-
1
-
-
49249113484
-
Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
-
Azad NS, Posadas EM, Kwitkowski VE, Steinberg SM, Jain L, Annunziata CM, Minasian L, Sarosy G, Kotz HL, Premkumar A, Cao L, McNally D, Chow C, Chen HX, Wright JJ, Figg WD, Kohn EC (2008) Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 26: 3709-3714
-
(2008)
J Clin Oncol
, vol.26
, pp. 3709-3714
-
-
Azad, N.S.1
Posadas, E.M.2
Kwitkowski, V.E.3
Steinberg, S.M.4
Jain, L.5
Annunziata, C.M.6
Minasian, L.7
Sarosy, G.8
Kotz, H.L.9
Premkumar, A.10
Cao, L.11
McNally, D.12
Chow, C.13
Chen, H.X.14
Wright, J.J.15
Figg, W.D.16
Kohn, E.C.17
-
2
-
-
32944466693
-
Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
-
Baffert F, Le T, Sennino B, Thurston G, Kuo CJ, Hu-Lowe D, McDonald DM (2006) Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol 290: H547-H559
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Baffert, F.1
Le, T.2
Sennino, B.3
Thurston, G.4
Kuo, C.J.5
Hu-Lowe, D.6
McDonald, D.M.7
-
3
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK (2007) AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11: 83-95
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
Zhang, W.T.4
Duda, D.G.5
Cohen, K.S.6
Kozak, K.R.7
Cahill, D.P.8
Chen, P.J.9
Zhu, M.10
Ancukiewicz, M.11
Mrugala, M.M.12
Plotkin, S.13
Drappatz, J.14
Louis, D.N.15
Ivy, P.16
Scadden, D.T.17
Benner, T.18
Loeffler, J.S.19
Wen, P.Y.20
Jain, R.K.21
more..
-
4
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8: 592-603
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
5
-
-
58149248099
-
A phase II study of sunitinib (SU11248) in patients (pts) with recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma - NCIC CTG IND 185
-
Biagi JJ, Oza AM, Grimshaw R, Ellard SL, Lee U, Sederias J, Ivy SP, Eisenhauer EA (2008) A phase II study of sunitinib (SU11248) in patients (pts) with recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma - NCIC CTG IND 185. J Clin Oncol 26: 5522
-
(2008)
J Clin Oncol
, vol.26
, pp. 5522
-
-
Biagi, J.J.1
Oza, A.M.2
Grimshaw, R.3
Ellard, S.L.4
Lee, U.5
Sederias, J.6
Ivy, S.P.7
Eisenhauer, E.A.8
-
6
-
-
0034032882
-
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
-
Browder T, Butterfield CE, Kraling BM, Shi B, Marshall B, O'Reilly MS, Folkman J (2000) Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60: 1878-1886
-
(2000)
Cancer Res
, vol.60
, pp. 1878-1886
-
-
Browder, T.1
Butterfield, C.E.2
Kraling, B.M.3
Shi, B.4
Marshall, B.5
O'Reilly, M.S.6
Folkman, J.7
-
7
-
-
34447502449
-
Experience with bevacizumab in the management of epithelial ovarian cancer
-
Burger RA (2007) Experience with bevacizumab in the management of epithelial ovarian cancer. J Clin Oncol 25: 2902-2908
-
(2007)
J Clin Oncol
, vol.25
, pp. 2902-2908
-
-
Burger, R.A.1
-
8
-
-
36849019301
-
Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group Study
-
Burger RA, Sill MW, Monk BJ, Greer BE, Sorosky JI (2007) Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J Clin Oncol 25: 5165-5171
-
(2007)
J Clin Oncol
, vol.25
, pp. 5165-5171
-
-
Burger, R.A.1
Sill, M.W.2
Monk, B.J.3
Greer, B.E.4
Sorosky, J.I.5
-
9
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne AT, Ross L, Holash J, Nakanishi M, Hu L, Hofmann JI, Yancopoulos GD, Jaffe RB (2003) Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 9: 5721-5728
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
Nakanishi, M.4
Hu, L.5
Hofmann, J.I.6
Yancopoulos, G.D.7
Jaffe, R.B.8
-
10
-
-
36849056497
-
Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
-
