Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene

FEBS Letters

Volumn 586, Issue 12, 2012, Pages 1708-1714

  Saito, Makoto ^a   Kato, Yukiko ^a   Ito, Emi ^b   Fujimoto, Jiro ^a   Ishikawa, Kosuke ^a,c   Doi, Ayano ^a   Kumazawa, Kentaro ^a   Matsui, Atsuka ^a   Takebe, Shiori ^a   Ishida, Takaomi ^a   Azuma, Sakura ^a   Mochizuki, Hiromi ^c   Kawamura, Yoshifumi ^c   Yanagisawa, Yuka ^b,d   Honma, Reiko ^b,d   Imai, Jun Ichi ^b   Ohbayashi, Hirokazu ^e   Goshima, Naoki ^f   Semba, Kentaro ^a   Watanabe, Shinya ^b  

^a WASEDA UNIVERSITY   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c Koto ku   (Japan)

^d NIPPON GENE Co Ltd   (Japan)

^e Research and Development Center   (Japan)

^f NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

ERBB2; Expression screening; Gene amplification; GRB7; Tumorigenesis

Indexed keywords

COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GENOMIC DNA; PROTEIN KINASE B;

AMPLICON; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVITY; GENE AMPLIFICATION; GENE EXPRESSION; GRB7 GENE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 17; DOWN-REGULATION; GENE AMPLIFICATION; GRB7 ADAPTOR PROTEIN; HUMANS; MICE; MUTAGENESIS; NIH 3T3 CELLS; PHOSPHORYLATION; POINT MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENES; RECEPTOR, ERBB-2; RECOMBINANT PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION;

EID: 84861963313     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.05.003     Document Type: Article

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