-
1
-
-
33746255899
-
Gene amplification in cancer
-
Albertson DG. Gene amplification in cancer. Trends Genet 2006; 22: 447-55.
-
(2006)
Trends Genet
, vol.22
, pp. 447-455
-
-
Albertson, D.G.1
-
2
-
-
0010521212
-
Amplification of genes for chorion proteins during oogenesis in drosophila melanogaster
-
Spradling AC, Mahowald AP. Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster. Proc Natl Acad Sci USA 1980; 77: 1096-100.
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, pp. 1096-1100
-
-
Spradling, A.C.1
Mahowald, A.P.2
-
3
-
-
0014422789
-
Specific gene amplification in oocytes. Oocyte nuclei contain extrachromosomal replicas of the genes for ribosomal rna
-
Brown DD, Dawid IB. Specific gene amplification in oocytes. Oocyte nuclei contain extrachromosomal replicas of the genes for ribosomal RNA. Science 1968; 160: 272-80.
-
(1968)
Science
, vol.160
, pp. 272-280
-
-
Brown, D.D.1
Dawid, I.B.2
-
4
-
-
0023590844
-
Gene amplification in rhynchosciara (1955-1987)
-
Lara FJ. Gene amplification in Rhynchosciara (1955-1987). Memórias Do Instituto Oswaldo Cruz 1987; 82 (Suppl 3): 125-8.
-
(1987)
Memórias Do Instituto Oswaldo Cruz
, vol.82
, Issue.SUPPL. 3
, pp. 125-128
-
-
Lara, F.J.1
-
5
-
-
0000557527
-
Behavior of polytene chromosomes of rhynchosciara angelae at different stages of larval development
-
Breuer ME, Pavan C. Behavior of polytene chromosomes of Rhynchosciara angelae at different stages of larval development. Chromosoma 1955; 7: 371-86.
-
(1955)
Chromosoma
, vol.7
, pp. 371-386
-
-
Breuer, M.E.1
Pavan, C.2
-
6
-
-
0000655785
-
Disproportionate synthesis of dna in a polytene chromosome region
-
Rudkin GT, Corlette SL. Disproportionate synthesis of DNA in a polytene chromosome region. Proc Natl Acad Sci USA 1957; 43: 964-8.
-
(1957)
Proc Natl Acad Sci USA
, vol.43
, pp. 964-968
-
-
Rudkin, G.T.1
Corlette, S.L.2
-
7
-
-
13944274945
-
Developmental gene amplification: Insights into dna replication and gene expression
-
Claycomb JM, Orr-Weaver TL. Developmental gene amplification: insights into DNA replication and gene expression. Trends Genet 2005; 21: 149-62.
-
(2005)
Trends Genet
, vol.21
, pp. 149-162
-
-
Claycomb, J.M.1
Orr-Weaver, T.L.2
-
8
-
-
0035954234
-
Amplification of oncogenes revisited: From expression profiling to clinical application
-
Savelyeva L, Schwab M. Amplification of oncogenes revisited: from expression profiling to clinical application. Cancer Lett 2001; 167: 115-23.
-
(2001)
Cancer Lett
, vol.167
, pp. 115-123
-
-
Savelyeva, L.1
Schwab, M.2
-
9
-
-
0017807188
-
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells
-
Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem 1978; 253: 1357-70.
-
(1978)
J Biol Chem
, vol.253
, pp. 1357-1370
-
-
Alt, F.W.1
Kellems, R.E.2
Bertino, J.R.3
Schimke, R.T.4
-
10
-
-
0018263636
-
Gene amplification and drug resistance in cultured murine cells
-
Schimke RT, Kaufman RJ, Alt FW, Kellems RF. Gene amplification and drug resistance in cultured murine cells. Science 1978; 202: 1051-5.
-
(1978)
Science
, vol.202
, pp. 1051-1055
-
-
Schimke, R.T.1
Kaufman, R.J.2
Alt, F.W.3
Kellems, R.F.4
-
11
-
-
0018787266
-
Gene amplification causes overproduction of the first three enzymes of ump synthesis in n-(phosphonacetyl)-l-aspartate-resistant hamster cells
-
Wahl GM, Padgett RA, Stark GR. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate- resistant hamster cells. J Biol Chem 1979; 254: 8679-89.
-
(1979)
J Biol Chem
, vol.254
, pp. 8679-8689
-
-
Wahl, G.M.1
Padgett, R.A.2
Stark, G.R.3
-
12
-
-
8344271026
-
Production of recombinant protein therapeutics in cultivated mammalian cells
-
Wurm FM. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol 2004; 22: 1393-8.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 1393-1398
-
-
Wurm, F.M.1
-
13
-
-
0025139423
-
Effects of methotrexate on transfected dna stability in mammalian cells
-
Pallavicini MG, DeTeresa PS, Rosette C, Gray JW, Wurm FM. Effects of methotrexate on transfected DNA stability in mammalian cells. Mol Cell Biol 1990; 10: 401-4.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 401-404
-
-
Pallavicini, M.G.1
Deteresa, P.S.2
Rosette, C.3
Gray, J.W.4
Wurm, F.M.5
-
14
-
-
0343148872
-
Inducible overproduction of the mouse c-myc protein in mammalian cells
-
Wurm FM, Gwinn KA, Kingston RE. Inducible overproduction of the mouse c-myc protein in mammalian cells. Proc Natl Acad Sci USA 1986; 83: 5414-8.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 5414-5418
-
-
Wurm, F.M.1
Gwinn, K.A.2
Kingston, R.E.3
-
15
-
-
0017289341
-
Metaphase chromosome anomaly: Association with drug resistance and cell-specific products
-
Biedler JL, Spengler BA. Metaphase chromosome anomaly: association with drug resistance and cell-specific products. Science 1976; 191: 185-7.
-
(1976)
Science
, vol.191
, pp. 185-187
-
-
Biedler, J.L.1
Spengler, B.A.2
-
16
-
-
0011815638
-
Amplified dihydrofolate reductase genes in unstably methotrexate- resistant cells are associated with double minute chromosomes
-
Kaufman RJ, Brown PC, Schimke RT. Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proc Natl Acad Sci USA 1979; 76: 5669-73.
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 5669-5673
-
-
Kaufman, R.J.1
Brown, P.C.2
Schimke, R.T.3
-
17
-
-
0021735425
-
Gene amplification in cultured animal cells
-
Schimke RT. Gene amplification in cultured animal cells. Cell 1984; 37: 705-13.