Cannistra SA, Matulonis UA, Penson RT, Hambleton J, Dupont J, Mackey H, Douglas J, Burger RA, Armstrong D, Wenham R, McGuire W (2007) Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol 25: 5180-5186
-
(2007)
J Clin Oncol
, vol.25
, pp. 5180-5186
-
-
Cannistra, S.A.1
Matulonis, U.A.2
Penson, R.T.3
Hambleton, J.4
Dupont, J.5
Mackey, H.6
Douglas, J.7
Burger, R.A.8
Armstrong, D.9
Wenham, R.10
McGuire, W.11
-
11
-
-
33748670455
-
Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
-
Carducci MA, Musib L, Kies MS, Pili R, Truong M, Brahmer JR, Cole P, Sullivan R, Riddle J, Schmidt J, Enas N, Sinha V, Thornton DE, Herbst RS (2006) Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. J Clin Oncol 24: 4092-4099
-
(2006)
J Clin Oncol
, vol.24
, pp. 4092-4099
-
-
Carducci, M.A.1
Musib, L.2
Kies, M.S.3
Pili, R.4
Truong, M.5
Brahmer, J.R.6
Cole, P.7
Sullivan, R.8
Riddle, J.9
Schmidt, J.10
Enas, N.11
Sinha, V.12
Thornton, D.E.13
Herbst, R.S.14
-
12
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8: 299-309
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
13
-
-
36048955738
-
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: A pilot study
-
Chen W, Delaloye S, Silverman DH, Geist C, Czernin J, Sayre J, Satyamurthy N, Pope W, Lai A, Phelps ME, Cloughesy T (2007) Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. J Clin Oncol 25: 4714-4721
-
(2007)
J Clin Oncol
, vol.25
, pp. 4714-4721
-
-
Chen, W.1
Delaloye, S.2
Silverman, D.H.3
Geist, C.4
Czernin, J.5
Sayre, J.6
Satyamurthy, N.7
Pope, W.8
Lai, A.9
Phelps, M.E.10
Cloughesy, T.11
-
14
-
-
0031785456
-
The effects of platelet-derived growth factor and receptor on normal and neoplastic human ovarian surface epithelium
-
Dabrow MB, Francesco MR, McBrearty FX, Caradonna S (1998) The effects of platelet-derived growth factor and receptor on normal and neoplastic human ovarian surface epithelium. Gynecol Oncol 71: 29-37
-
(1998)
Gynecol Oncol
, vol.71
, pp. 29-37
-
-
Dabrow, M.B.1
Francesco, M.R.2
McBrearty, F.X.3
Caradonna, S.4
-
15
-
-
54449099774
-
Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer
-
Dellapasqua S, Bertolini F, Bagnardi V, Campagnoli E, Scarano E, Torrisi R, Shaked Y, Mancuso P, Goldhirsch A, Rocca A, Pietri E, Colleoni M (2008) Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer. J Clin Oncol 26: 4899-4905
-
(2008)
J Clin Oncol
, vol.26
, pp. 4899-4905
-
-
Dellapasqua, S.1
Bertolini, F.2
Bagnardi, V.3
Campagnoli, E.4
Scarano, E.5
Torrisi, R.6
Shaked, Y.7
Mancuso, P.8
Goldhirsch, A.9
Rocca, A.10
Pietri, E.11
Colleoni, M.12
-
16
-
-
58149273695
-
A comparative study of circulating endothelial cells (CECs) and circulating progenitor cells (CPCs) kinetics in four multidisciplinary phase II studies of antiangiogenic agents
-
Duda DG, Ancukiewicz M, di Tomaso E, Zhu AX, Penson RT, Horowitz NS, Batchelor TT, Willett CG, Jain RK (2008) A comparative study of circulating endothelial cells (CECs) and circulating progenitor cells (CPCs) kinetics in four multidisciplinary phase II studies of antiangiogenic agents. J Clin Oncol 26: 3544
-
(2008)
J Clin Oncol
, vol.26
, pp. 3544
-
-
Duda, D.G.1
Ancukiewicz, M.2
di Tomaso, E.3
Zhu, A.X.4
Penson, R.T.5
Horowitz, N.S.6
Batchelor, T.T.7
Willett, C.G.8
Jain, R.K.9
-
17
-
-
0024384470
-
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
-
Ferrara N, Henzel WJ (1989) Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161: 851-858
-
(1989)
Biochem Biophys Res Commun
, vol.161
, pp. 851-858
-
-
Ferrara, N.1
Henzel, W.J.2
-
18
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438: 967-974
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
19
-
-
0024549349
-
