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Volumn 23, Issue 1, 2014, Pages 37-53

Beyond bevacizumab: Investigating new angiogenesis inhibitors in ovarian cancer

Author keywords

Aflibercept; Angiogenesis; Bevacizumab; Chemotherapy; Epithelial ovarian cancer; Tyrosine kinase inhibitors; Vascular endothelial growth factor

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; BRIVANIB; CABOZANTINIB; CARBOPLATIN; CEDIRANIB; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; ENMD 2079; FIBROBLAST GROWTH FACTOR; GEMCITABINE; IMATINIB; NINTEDANIB; OMBRABULIN; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR; RAMUCIRUMAB; SORAFENIB; SUNITINIB; TOPOTECAN; TREBANANIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR TARGETING AGENT; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VATALANIB; VOLOCIXIMAB;

EID: 84889783720     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2013.839657     Document Type: Review
Times cited : (16)

References (151)
  • 2
    • 84870891860 scopus 로고    scopus 로고
    • Tumor-derived microvesicles: The metastasomes
    • Ghasemi R, Grassadonia A, Tinari N, et al. Tumor-derived microvesicles: the metastasomes. Med Hypotheses 2013;80(1):75-82
    • (2013) Med Hypotheses , vol.80 , Issue.1 , pp. 75-82
    • Ghasemi, R.1    Grassadonia, A.2    Tinari, N.3
  • 5
    • 0036583718 scopus 로고    scopus 로고
    • Update on the management of ovarian cancer
    • Ozols RF. Update on the management of ovarian cancer. Cancer J 2002;8(Suppl 1):S22-30
    • (2002) Cancer J , vol.8 , Issue.SUPPL. 1
    • Ozols, R.F.1
  • 6
    • 0026018186 scopus 로고
    • Responses to second-line cisplatinbased intraperitoneal therapy in ovarian cancer: Influence of a prior response to intravenous cisplatin
    • Markman M, Reichman B, Hakes T, et al. Responses to second-line cisplatinbased intraperitoneal therapy in ovarian cancer: influence of a prior response to intravenous cisplatin. J Clin Oncol 1991;9(10):1801-5
    • (1991) J Clin Oncol , vol.9 , Issue.10 , pp. 1801-1805
    • Markman, M.1    Reichman, B.2    Hakes, T.3
  • 7
    • 77949447507 scopus 로고    scopus 로고
    • Treatment of recurrent epithelial ovarian cancer
    • Pisano C, Bruni GS, Facchini G, et al. Treatment of recurrent epithelial ovarian cancer. Ther Clin Risk Manag 2009;5(4):421-6
    • (2009) Ther Clin Risk Manag , vol.5 , Issue.4 , pp. 421-426
    • Pisano, C.1    Bruni, G.S.2    Facchini, G.3
  • 8
    • 73349089623 scopus 로고    scopus 로고
    • Emerging role of pemetrexed in ovarian cancer
    • Tomao F, Panici PB, Frati L, et al. Emerging role of pemetrexed in ovarian cancer. Expert Rev Anticancer Ther 2009;9(12):1727-35
    • (2009) Expert Rev Anticancer Ther , vol.9 , Issue.12 , pp. 1727-1735
    • Tomao, F.1    Panici, P.B.2    Frati, L.3
  • 9
    • 84863627222 scopus 로고    scopus 로고
    • Intraperitoneal chemotherapy by ultrasound-guided direct puncture in recurrent ovarian cancer: Feasibility, compliance, and complications
    • Benedetti-Panici P, Perniola G, Marchetti C, et al. Intraperitoneal chemotherapy by ultrasound-guided direct puncture in recurrent ovarian cancer: feasibility, compliance, and complications. Int J Gynecol Cancer 2012;22(6):1069-74
    • (2012) Int J Gynecol Cancer , vol.22 , Issue.6 , pp. 1069-1074
    • Benedetti-Panici, P.1    Perniola, G.2    Marchetti, C.3
  • 10
    • 84862127138 scopus 로고    scopus 로고
    • Current knowledge and open issues regarding bevacizumab in gynecological neoplasms
    • Bellati F, Napoletano C, Gasparri ML, et al. Current knowledge and open issues regarding bevacizumab in gynecological neoplasms. Crit Rev Oncol Hematol 2012;83(1):35-46
    • (2012) Crit Rev Oncol Hematol , vol.83 , Issue.1 , pp. 35-46
    • Bellati, F.1    Napoletano, C.2    Gasparri, M.L.3
  • 11
    • 84855466019 scopus 로고    scopus 로고
    • A phase 3 trial of bevacizumab in ovarian cancer
    • Perren TJ, Swart AM, Pfisterer J, et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011;365:2484-96
    • (2011) N Engl J Med , vol.365 , pp. 2484-2496
    • Perren, T.J.1    Swart, A.M.2    Pfisterer, J.3
  • 12
    • 84855425106 scopus 로고    scopus 로고
    • Incorporation of bevacizumab in the primary treatment of ovarian cancer
    • Burger RA, Brady MF, Bookman MA, et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 2011;365:2473-83
    • (2011) N Engl J Med , vol.365 , pp. 2473-2483
    • Burger, R.A.1    Brady, M.F.2    Bookman, M.A.3
  • 13
    • 84877902627 scopus 로고    scopus 로고
    • Bevacizumab and ovarian cancer
    • Garcia A, Singh H. Bevacizumab and ovarian cancer. Ther Adv Med Oncol 2013;5(2):133-41
    • (2013) Ther Adv Med Oncol , vol.5 , Issue.2 , pp. 133-141
    • Garcia, A.1    Singh, H.2
  • 14
    • 84861736119 scopus 로고    scopus 로고
    • OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
    • Aghajanian C, Blank SV, Goff BA, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 2012;30:2039-45
    • (2012) J Clin Oncol , vol.30 , pp. 2039-2045
    • Aghajanian, C.1    Blank, S.V.2    Goff, B.A.3
  • 15
    • 84871739036 scopus 로고    scopus 로고
    • Improvement in progression free survival in OCEANS bevacizumab arm: A critical point of view
    • Tomao F, Tomao S, Panici PB, et al. Improvement in progression free survival in OCEANS bevacizumab arm: a critical point of view. J Clin Oncol 2013;31(1):166-7
    • (2013) J Clin Oncol , vol.31 , Issue.1 , pp. 166-167
    • Tomao, F.1    Tomao, S.2    Panici, P.B.3
  • 16
    • 84866493383 scopus 로고    scopus 로고
    • AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC)
    • Pujade-Lauraine E, Hilpert F, Weber B, et al. AURELIA: a randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC). J Clin Oncol 2012;30:LBA5002
    • (2012) J Clin Oncol , vol.30
    • Pujade-Lauraine, E.1    Hilpert, F.2    Weber, B.3
  • 17
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 18
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent J Natl Cancer Inst 1990;82(1):4-6 (Pubitemid 20020880)
    • (1990) Journal of the National Cancer Institute , vol.82 , Issue.1 , pp. 4-6
    • Folkman, J.1
  • 19
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • DOI 10.1038/nature04483, PII NATURE04483
