not testing. Journal of Behavior Therapy and Experimental Psychiatry. 1999;30:21-22.
186. Reboussin DM, Morgan TM. Statistical considerations in the use and analysis of singlesubject designs. Medicine and Science in Sports and Exercise. 1996;28:639-644.
187. Silvestri SM. How to make a graph using Microsoft Excel. Unpublished manuscript. Columbus, OH: The Ohio State University, 2005.
188. Steinbock B, London A, Arras J. Ethical issues in modern medicine: Contemporary readings in bioethics. New York: McGraw-Hill, 2008.
189. Rosen F. Classical utilitarianism from Hume to mill. New York: Routledge, 2003.
190. Norton D. The Cambridge companion to Hume. Cambridge: Cambridge University Press, 1993.
191. Hoerger M, Quirk S, Lucas R, Carr T. Immune neglect in affective forecasting. Journal of Research in Personality. 2009;43:91-94.
192. Cooper J, Heron T, Heward W. Applied behavior analysis (2nd ed.). Columbus, OH: Pearson, 2007.
193. Brody B, Rothstein, M. Medical ethics: Analysis of the issues raised by the codes, opinions, and statements. Washington, DC: BNA Books, 2001.
194. U. S. Department of Health, Education, and Welfare, Report on Licensure and Related Health Personnel Credentialing (Washington, D. C.: June, 1971, p. 7).
195. NCCA Standards for the Accreditation of Certification Programs, approved by the member organizations of the National Commission for Certifying Agencies in February, 2002 (effective January, 2003).
196. American Medical Association. State medical licensure requirements and statistics 2009. Chicago, IL: AMA Books, 2009.
197. Janosky J. Use of the single subject design for practice based primary care research. Postgraduate Medical Journal. 2005;81:549-551.
198. Logan LR, Hickman RR, Harris SR, Heriza CB. Single-subject research design: Recommendations for levels of evidence and quality rating. Developmental medicine & child neurology. 2008;50:99-103.
199. Mann T. Informed consent for psychological research: Do subjects comprehend consent forms and understand their legal rights? Psychological Science. 1994;5:140-143.
200. Brody B. The ethics of biomedical research: an international perspective. New York: Oxford University Press, 1998.
201. Avins AL, Bent S, Neuhaus JM. Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study. Contemporary Clinical Trials. 2005;26:397-401.
202. Erlen JA. How confidential is confidential? Orthopedic Nursing. 2008:27: 357-60.
203. Harris G. F. D. A. Requiring suicide studies in drug trials. New York Times. January 24, 2008.
204. Evans M. Justified deception? The single blind placebo in drug research. Journal of Medical Ethics. 2000;26:188-193.
205. Kazdin A. Single-case research designs: Methods for clinical and applied settings. New York: Oxford University Press, 1982.
206. Richards S, Taylor R, Ramasamy R, Richards R. Single subject research: Applications in educational and clinical settings. Belmont, CA: Wadsworth, 1999.
207. Goodwin RD, Friedman HS. Health status and the five-factor personality traits in a nationally representative sample. Journal of Health Psychology. 2006;11:643-654.
208. Dimidjian S, Hollon S, Dobson K, Schmaling K, Kohlenberg R, Addis M, et al. Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression. Journal of Consulting and Clinical Psychology. 2006;74:658-670.
209. Piccirillo JF, Vlahiotis A, Barrett LB, Flood KL, Spitznagel EL, Steyerberg EW. The changing prevalence of comorbidity across the age spectrum. Critical Review of Oncology Hematology. 2008;67:124-32.
210. Tonelli MR. Conflict of interest in clinical practice. Chest. 2007;132:664-670.
211. Breggin P, Cohen D. Your drug may be your problem. New York: Perseus Books. 1999.
212. Reiss S, Aman M. Psychotropic medications & developmental disabilities: The international consensus handbook. Columbus, OH: The Ohio State University, Nisonger Center Publisher, 1997.
213. Janosky JE. Use of the single subject design for practice based primary care research. Postgraduate Medical Journal. 2005;81(959):549-551.
214. Rapoff M, Stark L. Editorial: Journal of Pediatric Psychology statement of purpose: Section on single-subject studies. Journal of Pediatric Psychology. 2008;33 (1), 16-21.
215. Janosky JE, Leininger SL, Hoerger M. The use of single-subject methodology for research reported in biomedical journals. White Paper, Central Michigan University.