Induction of angiogenesis during the transition from hyperplasia to neoplasia
-
Folkman J, Watson K, Ingber D, Hanahan D (1989) Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339: 58-61
-
(1989)
Nature
, vol.339
, pp. 58-61
-
-
Folkman, J.1
Watson, K.2
Ingber, D.3
Hanahan, D.4
-
20
-
-
14044253618
-
Single injections of vascular endothelial growth factor trap block ovulation in the macaque and produce a prolonged, dose-related suppression of ovarian function
-
Fraser HM, Wilson H, Rudge JS, Wiegand SJ (2005) Single injections of vascular endothelial growth factor trap block ovulation in the macaque and produce a prolonged, dose-related suppression of ovarian function. J Clin Endocrinol Metab 90: 1114-1122
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 1114-1122
-
-
Fraser, H.M.1
Wilson, H.2
Rudge, J.S.3
Wiegand, S.J.4
-
21
-
-
33845287895
-
Bevacizumab (B) plus erlotinib (E) for patients (pts) with recurrent ovarian (OC) and fallopian tube (FT) cancer: Preliminary results of a multi-center phase II trial
-
Friberg G, Oza R, Morgan J, Vokes EE, Gandara DR, Fleming G (2006) Bevacizumab (B) plus erlotinib (E) for patients (pts) with recurrent ovarian (OC) and fallopian tube (FT) cancer: Preliminary results of a multi-center phase II trial. J Clin Oncol 24: 5018
-
(2006)
J Clin Oncol
, vol.24
, pp. 5018
-
-
Friberg, G.1
Oza, R.2
Morgan, J.3
Vokes, E.E.4
Gandara, D.R.5
Fleming, G.6
-
22
-
-
36549038661
-
Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: Initial results of a phase II study
-
Friedlander M, Hancock KC, Benigno B, Rischin D, Messing MC, Stringer A, Tay EH, Kathman S, Matthys G, Lager JJ (2007) Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: Initial results of a phase II study. J Clin Oncol 25: 5561
-
(2007)
J Clin Oncol
, vol.25
, pp. 5561
-
-
Friedlander, M.1
Hancock, K.C.2
Benigno, B.3
Rischin, D.4
Messing, M.C.5
Stringer, A.6
Tay, E.H.7
Kathman, S.8
Matthys, G.9
Lager, J.J.10
-
23
-
-
33750730607
-
Intratumoral microvessel density in advanced epithelial ovarian cancer and its use as a prognostic variable
-
Gadducci A, Ferrero A, Cosio S, Zola P, Viacava P, Dompe D, Fanelli G, Ravarino N, Motta M, Cristofani R, Genazzani AR (2006) Intratumoral microvessel density in advanced epithelial ovarian cancer and its use as a prognostic variable. Anticancer Res 26: 3925-3932
-
(2006)
Anticancer Res
, vol.26
, pp. 3925-3932
-
-
Gadducci, A.1
Ferrero, A.2
Cosio, S.3
Zola, P.4
Viacava, P.5
Dompe, D.6
Fanelli, G.7
Ravarino, N.8
Motta, M.9
Cristofani, R.10
Genazzani, A.R.11
-
24
-
-
37849035249
-
Phase II clinical trial of bevacizumab and lowdose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
-
Garcia AA, Hirte H, Fleming G, Yang D, Tsao-Wei DD, Roman L, Groshen S, Swenson S, Markland F, Gandara D, Scudder S, Morgan R, Chen H, Lenz HJ, Oza AM (2008) Phase II clinical trial of bevacizumab and lowdose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia. J Clin Oncol 26: 76-82
-
(2008)
J Clin Oncol
, vol.26
, pp. 76-82
-
-
Garcia, A.A.1
Hirte, H.2
Fleming, G.3
Yang, D.4
Tsao-Wei, D.D.5
Roman, L.6
Groshen, S.7
Swenson, S.8
Markland, F.9
Gandara, D.10
Scudder, S.11
Morgan, R.12
Chen, H.13
Lenz, H.J.14
Oza, A.M.15
-
25
-
-
18844363423
-
The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer
-
Goodheart MJ, Ritchie JM, Rose SL, Fruehauf JP, De Young BR, Buller RE (2005) The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer. Clin Cancer Res 11: 3733-3742
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3733-3742
-
-
Goodheart, M.J.1
Ritchie, J.M.2
Rose, S.L.3
Fruehauf, J.P.4
De Young, B.R.5
Buller, R.E.6