-
(1984)
Cell
, vol.37
, pp. 705-713
-
-
Schimke, R.T.1
-
18
-
-
77956277959
-
Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure
-
Storlazzi CT, Lonoce A, Guastadisegni MC, Trombetta D, D'Addabbo P, Daniele G, L'Abbate A, Macchia G, Surace C, Kok K, Ullmann R, Purgato S, Palumbo O, Carella M, Ambros PF, Rocchi M. Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure. Genome Res 2010; 20: 1198-206.
-
(2010)
Genome Res
, vol.20
, pp. 1198-1206
-
-
Storlazzi, C.T.1
Lonoce, A.2
Guastadisegni, M.C.3
Trombetta, D.4
D'Addabbo, P.5
Daniele, G.6
L'Abbate, A.7
Macchia, G.8
Surace, C.9
Kok, K.10
Ullmann, R.11
Purgato, S.12
Palumbo, O.13
Carella, M.14
Ambros, P.F.15
Rocchi, M.16
-
19
-
-
0015518699
-
Small polydisperse circular dna of hela cells
-
Smith CA, Vinograd J. Small polydisperse circular DNA of HeLa cells. J Mol Biol 1972; 69: 163-78.
-
(1972)
J Mol Biol
, vol.69
, pp. 163-178
-
-
Smith, C.A.1
Vinograd, J.2
-
20
-
-
0019432692
-
Evidence for double replication of chromosomal dna segments as a general consequence of dna replication inhibition
-
Woodcock DM, Cooper IA. Evidence for double replication of chromosomal DNA segments as a general consequence of DNA replication inhibition. Cancer Res 1981; 41: 2483-90.
-
(1981)
Cancer Res
, vol.41
, pp. 2483-2490
-
-
Woodcock, D.M.1
Cooper, I.A.2
-
21
-
-
0019777535
-
Cytogenetic features of human neuroblastomas and cell lines
-
Brodeur GM, Green AA, Hayes FA, Williams KJ, Williams DL, Tsiatis AA. Cytogenetic features of human neuroblastomas and cell lines. Cancer Res 1981; 41: 4678-86.
-
(1981)
Cancer Res
, vol.41
, pp. 4678-4686
-
-
Brodeur, G.M.1
Green, A.A.2
Hayes, F.A.3
Williams, K.J.4
Williams, D.L.5
Tsiatis, A.A.6
-
22
-
-
0020966331
-
Novel amplification and transcriptional activity of chorion genes in drosophila melanogaster follicle cells
-
Osheim YN, Miller OL. Novel amplification and transcriptional activity of chorion genes in Drosophila melanogaster follicle cells. Cell 1983; 33: 543-53.
-
(1983)
Cell
, vol.33
, pp. 543-553
-
-
Osheim, Y.N.1
Miller, O.L.2
-
23
-
-
76949127123
-
Chromosome organization and genic expression
-
McClintock B. Chromosome organization and genic expression. Cold Spring Harb Symp Quant Biol 1951; 16: 13-47.
-
(1951)
Cold Spring Harb Symp Quant Biol
, vol.16
, pp. 13-47
-
-
McClintock, B.1
-
24
-
-
0030904279
-
Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
-
Coquelle A, Pipiras E, Toledo F, Buttin G, Debatisse M. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell 1997; 89: 215-25.
-
(1997)
Cell
, vol.89
, pp. 215-225
-
-
Coquelle, A.1
Pipiras, E.2
Toledo, F.3
Buttin, G.4
Debatisse, M.5
-
25
-
-
33750410484
-
The breakage-fusion-bridge (bfb) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma
-
Selvarajah S, Yoshimoto M, Park PC, Maire G, Paderova J, Bayani J, Lim G, Al-Romaih K, Squire JA, Zielenska M. The breakage-fusion-bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma. Chromosoma 2006; 115: 459-67.
-
(2006)
Chromosoma
, vol.115
, pp. 459-467
-
-
Selvarajah, S.1
Yoshimoto, M.2
Park, P.C.3
Maire, G.4
Paderova, J.5
Bayani, J.6
Lim, G.7
Al-Romaih, K.8
Squire, J.A.9
Zielenska, M.10
-
26
-
-
0022596135
-
Copy number amplification of the 2 micron circle plasmid of saccharomyces cerevisiae
-
Futcher AB. Copy number amplification of the 2 micron circle plasmid of Saccharomyces cerevisiae. J Theor Biol 1986; 119: 197-204.
-
(1986)
J Theor Biol
, vol.119
, pp. 197-204
-
-
Futcher, A.B.1
-
27
-
-
0022497169
-
Site-specific recombination promotes plasmid amplification in yeast
-
Volkert FC, Broach Jr. Site-specific recombination promotes plasmid amplification in yeast. Cell 1986; 46: 541-50.
-
(1986)
Cell
, vol.46
, pp. 541-550
-
-
Volkert, F.C.1
Broach2
-
28
-
-
0023959559
-
The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification
-
Hyrien O, Debatisse M, Buttin G, de Saint Vincent BR. The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification. EMBO J 1988; 7: 407-17.
-
(1988)
EMBO J
, vol.7
, pp. 407-417
-
-
Hyrien, O.1
Debatisse, M.2
Buttin, G.3
De Saint Vincent, B.R.4
-
29
-
-
13244299108
-
A novel gene amplification system in yeast based on double rolling-circle replication
-
Watanabe T, Horiuchi T. A novel gene amplification system in yeast based on double rolling-circle replication. EMBO J 2005; 24: 190-8.
-
(2005)
EMBO J
, vol.24
, pp. 190-198
-
-
Watanabe, T.1
Horiuchi, T.2
-
30
-
-
80052426788
-
Gene amplification system based on double rolling-circle replication as a model for oncogene-type amplification
-
Watanabe T, Tanabe H, Horiuchi T. Gene amplification system based on double rolling-circle replication as a model for oncogene-type amplification. Nucleic Acids Res 2011; 39: e106.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Watanabe, T.1
Tanabe, H.2
Horiuchi, T.3
-
31
-
-
33646490411
-
On the mechanism of gene amplification induced under stress in escherichia coli
-
Slack A, Thornton PC, Magner DB, Rosenberg SM, Hastings PJ. On the mechanism of gene amplification induced under stress in Escherichia coli. PLoS Genet 2006; 2: e48.