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74 (Pubitemid 43093963)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 20
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • DOI 10.1126/science.1104819
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62 (Pubitemid 40093472)
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 21
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • DOI 10.1038/nm0901-987
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001;7:987-9 (Pubitemid 32937367)
    • (2001) Nature Medicine , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 22
    • 0029328266 scopus 로고
    • Intratumor microvessel density as a prognostic factor in cancer
    • Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 1995;147(1):9-19
    • (1995) Am J Pathol , vol.147 , Issue.1 , pp. 9-19
    • Weidner, N.1
  • 23
    • 0142009696 scopus 로고    scopus 로고
    • The influence of microvessel density on ovarian carcinogenesis
    • Stone PJ, Goodheart MJ, Rose SL, et al. The influence of microvessel density on ovarian carcinogenesis. Gynecol Oncol 2003;90(3):566-71
    • (2003) Gynecol Oncol , vol.90 , Issue.3 , pp. 566-571
    • Stone, P.J.1    Goodheart, M.J.2    Rose, S.L.3
  • 27
    • 60449117723 scopus 로고    scopus 로고
    • Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A gynecologic oncology group study
    • Rubatt JM, Darcy KM, Hutson A, et al. Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: a Gynecologic Oncology Group study. Gynecol Oncol 2009;112(3):469-74
    • (2009) Gynecol Oncol , vol.112 , Issue.3 , pp. 469-474
    • Rubatt, J.M.1    Darcy, K.M.2    Hutson, A.3
  • 28
    • 0029117933 scopus 로고
    • Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGFbeta type i and type II receptors, and endoglin in normal ovary and ovarian neoplasms
    • Henriksen R, Gobl A, Wilander E, et al. Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGFbeta type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms. Lab Invest 1995;73:213-20
    • (1995) Lab Invest , vol.73 , pp. 213-220
    • Henriksen, R.1    Gobl, A.2    Wilander, E.3
  • 29
    • 84877279673 scopus 로고    scopus 로고
    • Overexpression of clusterin promotes angiogenesis via the vascular endothelial growth factor in primary ovarian cancer
    • Fu Y, Lai Y, Wang Q, et al. Overexpression of clusterin promotes angiogenesis via the vascular endothelial growth factor in primary ovarian cancer. Mol Med Rep 2013;7(6):1726-32
    • (2013) Mol Med Rep , vol.7 , Issue.6 , pp. 1726-1732
    • Fu, Y.1    Lai, Y.2    Wang, Q.3
  • 30
    • 49149124199 scopus 로고    scopus 로고
    • Mechanism of angiogenesis
    • Karamysheva AF. Mechanism of angiogenesis. Biochemistry (Mosc) 2008;73(7):751-62
    • (2008) Biochemistry (Mosc) , vol.73 , Issue.7 , pp. 751-762
    • Karamysheva, A.F.1
  • 31
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • DOI 10.1038/nrc1093
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3(6):401-10 (Pubitemid 37328844)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 32
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23(5):1011-27 (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 33
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • DOI 10.1634/theoncologist.9-suppl-1-2
    • Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 2004;9(Suppl 1):2-10 (Pubitemid 38747842)
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 2-10
    • Ferrara, N.1
  • 34
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-angiogenic therapy
    • Fischer C, Mazzone M, Jonckx B, et al. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy Nat Rev Cancer 2008;8:942-56
    • (2008) Nat Rev Cancer , vol.8 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jonckx, B.3
  • 35
    • 79952818552 scopus 로고    scopus 로고
    • Overview of anti-angiogenic agents in development for ovarian cancer
    • Burger RA. Overview of anti-angiogenic agents in development for ovarian cancer. Gynecol Oncol 2011;121:230-8
    • (2011) Gynecol Oncol , vol.121 , pp. 230-238
    • Burger, R.A.1
  • 36
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • DOI 10.1038/nm0603-677
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003;9:677-84 (Pubitemid 36749216)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 37
    • 34447499062 scopus 로고    scopus 로고
    • Novel approaches in advancing the treatment of epithelial ovarian cancer: The role of angiogenesis inhibition
    • DOI 10.1200/JCO.2007.11.1088
    • Martin L, Schilder R. Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition. J Clin Oncol 2007;25(20):2894-901 (Pubitemid 47123153)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.20 , pp. 2894-2901
    • Martin, L.1    Schilder, R.2
  • 38
    • 0029001244 scopus 로고    scopus 로고
    • Distinct roles of the receptor tyrosine kinases tie-1 and tie-2 in blood vessel formation
    • Sato TN, Tozawa Y, Deutsch U, et al. Distinct roles of the receptor tyrosine kinases tie-1 and tie-2 in blood vessel formation. Nature 2002;376:70-4
    • (2002) Nature , vol.376 , pp. 70-74
    • Sato, T.N.1    Tozawa, Y.2    Deutsch, U.3
  • 40
    • 33748750051 scopus 로고    scopus 로고
    • Cancer immunosuppression and autoimmune disease: Beyond immunosuppressive networks for tumour immunity
    • DOI 10.1111/j.1365-2567.2006.02430.x
    • Kim R, Emi M, Tanabe K. Cancer immunosuppression and autoimmune disease: beyond immunosuppressive network for tumor immunity. Immunology 2006;119:254-64 (Pubitemid 44401644)
    • (2006) Immunology , vol.119 , Issue.2 , pp. 254-264
    • Kim, R.1    Emi, M.2    Tanabe, K.3
  • 41
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • DOI 10.1038/nrc909
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002;2:795-803 (Pubitemid 37328914)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.10 , pp. 795-803
    • Ferrara, N.1
  • 42
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008;8:579-91
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 43
    • 28244490502 scopus 로고    scopus 로고
    • Angiogenesis in normal and neoplastic ovaries
    • DOI 10.1007/s10456-005-9001-1