216. Institute of Medicine. Committee on strategies for small-number- participant clinical research trials. Washington, DC: Institute of Medicine, 2001.
217. Guyatt GH, Keller JL, Jaeschke R, et al. The n-of-1 randomized controlled trial: Clinical usefulness. Annals of Internal Medicine. 1990;112:293-299.
218. Nikles CJ, Mitchell GK, Del Mar. CB, Clavarino A, McNairn N. An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics, 2006;117(6):2040-2046.
219. Powers SW, Piazza-Waggoner C, Jones JF, Ferguson KS, Dianes C, Acton JD. Examining clinical trial results with single-subject analysis: An example involving behavioral and nutrition treatment for young children with cystic fibrosis. Journal of Pediatric Psychology, 2006;31(6):574-581.
220. Tsapas A, Matthews DR. N of 1 trials in diabetes: Making individual therapeutic decisions. Source Diabetologia. 2008;51(6):921-925.
221. Beeson PM, Robey RR. Evaluating single-subject treatment research: Lessons learned from the aphasia literature. Neuropsychology Review. 2006;16(4):161-169.
222. NIH Roadmap Initiative (http://www.nihroadmap. nih.gov).
223. Janosky JE. Use of the nonparametric smoother for examination of data from a single-subject design. Behavior Modification. 1992;16(3):387-399.
224. Janosky JE, Al-Shboul QM, Pellitieri TR. Validation of the use of a nonparametric smoother for the examination of data from a single-subject design. Behavior Modification. 1995;19(3):307-324.
225. Kazdin A. Single-case research designs: Methods for clinical and applied settings. NewYork: Oxford University Press, 1982.
226. Barlow DH, Hersen M. Single case experimental designs: Strategies for studying behavior change (2nd ed.). New York: Pergamon Press, 1984.
227. Haynes SN, Wilson CC. Behavioral assessment: Recent advances in methods, concepts, and applications. San Francisco, CA: Jossey-Bass, 1979.
228. Brown-Chidsey R, Steege MW. Response to intervention: Principles and strategies for effective practice. New York: The Guilford Press, 2005.
229. Richards SB, Taylor RL, Ramasamy R, Richards RY. Single subject research: Applications in educational and clinical settings. San Diego, CA: Singular Publishing Group, Inc, 1999.
230. Komaki JI, Coombs T, Redding Jr. TP, Schepman S. A rich and rigorous examination of applied behavior analysis research in the world of work. In CL Cooper, IT Robertson (Eds.). International review of industrial and organization psychology. Sussex: John Wiley, 2000.
231. Cooper JO, Heron, TE, Heward, WL. Applied behavior analysis. Upper Saddle River, NJ: Pearson, 2007.
232. Krishef CH. Fundamental approaches to single subject design and analysis. Malabar, FL: Krieger, 1991.
233. Tukey JW. Exploratory data analysis. Reading, MA: Addison-Wesley.
234. Leitenburg H. The use of single-case methodology in psychotherapy research. Journal of Abnormal Psychology. 1973;82(1):87-101.
235. Applegate SL, Rice MS, Stein F, Maitra KK. Knowledge of results and learning to tell the time in an adult male with an intellectual disability: A single-subject research design. Occupational Therapy International. 2008;15(1):32-44.
236. Aust TR, Brookes S, Troup SA, FraserWD, Lewis-Jones DI. Development and in vitro testing of a new method of urine preparation for retrograde ejaculation: The Liverpool solution. Fertility & Sterility. 2008;89(4):885-891.
237. Avins AL, Bent S, Neuhaus JM. Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study. Contemporary Clinical Trials. 2005;26(3):397-401.
238. Bailey MJ, RiddochMJ, Crome P. Treatment of visual neglect in elderly patients with stroke: A single-subject series using either a scanning and cueing strategy or a left-limb activation strategy. Physical Therapy. 2002;82(8):782-797.
239. Balkany TJ, Connell SS, Hodges AV, Payne SL, Telischi FF, Eshraghi AA, Angeli SI, Germani R, Messiah S, Arheart KL.. Conservation of residual acoustic hearing after cochlear implantation. Otology & Neurotology. 2006;27(8):1083-1088.
240. Ballard KJ, Maas E, Robin DA. Treating control of voicing in apraxia of speech with variable practice. Aphasiology. 2007;21(12):1195-1217.