-
(2006)
PLoS Genet
, vol.2
-
-
Slack, A.1
Thornton, P.C.2
Magner, D.B.3
Rosenberg, S.M.4
Hastings, P.J.5
-
32
-
-
37349109667
-
A dna replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders
-
Lee JA, Carvalho CMB, Lupski Jr. A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell 2007; 131: 1235-47.
-
(2007)
Cell
, vol.131
, pp. 1235-1247
-
-
Lee, J.A.1
Carvalho, C.M.B.2
Lupski3
-
33
-
-
67649878596
-
The dna replication fostes/mmbir mechanism can generate genomic, genic and exonic complex rearrangements in humans
-
Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD, Lupski Jr. The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans. Nat Genet 2009; 41: 849-53.
-
(2009)
Nat Genet
, vol.41
, pp. 849-853
-
-
Zhang, F.1
Khajavi, M.2
Connolly, A.M.3
Towne, C.F.4
Batish, S.D.5
Lupski6
-
34
-
-
0022628653
-
Conditioned tumorigenicity of activated oncogenes
-
Klein G, Klein E. Conditioned tumorigenicity of activated oncogenes. Cancer Res 1986; 46: 3211-24.
-
(1986)
Cancer Res
, vol.46
, pp. 3211-3224
-
-
Klein, G.1
Klein, E.2
-
35
-
-
0019797847
-
Gene-amplification model of carcinogenesis
-
Pall ML. Gene-amplification model of carcinogenesis. Proc Natl Acad Sci USA 1981; 78: 2465-8.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 2465-2468
-
-
Pall, M.L.1
-
37
-
-
0025271662
-
Amplification of cellular oncogenes: A predictor of clinical outcome in human cancer
-
Schwab M, Amler LC. Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer. Genes Chromosomes Cancer 1990; 1: 181-93.
-
(1990)
Genes Chromosomes Cancer
, vol.1
, pp. 181-193
-
-
Schwab, M.1
Amler, L.C.2
-
38
-
-
0034652585
-
Detection of gene amplification by genomic hybridization to cdna microarrays
-
Heiskanen MA, Bittner ML, Chen Y, Khan J, Adler KE, Trent JM, Meltzer PS. Detection of gene amplification by genomic hybridization to cDNA microarrays. Cancer Res 2000; 60: 799-802.
-
(2000)
Cancer Res
, vol.60
, pp. 799-802
-
-
Heiskanen, M.A.1
Bittner, M.L.2
Chen, Y.3
Khan, J.4
Adler, K.E.5
Trent, J.M.6
Meltzer, P.S.7
-
39
-
-
4143096081
-
Comparative genomic hybridization (cgh)-arrays pave the way for identification of novel cancerrelated genes
-
Inazawa J, Inoue J, Imoto I. Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancerrelated genes. Cancer Sci 2004; 95: 559-63.
-
(2004)
Cancer Sci
, vol.95
, pp. 559-563
-
-
Inazawa, J.1
Inoue, J.2
Imoto, I.3
-
40
-
-
0028907211
-
Computer image analysis of comparative genomic hybridization
-
Piper J, Rutovitz D, Sudar D, Kallioniemi A, Kallioniemi OP, Waldman FM, Gray JW, Pinkel D. Computer image analysis of comparative genomic hybridization. Cytometry 1995; 19: 10-26.
-
(1995)
Cytometry
, vol.19
, pp. 10-26
-
-
Piper, J.1
Rutovitz, D.2
Sudar, D.3
Kallioniemi, A.4
Kallioniemi, O.P.5
Waldman, F.M.6
Gray, J.W.7
Pinkel, D.8
-
41
-
-
17344371740
-
High resolution analysis of dna copy number variation using comparative genomic hybridization to microarrays
-
Pinkel D, Segraves R, Sudar D, Clark S, Poole I, Kowbel D, Collins C, Kuo WL, Chen C, Zhai Y, Dairkee SH, Ljung BM, Gray JW, Albertson DG. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 1998; 20: 207-11.
-
(1998)
Nat Genet
, vol.20
, pp. 207-211
-
-
Pinkel, D.1
Segraves, R.2
Sudar, D.3
Clark, S.4
Poole, I.5
Kowbel, D.6
Collins, C.7
Kuo, W.L.8
Chen, C.9
Zhai, Y.10
Dairkee, S.H.11
Ljung, B.M.12
Gray, J.W.13
Albertson, D.G.14
-
42
-
-
44349191457
-
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
-
Campbell PJ, Stephens PJ, Pleasance ED, O'Meara S, Li H, Santarius T, Stebbings LA, Leroy C, Edkins S, Hardy C, Teague JW, Menzies A, Goodhead I, Turner DJ, Clee CM, Quail MA, Cox A, Brown C, Durbin R, Hurles ME, Edwards PAW, Bignell GR, Stratton MR, Futreal PA. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet 2008; 40: 722-9.
-
(2008)
Nat Genet
, vol.40
, pp. 722-729
-
-
Campbell, P.J.1
Stephens, P.J.2
Pleasance, E.D.3
O'Meara, S.4
Li, H.5
Santarius, T.6
Stebbings, L.A.7
Leroy, C.8
Edkins, S.9
Hardy, C.10
Teague, J.W.11
Menzies, A.12
Goodhead, I.13
Turner, D.J.14
Clee, C.M.15
Quail, M.A.16
Cox, A.17
Brown, C.18
Durbin, R.19
Hurles, M.E.20
Edwards, P.A.W.21
Bignell, G.R.22
Stratton, M.R.23
Futreal, P.A.24
more..
-
43
-
-
84863037350
-
Massively parallel sequencing approaches for characterization of structural variation
-
Koboldt DC, Larson DE, Chen K, Ding L, Wilson RK. Massively parallel sequencing approaches for characterization of structural variation. Methods Mol Biol 2012; 838: 369-84.