    • Ramakrishnan S, Subramanian IV, Yokoyama Y, et al. Angiogenesis in normal and neoplastic ovaries. Angiogenesis 2005;8(2):169-82 (Pubitemid 41712846)
    • (2005) Angiogenesis , vol.8 , Issue.2 , pp. 169-182
    • Ramakrishnan, S.1    Subramanian, I.V.2    Yokoyama, Y.3    Geller, M.4
  • 44
    • 4444324696 scopus 로고    scopus 로고
    • VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma
    • DOI 10.1016/j.ygyno.2004.05.056, PII S0090825804003488
    • Chen H, Ye D, Xie X, et al. VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma. Gynecol Oncol 2004;94:630-5 (Pubitemid 39194453)
    • (2004) Gynecologic Oncology , vol.94 , Issue.3 , pp. 630-635
    • Chen, H.1    Ye, D.2    Xie, X.3    Chen, B.4    Lu, W.5
  • 45
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform- specific receptor for vascular endothelial growth factor
    • DOI 10.1016/S0092-8674(00)81402-6
    • Soker S, Takashima S, Miao HQ, et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998;92:735-45 (Pubitemid 28155313)
    • (1998) Cell , vol.92 , Issue.6 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 46
    • 33750069768 scopus 로고    scopus 로고
    • Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: Increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas
    • DOI 10.1016/j.humpath.2006.04.031, PII S0046817706003480
    • Osada R, Horiuchi A, Kikuchi N, et al. Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas. Hum Pathol 2006;37:1414-25 (Pubitemid 44584330)
    • (2006) Human Pathology , vol.37 , Issue.11 , pp. 1414-1425
    • Osada, R.1    Horiuchi, A.2    Kikuchi, N.3    Ohira, S.4    Ota, M.5    Katsuyama, Y.6    Konishi, I.7
  • 47
    • 79959280313 scopus 로고    scopus 로고
    • Overall survival as the outcome of randomized clinical trials with effective subsequent therapies
    • Korn EL, Freidlin B, Abrams JS. Overall survival as the outcome of randomized clinical trials with effective subsequent therapies. J Clin Oncol 2011;29:2439-42
    • (2011) J Clin Oncol , vol.29 , pp. 2439-2442
    • Korn, E.L.1    Freidlin, B.2    Abrams, J.S.3
  • 49
    • 84862127138 scopus 로고    scopus 로고
    • Current knowledge and open issues regarding bevacizumab in gynaecological neoplasms
    • Bellati F, Napoletano C, Gasparri ML, et al. Current knowledge and open issues regarding bevacizumab in gynaecological neoplasms. Crit Rev Oncol Hematol 2011;83(1):35-46
    • (2011) Crit Rev Oncol Hematol , vol.83 , Issue.1 , pp. 35-46
    • Bellati, F.1    Napoletano, C.2    Gasparri, M.L.3
  • 53
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T, Hemo I, Itin A, et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995;1(10):1024-8
    • (1995) Nat Med , vol.1 , Issue.10 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3
  • 54
    • 1842850792 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients
    • DOI 10.1016/j.clinbiochem.2004.01.014, PII S0009912004000281
    • Kassim SK, El-Salahy EM, Fayed ST, et al. Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients. Clin Biochem 2004;37(5):363-9 (Pubitemid 38490454)
    • (2004) Clinical Biochemistry , vol.37 , Issue.5 , pp. 363-369
    • Kassim, S.K.1    El-Salahy, E.M.2    Fayed, S.T.3    Helal, S.A.4    Helal, T.5    Azzam, E.E.-D.6    Khalifa, A.7
  • 56
    • 0035862972 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in ovarian cyst fluid
    • DOI 10.1002/1097-0142(20010115)91:2<371::AID-CNCR1011>3.0.CO;2-2
    • Boss EA, Massuger LF, Thomas CM, et al. Vascular endothelial growth factor in ovarian cyst fluid. Cancer 2001;91:371-7 (Pubitemid 32099239)
    • (2001) Cancer , vol.91 , Issue.2 , pp. 371-377
    • Boss, E.A.1    Massuger, L.F.A.G.2    Thomas, C.M.G.3    Geurts-Moespot, A.4    Boonstra, H.5
  • 57
  • 60
    • 34447253095 scopus 로고    scopus 로고
    • Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies
    • DOI 10.2174/138161207781039689
    • Rusnati M, Presta M. Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies. Curr Pharm Des 2007;13:2025-44 (Pubitemid 47040487)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.20 , pp. 2025-2044
    • Rusnati, M.1    Presta, M.2
  • 61
    • 77955541508 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by EZH2
    • Lu C, Han HD, Mangala LS, et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell 2010;18(2):185-97
    • (2010) Cancer Cell , vol.18 , Issue.2 , pp. 185-197
    • Lu, C.1    Han, H.D.2    Mangala, L.S.3
  • 62
    • 81255188940 scopus 로고    scopus 로고
    • Tumor angiogenesis: Molecular pathways and therapeutic targets
    • Weis SM, Cheresh DA. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med 2011;17:1359-70
    • (2011) Nat Med , vol.17 , pp. 1359-1370
    • Weis, S.M.1    Cheresh, D.A.2
  • 63
    • 34447632218 scopus 로고    scopus 로고
    • Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis
    • DOI 10.1161/CIRCRESAHA.107.153916, PII 0000301220070706000008
    • Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res 2007;101:59-68 (Pubitemid 47094624)
    • (2007) Circulation Research , vol.101 , Issue.1 , pp. 59-68
    • Kuehbacher, A.1    Urbich, C.2    Zeiher, A.M.3    Dimmeler, S.4
  • 64
    • 84871953641 scopus 로고    scopus 로고
    • MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells
    • Plummer PN, Freeman R, Taft R, et al. MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells. Cancer Res 2013;73(1):341-52
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 341-352
    • Plummer, P.N.1    Freeman, R.2    Taft, R.3
  • 65
    • 84864881089 scopus 로고    scopus 로고
    • Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer
    • Sasahira T, Kurihara M, Bhawal UK, et al. Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer. Br J Cancer 2012;107:700-6
    • (2012) Br J Cancer , vol.107 , pp. 700-706
    • Sasahira, T.1    Kurihara, M.2    Bhawal, U.K.3
  • 66
    • 80455135021 scopus 로고    scopus 로고
    • Role of microRNAs in endothelial cell pathophysiology
    • Staszel T, Zapala B, Polus A, et al. Role of microRNAs in endothelial cell pathophysiology. Pol Arch Med Wewn 2011;121:361-6
    • (2011) Pol Arch Med Wewn , vol.121 , pp. 361-366
    • Staszel, T.1    Zapala, B.2    Polus, A.3
  • 67