-
26
-
-
0034048358
-
Less is more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
-
Hanahan D, Bergers G, Bergsland E (2000) Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 105: 1045-1047
-
(2000)
J Clin Invest
, vol.105
, pp. 1045-1047
-
-
Hanahan, D.1
Bergers, G.2
Bergsland, E.3
-
27
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
28
-
-
33847355587
-
Vascular endothelial growth factor gene polymorphisms are associated with prognosis in ovarian cancer
-
Hefler LA, Mustea A, Konsgen D, Concin N, Tanner B, Strick R, Heinze G, Grimm C, Schuster E, Tempfer C, Reinthaller A, Zeillinger R (2007) Vascular endothelial growth factor gene polymorphisms are associated with prognosis in ovarian cancer. Clin Cancer Res 13: 898-901
-
(2007)
Clin Cancer Res
, vol.13
, pp. 898-901
-
-
Hefler, L.A.1
Mustea, A.2
Konsgen, D.3
Concin, N.4
Tanner, B.5
Strick, R.6
Heinze, G.7
Grimm, C.8
Schuster, E.9
Tempfer, C.10
Reinthaller, A.11
Zeillinger, R.12
-
29
-
-
8544249895
-
Tumor-associated endothelial cells with cytogenetic abnormalities
-
Hida K, Hida Y, Amin DN, Flint AF, Panigrahy D, Morton CC, Klagsbrun M (2004) Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 64: 8249-8255
-
(2004)
Cancer Res
, vol.64
, pp. 8249-8255
-
-
Hida, K.1
Hida, Y.2
Amin, D.N.3
Flint, A.F.4
Panigrahy, D.5
Morton, C.C.6
Klagsbrun, M.7
-
30
-
-
36148937125
-
Tumour vascularization: Sprouting angiogenesis and beyond
-
Hillen F, Griffioen AW (2007) Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev 26: 489-502
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 489-502
-
-
Hillen, F.1
Griffioen, A.W.2
-
31
-
-
58149219264
-
A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Final results of a PMH, Chicago and California consortia trial
-
Hirte HW, Vidal L, Fleming GF, Sugimoto AK, Morgan RJ, Biagi JJ, Wang L, McGill S, Ivy SP, Oza AM (2008) A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Final results of a PMH, Chicago and California consortia trial. J Clin Oncol 26: 5521
-
(2008)
J Clin Oncol
, vol.26
, pp. 5521
-
-
Hirte, H.W.1
Vidal, L.2
Fleming, G.F.3
Sugimoto, A.K.4
Morgan, R.J.5
Biagi, J.J.6
Wang, L.7
McGill, S.8
Ivy, S.P.9
Oza, A.M.10
-
32
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350: 2335-2342
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
33
-
-
34447635695
-
Angiogenesis inhibitor therapies: Focus on kidney toxicity and hypertension
-
Izzedine H, Rixe O, Billemont B, Baumelou A, Deray G (2007) Angiogenesis inhibitor therapies: focus on kidney toxicity and hypertension. Am J Kidney Dis 50: 203-218
-
(2007)
Am J Kidney Dis
, vol.50
, pp. 203-218
-
-
Izzedine, H.1
Rixe, O.2
Billemont, B.3
Baumelou, A.4
Deray, G.5
-
34
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
-
Jain RK (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7: 987-989
-
(2001)
Nat Med
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
35
-
-
20044396551
-
Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume
-
Jayson GC, Parker GJ, Mullamitha S, Valle JW, Saunders M, Broughton L, Lawrance J, Carrington B, Roberts C, Issa B, Buckley DL, Cheung S, Davies K, Watson Y, Zinkewich-Peotti K, Rolfe L, Jackson A (2005) Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume. J Clin Oncol 23: 973-981
-
(2005)
J Clin Oncol
, vol.23
, pp. 973-981
-
-
Jayson, G.C.1
Parker, G.J.2
Mullamitha, S.3
Valle, J.W.4
Saunders, M.5
Broughton, L.6
Lawrance, J.7
Carrington, B.8
Roberts, C.9
Issa, B.10
Buckley, D.L.11
Cheung, S.12
Davies, K.13
Watson, Y.14
Zinkewich-Peotti, K.15
Rolfe, L.16
Jackson, A.17
-
36
-
-
33846441659
-
Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer
-
Kamat AA, Kim TJ, Landen Jr CN, Lu C, Han LY, Lin YG, Merritt WM, Thaker PH, Gershenson DM, Bischoff FZ, Heymach JV, Jaffe RB, Coleman RL, Sood AK (2007) Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer. Cancer Res 67: 281-288
-
(2007)
Cancer Res
, vol.67
, pp. 281-288
-
-
Kamat, A.A.1
Kim, T.J.2
Landen Jr, C.N.3
Lu, C.4
Han, L.Y.5
Lin, Y.G.6
Merritt, W.M.7
Thaker, P.H.8
Gershenson, D.M.9
Bischoff, F.Z.10
Heymach, J.V.11
Jaffe, R.B.12
Coleman, R.L.13
Sood, A.K.14
-
37
-
-
32944474182
-
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
-
Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM (2006) VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 290: H560-H576
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Kamba, T.1
Tam, B.Y.2
Hashizume, H.3
Haskell, A.4
Sennino, B.5
Mancuso, M.R.6
Norberg, S.M.7
O'Brien, S.M.8
Davis, R.B.9
Gowen, L.C.10
Anderson, K.D.11
Thurston, G.12
Joho, S.13
Springer, M.L.14
Kuo, C.J.15
McDonald, D.M.16
-
38
-
-
0034087691
-
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
-
Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, Bohlen P, Kerbel RS (2000) Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 105: R15-R24
-
(2000)
J Clin Invest
, vol.105
-
-
Klement, G.1
Baruchel, S.2
Rak, J.3
Man, S.4
Clark, K.5
Hicklin, D.J.6
Bohlen, P.7
Kerbel, R.S.8
-
39
-
-
34547100525
-
Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma
-
Lu C, Kamat AA, Lin YG, Merritt WM, Landen CN, Kim TJ, Spannuth W, Arumugam T, Han LY, Jennings NB, Logsdon C, Jaffe RB, Coleman RL, Sood AK (2007) Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma. Clin Cancer Res 13: 4209-4217
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4209-4217
-
-
Lu, C.1
Kamat, A.A.2
Lin, Y.G.3
Merritt, W.M.4
Landen, C.N.5
Kim, T.J.6
Spannuth, W.7
Arumugam, T.8
Han, L.Y.9
Jennings, N.B.10
Logsdon, C.11
Jaffe, R.B.12
Coleman, R.L.13
Sood, A.K.14
-
40
-
-
33745939679
-
Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy
-
Mancuso P, Colleoni M, Calleri A, Orlando L, Maisonneuve P, Pruneri G, Agliano A, Goldhirsch A, Shaked Y, Kerbel RS, Bertolini F (2006) Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy. Blood 108: 452-459
-
(2006)
Blood
, vol.108
, pp. 452-459
-
-
Mancuso, P.1
Colleoni, M.2
Calleri, A.3
Orlando, L.4
Maisonneuve, P.5
Pruneri, G.6
Agliano, A.7
Goldhirsch, A.8
Shaked, Y.9
Kerbel, R.S.10
Bertolini, F.11
-
41
-
-
34548764576
-
A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake
-
Mannavola D, Coco P, Vannucchi G, Bertuelli R, Carletto M, Casali PG, Beck-Peccoz P, Fugazzola L (2007) A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake. J Clin Endocrinol Metab 92: 3531-3534
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 3531-3534
-
-
Mannavola, D.1
Coco, P.2
Vannucchi, G.3
Bertuelli, R.4
Carletto, M.5
Casali, P.G.6
Beck-Peccoz, P.7
Fugazzola, L.8
-
42
-
-
58149225750
-
Phase II trial of sorafenib in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): A Gynecologic Oncology Group (GOG) study
-
Matei D, Sill MW, DeGeest K, Bristow RE (2008) Phase II trial of sorafenib in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): A Gynecologic Oncology Group (GOG) study. J Clin Oncol 26: 5537
-
(2008)
J Clin Oncol
, vol.26
, pp. 5537
-
-
Matei, D.1
Sill, M.W.2
DeGeest, K.3
Bristow, R.E.4
-
43
-
-
58149257819
-
Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer
-
Matulonis UA, Berlin ST, Krasner CN, Tyburski K, Lee J, Roche M, Ivy SP, Lenahan C, King M, Penson RT (2008) Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer. J Clin Oncol 26: 5501
-