-
(2012)
Methods Mol Biol
, vol.838
, pp. 369-384
-
-
Koboldt, D.C.1
Larson, D.E.2
Chen, K.3
Ding, L.4
Wilson, R.K.5
-
44
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho Y-J, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao M-S, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M. The landscape of somatic copy-number alteration across human cancers. Nature 2010; 463: 899-905.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
Barretina, J.7
Boehm, J.S.8
Dobson, J.9
Urashima, M.10
Mc Henry, K.T.11
Pinchback, R.M.12
Ligon, A.H.13
Cho, Y.-J.14
Haery, L.15
Greulich, H.16
Reich, M.17
Winckler, W.18
Lawrence, M.S.19
Weir, B.A.20
Tanaka, K.E.21
Chiang, D.Y.22
Bass, A.J.23
Loo, A.24
Hoffman, C.25
Prensner, J.26
Liefeld, T.27
Gao, Q.28
Yecies, D.29
Signoretti, S.30
Maher, E.31
Kaye, F.J.32
Sasaki, H.33
Tepper, J.E.34
Fletcher, J.A.35
Tabernero, J.36
Baselga, J.37
Tsao, M.-S.38
Demichelis, F.39
Rubin, M.A.40
Janne, P.A.41
Daly, M.J.42
Nucera, C.43
Levine, R.L.44
Ebert, B.L.45
Gabriel, S.46
Rustgi, A.K.47
Antonescu, C.R.48
Ladanyi, M.49
Letai, A.50
Garraway, L.A.51
Loda, M.52
Beer, D.G.53
True, L.D.54
Okamoto, A.55
Pomeroy, S.L.56
Singer, S.57
Golub, T.R.58
Lander, E.S.59
Getz, G.60
Sellers, W.R.61
Meyerson, M.62
more..
-
45
-
-
84874259591
-
Transforming mutations of rac guanosine triphosphatases in human cancers
-
Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T, Yamashita Y, Katada T, Choi YL, Mano H. Transforming mutations of RAC guanosine triphosphatases in human cancers. Proc Natl Acad Sci USA 2013; 110: 3029-34.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 3029-3034
-
-
Kawazu, M.1
Ueno, T.2
Kontani, K.3
Ogita, Y.4
Ando, M.5
Fukumura, K.6
Yamato, A.7
Soda, M.8
Takeuchi, K.9
Miki, Y.10
Yamaguchi, H.11
Yasuda, T.12
Naoe, T.13
Yamashita, Y.14
Katada, T.15
Choi, Y.L.16
Mano, H.17
-
46
-
-
33645960993
-
Activation of multiple cancerassociated genes at the erbb2 amplicon in breast cancer
-
Kauraniemi P, Kallioniemi A. Activation of multiple cancerassociated genes at the ERBB2 amplicon in breast cancer. Endocr Relat Cancer 2006; 13: 39-49.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 39-49
-
-
Kauraniemi, P.1
Kallioniemi, A.2
-
47
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the her-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-82.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
48
-
-
84861961216
-
ErbB2/her2: Its contribution to basic cancer biology and the development of molecular targeted therapy
-
Gunduz M, Gunduz E, editors. Croatia: InTech
-
Yamamoto T, Saito M, Kumazawa K, Doi A, Matsui A, Takebe S, Amari T, Oyama M, Semba K. ErbB2/HER2: its contribution to basic cancer biology and the development of molecular targeted therapy. In: Gunduz M, Gunduz E, editors. Breast cancer - carcinogenesis, cell growth and signalling pathways. Croatia: InTech, 2011: 139-70.
-
(2011)
Breast Cancer - Carcinogenesis, Cell Growth and Signalling Pathways
, pp. 139-170
-
-
Yamamoto, T.1
Saito, M.2
Kumazawa, K.3
Doi, A.4
Matsui, A.5
Takebe, S.6
Amari, T.7
Oyama, M.8
Semba, K.9
-
49
-
-
1442265950
-
Amplification of her2 and top2a and deletion of top2a genes in breast cancer investigated by new fish probes
-
Olsen KE, Knudsen H, Rasmussen BB, Balslev E, Knoop A, Ejlertsen B, Nielsen KV, Schönau A, Overgaard J. Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes. Acta Oncol 2004;43: 35-42.
-
(2004)
Acta Oncol
, vol.43
, pp. 35-42
-
-
Olsen, K.E.1
Knudsen, H.2
Rasmussen, B.B.3
Balslev, E.4
Knoop, A.5
Ejlertsen, B.6
Nielsen, K.V.7
Schönau, A.8
Overgaard, J.9
-
50
-
-
33644876397
-
Comparison of her2 gene amplification assessed by fluorescence in situ hybridization and her2 protein expression assessed by immunohistochemistry in gastric cancer
-
Yano T, Doi T, Ohtsu A, Boku N, Hashizume K, Nakanishi M, Ochiai A. Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer. Oncol Rep 2006; 15: 65-71.
-
(2006)
Oncol Rep
, vol.15
, pp. 65-71
-
-
Yano, T.1
Doi, T.2
Ohtsu, A.3
Boku, N.4
Hashizume, K.5
Nakanishi, M.6
Ochiai, A.7
-
51
-
-
18044376819
-
Frequencies of her-2/neu expression and gene amplification in patients with oesophageal squamous cell carcinoma
-
Mimura K, Kono K, Hanawa M, Mitsui F, Sugai H, Miyagawa N, Ooi A, Fujii H. Frequencies of HER-2/neu expression and gene amplification in patients with oesophageal squamous cell carcinoma. Br J Cancer 2005; 92: 1253-60.
-
(2005)
Br J Cancer
, vol.92
, pp. 1253-1260
-
-
Mimura, K.1
Kono, K.2
Hanawa, M.3
Mitsui, F.4
Sugai, H.5
Miyagawa, N.6
Ooi, A.7
Fujii, H.8
-
52
-
-
0037738887
-
HER-2/neu and topoisomerase ii〈 in breast cancer
-
Järvinen TAH, Liu ET. HER-2/neu and topoisomerase II〈 in breast cancer. Breast Cancer Res Treat 2003; 78: 299-311.
-
(2003)
Breast Cancer Res Treat
, vol.78
, pp. 299-311
-
-
Järvinen, T.A.H.1
Liu, E.T.2
-
54
-
-
84861963313
-
Expression screening of 17q12-21 amplicon reveals grb7 as an erbb2-dependent oncogene
-
Saito M, Kato Y, Ito E, Fujimoto J, Ishikawa K, Doi A, Kumazawa K, Matsui A, Takebe S, Ishida T, Azuma S, Mochizuki H, Kawamura Y, Yanagisawa Y, Honma R, Imai J, Ohbayashi H, Goshima N, Semba K, Watanabe S. Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene. FEBS Lett 2012; 586: 1708-14.
-
(2012)
FEBS Lett
, vol.586
, pp. 1708-1714
-
-
Saito, M.1
Kato, Y.2
Ito, E.3
Fujimoto, J.4
Ishikawa, K.5
Doi, A.6
Kumazawa, K.7
Matsui, A.8
Takebe, S.9
Ishida, T.10
Azuma, S.11
Mochizuki, H.12
Kawamura, Y.13
Yanagisawa, Y.14
Honma, R.15
Imai, J.16
Ohbayashi, H.17
Goshima, N.18
Semba, K.19
Watanabe, S.20
more..
