Predicting bilirubin neurotoxicity in jaundiced newborns

Current Opinion in Pediatrics

Volumn 22, Issue 2, 2010, Pages 129-133

  Ahlfors, Charles E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bilirubin encephalopathy; Bilirubin neurotoxicity; Kernicterus; Unbound or free bilirubin

Indexed keywords

BILIRUBIN;

BILIRUBIN BINDING; BILIRUBIN BLOOD LEVEL; EVOKED BRAIN STEM AUDITORY RESPONSE; HUMAN; KERNICTERUS; NEUROTOXICITY; NEWBORN; NEWBORN JAUNDICE; NEWBORN SCREENING; PREDICTION; PRIORITY JOURNAL; REFERENCE VALUE; REVIEW; RISK ASSESSMENT;

BILIRUBIN; HUMANS; INFANT, NEWBORN; JAUNDICE, NEONATAL;

EID: 77952257683     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e328336eb28     Document Type: Review

References (47)

1. Wennberg RP, Ahlfors CE, Bhutani VK, et al. Toward understanding kernicterus: a challenge to improve the management of jaundiced Newborns. Pediatrics 2006;117:474-485.
2. Suresh G. Cost-effectiveness of strategies intended to prevent kernicterus in Newborn infants. Pediatrics 2004;114:917-927. (Pubitemid 41529753)
3. Ebbesen F. Recurrence of kernicterus in term and near-term infants in Denmark. Acta Paediatr 2000;89:1213-1217.
4. Ahlfors CE, Herbsman O. Unbound bilirubin in a term Newborn with kernicterus. Pediatrics 2003;111:1110-1112. (Pubitemid 36542630)
5. Mollen TJ, Scarfone R, Harris MC. Acute, severe bilirubin encephalopathy in a Newborn. Pediatr Emerg Care 2004;20:599-601. (Pubitemid 39244590)
6. Sheridan SE. Parents of infants and children with kernicterus. J Perinatol 2005;25:227-228.
7. Slusher TM, Vreman HJ, McLaren DW, et al. Glucose-6-phosphate dehydrogenase deficiency and carboxyhemoglobin concentrations associated with bilirubin-related morbidity and death in Nigerian infants. J Pediatr 1995;126:102-108.
8. Shapiro SM. Definition of the clinical spectrum of kernicterus and bilirubin induced neurological dysfunction (BIND). J Perinatol 2005;25:54-59.
9. T alone as intervention criterion.
10. Ip S, Chung M, Kulig J, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics 2004; 114: e130-e153.
11. Wennberg RP, Ahlfors CE, Aravkin AY. Intervention guidelines for neonatal hyperbilirubinemia: an evidence based quagmire. Curr Pharm Des 2009;15:2939-2945. Reviews the lack of evidence-based information and its impact on managing Newborn jaundice.
12. Ahlfors CE, Wennberg RP, Ostrow JD, Tiribelli C. Unbound (free) bilirubin (Bf) : improving the paradigm for evaluating neonatal jaundice. Clin Chem 2009;55:1288-1299. Reviews the reasons why bilirubin-binding measurements are not widely available as well as the rationale and details concerning their measurement.
13. Ross G. Hyperbilirubinemia in the 2000 s: what should we do next? Am J Perinatol 2003;20:415-424. (Pubitemid 37493878)
14. Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hourspecific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term Newborns. Pediatrics 2001;103:6-14. (Pubitemid 29281921)
15. Harris RC, Lucey JF, MacClean JR. Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. Pediatrics 1958;21:875-884.
16. McDonagh AF, Maisels MJ. Bilirubin unbound: deja vu all over again? Pediatrics 2006;117:523-525.
17. Newman T, Liljestrand P, Jeremy RJ, et al. Outcomes among Newborns with total serum bilirubin levels of 25 mg per deciliter or more. New Engl J Med 2006;354:1889-1900. (Pubitemid 43872690)
18. Ahlfors CE, Parker AE. Unbound bilirubin is associated with abnormal auto-mated auditory brainstem responses in jaundiced Newborns. Pediatrics 2008;121:976-978. Demonstrates how a robust measure of bilirubin neurotoxicity can be used to assess the clinical impact of measuring binding.
19. Lee YK, Daito Y, Katayama Y, et al. The significance of measurement of serum unbound bilirubin concentrations in high risk infants. Pediatr Int 2009;51:795-799.
20. T alone.
21. Penn AA, Enzmann DR, Hahn JS, Stevenson DK. Kernicterus in a full term infant. Pediatrics 1994;93:1003-1006.
22. Govaert P, Lequin M, Swarte R, et al. Changes in globus pallidus with (pre) term kernicterus. Pediatrics 2003;112:1256-1263. (Pubitemid 37523404)