    • 50849137458 scopus 로고    scopus 로고
    • MicroRNA expression profiles in serous ovarian carcinoma
    • Nam EJ, Yoon H, Kim SW, et al. MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 2008;14:2690-5
    • (2008) Clin Cancer Res , vol.14 , pp. 2690-2695
    • Nam, E.J.1    Yoon, H.2    Kim, S.W.3
  • 68
    • 84874274333 scopus 로고    scopus 로고
    • Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis
    • He J, Jing Y, Li W, et al. Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis. PLoS One 2013;8(2):e56647
    • (2013) PLoS One , vol.8 , Issue.2
    • He, J.1    Jing, Y.2    Li, W.3
  • 69
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76 (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 71
    • 34247249906 scopus 로고    scopus 로고
    • Vascular disrupting agents in clinical development
    • DOI 10.1038/sj.bjc.6603694, PII 6603694
    • Hinnen P, Eskens FA. Vascular disrupting agents in clinical development. Br J Cancer 2007;96(8):1159-65 (Pubitemid 46625071)
    • (2007) British Journal of Cancer , vol.96 , Issue.8 , pp. 1159-1165
    • Hinnen, P.1    Eskens, F.A.L.M.2
  • 73
    • 81255185158 scopus 로고    scopus 로고
    • Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer
    • Coleman RL, Duska LR, Ramirez PT, et al. Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. Lancet Oncol 2011;12:1109-17
    • (2011) Lancet Oncol , vol.12 , pp. 1109-1117
    • Coleman, R.L.1    Duska, L.R.2    Ramirez, P.T.3
  • 74
    • 84856509199 scopus 로고    scopus 로고
    • Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: A phase 2 randomised double-blind placebo-controlled study
    • Gotlieb WH, Amant F, Advani S, et al. Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol 2012;13(2):154-62
    • (2012) Lancet Oncol , vol.13 , Issue.2 , pp. 154-162
    • Gotlieb, W.H.1    Amant, F.2    Advani, S.3
  • 75
    • 69849111795 scopus 로고    scopus 로고
    • Aflibercept in epithelial ovarian carcinoma
    • Moroney JW, Sood AK, Coleman RL. Aflibercept in epithelial ovarian carcinoma. Future Oncol 2009;5(5):591-600
    • (2009) Future Oncol , vol.5 , Issue.5 , pp. 591-600
    • Moroney, J.W.1    Sood, A.K.2    Coleman, R.L.3
  • 76
    • 69849106709 scopus 로고    scopus 로고
    • VEGF-Trap for patients with recurrent platinum-resistant epithelial ovarian cancer (EOC): Preliminary results of a randomized multicenter Phase II study [abstract 5508]
    • Chicago IL USA
    • Tew CN, Ray-Coquard I, Oza A, et al. VEGF-Trap for patients with recurrent platinum-resistant epithelial ovarian cancer (EOC): preliminary results of a randomized, multicenter Phase II study [abstract 5508]. Proceedings of the American Society of Clinical Oncology (ASCO) Annual Meeting; Chicago, IL, USA; 2007
    • (2007) Proceedings of the American Society of Clinical Oncology (ASCO) Annual Meeting
    • Tew, C.N.1    Ray-Coquard, I.2    Oza, A.3
  • 77
    • 77649213706 scopus 로고    scopus 로고
    • Phase i pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 2010;28:780-7
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 78
    • 69949135318 scopus 로고    scopus 로고
    • EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma
    • Lee JW, Han HD, Shahzad MM, et al. EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma. J Natl Cancer Inst 2009;101(17):1193-205
    • (2009) J Natl Cancer Inst , vol.101 , Issue.17 , pp. 1193-1205
    • Lee, J.W.1    Han, H.D.2    Shahzad, M.M.3
  • 79
    • 70149102260 scopus 로고    scopus 로고
    • Results from a phase 1/2 study of volociximab in combination with liposomal doxorubicin in relapsed advanced epithelial ovarian and primary peritoneal carcinoma
    • May 20 abstract 16527
    • Delmonte A, Del Conte G, Sessa C, et al. Results from a phase 1/2 study of volociximab in combination with liposomal doxorubicin in relapsed advanced epithelial ovarian and primary peritoneal carcinoma. J Clin Oncol 2008;26(May 20 Suppl):abstract 16527
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Delmonte, A.1    Del Conte, G.2    Sessa, C.3
  • 80
    • 77958042477 scopus 로고    scopus 로고
    • Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: Implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody
    • Coxon A, Bready J, Min H, et al. Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther 2010;9:2641-51
    • (2010) Mol Cancer Ther , vol.9 , pp. 2641-2651
    • Coxon, A.1    Bready, J.2    Min, H.3
  • 81
    • 84863012011 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer
    • Karlan BY, Oza AM, Richardson GE, et al. Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer. J Clin Oncol 2012;30:362-71
    • (2012) J Clin Oncol , vol.30 , pp. 362-371
    • Karlan, B.Y.1    Oza, A.M.2    Richardson, G.E.3
  • 82
    • 84857829255 scopus 로고    scopus 로고
    • Targeting TNF-a to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy
    • Calcinotto A, Grioni M, Jachetti E, et al. Targeting TNF-a to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy. J Immunol 2012;188:2687-94
    • (2012) J Immunol , vol.188 , pp. 2687-2694
    • Calcinotto, A.1    Grioni, M.2    Jachetti, E.3
  • 83
    • 0033764170 scopus 로고    scopus 로고
    • Enhancement of tumour necrosis factor alpha antitumour immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)
    • Curnis F, Sacchi A, Borgna L, et al. Enhancement of tumour necrosis factor alpha antitumour immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13). Nat Biotechnol 2000;18:1185-90
    • (2000) Nat Biotechnol , vol.18 , pp. 1185-1190
    • Curnis, F.1    Sacchi, A.2    Borgna, L.3
  • 84
    • 0036678474 scopus 로고    scopus 로고
    • Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
    • DOI 10.1172/JCI200215223
    • Curnis F, Sacchi A, Corti A. Improving chemotherapeutic drug penetration in tumours by vascular targeting and barrier alteration. J Clin Invest 2002;475-82 (Pubitemid 34919701)
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.4 , pp. 475-482
    • Curnis, F.1    Sacchi, A.2    Corti, A.3
  • 85
    • 84863007720 scopus 로고    scopus 로고
    • Phase II study of NGR-hTNF in combination with doxorubicin in relapsed ovarian cancer patients
