The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1

Biochemical Journal

Volumn 417, Issue 1, 2009, Pages 305-312

  Corich, Lucia ^a,b   Aranda, Alejandro ^a   Carrassa, Laura ^c   Bellarosa, Cristina ^a   Ostrow, J Donald ^d   Tiribelli, Claudio ^a  

^a Centro Studi Fegato   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Bilirubin; Kernicterus; MDR1; MRP1; Neurotoxicity

Indexed keywords

BILIRUBIN; KERNICTERUS; MDR1; MRP1; NEUROTOXICITY;

CELL MEMBRANES; NUCLEIC ACIDS; RNA;

CYTOTOXICITY;

BILIRUBIN; MULTIDRUG RESISTANCE PROTEIN 1; SMALL INTERFERING RNA; BENZIMIDAZOLE DERIVATIVE; DOXYCYCLINE; GLYCOPROTEIN P; HOE 33342; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION SYSTEM; GENE SILENCING; HUMAN; HUMAN CELL; KERNICTERUS; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; NEUROBLASTOMA; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; WESTERN BLOTTING;

BENZIMIDAZOLES; BILIRUBIN; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; DOXYCYCLINE; GENE EXPRESSION; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEUROBLASTOMA; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 58249089412     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20080918     Document Type: Article

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