241. Baron A, Derenne, A. Quantitative summaries of single-subject studies: What do group comparisons tell us about individual performances? Behavior Analyst. 2000;23(1):101-106.
242. Barreca S, Velikonja D, Brown L, Williams L, Davis L, Sigouin CS. Evaluation of the effectiveness of two clinical training procedures to elicit yes/no responses from patients with a severe acquired brain injury: A randomized single-subject design. Brain Injury. 2003;17(12):1065-1075.
243. Bean J, Walsh A, FronteraW. Brace modification improves aerobic performance in Charcot-Marie-Tooth disease: A single-subject design. American Journal of Physical Medicine & Rehabilitation. 2001;80(8):578-582.
244. Beeson PM, Robey RR. Evaluating single-subject treatment research: Lessons learned from the aphasia literature. Neuropsychology Review. 2006;16(4):161-169.
245. Betker AL, Szturm T, Moussavi ZK, Nett C. Video game-based exercise for balance rehabilitation: A single-subject design. Archives of Physical Medicine & Rehabilitation. 2006;87(8):1141-1149.
246. Billingsley, GM. A comparison of three instructional methods for teaching math skills to secondary students with emotional/behavioral disorders. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2008;68(10-A):4253.
247. Boyd BA, Conroy MA, Mancil RG, Nakao T, Alter PJ. Effects of circumscribed interests on the social behaviors of children with autism spectrum disorders. Journal of Autism and Developmental Disorders. 2007;37(8):1550-1561.
248. Boyer JA. Meta-analysis of single case design: Linking preservice teacher preparation coursework to outcomes for children. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2004;65(2-B):1015.
249. Butler J. Rehabilitation in severe ideomotor apraxia using sensory stimulation strategies: A single-case experimental design study. British Journal of Occupational Therapy. 2000;63(7):319-328.
250. Cadenhead SL, McEwen IR, Thompson DM. Effect of passive range of motion exercises on lower-extremity goniometric measurements of adults with cerebral palsy: A single-subject design. Physical Therapy. 2002;82(7):658-669.
251. Callaghan GM, Summers CJ, Weidman Ml. The treatment of histrionic and narcissistic personality disorder behaviors: A single-subject demonstration of clinical improvement using functional analytic psychotherapy. Journal of Contemporary Psychotherapy. 2003;33(4):321-339.
252. Callahan CD, Barisa MT. Statistical process control and rehabilitation outcome: The single subject design reconsidered. Rehabilitation Psychology. 2005:50: 24-33.
253. Campbell, JM. Efficacy of behavioral intervention for reducing problematic behaviors in persons with autism: A quantitative synthesis of single-subject research. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2001;61(7-B):3834.
254. Campbell JM. Efficacy of behavioral interventions for reducing problem behavior in persons with autism: A quantitative synthesis of single-subject research. Research in Developmental Disabilities. 2003;24(2):120-138.
255. Campbell, JM. Statistical comparison of four effect sizes for single-subject designs. Behavior Modification. 2004;28(2):234-246.
256. Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L. The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects. Alternative Medicine Review. 2007;12(4):343-351. 04;28(2):234-246.
257. Cardaciotto L, Herbert JD. Cognitive behavior therapy for social anxiety disorder in the context of Asperger's syndrome: A single-subject report. Cognitive and Behavioral Practice. 2004;11(1):75-81.
258. Chen X, Pereira F, Lee W, Strother S, Mitchell T. Exploring predictive and reproducible modeling with the single-subject FIAC dataset. Human Brain Mapping. 2006;27(5):452-461.
259. Cicero FR. The effects of noncontingent reinforcement and response interruption on stereotypic behavior maintained by automatic reinforcement. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2008;68(10-A):4193.
260. Cleland J, Palmer J. Effectiveness of manual physical therapy, therapeutic exercise, and patient education on bilateral disc displacement without reduction-of the emporomandibular joint: A single-case design. Journal of Orthopaedic & Sports Physical Therapy. 2004;34(9):535-548.
261. Crooke PJ, Hendrix RE, Rachman JY. Brief report: Measuring the effectiveness of teaching social thinking to children with Asperger syndrome (AS) and high functioning autism (HFA). Journal of Autism and Developmental Disorders. 2008;38(3):581-591.