    • Lorusso D, Scambia G, Amadio G, et al. Phase II study of NGR-hTNF in combination with doxorubicin in relapsed ovarian cancer patients. Br J Cancer 2012;107:37-42
    • (2012) Br J Cancer , vol.107 , pp. 37-42
    • Lorusso, D.1    Scambia, G.2    Amadio, G.3
  • 86
    • 84889870680 scopus 로고    scopus 로고
    • Available from NCT01358071
    • Available from: www.clinicaltrial.gov NCT01358071
  • 88
    • 77951917301 scopus 로고    scopus 로고
    • Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer
    • Polcher M, Eckhardt M, Coch C, et al. Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer. Cancer Chemother Pharmacol 2010;66:203-7
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 203-207
    • Polcher, M.1    Eckhardt, M.2    Coch, C.3
  • 89
    • 79951988792 scopus 로고    scopus 로고
    • Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: A Gynecologic Oncology Group trial
    • Matei D, Sill MW, Lankes HA, et al. Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a Gynecologic Oncology Group trial. J Clin Oncol 2011;29(1):69-75
    • J Clin Oncol 2011 , vol.29 , Issue.1 , pp. 69-75
    • Matei, D.1    Sill, M.W.2    Lankes, H.A.3
  • 90
    • 80052604394 scopus 로고    scopus 로고
    • Sorafenib as a third line therapy in patients with epithelial ovarian cancer or primary peritoneal cancer: A phase II study
    • Bodnar L, Górnas M, Szczylik C. Sorafenib as a third line therapy in patients with epithelial ovarian cancer or primary peritoneal cancer: a phase II study. Gynecol Oncol 2011;123(1):33-6
    • (2011) Gynecol Oncol , vol.123 , Issue.1 , pp. 33-36
    • Bodnar, L.1    Górnas, M.2    Szczylik, C.3
  • 91
    • 81155148279 scopus 로고    scopus 로고
    • Sorafenib in combination with weekly topotecan in recurrent ovarian cancer, a phase I/II study of the hoosier oncology group
    • Ramasubbaiah R, Perkins SM, Schilder J, et al. Sorafenib in combination with weekly topotecan in recurrent ovarian cancer, a phase I/II study of the Hoosier Oncology Group. Gynecol Oncol 2011;123:499-504
    • (2011) Gynecol Oncol , vol.123 , pp. 499-504
    • Ramasubbaiah, R.1    Perkins, S.M.2    Schilder, J.3
  • 92
    • 77956799700 scopus 로고    scopus 로고
    • Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer: A study of the princess margaret hospital Phase II consortium
    • Welch SA, Hirte HW, Elit L, et al. Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer: a study of the Princess Margaret Hospital Phase II Consortium. Int J Gynecol Cancer 2010;20(5):787-93
    • Int J Gynecol Cancer 2010 , vol.20 , Issue.5 , pp. 787-793
    • Welch, S.A.1    Hirte, H.W.2    Elit, L.3
  • 93
    • 84867882609 scopus 로고    scopus 로고
    • A phase II study of intermittent sorafenib with bevacizumab in bevacizumab-näve epithelial ovarian cancer (EOC) patients
    • abstract5019
    • Kohn EC, Lee J, Annunziata CM, et al. A phase II study of intermittent sorafenib with bevacizumab in bevacizumab-näve epithelial ovarian cancer (EOC) patients. J Clin Oncol 2011;29:abstract5019
    • (2011) J Clin Oncol , pp. 29
    • Kohn, E.C.1    Lee, J.2    Annunziata, C.M.3
  • 94
    • 84901601739 scopus 로고    scopus 로고
    • Paclitaxel/carboplatin with or without sorafenib in the first-line treatment of patients with stage III/IV epithelial ovarian cancer: A randomized phase II study of the sarah cannon research institute. 2013 ASCO annual meeting
    • abstract 5513
    • Thompson DS, Dudley BS, Bismayer JA, et al. Paclitaxel/carboplatin with or without sorafenib in the first-line treatment of patients with stage III/IV epithelial ovarian cancer: a randomized phase II study of the Sarah Cannon Research Institute. 2013 ASCO annual meeting. J Clin Oncol 2013;31(Suppl): abstract 5513
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Thompson, D.S.1    Dudley, B.S.2    Bismayer, J.A.3
  • 96
    • 84865556743 scopus 로고    scopus 로고
    • A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: A randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy
    • Baumann KH, du Bois A, Meier W, et al. A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: a randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy. Ann Oncol 2012;23:2265-71
    • (2012) Ann Oncol , vol.23 , pp. 2265-2271
    • Baumann, K.H.1    Du Bois, A.2    Meier, W.3
  • 97
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120, triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al. BIBF, 1120, triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008;68:4774-82
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 98
    • 80053561888 scopus 로고    scopus 로고
    • Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer
    • Ledermann JA, Hackshaw A, Kaye S, et al. Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol 2011;29:3798-804
    • (2011) J Clin Oncol , vol.29 , pp. 3798-3804
    • Ledermann, J.A.1    Hackshaw, A.2    Kaye, S.3
  • 99
    • 84889865139 scopus 로고    scopus 로고
    • Available from NCT01015118
    • Available from: www.clinicaltrial.gov NCT01015118
  • 101
    • 67449164582 scopus 로고    scopus 로고
    • Phase i trial of pazopanib in patients with advanced cancer
    • Hurwitz HI, Dowlati A, Saini S, et al. Phase I trial of pazopanib in patients with advanced cancer. Clin Cancer Res 2009;15:4220-7
    • (2009) Clin Cancer Res , vol.15 , pp. 4220-4227
    • Hurwitz, H.I.1    Dowlati, A.2    Saini, S.3
  • 102
    • 77956649079 scopus 로고    scopus 로고
    • A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer
    • Friedlander M, Hancock KC, Rischin D, et al. A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer. Gynecol Oncol 2010;119:32-7
    • (2010) Gynecol Oncol , vol.119 , pp. 32-37
    • Friedlander, M.1    Hancock, K.C.2    Rischin, D.3
  • 103
    • 84885594084 scopus 로고    scopus 로고
    • Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): Results of an international intergroup trial (AGOOVAR16)
    • abstract: LBA5503
    • Du Bois A, Floquet A, Kim JW, et al. Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): results of an International Intergroup trial (AGOOVAR16). J Clin Oncol ASCO Annual Meeting 2013;31(Suppl):abstract: LBA5503
    • (2013) J Clin Oncol ASCO Annual Meeting , vol.31 , Issue.SUPPL.