23. Schmid R, Hammaker L. Metabolism and disposition of C14-bilirubin in congenital nonhemolytic jaundice. J Clin Invest 1963;42:1720-1734.
24. Berk PD, Howe RB, Bloomer JR, Berlin NI. Studies of bilirubin kinetics in normal adults. J Clin Invest 1969;48:2176-2190.
25. Odell G. Studies in kernicterus. I. The protein binding of bilirubin. J Clin Invest 1959;38:823-833.
26. Cashore WJ, Oh W. Unbound bilirubin and kernicterus in low birth weight infants. Pediatrics 1982;69:481-485. (Pubitemid 12135952)
27. Nakamura H, Yonetani M, Uetani Y, et al. Determination of serum unbound bilirubin for prediction of kernicterus in low birth weight infants. Acta Paediatr Jpn 1992;34:642-647. (Pubitemid 23029101)
28. Funato M, Tamai H, Shimada S, Nakamura H. Vigintiphobia, unbound bilirubin, and auditory brainstem responses. Pediatrics 1994;93:50-53.
29. Amin SB, Ahlfors C, Orlando MS, et al. Bilirubin and serial auditory brainstem responses in premature infants. Pediatrics 2001;107:664-670. (Pubitemid 32268449)
30. Ahlfors CE. Criteria for exchange transfusion in jaundiced Newborns. Pediatrics 1994;93:488-494.
31. Ahlfors CE, Parker AE. Evaluation of a model for brain bilirubin uptake in jaundiced Newborns. Pediatr Res 2005;58:1175-1179. (Pubitemid 43755694)
32. Ostrow JD, Pascolo L, Brites D, Tiribelli C. Molecular basis of bilirubininduced neurotoxicity. Trends Mol Med 2004;10:65-70.
33. Shimabuku R, Nakamura H. Totaland unbound bilirubindetermined using an automated peroxidase micromethod. Kobe J Med Sci 1982;28:91-104. (Pubitemid 12064147)
34. Lott JA, Mitchell LC, Moeschberger ML, Sutherland DE. Estimation of reference ranges: how many subjects are needed? Clin Chem 1992;38:648-650.
35. Jacobsen J. Binding of bilirubin to albumin: determination of the dissociation constants. FEBS Lett 1969;6:112-114.
36. Bender GJ, Cashore WJ, Oh W. Ontogeny of bilirubin-binding capacity and the effects of clinical status in premature infants born at less than 1300 grams. Pediatrics 2007;120:1067-1070. (Pubitemid 350085541)
37. Boobis SW, Chignell CF. Effect of protein concentration on the binding of drugs to human serum albumin-I. Sulfadiazine, salicylate and phenylbutazone. Biochem Pharmacol 1979;28:751-756.
38. Wennberg RP, Ahlfors CE, Bickers R, et al. Abnormal auditory brainstem response in a Newborn infant with hyperbilirubinemia: improvement with exchange transfusion. J Pediatr 1982;100:624-626. (Pubitemid 12136043)
39. Kaga K, Kitazumi E, Kodama K. Auditory brain stem responses of kernicterus infants. Int J Pediatr Otorhinolaryngol 1979;1:255-264. (Pubitemid 10093480)
40. Perlman M, Fainmesser P, Sohmer H, et al. Auditory nerve-brainstem evoked responses in hyperbilirubinemic neonates. Pediatrics 1983;72:658-664. (Pubitemid 14232886)
41. Lenhardt ML, McArtor R, Bryant B. Effects of neonatal hyperbilirubinemia on the brainstem electric response. J Pediatr 1984;104:281-284. (Pubitemid 14188945)
42. Kuriyama M, Tomiwa K, Konishi Y, Mikawa H. Improvement in auditory brainstem response of hyperbilirubinemic infants after exchange transfusions. Pediatr Neurol 1986;2:127-132. (Pubitemid 17029812)
43. Worley G, Erwin CW, Goldstein RF, et al. Delayed development of sensorineural hearing loss after neonatal hyperbilirubinemia: a case report with brain magnetic resonance imaging. Dev Med Child Neurol 1996;38:271-277. (Pubitemid 26083698)
44. Ahlfors CE, Bennett SH, Shoemaker CT, et al. Changes in the auditory brainstem response associated with intravenous infusion of unconjugated bilirubin into infant rhesus monkeys. Pediatr Res 1986;20:511-515.
45. Ahlfors CE, Shapiro SM. Auditory brainstem response and unbound bilirubin in jaundiced (jj) Gunn rat pups. Biol Neonate 2001;80:158-162.
46. Shapiro SM, Nakamura H. Bilirubin and the auditory system. J Perinatol 2001; 21: S52-S55. (Pubitemid 34055874)
47. Smitherman H, Stark AR, Bhutani AK. Early recognition of neonatal hyperbilirubinemia and its emergent management. Semin Fetal Neonatal Med 2006;11:214-224.