-
55
-
-
0028343550
-
The sh2 domain protein grb-7 is co-amplified, overexpressed and in a tight complex with her2 in breast cancer
-
Stein D, Wu J, Fuqua SA, Roonprapunt C, Yajnik V, D'Eustachio P, Moskow JJ, Buchberg AM, Osborne CK, Margolis B. The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J 1994; 13: 1331-40.
-
(1994)
EMBO J
, vol.13
, pp. 1331-1340
-
-
Stein, D.1
Wu, J.2
Fuqua, S.A.3
Roonprapunt, C.4
Yajnik, V.5
D'Eustachio, P.6
Moskow, J.J.7
Buchberg, A.M.8
Osborne, C.K.9
Margolis, B.10
-
56
-
-
33846341486
-
The 17q12-q21 amplicon: Her2 and topoisomerase-ii〈 and their importance to the biology of solid tumours
-
Mano MS, Rosa DD, De Azambuja E, Ismael GFV, Durbecq V. The 17q12-q21 amplicon: Her2 and topoisomerase-II〈 and their importance to the biology of solid tumours. Cancer Treat Rev 2007; 33: 64-77.
-
(2007)
Cancer Treat Rev
, vol.33
, pp. 64-77
-
-
Mano, M.S.1
Rosa, D.D.2
De Azambuja, E.3
Ismael, G.F.V.4
Durbecq, V.5
-
57
-
-
84864141638
-
Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of erbb2 and rara
-
Paroni G, Fratelli M, Gardini G, Bassano C, Flora M, Zanetti A, Guarnaccia V, Ubezio P, Centritto F, Terao M, Garattini E. Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA. Oncogene 2012; 31: 3431-43.
-
(2012)
Oncogene
, vol.31
, pp. 3431-3443
-
-
Paroni, G.1
Fratelli, M.2
Gardini, G.3
Bassano, C.4
Flora, M.5
Zanetti, A.6
Guarnaccia, V.7
Ubezio, P.8
Centritto, F.9
Terao, M.10
Garattini, E.11
-
58
-
-
0030737565
-
MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (star) that stimulates steroidogenesis
-
Watari H, Arakane F, Moog-Lutz C, Kallen CB, Tomasetto C, Gerton GL, Rio MC, Baker ME, Strauss JF. MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis. Proc Natl Acad Sci USA 1997; 94: 8462-7.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8462-8467
-
-
Watari, H.1
Arakane, F.2
Moog-Lutz, C.3
Kallen, C.B.4
Tomasetto, C.5
Gerton, G.L.6
Rio, M.C.7
Baker, M.E.8
Strauss, J.F.9
-
59
-
-
0034064138
-
Structure and lipid transport mechanism of a star-related domain
-
Tsujishita Y, Hurley JH. Structure and lipid transport mechanism of a StAR-related domain. Nat Struct Biol 2000; 7: 408-14.
-
(2000)
Nat Struct Biol
, vol.7
, pp. 408-414
-
-
Tsujishita, Y.1
Hurley, J.H.2
-
60
-
-
0043145754
-
Characterization of topoisomerase ii〈 gene amplification and deletion in breast cancer
-
Järvinen TA, Tanner M, Bärlund M, Borg A, Isola J. Characterization of topoisomerase II〈 gene amplification and deletion in breast cancer. Genes Chromosomes Cancer 1999; 26: 142-50.
-
(1999)
Genes Chromosomes Cancer
, vol.26
, pp. 142-150
-
-
Järvinen, T.A.1
Tanner, M.2
Bärlund, M.3
Borg, A.4
Isola, J.5
-
61
-
-
20944439542
-
The incidence of topoisomerase ii〈 genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: A fluorescence in situ hybridization study
-
Hicks DG, Yoder BJ, Pettay J, Swain E, Tarr S, Hartke M, Skacel M, Crowe JP, Budd GT, Tubbs RR. The incidence of topoisomerase II〈 genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study. Hum Pathol 2005; 36: 348-56.
-
(2005)
Hum Pathol
, vol.36
, pp. 348-356
-
-
Hicks, D.G.1
Yoder, B.J.2
Pettay, J.3
Swain, E.4
Tarr, S.5
Hartke, M.6
Skacel, M.7
Crowe, J.P.8
Budd, G.T.9
Tubbs, R.R.10
-
62
-
-
84863168027
-
DNA cleavage and opening reactions of human topoisomerase ii〈 are regulated via mg2+-mediated dynamic bending of gate-dna
-
Lee S, Jung S-R, Heo K, Byl JAW, Deweese JE, Osheroff N, Hohng S. DNA cleavage and opening reactions of human topoisomerase II〈 are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci USA 2012; 109: 2925-30.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 2925-2930
-
-
Lee, S.1
Jung, S.-R.2
Heo, K.3
Byl, J.A.W.4
Deweese, J.E.5
Osheroff, N.6
Hohng, S.7
-
63
-
-
77951204423
-
17q12-21 - The pursuit of targeted therapy in breast cancer
-
Glynn RW, Miller N, Kerin MJ. 17q12-21-the pursuit of targeted therapy in breast cancer. Cancer Treat Rev 2010; 36: 224-9.
-
(2010)
Cancer Treat Rev
, vol.36
, pp. 224-229
-
-
Glynn, R.W.1
Miller, N.2
Kerin, M.J.3
-
64
-
-
72949103929
-
A census of amplified and overexpressed human cancer genes
-
Santarius T, Shipley J, Brewer D, Stratton MR, Cooper CS. A census of amplified and overexpressed human cancer genes. Nat Rev Cancer 2010; 10: 59-64.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 59-64
-
-
Santarius, T.1
Shipley, J.2
Brewer, D.3
Stratton, M.R.4
Cooper, C.S.5
-
65
-
-
21844478747
-
Integrative genomic analyses identify mitf as a lineage survival oncogene amplified in malignant melanoma
-
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 2005; 436: 117-22.
-
(2005)
Nature
, vol.436
, pp. 117-122
-
-
Garraway, L.A.1
Widlund, H.R.2
Rubin, M.A.3
Getz, G.4
Berger, A.J.5
Ramaswamy, S.6
Beroukhim, R.7
Milner, D.A.8
Granter, S.R.9
Du, J.10
Lee, C.11
Wagner, S.N.12
Li, C.13
Golub, T.R.14
Rimm, D.L.15
Meyerson, M.L.16
Fisher, D.E.17
Sellers, W.R.18
-
66
-
-
33747882661
-
MITF: Master regulator of melanocyte development and melanoma oncogene
-
Levy C, Khaled M, Fisher DE. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med 2006; 12: 406-14.