262. Crosbie J. (1999). Statistical inference in behavior analysis: Useful friend. Behavior Analyst. 1999;22(2):105-108.
263. De la Casa LG, Lubow RE. Latent inhibition with a response time measure from a withinsubject design: Effects of number of preexposures, masking task, context change, and delay. Neuropsychology. 2001;15(2):244-253.
264. Dermer ML. Using chains, a Quick BASIC 4.5 program, to teach single-subject experimentation with humans. Teaching of Psychology, 2004;31(4):285-288.
265. DeVoe D. Comparison of the RT3 research tracker and Tritrac R3D accelerometers during a backpacking expedition by a single subject. Perceptual and Motor Skills. 2004;99(2):545-546.
266. Didden R, Korzilius H, Van Oorsouw W, Sturmey P. Behavioral treatment of challenging behaviors in individuals with mild mental retardation: Meta-analysis of single-subject research. American Journal of Mental Retardation. 2006;111(4):290-298.
267. Dixon MR. Single-subject research designs: Dissolving the myths and demonstrating the utility for rehabilitation research. Rehabilitation Education. 2002;16(4):331-343.
268. Doepke KJ, Henderson AL, Critchfield TL. Social antecedents of children's eyewitness testimony: A single-subject experimental analysis. Journal of Applied Behavior Analysis. 2003;36(4):459-463.
269. Dudsic JA. Priming asymmetries in Chinese-English bilinguals: A series of single-subject studies. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2000;61(1-A):152.
270. Durrant JD, Palmer CV, Lunner T. Analysis of counted behaviors in a single-subject design: Modeling of hearing-aid intervention in hearing-impaired patients with Alzheimer's disease. International Journal of Audiology. 2005;44:31-38.
271. Dziegielewski SF, Wolfe P. Eye movement desensitization and reprocessing (EMDR) as a time-limited treatment intervention for body image disturbance and self-esteem: A single subject case study design. Journal of Psychotherapy in Independent Practice. 2000;1(3):1-16.
272. EggerM, Chiu B, Spence JD, Fenster A, Parraga G. Mapping spatial and temporal changes in carotid atherosclerosis from three-dimensional ultrasound images. Ultrasound in Medicine & Biology. 2008;34(1):64-72.
273. Elder JH, Valcante G, Yarandi H, White D, Elder TH. Evaluating in-home training for fathers of children with autism using single-subject experimentation and group analysis methods. Nursing Research. 2005;54(1):22-32.
274. Flanagan SP, Salem GJ. Lower extremity joint kinetic responses to external resistance variations. Journal of Applied Biomechanics. 2008;24(1):58-68.
275. Foster LH, Watson T, Steuart Y, Scott J. Single-subject research design for school counselors: Becoming an applied researcher. Professional School Counseling. 2002;6 (2) 146-154.
276. Francis NA. Single subject trials in primary care. Postgraduate Medical Journa l. 2005;81(959):547-548.
277. Fredriksen B, Mengshoel AM. The effect of static traction and orthoses in the treatment of knee contractures in preschool children with juvenile chronic arthritis: A single-subject design. Arthritis Care & Research. 2000;13(6):352-359.
278. Gliner JA, Morgan GA, Harmon RJ. Single-subject designs. Journal of the American Academy of Child & Adolescent Psychiatry. 2000;39(10):1327-1329.
279. Goebel R, Esposito F, Formisano E. Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: From single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis. Human Brain Mapping. 2006;27(5):392-401.
280. Goetz LL, Stiens SA. Abdominal electric stimulation facilitates penile vibratory stimulation for ejaculation after spinal cord injury: A single-subject trial. Archives of Physical Medicine & Rehabilitation. 2005;86(9):1879- 1883.
281. Goodrich, DE. Effect of daily step count goals on mood states of middle-aged women: A multiple treatment single-subject design. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2005;65(12-B):6703.
282. Green D, Beaton L, Moore D, Warren L, Wick V, Sanford JE, Santosh P. Clinical incidence of sensory integration difficulties in adults with learning disabilities and illustration of management. British Journal of Occupational Therapy. 2003;66(10):454-463.
283. Habedank LK. The effects of reintegrating students with mild disabilities in reading. Dissertation Abstracts International Section A: Humanities and Social Sciences. 1995;55(9-A):2772.
284. Hannah SD, Hudak PL. Splinting and radial nerve palsy: A single-subject experiment. Journal of Hand Therapy. 2001;14(3):195-201.