    • Du Bois, A.1    Floquet, A.2    Kim, J.W.3
  • 104
    • 67651242368 scopus 로고    scopus 로고
    • Current status of cediranib: The rapid development of a novel anti-angiogenic therapy
    • Lindsay CR, MacPherson IR, Cassidy J. Current status of cediranib: the rapid development of a novel anti-angiogenic therapy. Future Oncol 2009;5:421-32
    • (2009) Future Oncol , vol.5 , pp. 421-432
    • Lindsay, C.R.1    MacPherson, I.R.2    Cassidy, J.3
  • 105
    • 73949123481 scopus 로고    scopus 로고
    • Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer
    • Matulonis UA, Berlin S, Ivy P, et al. Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer. J Clin Oncol 2009;27:5601-6
    • (2009) J Clin Oncol , vol.27 , pp. 5601-5606
    • Matulonis, U.A.1    Berlin, S.2    Ivy, P.3
  • 106
    • 58149219264 scopus 로고    scopus 로고
    • A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Final results of a PMH, Chicago and California consortia trial
    • abstract 5521
    • Hirte HW, Vidal L, Fleming GF, et al. A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: final results of a PMH, Chicago and California consortia trial. J Clin Oncol 2008;26:abstract 5521
    • (2008) J Clin Oncol , vol.26
    • Hirte, H.W.1    Vidal, L.2    Fleming, G.F.3
  • 107
    • 80053232638 scopus 로고    scopus 로고
    • Initial toxicity assessment of ICON6: A randomised trial of cediranib plus chemotherapy in platinum-sensitive relapsed ovarian cancer
    • Raja FA, Griffin CL, Qian W. Initial toxicity assessment of ICON6: a randomised trial of cediranib plus chemotherapy in platinum-sensitive relapsed ovarian cancer. Br J Cancer 2011;105:884-9
    • (2011) Br J Cancer , vol.105 , pp. 884-889
    • Raja, F.A.1    Griffin, C.L.2    Qian, W.3
  • 108
    • 34447320826 scopus 로고    scopus 로고
    • A phase IB, open label, safety and pharmacokinetic (PK) study of escalating doses of PTK787/ZK 222584 in combination with paclitaxel and carboplatin in patients (PTs) with stage IIC to IV epithelial ovarian cancer [abstract]. 2007 ASCO Ann Meet Proc (Post-Meet Ed)
    • June 1
    • Schroder W, Witteveen E, Abadie S, et al. A phase IB, open label, safety and pharmacokinetic (PK) study of escalating doses of PTK787/ZK 222584 in combination with paclitaxel and carboplatin in patients (PTs) with stage IIC to IV epithelial ovarian cancer [abstract]. 2007 ASCO Ann Meet Proc (Post-Meet Ed). J Clin Oncol 2005;23(16S June 1 Suppl):5042
    • (2005) J Clin Oncol , vol.23 , Issue.16 S JUNE 1 SUPPL. , pp. 5042
    • Schroder, W.1    Witteveen, E.2    Abadie, S.3
  • 109
    • 84873743140 scopus 로고    scopus 로고
    • Phase i trial of PTK787/ZK222584 (PTK/ZK) in combination with carboplatin (C) and paclitaxel (T) in platinum-sensitive recurrent epithelial ovarian (EOC), fallopian tube (FT), or primary peritoneal (PPC) cancers [abstract]. 2007 ASCO ann meet proc (Post-Meet Ed)
    • June 20
    • Juretzka MM, Aghajanian C, Hensley ML, et al. Phase I trial of PTK787/ZK222584 (PTK/ZK) in combination with carboplatin (C) and paclitaxel (T) in platinum-sensitive recurrent epithelial ovarian (EOC), fallopian tube (FT), or primary peritoneal (PPC) cancers [abstract]. 2007 ASCO Ann Meet Proc (Post-Meet Ed). J Clin Oncol 2007;25(18S June 20 Suppl):5564
    • (2007) J Clin Oncol , vol.25 , Issue.18 S JUNE 20 SUPPL. , pp. 5564
    • Juretzka, M.M.1    Aghajanian, C.2    Hensley, M.L.3
  • 110
    • 78751492146 scopus 로고    scopus 로고
    • ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action
    • Fletcher GC, Brokx RD, Denny TA, et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther 2011;10(1):126-37
    • (2011) Mol Cancer Ther , vol.10 , Issue.1 , pp. 126-137
    • Fletcher, G.C.1    Brokx, R.D.2    Denny, T.A.3
  • 111
    • 84871416340 scopus 로고    scopus 로고
    • ENMD-2076, an oral inhibitor of angiogenic and proliferation kinases, has activity in recurrent, platinum resistant ovarian cancer
    • Matulonis UA, Lee J, Lasonde B, et al. ENMD-2076, an oral inhibitor of angiogenic and proliferation kinases, has activity in recurrent, platinum resistant ovarian cancer. Eur J Cancer 2013;49(1):121-31
    • (2013) Eur J Cancer , vol.49 , Issue.1 , pp. 121-131
    • Matulonis, U.A.1    Lee, J.2    Lasonde, B.3
  • 112
    • 0028968622 scopus 로고
    • Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
    • Buchdunger E, Zimmermann J, Mett H, et al. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci USA 1995;92:2558-62
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2558-2562
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3
  • 113
    • 84889782804 scopus 로고    scopus 로고
    • Imatinib mesylate in combination with docetaxel for the treatment of patients with advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis
    • Matei D, Emerson RE, Schilder J, et al. Imatinib mesylate in combination with docetaxel for the treatment of patients with advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis. Cancer 2008;15:113-14
    • (2008) Cancer , vol.15 , pp. 113-114
    • Matei, D.1    Emerson, R.E.2    Schilder, J.3
  • 114
    • 49149108140 scopus 로고    scopus 로고
    • Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group Study
    • Russel J, Schilder RJ, Sill MW, et al. Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 2008;26:3418-25
    • (2008) J Clin Oncol , vol.26 , pp. 3418-3425
    • Russel, J.1    Schilder, R.J.2    Sill, M.W.3
  • 115
    • 33645670595 scopus 로고    scopus 로고
    • Discovery and preclinical studies of (R)-1-(4-(4-fluoro 2-methyl-1Hindol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4] triazin-6-yloxy)propan- 2-ol(BMS-540215), an in vivo active potent VEGFR-2 inhibitor