-
(2006)
Trends Mol Med
, vol.12
, pp. 406-414
-
-
Levy, C.1
Khaled, M.2
Fisher, D.E.3
-
67
-
-
0035015781
-
Microphthalmia transcription factor: Not a sensitive or specific marker for the diagnosis of desmoplastic melanoma and spindle cell (non-desmoplastic) melanoma
-
Granter SR, Weilbaecher KN, Quigley C, Fletcher CD, Fisher DE. Microphthalmia transcription factor: not a sensitive or specific marker for the diagnosis of desmoplastic melanoma and spindle cell (non-desmoplastic) melanoma. Am J Dermatopathol 2001; 23: 185-9.
-
(2001)
Am J Dermatopathol
, vol.23
, pp. 185-189
-
-
Granter, S.R.1
Weilbaecher, K.N.2
Quigley, C.3
Fletcher, C.D.4
Fisher, D.E.5
-
69
-
-
35949002429
-
Malignant astrocytic glioma: Genetics, biology, and paths to treatment
-
Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007; 21: 2683-710.
-
(2007)
Genes Dev
, vol.21
, pp. 2683-2710
-
-
Furnari, F.B.1
Fenton, T.2
Bachoo, R.M.3
Mukasa, A.4
Stommel, J.M.5
Stegh, A.6
Hahn, W.C.7
Ligon, K.L.8
Louis, D.N.9
Brennan, C.10
Chin, L.11
Depinho, R.A.12
Cavenee, W.K.13
-
70
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 2006; 12: 5268-72.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
71
-
-
0142188691
-
Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
-
Shinojima N, Tada K, Shiraishi S, Kamiryo T, Kochi M, Nakamura H, Makino K, Saya H, Hirano H, Kuratsu J-I, Oka K, Ishimaru Y, Ushio Y. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res 2003; 63: 6962-70.
-
(2003)
Cancer Res
, vol.63
, pp. 6962-6970
-
-
Shinojima, N.1
Tada, K.2
Shiraishi, S.3
Kamiryo, T.4
Kochi, M.5
Nakamura, H.6
Makino, K.7
Saya, H.8
Hirano, H.9
Kuratsu, J.-I.10
Oka, K.11
Ishimaru, Y.12
Ushio, Y.13
-
72
-
-
84857130051
-
Targeting egfr for treatment of glioblastoma: Molecular basis to overcome resistance
-
Taylor TE, Furnari FB, Cavenee WK. Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance. Curr Cancer Drug Targets 2012; 12: 197-209.
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 197-209
-
-
Taylor, T.E.1
Furnari, F.B.2
Cavenee, W.K.3
-
73
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating erbb3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale C-M, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316: 1039-43.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Jänne, P.A.19
-
74
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, Zakowski MF, Heelan RT, Kris MG, Varmus HE. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2005; 2: e17.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
Miller, V.A.4
Pan, Q.5
Ladanyi, M.6
Zakowski, M.F.7
Heelan, R.T.8
Kris, M.G.9
Varmus, H.E.10
-
75
-
-
46349092797
-
Primary resistance to cetuximab therapy in egfr fish-positive colorectal cancer patients
-
Cappuzzo F, Varella-Garcia M, Finocchiaro G, Skokan M, Gajapathy S, Carnaghi C, Rimassa L, Rossi E, Ligorio C, Di Tommaso L, Holmes AJ, Toschi L, Tallini G, Destro A, Roncalli M, Santoro A, Jänne PA. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br J Cancer 2008; 99: 83-9.
-
(2008)
Br J Cancer
, vol.99
, pp. 83-89
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Finocchiaro, G.3
Skokan, M.4
Gajapathy, S.5
Carnaghi, C.6
Rimassa, L.7
Rossi, E.8
Ligorio, C.9
Di Tommaso, L.10
Holmes, A.J.11
Toschi, L.12
Tallini, G.13
Destro, A.14
Roncalli, M.15
Santoro, A.16
Jänne, P.A.17
-
76
-
-
57449095367
-
Wild-type braf is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008; 26: 5705-12.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
Sartore-Bianchi, A.4
Arena, S.5
Saletti, P.6
De Dosso, S.7
Mazzucchelli, L.8
Frattini, M.9
Siena, S.10
Bardelli, A.11
-
77
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to egfr-targeted monoclonal antibodies
-
Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, Di Nicolantonio F, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009; 69: 1851-7.
-
(2009)
Cancer Res
, vol.69
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
Veronese, S.4
Nichelatti, M.5
Artale, S.6
Di Nicolantonio, F.7
Saletti, P.8
De Dosso, S.9
Mazzucchelli, L.10
Frattini, M.11
Siena, S.12
Bardelli, A.13
-
79
-
-
0032417695
-
Overexpression of mdm2 in mice reveals a p53-independent role for mdm2 in tumorigenesis
-
Jones SN, Hancock AR, Vogel H, Donehower LA, Bradley A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci USA 1998; 95: 15608-12.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15608-15612
-
-
Jones, S.N.1
Hancock, A.R.2
Vogel, H.3
Donehower, L.A.4
Bradley, A.5
-
80
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of mdm2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303: 844-8.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
81
-
-
84873055344
-
MDM2, mdmx and p53 in oncogenesis and cancer therapy
-
Wade M, Li Y-C, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 2013; 13: 83-96.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.-C.2
Wahl, G.M.3
-
82
-
-
0032104542
-
Amplification of oncogenes in human cancer cells
-
Schwab M. Amplification of oncogenes in human cancer cells. Bioessays 1998; 20: 473-9.
-
(1998)
Bioessays
, vol.20
, pp. 473-479
-
-
Schwab, M.1
-
83
-
-
79960836823
-
Cyclin d as a therapeutic target in cancer
-
Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL. Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 2011; 11: 558-72.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 558-572
-
-
Musgrove, E.A.1
Caldon, C.E.2
Barraclough, J.3
Stone, A.4
Sutherland, R.L.5
-
84
-
-
33845951110
-
Cyclin d1 in non-small cell lung cancer: A key driver of malignant transformation
-
Gautschi O, Ratschiller D, Gugger M, Betticher DC, Heighway J. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer 2007; 55: 1-14.