285. Havstam C, Buchholz M, Hartelius L. Speech recognition and dysarthria: A single subject study of two individuals with profound impairment of speech and motor control. Logopedics, Phoniatrics, Vocology. 2003;28(2):81-90.
286. Hayes SL, Savinelli S, Roberts E, Caldito G. Use of nonspeech oral motor treatment for functional articulation disorders. Early Childhood Services: An Interdisciplinary Journal of Effectiveness. 2007;1 (4), 261-281.
287. Herman PM, Drost LM. Evaluating the clinical relevance of food sensitivity tests: A single subject experiment. Alternative Medicine Review. 2004;9(2):198-207.
288. Hobbs JL, Yan Z. Cracking the walnut: Using a computer game to impact cognition, emotion, and behavior of highly aggressive fifth grade students. Computers in Human Behavior. 2008;24(2):421-438.
289. Horner RH, Carr EG, Halle J, McGee G, Odom S, Wolery M. The use of single-subject research to identify evidence-based practice in special education. Exceptional Children. 2005;71:165-179.
290. Hume K, Odom S. Effects of an individual work system on the independent functioning of students with autism. Journal of Autism and Developmental Disorders. 2007;37(6):1166-1180.
291. Ingersoll B, Lewis E, Kroman E. Teaching the imitation and spontaneous use of descriptive gestures in young children with autism using a naturalistic behavioral intervention. Journal of Autism and Developmental Disorders. 2007;37(8):1446-1456.
292. Janosky JE. Use of the single subject design for practice based primary care research. Postgraduate Medical Journal, 2005;81(959):549-551.
293. Kavale KA, Mathur SR, Forness SR, Quinn MM, Rutherford RB. Right reason in the integration of group and single-subject research in behavioral disorders. Behavioral Disorders. 2000;25(2):142-157.
294. Keays KS, Harris SR, Lucyshyn JM, MacIntyre DL. Effects of pilates exercises on shoulder range of motion, pain, mood, and upper-extremity function in women living with breast cancer: A pilot study. Physical Therapy. 2008;88(4):494-510.
295. Kennedy MR, Coelho C, Turkstra L, Ylvisaker M, Sohlberg MM, Yorkston K, Chiou H, Kan P. Intervention for executive functions after traumatic brain injury: A systematic review, meta-analysis and clinical recommendations. Neuropsychological Rehabilitation. 2008;18(3):257-299.
296. Kinugasa T, Cerin E, Hooper S. Single-subject research designs and data analyses for assessing elite athletes' conditioning. Sports Medicine. 2004;34(15):1035-1050.
297. Kinugasa T, Miyanaga Y, Shimojo H, Nishijima T. Statistical evaluation of conditioning for an elite collegiate tennis player using a single-case design. Journal of Strength & Conditioning Research. 2002;16(3):466-471.
298. Kovtoun TA, Arnold RW. Calibration of photoscreeners for single-subject, contact-induced hyperopic anisometropia. Journal of Pediatric Ophthalmology & Strabismus. 2004;41(3):150-158.
299. LaConte S, Anderson J, Muley S, Ashe J, Frutiger S, Rehm K, Hansen LK, Yacoub E, Hu X, Rottenberg D, Strother S.. The evaluation of preprocessing choices in single-subject boldfMRI using npairs performance metrics. Neuroimage. 2003;18(1):10-27.
300. Lange R, Weiller C, Liepert J. Chronic dose effects of reboxetine on motor skill acquisition and cortical excitability. Journal of Neural Transmission. 2007;114(8):1085-1089.
301. Larosa VR. Validation of preference assessment involving persons with varying degrees of multiple disabilities through contingent and non-contingent stimulus use in daily activity routines. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2007;68(5-B):3382.
302. Law I, Jensen M, Holm S, Nickles RJ, Paulson OB; Using (10) CO2 for single subject characterization of the stimulus frequency dependence in visual cortex: A novel positron emission tomography tracer for human brain mapping. Journal of Cerebral Blood Flow & Metabolism. 2001;21(8):1003-1012.
303. Lee DG. An experimental examination of children's sleep quality and improvements resulting from a parent education intervention. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2008;68(7-A):2829.
304. Linday LA, Tsiouris JA, Cohen IL, Shindledecker R, DeCresce R. Famotidine treatment of children with autistic spectrum disorders: Pilot research using single subject research design. Journal of Neural Transmission. 108(5):593-611, 2001.