    • Bhide RS, Cai ZW, Zhang YZ, et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro 2-methyl-1Hindol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4] triazin-6-yloxy)propan-2-ol(BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem 2006;2143-6
    • (2006) J Med Chem , pp. 2143-2146
    • Bhide, R.S.1    Cai, Z.W.2    Zhang, Y.Z.3
  • 116
    • 70349618646 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate
    • Marathe PH, Kamath AV, Zhang Y, et al. Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate. Cancer Chemother Pharmacol 2009;65:55-66
    • (2009) Cancer Chemother Pharmacol , vol.65 , pp. 55-66
    • Marathe, P.H.1    Kamath, A.V.2    Zhang, Y.3
  • 117
    • 84886725825 scopus 로고    scopus 로고
    • Brivanib (B) advanced ovarian cancer (Oc): Subset results of a phase 2 randomized discontinuation trial (Rdt). 37th Congress of the European-Societyfor-Medical-Oncology (ESMO)
    • Kaye SB, Siu LL, Jassem J, et al. Brivanib (B) in advanced ovarian cancer (Oc): subset results of a phase 2 randomized discontinuation trial (Rdt). 37th Congress of the European-Societyfor-Medical-Oncology (ESMO). Ann Oncol 2012;23(Suppl 9):319
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9 , pp. 319
    • Kaye, S.B.1    Siu, L.L.2    Jassem, J.3
  • 118
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther 2011;10:2298-08
    • (2011) Mol Cancer Ther , vol.10 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 119
    • 84875469411 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a dual MET-VEGFR2 inhibitor, blocks osteoblastic and osteolytic progression of human prostate cancer xenografts in mouse bone [abstract]
    • Schimmoller F, Zayzafoon M, Chung LWK, et al. Cabozantinib (XL184), a dual MET-VEGFR2 inhibitor, blocks osteoblastic and osteolytic progression of human prostate cancer xenografts in mouse bone [abstract]. Mol Cancer Ther 2011;10(Suppl):233
    • (2011) Mol Cancer Ther , vol.10 , Issue.SUPPL. , pp. 233
    • Schimmoller, F.1    Zayzafoon, M.2    Chung, L.W.K.3
  • 121
    • 33748869678 scopus 로고    scopus 로고
    • Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
    • DOI 10.1158/0008-5472.CAN-06-2848
    • Horsman MR, Siemann DW. Pathophysiologic effects of vascular targeting agents and the implications for combination with conventional therapies. Cancer Res 2006;66(24):11520-39 (Pubitemid 46094158)
    • (2006) Cancer Research , vol.66 , Issue.24 , pp. 11520-11539
    • Horsman, M.R.1    Siemann, D.W.2
  • 122
    • 79953648492 scopus 로고    scopus 로고
    • Phase II trial of combretastatin A4 phosphate carboplatin and paclitaxel in patients with platinum-resistant ovarian cancer
    • Zweifel M, Jayson GC, Reed NS, et al. Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer. Ann Oncol 2011;22(9):2036-41
    • (2011) Ann Oncol , vol.22 , Issue.9 , pp. 2036-2041
    • Zweifel, M.1    Jayson, G.C.2    Reed, N.S.3
  • 124
    • 67649371461 scopus 로고    scopus 로고
    • DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda TB, Cortez CC, Yoo CB, et al. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther 2009;8:1579-88
    • (2009) Mol Cancer Ther , vol.8 , pp. 1579-1588
    • Miranda, T.B.1    Cortez, C.C.2    Yoo, C.B.3
  • 125
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012;492:108-12
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3
  • 126
    • 84867632489 scopus 로고    scopus 로고
    • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    • Knutson SK, Wigle TJ, Warholic NM, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol 2012;8:890-6
    • (2012) Nat Chem Biol , vol.8 , pp. 890-896
    • Knutson, S.K.1    Wigle, T.J.2    Warholic, N.M.3
  • 127
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • Qi W, Chan H, Teng L, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci USA 2012;109:21360-5
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3
  • 129
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • DOI 10.1158/1078-0432.CCR-0642-03
    • Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004;10:415-27 (Pubitemid 38173977)
    • (2004) Clinical Cancer Research , vol.10 , Issue.2 , pp. 415-427
    • Thorpe, P.E.1
  • 131
    • 84933671792 scopus 로고    scopus 로고
    • A phase II placebo (Pbo)-controlled randomized study of ombrabulin in patients with platinum-sensitive recurrent ovarian cancer (OC) treated with carboplatin (Cb) and paclitaxel (P)
    • abstract 5516
    • Birrer MJ, Bondarenko I, Tjulandin S, et al. A phase II placebo (Pbo)-controlled randomized study of ombrabulin in patients with platinum-sensitive recurrent ovarian cancer (OC) treated with carboplatin (Cb) and paclitaxel (P). J Clin Oncol 2013;31(Suppl):abstract 5516
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Birrer, M.J.1    Bondarenko, I.2    Tjulandin, S.3
  • 132
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospitalphase II consortia
    • Garcia AA, Hirte H, Fleming G, et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospitalphase II consortia. J Clin Oncol 2008;26(1):76-82
    • (2008) J Clin Oncol , vol.26 , Issue.1 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 135
    • 73949092398 scopus 로고    scopus 로고
    • Phase II study of carboplatin, paclitaxel, and bevacizumab with maintenance bevacizumab as first-line chemotherapy for advanced mullerian tumors
    • Penson RT, Dizon DS, Cannistra SA, et al. Phase II study of carboplatin, paclitaxel, and bevacizumab with maintenance bevacizumab as first-line chemotherapy for advanced mullerian tumors. J Clin Oncol 2010;28(1):154-9
    • (2010) J Clin Oncol , vol.28 , Issue.1 , pp. 154-159
    • Penson, R.T.1    Dizon, D.S.2    Cannistra, S.A.3
  • 136