(2008)
J Clin Oncol
, vol.26
, pp. 5501
-
-
Matulonis, U.A.1
Berlin, S.T.2
Krasner, C.N.3
Tyburski, K.4
Lee, J.5
Roche, M.6
Ivy, S.P.7
Lenahan, C.8
King, M.9
Penson, R.T.10
-
44
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K, Wang M, Gralow J, Dickler M, Cobleigh M, Perez EA, Shenkier T, Cella D, Davidson NE (2007) Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357: 2666-2676
-
(2007)
N Engl J Med
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
Dickler, M.4
Cobleigh, M.5
Perez, E.A.6
Shenkier, T.7
Cella, D.8
Davidson, N.E.9
-
45
-
-
33846478656
-
DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
-
O'Connor JP, Jackson A, Parker GJ, Jayson GC (2007) DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer 96: 189-195
-
(2007)
Br J Cancer
, vol.96
, pp. 189-195
-
-
O'Connor, J.P.1
Jackson, A.2
Parker, G.J.3
Jayson, G.C.4
-
46
-
-
33750069768
-
Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: Increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas
-
Osada R, Horiuchi A, Kikuchi N, Ohira S, Ota M, Katsuyama Y, Konishi I (2006) Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas. Hum Pathol 37: 1414-1425
-
(2006)
Hum Pathol
, vol.37
, pp. 1414-1425
-
-
Osada, R.1
Horiuchi, A.2
Kikuchi, N.3
Ohira, S.4
Ota, M.5
Katsuyama, Y.6
Konishi, I.7
-
47
-
-
33947304431
-
Phase II study of carboplatin, paclitaxel and bevacizumab as first line chemotherapy and consolidation for advanced müllerian tumors
-
Penson RT, Cannistra SA, Seiden MV, Krasner CN, Matulonis UA, Horowitz NS, Berlin S, Dizon DS, Lee H, Campos SM (2006) Phase II study of carboplatin, paclitaxel and bevacizumab as first line chemotherapy and consolidation for advanced müllerian tumors. J Clin Oncol 24: 5020
-
(2006)
J Clin Oncol
, vol.24
, pp. 5020
-
-
Penson, R.T.1
Cannistra, S.A.2
Seiden, M.V.3
Krasner, C.N.4
Matulonis, U.A.5
Horowitz, N.S.6
Berlin, S.7
Dizon, D.S.8
Lee, H.9
Campos, S.M.10
-
49
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Hutson TE, Margolin K, Harmon CS, DePrimo SE, Kim ST, Chen I, George DJ (2008) Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 26: 3743-3748
-
(2008)
J Clin Oncol
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
Bukowski, R.M.4
Sosman, J.A.5
Stadler, W.M.6
Hutson, T.E.7
Margolin, K.8
Harmon, C.S.9
DePrimo, S.E.10
Kim, S.T.11
Chen, I.12
George, D.J.13
-
50
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355: 2542-2550
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
51
-
-
34249822498
-
Genes that distinguish physiological and pathological angiogenesis
-
Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B (2007) Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 11: 539-554
-
(2007)
Cancer Cell
, vol.11
, pp. 539-554
-
-
Seaman, S.1
Stevens, J.2
Yang, M.Y.3
Logsdon, D.4
Graff-Cherry, C.5
St Croix, B.6
-
52
-
-
27144468094
-
Cellular and molecular surrogate markers to monitor targeted and non-targeted antiangiogenic drug activity and determine optimal biologic dose
-
Shaked Y, Bocci G, Munoz R, Man S, Ebos JM, Hicklin DJ, Bertolini F, D'Amato R, Kerbel RS (2005) Cellular and molecular surrogate markers to monitor targeted and non-targeted antiangiogenic drug activity and determine optimal biologic dose. Curr Cancer Drug Targets 5: 551-559
-
(2005)
Curr Cancer Drug Targets
, vol.5
, pp. 551-559
-
-
Shaked, Y.1
Bocci, G.2
Munoz, R.3
Man, S.4
Ebos, J.M.5
Hicklin, D.J.6
Bertolini, F.7
D'Amato, R.8
Kerbel, R.S.9
-
53
-
-
0034046917
-
Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma
-
Shen GH, Ghazizadeh M, Kawanami O, Shimizu H, Jin E, Araki T, Sugisaki Y (2000) Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma. Br J Cancer 83: 196-203