305. Ma HH. An Alternative method for quantitative synthesis of single-subject researches: Percentage of data points exceeding the median. Behavior Modification. 2006;30(5):598-617.
306. Madsen LG, Bytzer P. Review article: Single subject trials as a research instrument in gastrointestinal pharmacology. Alimentary Pharmacology & Therapeutics. 2002;16(2):89-96.
307. Marklund I, Klassbo M. Effects of lower limb intensive mass practice in poststroke patients: Single-subject experimental design with long-term follow-up. Clinical Rehabilitation. 2006;20(7):568-576.
308. Martin GL, Thompson K, Regehr K. Studies using single-subject designs in sport psychology: 30 years of research. Behavior Analyst. 2004;27(2):263-280.
309. McCracken, JA. An intensive single subject investigation of clinical supervision: In-person and distance formats. Dissertation Abstracts International: Section B: The sciences and Engineering. 2005;65(12-B):6663.
310. McDonnell J, O'Neill R. A Perspective on single/within subject research methods and "scientifically based research". Research and Practice for Persons with Severe Disabilities. 2003;28(3):138-142.
311. McKelvey ML, Dietz AR, Hux K, Weissling K, Beukelman DR. Performance of a person with chronic aphasia using personal and contextual pictures in a visual scene display prototype. Journal of Medical Speech-Language Pathology. 2007;15(3):305-317.
312. McKerracher G, Powell T, Oyebode J. A single case experimental design comparing two memory notebook formats for a man with memory problems caused by traumatic brain injury. Neuropsychological Rehabilitation. 2005;15:115-128.
313. Megna J, O'dell M. Ataxia from lithium toxicity successfully treated with high-dose buspirone: A single-case experimental design. Archives of Physical Medicine & Rehabilitation. 2001;82(8):1145-1148.
314. Michaud TC, Nawoczenski DA. The influence of two different types of foot orthoses on first metatarsophalangel joint kinematics during gait in a single subject. Journal of Manipulative and Physiological Therapeutics. 2006;29(1):60-65.
315. Miller EW, Combs SA, Fish C, Bense B, Owens A, Burch A. Running training after stroke: A single-subject report. Physical Therapy. 2008;88(4):511-22.
316. Murphy PS. The effect of classroom meetings on the reduction of recess problems: A single case design. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2002;63(4-A):1256.
317. Nash MS, Johnson BM, Jacobs PL. Combined hyperlipidemia in a single subject with tetraplegia: Ineffective risk reduction after atorvastatin monotherapy. Journal of Spinal Cord Medicine. 2004;27(5):484-487.
318. Naude JH. Evaluating the efficacy of solution-focused couple therapy using single case design. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2000;61(3-B):1646.
319. Newcombe RG. Should the single subject design be regarded as a valid alternative to the randomized controlled trial?. Postgraduate Medical Journal. 2005;81(959):546-547.
320. Nikles CJ, Mitchell GK, Del Mar. CB, Clavarino A, McNairn N. An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics. 2006;117(6):2040-2046.
321. Odom SL, Brown WH, Frey T, Karasu N, Smith-Canter LL, Strain, PS. Evidence-based practices for young children with autism: Contributions for single-subject design research. Focus on Autism and Other Developmental Disabilities. 2003;18(3):166-175.
322. Odom SL, Strain PS. Evidence-based practice in early intervention/early childhood special education: Single-subject design research. Journal of Early Intervention. 2002;25(2):151-160.
323. O'Grady AC. A single subject investigation of behavioral and cognitive therapies for body dysmorphic disorder. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2002;63(6-B):3019.
324. Olive ML, Smith BW. Effect size calculations and single subject designs. Educational Psychology. 2005;25:313-324.
325. Onghena P, Edgington ES. Customization of pain treatments: Single-case design and analysis. Clinical Journal of Pain. 2005;21(1):56-68.
326. Orme JG, Cox ME. Analyzing single-subject design data using statistical process control charts. Social Work Research. 2001;25(2):115-127.
327. Ownsworth T, Fleming J, Desbois J, Strong J, Kuipers P. A metacognitive contextual intervention to enhance error awareness and functional outcome following traumatic brain injury: A single-case experimental design. Journal of the International Neuropsychological Society. 2006;12(1):54-63.
328. Parker AT, Davidson R, Banda DR. Emerging evidence from single-subject research in the field of deaf-blindness. Journal of Visual Impairment & Blindness. 2007;101(11):690-700.