    • 71749110151 scopus 로고    scopus 로고
    • Preliminary results of a phase II study of oxaliplatin, docetaxel, and bevacizumab as first-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube
    • abstract 5546
    • Rose PG, Drake R, Braly PS, et al. Preliminary results of a phase II study of oxaliplatin, docetaxel, and bevacizumab as first-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube. J Clin Oncol 2009;27(15 Suppl): abstract 5546
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Rose, P.G.1    Drake, R.2    Braly, P.S.3
  • 137
    • 83355169742 scopus 로고    scopus 로고
    • Phase II study of intraperitoneal paclitaxel plus cisplatin and intravenous paclitaxel plusbevacizumab as adjuvant treatment of optimal stage II/III epithelial ovarian cancer
    • Konner JA, Grabon DM, Gerst SR, et al. Phase II study of intraperitoneal paclitaxel plus cisplatin and intravenous paclitaxel plusbevacizumab as adjuvant treatment of optimal stage II/III epithelial ovarian cancer. J Clin Oncol 2011;29(35):4662-8
    • (2011) J Clin Oncol , vol.29 , Issue.35 , pp. 4662-4668
    • Konner, J.A.1    Grabon, D.M.2    Gerst, S.R.3
  • 138
    • 79952680888 scopus 로고    scopus 로고
    • A phase II study of bevacizumab with nab-paclitaxel in patients with recurrent, platinumresistant primary epithelial ovarian or primary peritoneal carcinoma
    • abstract 5009
    • Tillmanns TD, Lowe MP, Schwartzberg LS, et al. A phase II study of bevacizumab with nab-paclitaxel in patients with recurrent, platinumresistant primary epithelial ovarian or primary peritoneal carcinoma. J Clin Oncol 2010;28(15 Suppl):abstract 5009
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Tillmanns, T.D.1    Lowe, M.P.2    Schwartzberg, L.S.3
  • 139
    • 80052514816 scopus 로고    scopus 로고
    • Safety efficacy and biomarker exploration in a phase II study of bevacizumab oxaliplatin and gemcitabine in recurrent müllerian carcinoma
    • Horowitz NS, Penson RT, Duda DG, et al. Safety, efficacy, and biomarker exploration in a phase II study of bevacizumab, oxaliplatin, and gemcitabine in recurrent müllerian carcinoma. Clin Ovarian Cancefr Other Gynecol Malig 2011;4(1):26-33
    • (2011) Clin Ovarian Cancefr Other Gynecol Malig , vol.4 , Issue.1 , pp. 26-33
    • Horowitz, N.S.1    Penson, R.T.2    Duda, D.G.3
  • 140
    • 84871448485 scopus 로고    scopus 로고
    • Phase i dose-escalation study of intravenous aflibercept administered in combination with irinotecan, 5-fluorouracil and leucovorin in patients with advanced solid tumours
    • Van Cutsem E, Khavat D, Verslype C, et al. Phase I dose-escalation study of intravenous aflibercept administered in combination with irinotecan, 5-fluorouracil and leucovorin in patients with advanced solid tumours. Eur J Cancer 2013;49(1):17-24
    • (2013) Eur J Cancer , vol.49 , Issue.1 , pp. 17-24
    • Van Cutsem, E.1    Khavat, D.2    Verslype, C.3
  • 141
    • 84858193113 scopus 로고    scopus 로고
    • Phase i dose-escalation study of intravenous aflibercept in combination with docetaxel in patients with advanced solid tumors
    • Isambert N, Frever G, Zanetta S, et al. Phase I dose-escalation study of intravenous aflibercept in combination with docetaxel in patients with advanced solid tumors. Clin Cancer Res 2012;18(6):1743-50
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1743-1750
    • Isambert, N.1    Frever, G.2    Zanetta, S.3
  • 142
    • 77649213706 scopus 로고    scopus 로고
    • Phase i pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 2010;28:780-7
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 143
    • 70249114453 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
    • Herbst RS, Hong D, Chap L, et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009;27(21):3557-65
    • (2009) J Clin Oncol , vol.27 , Issue.21 , pp. 3557-3565
    • Herbst, R.S.1    Hong, D.2    Chap, L.3
  • 146
    • 79251585977 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: An NCIC clinical trials group study
    • Biagi JJ, OZa AM, Chalcal HI, et al. A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study. Ann Oncol 2011;22(2):335-40
    • (2011) Ann Oncol , vol.22 , Issue.2 , pp. 335-340
    • Biagi, J.J.1    Oza, A.M.2    Chalcal, H.I.3
  • 147
    • 77951895481 scopus 로고    scopus 로고
    • A phase i open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies
    • Du Bois A, Huober J, Stopfer P, et al. A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies. Ann Oncol 2010;21(2):370-5
    • (2010) Ann Oncol , vol.21 , Issue.2 , pp. 370-375
    • Du Bois, A.1    Huober, J.2    Stopfer, P.3
  • 148
    • 84871416340 scopus 로고    scopus 로고
    • ENMD-2076, an oral inhibitor of angiogenic and proliferation kinases, has activity in recurrent, platinum resistant ovarian cancer
    • Matulonis UA, Lee J, Lasonde B, et al. ENMD-2076, an oral inhibitor of angiogenic and proliferation kinases, has activity in recurrent, platinum resistant ovarian cancer. Eur J Cancer 2013;49(1):121-31
    • (2013) Eur J Cancer , vol.49 , Issue.1 , pp. 121-131
    • Matulonis, U.A.1    Lee, J.2    Lasonde, B.3
  • 150
    • 33644509244 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in patients with recurrent platinum-and taxane-resistant epithelial ovarian and primary peritoneal cancers
    • Coleman RL, Broaddus RR, Bodurka DC, et al. Phase II trial of imatinib mesylate in patients with recurrent platinum-and taxane-resistant epithelial ovarian and primary peritoneal cancers. Gynecol Oncol 2006;101(1):126-31
    • (2006) Gynecol Oncol , vol.101 , Issue.1 , pp. 126-131
    • Coleman, R.L.1    Broaddus, R.R.2    Bodurka, D.C.3


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