-
(2000)
Br J Cancer
, vol.83
, pp. 196-203
-
-
Shen, G.H.1
Ghazizadeh, M.2
Kawanami, O.3
Shimizu, H.4
Jin, E.5
Araki, T.6
Sugisaki, Y.7
-
54
-
-
18744423896
-
Prognostic significance of tumor angiogenesis in epithelial ovarian cancer: In association with transforming growth factor beta and vascular endothelial growth factor
-
Sonmezer M, Gungor M, Ensari A, Ortac F (2004) Prognostic significance of tumor angiogenesis in epithelial ovarian cancer: in association with transforming growth factor beta and vascular endothelial growth factor. Int J Gynecol Cancer 14: 82-88
-
(2004)
Int J Gynecol Cancer
, vol.14
, pp. 82-88
-
-
Sonmezer, M.1
Gungor, M.2
Ensari, A.3
Ortac, F.4
-
55
-
-
44349104675
-
Circulating endothelial cells in oncology: Pitfalls and promises
-
Strijbos MH, Gratama JW, Kraan J, Lamers CH, den Bakker MA, Sleijfer S (2008) Circulating endothelial cells in oncology: pitfalls and promises. Br J Cancer 98: 1731-1735
-
(2008)
Br J Cancer
, vol.98
, pp. 1731-1735
-
-
Strijbos, M.H.1
Gratama, J.W.2
Kraan, J.3
Lamers, C.H.4
den Bakker, M.A.5
Sleijfer, S.6
-
57
-
-
48349129069
-
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
-
Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Yla-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454: 656-660
-
(2008)
Nature
, vol.454
, pp. 656-660
-
-
Tammela, T.1
Zarkada, G.2
Wallgard, E.3
Murtomaki, A.4
Suchting, S.5
Wirzenius, M.6
Waltari, M.7
Hellstrom, M.8
Schomber, T.9
Peltonen, R.10
Freitas, C.11
Duarte, A.12
Isoniemi, H.13
Laakkonen, P.14
Christofori, G.15
Yla-Herttuala, S.16
Shibuya, M.17
Pytowski, B.18
Eichmann, A.19
Betsholtz, C.20
Alitalo, K.21
more..
-
58
-
-
36849005801
-
VEGF-Trap for patients (pts) with recurrent platinum-resistant epithelial ovarian cancer (EOC): Preliminary results of a randomized, multicenter phase II study
-
Tew WP, Colombo N, Ray-Coquard A, Oza AJ, del Campo G, Scambia D, Spriggs (2007) VEGF-Trap for patients (pts) with recurrent platinum-resistant epithelial ovarian cancer (EOC): Preliminary results of a randomized, multicenter phase II study. J Clin Oncol 25: 5508
-
(2007)
J Clin Oncol
, vol.25
, pp. 5508
-
-
Tew, W.P.1
Colombo, N.2
Ray-Coquard, A.3
Oza, A.J.4
del Campo, G.5
Scambia, D.6
Spriggs7
-
59
-
-
34247539127
-
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
-
Thurston G, Noguera-Troise I, Yancopoulos GD (2007) The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer 7: 327-331
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 327-331
-
-
Thurston, G.1
Noguera-Troise, I.2
Yancopoulos, G.D.3
-
60
-
-
0027997863
-
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
-
Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 26988-26995
-
(1994)
J Biol Chem
, vol.269
, pp. 26988-26995
-
-
Waltenberger, J.1
Claesson-Welsh, L.2
Siegbahn, A.3
Shibuya, M.4
Heldin, C.H.5
-
61
-
-
33644863001
-
Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
-
Wedam SB, Low JA, Yang SX, Chow CK, Choyke P, Danforth D, Hewitt SM, Berman A, Steinberg SM, Liewehr DJ, Plehn J, Doshi A, Thomasson D, McCarthy N, Koeppen H, Sherman M, Zujewski J, Camphausen K, Chen H, Swain SM (2006) Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol 24: 769-777
-
(2006)
J Clin Oncol
, vol.24
, pp. 769-777
-
-
Wedam, S.B.1
Low, J.A.2
Yang, S.X.3
Chow, C.K.4
Choyke, P.5
Danforth, D.6
Hewitt, S.M.7
Berman, A.8
Steinberg, S.M.9
Liewehr, D.J.10
Plehn, J.11
Doshi, A.12
Thomasson, D.13
McCarthy, N.14
Koeppen, H.15
Sherman, M.16
Zujewski, J.17
Camphausen, K.18
Chen, H.19
Swain, S.M.20
more..
|