-
(2007)
Lung Cancer
, vol.55
, pp. 1-14
-
-
Gautschi, O.1
Ratschiller, D.2
Gugger, M.3
Betticher, D.C.4
Heighway, J.5
-
85
-
-
77953024302
-
Co-amplification of ccnd1 and emsy is associated with an adverse outcome in er-positive tamoxifen-treated breast cancers
-
Brown LA, Johnson K, Leung S, Bismar TA, Benítez J, Foulkes WD, Huntsman DG. Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers. Breast Cancer Res Treat 2010; 121: 347-54.
-
(2010)
Breast Cancer Res Treat
, vol.121
, pp. 347-354
-
-
Brown, L.A.1
Johnson, K.2
Leung, S.3
Bismar, T.A.4
Benítez, J.5
Foulkes, W.D.6
Huntsman, D.G.7
-
86
-
-
10744233204
-
EMSY links the brca2 pathway to sporadic breast and ovarian cancer
-
Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin S-F, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 2003; 115: 523-35.
-
(2003)
Cell
, vol.115
, pp. 523-535
-
-
Hughes-Davies, L.1
Huntsman, D.2
Ruas, M.3
Fuks, F.4
Bye, J.5
Chin, S.-F.6
Milner, J.7
Brown, L.A.8
Hsu, F.9
Gilks, B.10
Nielsen, T.11
Schulzer, M.12
Chia, S.13
Ragaz, J.14
Cahn, A.15
Linger, L.16
Ozdag, H.17
Cattaneo, E.18
Jordanova, E.S.19
Schuuring, E.20
Yu, D.S.21
Venkitaraman, A.22
Ponder, B.23
Doherty, A.24
Aparicio, S.25
Bentley, D.26
Theillet, C.27
Ponting, C.P.28
Caldas, C.29
Kouzarides, T.30
more..
-
87
-
-
35549002845
-
Amplification of ccnd1 and pak1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer
-
Bostner J, Ahnström Waltersson M, Fornander T, Skoog L, Nordenskjöld B, Stål O. Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Oncogene 2007; 26: 6997-7005.
-
(2007)
Oncogene
, vol.26
, pp. 6997-7005
-
-
Bostner, J.1
Ahnström Waltersson, M.2
Fornander, T.3
Skoog, L.4
Nordenskjöld, B.5
Stål, O.6
-
88
-
-
2942568370
-
Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin d1 in breast cancer cells
-
Balasenthil S, Barnes CJ, Rayala SK, Kumar R. Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. FEBS Lett 2004; 567: 243-7.
-
(2004)
FEBS Lett
, vol.567
, pp. 243-247
-
-
Balasenthil, S.1
Barnes, C.J.2
Rayala, S.K.3
Kumar, R.4
-
89
-
-
0036781812
-
C-myc: More than just a matter of life and death
-
Pelengaris S, Khan M, Evan G. c-MYC: more than just a matter of life and death. Nat Rev Cancer 2002; 2: 764-76.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 764-776
-
-
Pelengaris, S.1
Khan, M.2
Evan, G.3
-
90
-
-
0034538306
-
C-myc amplification in breast cancer: A meta-analysis of its occurrence and prognostic relevance
-
Deming SL, Nass SJ, Dickson RB, Trock BJ. C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance. Br J Cancer 2000; 83: 1688-95.
-
(2000)
Br J Cancer
, vol.83
, pp. 1688-1695
-
-
Deming, S.L.1
Nass, S.J.2
Dickson, R.B.3
Trock, B.J.4
-
91
-
-
53349103292
-
Modelling myc inhibition as a cancer therapy
-
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI. Modelling Myc inhibition as a cancer therapy. Nature 2008; 455: 679-83.
-
(2008)
Nature
, vol.455
, pp. 679-683
-
-
Soucek, L.1
Whitfield, J.2
Martins, C.P.3
Finch, A.J.4
Murphy, D.J.5
Sodir, N.M.6
Karnezis, A.N.7
Swigart, L.B.8
Nasi, S.9
Evan, G.I.10
-
92
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-myc
-
Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, Bergsagel PL, Ghobrial IM, Richardson PG, Young RA, Hahn WC, Anderson KC, Kung AL, Bradner JE, Mitsiades CS. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011; 146: 904-17.
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
Kastritis, E.7
Gilpatrick, T.8
Paranal, R.M.9
Qi, J.10
Chesi, M.11
Schinzel, A.C.12
McKeown, M.R.13
Heffernan, T.P.14
Vakoc, C.R.15
Bergsagel, P.L.16
Ghobrial, I.M.17
Richardson, P.G.18
Young, R.A.19
Hahn, W.C.20
Anderson, K.C.21
Kung, A.L.22
Bradner, J.E.23
Mitsiades, C.S.24
more..
-
93
-
-
80055000824
-
RNAi screen identifies brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011; 478: 524-8.
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
Taylor, M.J.11
Johns, C.12
Chicas, A.13
Mulloy, J.C.14
Kogan, S.C.15
Brown, P.16
Valent, P.17
Bradner, J.E.18
Lowe, S.W.19
Vakoc, C.R.20
more..
-
94
-
-
84864017026
-
Androgen receptor (ar) aberrations in castration-resistant prostate cancer
-
Waltering KK, Urbanucci A, Visakorpi T. Androgen receptor (AR) aberrations in castration-resistant prostate cancer. Mol Cell Endocrinol 2012; 360: 38-43.
-
(2012)
Mol Cell Endocrinol
, vol.360
, pp. 38-43
-
-
Waltering, K.K.1
Urbanucci, A.2
Visakorpi, T.3
-
95
-
-
0035496220
-
The development of androgenindependent prostate cancer
-
Feldman BJ, Feldman D. The development of androgenindependent prostate cancer. Nat Rev Cancer 2001; 1: 34-45.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 34-45
-
-
Feldman, B.J.1
Feldman, D.2
-
96
-
-
15644368237
-
Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer
-
Koivisto P, Kononen J, Palmberg C, Tammela T, Hyytinen E, Isola J, Trapman J, Cleutjens K, Noordzij A, Visakorpi T, Kallioniemi OP. Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res 1997; 57: 314-9.