329. Patrick PD, Patrick ST, Poole JD, Hostler S. Evaluation and treatment of the vegetative and minimally conscious child: A single subject design. Behavioral Interventions. 2000;15(3):225-242.
330. Pelletier, MH. Cognitive-behavioral therapy efficacy via videoconferencing for social (public speaking) anxiety disorder: Single case design. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2003;63(12-B):6103.
331. Perone M. Statistical inference in behavior analysis: Experimental control is better. Behavior Analyst. 1999;22(2):109-116.
332. Plant G, Gnosspelius J, Levitt H. The use of tactile supplements in lipreading Swedish and English: A single-subject study. Journal of Speech, Language, and Hearing Research. 2000;43(1):172-183.
333. Plumer, PJ. Using peers as intervention agents to improve the social behaviors of elementaryaged children with attention deficit hyperactivity disorder: Effects of a peer coaching package. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2008;68(7-A):2813.
334. Powers SW, Piazza-Waggoner C, Jones JF, Ferguson KS, Dianes C, Acton JD. Examining clinical trial results with single-subject analysis: An example involving behavioral and nutrition treatment for young children with cystic fibrosis. Journal of Pediatric Psychology. 2006;31(6):574-581.
335. Price JD, Grimley EJ. An N-of-1 randomized controlled trial ('N-of-1 trial') of donepezil in the treatment of non-progressive amnestic syndrome. Age & Ageing. 2002;31(4):307-309.
336. Rapoff M, Stark L. Editorial: Journal of Pediatric Psychology statement of purpose: Section on single-subject studies. Journal of Pediatric Psychology. 2008;33 (1), 16-21.
337. Reason R, Morfidi E. Literacy difficulties and single-case experimental design. Educational Psychology in Practice, 2001;17(3):227-244.
338. Reifin L, Hauser E. A single subject analysis of consultation process, consultee variables, and client outcomes. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2008;55(9-A):2776.
339. Rio DE, Rawlings RR, Woltz LA, Salloum JB, Hommer DW. Single subject image analysis using the complex general linear model - An application to functional magnetic resonance imaging with multiple inputs. Computer Methods and Programs in Biomedicine. 2006;82(1):10-19.
340. Romanczyk RG; Gillis JM. Commentary on Drash and Tudor: An analysis of autism as a contingency-shaped disorder of verbal behavior. Analysis of Verbal Behavior. 2004;20:45-47.
341. Romeiser LL, Hickman RR, Harris SR, Heriza CB. Single-subject research design: Recommendations for levels of evidence and quality rating. Developmental Medicine & Child Neurology. 2008;50(2):99-103
342. Ruka SM. The effects of reminiscence on promoting a comfort zone: A single subject study of people with dementia in a nursing home. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2004;65(2-B):658.
343. Rodman ML. A study of intensive, systematic direct instruction for an autistic child. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2008;68(7-A):2896.
344. Schlosser RW, Sigfoos J. Augmentative and alternative communication interventions for persons with elemental disabilities: Narrative review of comparative single-subject experimental studies. Research in Developmental Disabilities. 2006;27(1):1-29.
345. Schlosser RW. Meta-analysis of single-subject research: How should it be done? International Journal of Language & Communication Disorders. 2005;40:375-377.
346. Selkowitz DM, Cameron MH, Mainzer A. Wolfe R. Efficacy of pulsed low-intensity ultrasound in wound healing: Aa single-case design. Ostomy Wound Management. 2002;48(4):40-4, 46-50.
347. Sharp J, Espie CA. Brief exposure therapy for the relief of post-traumatic stress disorder: A single case experimental design. Behavioural and Cognitive Psychotherapy. 2004;32(3):365-369.
348. Shehab RL, Schlegel RE. Applying quality control charts to the analysis of single-subject data sequences. Human Factors. 2000;42(4):604-616.
349. Shull J, Deitz J, Billingsley F, Wendel S, Kartin D. Assistive technology programming for a young child with profound disabilities: A single-subject study. Physical & Occupational Therapy in Pediatrics. 2004;24(4):47-62.
350. SimonMJ. A comparison between EMDR and exposure for treating PTSD: A single-subject analysis. Behavior Therapist. 2000;23(8):172-175.
351. Skinner CH. Single-subject designs: Procedures that allow school psychologists to contribute to the intervention evaluation and validation process. Journal of Applied School Psychology. 2004;20(2):1-10.