-
(1997)
Cancer Res
, vol.57
, pp. 314-319
-
-
Koivisto, P.1
Kononen, J.2
Palmberg, C.3
Tammela, T.4
Hyytinen, E.5
Isola, J.6
Trapman, J.7
Cleutjens, K.8
Noordzij, A.9
Visakorpi, T.10
Kallioniemi, O.P.11
-
97
-
-
0033767930
-
Androgen receptor gene amplification at primary progression predicts response to combined androgen blockade as second line therapy for advanced prostate cancer
-
Palmberg C, Koivisto P, Kakkola L, Tammela TL, Kallioniemi OP, Visakorpi T. Androgen receptor gene amplification at primary progression predicts response to combined androgen blockade as second line therapy for advanced prostate cancer. J Urol 2000; 164: 1992-5.
-
(2000)
J Urol
, vol.164
, pp. 1992-1995
-
-
Palmberg, C.1
Koivisto, P.2
Kakkola, L.3
Tammela, T.L.4
Kallioniemi, O.P.5
Visakorpi, T.6
-
98
-
-
18444374405
-
Mutations of the braf gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix- Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JWC, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix- Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmieri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
99
-
-
31144453233
-
BRAF mutation predicts sensitivity to mek inhibition
-
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006; 439: 358-62.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
Ye, Q.7
Lobo, J.M.8
She, Y.9
Osman, I.10
Golub, T.R.11
Sebolt-Leopold, J.12
Sellers, W.R.13
Rosen, N.14
-
100
-
-
38049097938
-
Identification of genotypecorrelated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
-
McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, Rothenberg SM, Supko JG, Sordella R, Ulkus LE, Iafrate AJ, Maheswaran S, Njauw CN, Tsao H, Drew L, Hanke JH, Ma X-J, Erlander MG, Gray NS, Haber DA, Settleman J. Identification of genotypecorrelated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci USA 2007; 104: 19936-41.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19936-19941
-
-
McDermott, U.1
Sharma, S.V.2
Dowell, L.3
Greninger, P.4
Montagut, C.5
Lamb, J.6
Archibald, H.7
Raudales, R.8
Tam, A.9
Lee, D.10
Rothenberg, S.M.11
Supko, J.G.12
Sordella, R.13
Ulkus, L.E.14
Iafrate, A.J.15
Maheswaran, S.16
Njauw, C.N.17
Tsao, H.18
Drew, L.19
Hanke, J.H.20
Ma, X.-J.21
Erlander, M.G.22
Gray, N.S.23
Haber, D.A.24
Settleman, J.25
more..
-
101
-
-
49649118852
-
Elevated craf as a potential mechanism of acquired resistance to braf inhibition in melanoma
-
Montagut C, Sharma S V, Shioda T, McDermott U, Ulman M, Ulkus LE, Dias-Santagata D, Stubbs H, Lee DY, Singh A, Drew L, Haber DA, Settleman J. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res 2008; 68: 4853-61.
-
(2008)
Cancer Res
, vol.68
, pp. 4853-4861
-
-
Montagut, C.1
Sharma, S.V.2
Shioda, T.3
McDermott, U.4
Ulman, M.5
Ulkus, L.E.6
Dias-Santagata, D.7
Stubbs, H.8
Lee, D.Y.9
Singh, A.10
Drew, L.11
Haber, D.A.12
Settleman, J.13
-
102
-
-
73949083834
-
MEK1 mutations confer resistance to mek and b-raf inhibition
-
Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, Hatton C, Chopra R, Oberholzer PA, Karpova MB, MacConaill LE, Zhang J, Gray NS, Sellers WR, Dummer R, Garraway LA. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci USA 2009; 106: 20411-6.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
Sawyer, A.M.4
Niu, L.5
Kim, J.J.6
Hatton, C.7
Chopra, R.8
Oberholzer, P.A.9
Karpova, M.B.10
Macconaill, L.E.11
Zhang, J.12
Gray, N.S.13
Sellers, W.R.14
Dummer, R.15
Garraway, L.A.16
-
103
-
-
78649436372
-
BRAF gene amplification can promote acquired resistance to mek inhibitors in cancer cells harboring the braf v600e mutation
-
Corcoran RB, Dias-Santagata D, Bergethon K, Iafrate AJ, Settleman J, Engelman JA. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci Signal 2010; 3: ra84.
-
(2010)
Sci Signal
, vol.3
-
-
Corcoran, R.B.1
Dias-Santagata, D.2
Bergethon, K.3
Iafrate, A.J.4
Settleman, J.5
Engelman, J.A.6
-
104
-
-
9944235462
-
Involvement of overexpressed wild-type braf in the growth of malignant melanoma cell lines
-
Tanami H, Imoto I, Hirasawa A, Yuki Y, Sonoda I, Inoue J, Yasui K, Misawa-Furihata A, Kawakami Y, Inazawa J. Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene 2004;23: 8796-804.
-
(2004)
Oncogene
, vol.23
, pp. 8796-8804
-
-
Tanami, H.1
Imoto, I.2
Hirasawa, A.3
Yuki, Y.4
Sonoda, I.5
Inoue, J.6
Yasui, K.7
Misawa-Furihata, A.8
Kawakami, Y.9
Inazawa, J.10
-
105
-
-
0024411328
-
Recent progress in understanding mechanisms of mammalian dna amplification
-
Stark GR, Debatisse M, Giulotto E, Wahl GM. Recent progress in understanding mechanisms of mammalian DNA amplification. Cell 1989; 57: 901-8.
-
(1989)
Cell
, vol.57
, pp. 901-908
-
-
Stark, G.R.1
Debatisse, M.2
Giulotto, E.3
Wahl, G.M.4
-
106
-
-
0019169859
-
Supercoiled loops and eucaryotic dna replicaton
-
Vogelstein B, Pardoll DM, Coffey DS. Supercoiled loops and eucaryotic DNA replicaton. Cell 1980; 22: 79-85.
-
(1980)
Cell
, vol.22
, pp. 79-85
-
-
Vogelstein, B.1
Pardoll, D.M.2
Coffey, D.S.3
-
108
-
-
60749110613
-
Palindromic gene amplification - an evolutionarily conserved role for dna inverted repeats in the genome
-
Tanaka H, Yao M-C. Palindromic gene amplification - an evolutionarily conserved role for DNA inverted repeats in the genome. Nat Rev Cancer 2009; 9: 216-24.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 216-224
-
-
Tanaka, H.1
Yao, M.-C.2
-
109
-
-
0035902459
-
Break-induced replication: A review and an example in budding yeast
-
Kraus E, Leung WY, Haber JE. Break-induced replication: a review and an example in budding yeast. Proc Natl Acad Sci USA 2001; 98: 8255-62.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8255-8262
-
-
Kraus, E.1
Leung, W.Y.2
Haber, J.E.3
|