352. Smith JF, Chen K, Johnson S, Morrone-Strupinsky J, Reiman EM, Nelson A, Moeller JR, Alexander GE.. Network analysis of single-subject fMRI during a finger opposition task. NeuroImage. 2006;32(1):325-332.
353. Stovall KC, Dozier M. The development of attachment in new relationships: Single subject analyses for 10 foster infants. Development and Psychopathology. 2000;12(2):133-156.
354. Stetter ME. Computer assisted instruction to promote comprehension strategies in students with learning disabilities. Dissertation Abstracts International Section A: Humanities and Social Sciences. 2008;68(7-A):2897.
355. Suzuki R, OgawaM, Otake S, Izutsu T, Tobimatsu Y, Izumi S, Iwaya T. Analysis of activities of daily living in elderly people living alone: Single-subject feasibility study. Telemedicine Journal & E-Health. 2004;10(2):260-276.
356. Swanson HL, Sachse-Lee C. A meta-analysis of single-subject-design intervention research for students with LD. Journal of Learning Disabilities. 2000;33(2):114-136.
357. Tankersley M, McGoey KE, Dalton D, Rumrill PD Jr, Balan CM. Single subject research methods in rehabilitation. Work (Reading, MA). 2006;26(1):85-92.
358. Teipel S, Ewers M, Dietrich O, Schoenberg S, Jessen P, Heun R, Freymann N, Moller HJ, Hampel H.. Reliability of multicenter magnetic resonance imaging. Results of a phantom test and in vivo measurements by the German dementia competence network. Nervenarzt. 2006;77(9):1086-1095.
359. Thompson CK. Single subject controlled experiments in aphasia: The science and the state of the science. Journal of Common Disorders. 2006;39(4):266-291.
360. Trujillo-Barreto NJ, Aubert-Vazquez E, Penny WD. Bayesian M/EEG source reconstruction with spatio-temporal priors. Neuroimage. 2008;39(1):318-335.
361. Tsapas A, Matthews DR. N-of-1 trials in diabetes: Making individual therapeutic decisions. Source Diabetologia. 2008;51(6):921-925.
362. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M.. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002;15(1):273-289.
363. Van de Vliet P, Onghena P, Knapen J, Fox KR, Probst M, Van Coppenolle H, Pieters G. Assessing the additional impact of fitness training in depressed psychiatric patients receiving multifaceted treatment: A replicated single-subject design. Disability and Rehabilitation: An International Multidisciplinary Journal. 2003;25(24):1344-1353.
364. Van Deusen KM. Bilateral stimulation in EMDR: A replicated single-subject component analysis. Behavior Therapist. 2004;27(4):79-86.
365. Vingerhoets G, Stroobant N. Reliability and validity of day-to-day blood flow velocity reactivity in a single subject: an fTCD study. Ultrasound in Medicine & Biology. 2002;28(2):197-202.
366. Vlaeyen JWS, De Jong J, Geilen M, Heuts PHTG, Van Breukelen G. Graded exposure in vivo in the treatment of pain-related fear: A replicated single-case experimental design in four patients with chronic low back pain. Behaviour Research and Therapy. 2001;39(2):151-166.
367. Wehmeyer ML, Palmer SB, Smith SJ, Parent W, Davies DK, Stock S. Technology use by people with intellectual and developmental disabilities to support employment actives: A single-subject design meta analysis. Journal of Vocational Rehabilitation. 2006;24(2):81-86.
368. Wenman R, Bowen A, Tallis RC, Gardener E, Cross S, Niven D. Use of a randomized single case experimental design to evaluate therapy for unilateral neglect. Neuropsychological Rehabilitation. 2003;13(4):441-459.
369. Winslow E, Hutchison R. Placebo use in the N-Of-1 Trial. American Journal of Nursing. 2006;106(9):16.
370. Wragg JA, Whitehead RE. CBT for adolescents with psychosis: Investigating the feasibility & effectiveness of early intervention using a single case design. Behavioral and Cognitive Psychotherapy. 2004;32(3):313-329.
371. Zhan S, Ottenbacher KJ. Single subject research designs for disability research. Disability & Rehabilitation. 2001;23(1):1-8.
372. Zhang H, Luo WL, Nichols TE. Diagnosis of single-subject and group fMRI data with SPMd. Human Brain Mapping. 2006;27(5):442-451.